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Q9QY42

- GPR37_MOUSE

UniProt

Q9QY42 - GPR37_MOUSE

Protein

Prosaposin receptor GPR37

Gene

Gpr37

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. dopamine biosynthetic process Source: MGI
    2. locomotion involved in locomotory behavior Source: MGI
    3. positive regulation of dopamine metabolic process Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prosaposin receptor GPR37
    Alternative name(s):
    G-protein coupled receptor 37
    Gene namesi
    Name:Gpr37
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1313297. Gpr37.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell
    4. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 600574Prosaposin receptor GPR37PRO_0000012800Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi321 ↔ 406PROSITE-ProRule annotation

    Post-translational modificationi

    Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ9QY42.

    PTM databases

    PhosphoSiteiQ9QY42.

    Expressioni

    Gene expression databases

    BgeeiQ9QY42.
    CleanExiMM_GPR37.
    GenevestigatoriQ9QY42.

    Interactioni

    Subunit structurei

    Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QY42.
    SMRiQ9QY42. Positions 230-547.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 252226ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 32215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 36623CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini388 – 43043ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini452 – 48029CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini502 – 51817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini540 – 60061CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei253 – 27321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei481 – 50121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei519 – 53921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi538 – 55821Cys-richAdd
    BLAST
    Compositional biasi550 – 5556Poly-Cys

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291459.
    GeneTreeiENSGT00690000101856.
    HOGENOMiHOG000252922.
    HOVERGENiHBG051808.
    InParanoidiQ9QY42.
    KOiK04243.
    OMAiIQRRSRD.
    OrthoDBiEOG79SDX9.
    PhylomeDBiQ9QY42.
    TreeFamiTF331292.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QY42-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPARGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIQR    50
    RSRDARGPGN SAKDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE 100
    AAAAGPLGPP TKPPSAWRWK SAQGKEPSGH LRRRDPTDPQ LFFPTSEGGE 150
    MSSKRDGIPQ SRQEHSVKTE PRDLFYWPRR TGQLQDSQHR PSAVHEGRTL 200
    APPGRALPQN GSADDWVPDQ GGPRRGNTTR RVRLKNPFYP LTQESYGAYA 250
    VMCLSVVIFG TGIIGNLAVM CIVCHNYYMR SISNSLLANL AFWDFLIIFF 300
    CLPLVIFHEL TKKWLLEDFS CKIVPYIEVA SLGVTTFTLC ALCIDRFRAA 350
    TNVQMYYEMI ENCSSTTAKL AVIWVGALLL ALPEVVLRQL SKEDLGFSGQ 400
    APAERCVIKI SPDLPDTIYV LALTYDGARL WWYFGCYFCL PTLFTITCSL 450
    VTARKIRKAE KASTRGNKRQ IHLESQMNCT VVALTILYGF CIIPENICNI 500
    VTAYMATGVS QQTMDLLNII SQFLLFFKSC VTPVLLFCLC RPFSRAFMEC 550
    CCCCCEECIQ KSSTVTSDDN DNEYTTELEL SPFSTIRREM STFASVGTHC 600
    Length:600
    Mass (Da):66,775
    Last modified:May 1, 2000 - v1
    Checksum:i5F92E65984746B30
    GO
    Isoform 2 (identifier: Q9QY42-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-251: Missing.

    Show »
    Length:349
    Mass (Da):39,278
    Checksum:i4064D99EE7258E42
    GO
    Isoform 3 (identifier: Q9QY42-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         418-440: IYVLALTYDGARLWWYFGCYFCL → VQVERDCFIKIRTRNHWIRLSHL
         441-600: Missing.

    Show »
    Length:440
    Mass (Da):48,926
    Checksum:i45B9B3940948FB76
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti205 – 2051R → M in BAC27911. (PubMed:16141072)Curated
    Sequence conflicti224 – 2241R → P in CAA11247. (PubMed:9799598)Curated
    Sequence conflicti224 – 2241R → P in CAA11579. (PubMed:9799598)Curated
    Sequence conflicti228 – 2281T → P in CAA11247. (PubMed:9799598)Curated
    Sequence conflicti228 – 2281T → P in CAA11579. (PubMed:9799598)Curated
    Sequence conflicti326 – 3261Y → N in BAC27911. (PubMed:16141072)Curated
    Sequence conflicti399 – 3991G → V in BAC31956. (PubMed:16141072)Curated
    Sequence conflicti551 – 5511C → Y in BAC27911. (PubMed:16141072)Curated
    Sequence conflicti598 – 5981T → N in BAC27911. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 251251Missing in isoform 2. 1 PublicationVSP_011762Add
    BLAST
    Alternative sequencei418 – 44023IYVLA…CYFCL → VQVERDCFIKIRTRNHWIRL SHL in isoform 3. 1 PublicationVSP_011763Add
    BLAST
    Alternative sequencei441 – 600160Missing in isoform 3. 1 PublicationVSP_011764Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223305 mRNA. Translation: CAA11247.1.
    AJ223834, AJ223835 Genomic DNA. Translation: CAA11579.1.
    AF132039 Genomic DNA. Translation: AAF22144.1.
    AK032525 mRNA. Translation: BAC27911.1.
    AK044508 mRNA. Translation: BAC31956.1.
    AK053287 mRNA. Translation: BAC35333.1.
    BC031918 mRNA. Translation: AAH31918.1.
    CCDSiCCDS19949.1. [Q9QY42-1]
    RefSeqiNP_034468.2. NM_010338.2. [Q9QY42-1]
    UniGeneiMm.409670.

    Genome annotation databases

    EnsembliENSMUST00000054867; ENSMUSP00000052185; ENSMUSG00000039904. [Q9QY42-1]
    GeneIDi14763.
    KEGGimmu:14763.
    UCSCiuc009bcd.2. mouse. [Q9QY42-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ223305 mRNA. Translation: CAA11247.1 .
    AJ223834 , AJ223835 Genomic DNA. Translation: CAA11579.1 .
    AF132039 Genomic DNA. Translation: AAF22144.1 .
    AK032525 mRNA. Translation: BAC27911.1 .
    AK044508 mRNA. Translation: BAC31956.1 .
    AK053287 mRNA. Translation: BAC35333.1 .
    BC031918 mRNA. Translation: AAH31918.1 .
    CCDSi CCDS19949.1. [Q9QY42-1 ]
    RefSeqi NP_034468.2. NM_010338.2. [Q9QY42-1 ]
    UniGenei Mm.409670.

    3D structure databases

    ProteinModelPortali Q9QY42.
    SMRi Q9QY42. Positions 230-547.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9QY42.

    Proteomic databases

    PRIDEi Q9QY42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054867 ; ENSMUSP00000052185 ; ENSMUSG00000039904 . [Q9QY42-1 ]
    GeneIDi 14763.
    KEGGi mmu:14763.
    UCSCi uc009bcd.2. mouse. [Q9QY42-1 ]

    Organism-specific databases

    CTDi 2861.
    MGIi MGI:1313297. Gpr37.

    Phylogenomic databases

    eggNOGi NOG291459.
    GeneTreei ENSGT00690000101856.
    HOGENOMi HOG000252922.
    HOVERGENi HBG051808.
    InParanoidi Q9QY42.
    KOi K04243.
    OMAi IQRRSRD.
    OrthoDBi EOG79SDX9.
    PhylomeDBi Q9QY42.
    TreeFami TF331292.

    Miscellaneous databases

    NextBioi 286843.
    PROi Q9QY42.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QY42.
    CleanExi MM_GPR37.
    Genevestigatori Q9QY42.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003909. GPR37_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01421. GPR37ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis."
      Marazziti D., Gallo A., Golini E., Matteoni R., Tocchini-Valentini G.P.
      Genomics 53:315-324(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Brain and Liver.
    2. "Genomic structure of the murine G protein-coupled receptor 37 on chromosome 6."
      Platzer M., Zhao W., Herman G.E., Rosenthal A.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Eye, Olfactory bulb and Retina.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.

    Entry informationi

    Entry nameiGPR37_MOUSE
    AccessioniPrimary (citable) accession number: Q9QY42
    Secondary accession number(s): Q8BKF8
    , Q8BXP9, Q8C022, Q9Z0G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3