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Q9QY42 (GPR37_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prosaposin receptor GPR37
Alternative name(s):
G-protein coupled receptor 37
Gene names
Name:Gpr37
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

Subunit structure

Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Post-translational modification

Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QY42-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QY42-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.
Isoform 3 (identifier: Q9QY42-3)

The sequence of this isoform differs from the canonical sequence as follows:
     418-440: IYVLALTYDGARLWWYFGCYFCL → VQVERDCFIKIRTRNHWIRLSHL
     441-600: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 600574Prosaposin receptor GPR37
PRO_0000012800

Regions

Topological domain27 – 252226Extracellular Potential
Transmembrane253 – 27321Helical; Name=1; Potential
Topological domain274 – 28613Cytoplasmic Potential
Transmembrane287 – 30721Helical; Name=2; Potential
Topological domain308 – 32215Extracellular Potential
Transmembrane323 – 34321Helical; Name=3; Potential
Topological domain344 – 36623Cytoplasmic Potential
Transmembrane367 – 38721Helical; Name=4; Potential
Topological domain388 – 43043Extracellular Potential
Transmembrane431 – 45121Helical; Name=5; Potential
Topological domain452 – 48029Cytoplasmic Potential
Transmembrane481 – 50121Helical; Name=6; Potential
Topological domain502 – 51817Extracellular Potential
Transmembrane519 – 53921Helical; Name=7; Potential
Topological domain540 – 60061Cytoplasmic Potential
Compositional bias538 – 55821Cys-rich
Compositional bias550 – 5556Poly-Cys

Amino acid modifications

Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Disulfide bond321 ↔ 406 By similarity

Natural variations

Alternative sequence1 – 251251Missing in isoform 2.
VSP_011762
Alternative sequence418 – 44023IYVLA…CYFCL → VQVERDCFIKIRTRNHWIRL SHL in isoform 3.
VSP_011763
Alternative sequence441 – 600160Missing in isoform 3.
VSP_011764

Experimental info

Sequence conflict2051R → M in BAC27911. Ref.3
Sequence conflict2241R → P in CAA11247. Ref.1
Sequence conflict2241R → P in CAA11579. Ref.1
Sequence conflict2281T → P in CAA11247. Ref.1
Sequence conflict2281T → P in CAA11579. Ref.1
Sequence conflict3261Y → N in BAC27911. Ref.3
Sequence conflict3991G → V in BAC31956. Ref.3
Sequence conflict5511C → Y in BAC27911. Ref.3
Sequence conflict5981T → N in BAC27911. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 5F92E65984746B30

FASTA60066,775
        10         20         30         40         50         60 
MPARGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIQR RSRDARGPGN 

        70         80         90        100        110        120 
SAKDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE AAAAGPLGPP TKPPSAWRWK 

       130        140        150        160        170        180 
SAQGKEPSGH LRRRDPTDPQ LFFPTSEGGE MSSKRDGIPQ SRQEHSVKTE PRDLFYWPRR 

       190        200        210        220        230        240 
TGQLQDSQHR PSAVHEGRTL APPGRALPQN GSADDWVPDQ GGPRRGNTTR RVRLKNPFYP 

       250        260        270        280        290        300 
LTQESYGAYA VMCLSVVIFG TGIIGNLAVM CIVCHNYYMR SISNSLLANL AFWDFLIIFF 

       310        320        330        340        350        360 
CLPLVIFHEL TKKWLLEDFS CKIVPYIEVA SLGVTTFTLC ALCIDRFRAA TNVQMYYEMI 

       370        380        390        400        410        420 
ENCSSTTAKL AVIWVGALLL ALPEVVLRQL SKEDLGFSGQ APAERCVIKI SPDLPDTIYV 

       430        440        450        460        470        480 
LALTYDGARL WWYFGCYFCL PTLFTITCSL VTARKIRKAE KASTRGNKRQ IHLESQMNCT 

       490        500        510        520        530        540 
VVALTILYGF CIIPENICNI VTAYMATGVS QQTMDLLNII SQFLLFFKSC VTPVLLFCLC 

       550        560        570        580        590        600 
RPFSRAFMEC CCCCCEECIQ KSSTVTSDDN DNEYTTELEL SPFSTIRREM STFASVGTHC 

« Hide

Isoform 2 [UniParc].

Checksum: 4064D99EE7258E42
Show »

FASTA34939,278
Isoform 3 [UniParc].

Checksum: 45B9B3940948FB76
Show »

FASTA44048,926

References

« Hide 'large scale' references
[1]"Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis."
Marazziti D., Gallo A., Golini E., Matteoni R., Tocchini-Valentini G.P.
Genomics 53:315-324(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
Strain: BALB/c.
Tissue: Brain and Liver.
[2]"Genomic structure of the murine G protein-coupled receptor 37 on chromosome 6."
Platzer M., Zhao W., Herman G.E., Rosenthal A.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Strain: C57BL/6J.
Tissue: Eye, Olfactory bulb and Retina.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ223305 mRNA. Translation: CAA11247.1.
AJ223834, AJ223835 Genomic DNA. Translation: CAA11579.1.
AF132039 Genomic DNA. Translation: AAF22144.1.
AK032525 mRNA. Translation: BAC27911.1.
AK044508 mRNA. Translation: BAC31956.1.
AK053287 mRNA. Translation: BAC35333.1.
BC031918 mRNA. Translation: AAH31918.1.
RefSeqNP_034468.2. NM_010338.2.
UniGeneMm.409670.

3D structure databases

ProteinModelPortalQ9QY42.
SMRQ9QY42. Positions 230-547.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9QY42.

Proteomic databases

PRIDEQ9QY42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054867; ENSMUSP00000052185; ENSMUSG00000039904. [Q9QY42-1]
GeneID14763.
KEGGmmu:14763.
UCSCuc009bcd.2. mouse. [Q9QY42-1]

Organism-specific databases

CTD2861.
MGIMGI:1313297. Gpr37.

Phylogenomic databases

eggNOGNOG291459.
GeneTreeENSGT00690000101856.
HOGENOMHOG000252922.
HOVERGENHBG051808.
InParanoidQ9QY42.
KOK04243.
OMAIQRRSRD.
OrthoDBEOG79SDX9.
PhylomeDBQ9QY42.
TreeFamTF331292.

Gene expression databases

BgeeQ9QY42.
CleanExMM_GPR37.
GenevestigatorQ9QY42.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286843.
PROQ9QY42.
SOURCESearch...

Entry information

Entry nameGPR37_MOUSE
AccessionPrimary (citable) accession number: Q9QY42
Secondary accession number(s): Q8BKF8 expand/collapse secondary AC list , Q8BXP9, Q8C022, Q9Z0G3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries