SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9QY42

- GPR37_MOUSE

UniProt

Q9QY42 - GPR37_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Prosaposin receptor GPR37
Gene
Gpr37
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. dopamine biosynthetic process Source: MGI
  2. locomotion involved in locomotory behavior Source: MGI
  3. positive regulation of dopamine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37
Alternative name(s):
G-protein coupled receptor 37
Gene namesi
Name:Gpr37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1313297. Gpr37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 252226Extracellular Reviewed prediction
Add
BLAST
Transmembranei253 – 27321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini274 – 28613Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei287 – 30721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini308 – 32215Extracellular Reviewed prediction
Add
BLAST
Transmembranei323 – 34321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini344 – 36623Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei367 – 38721Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini388 – 43043Extracellular Reviewed prediction
Add
BLAST
Transmembranei431 – 45121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini452 – 48029Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei481 – 50121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini502 – 51817Extracellular Reviewed prediction
Add
BLAST
Transmembranei519 – 53921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini540 – 60061Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
  4. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 600574Prosaposin receptor GPR37
PRO_0000012800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi321 ↔ 406 By similarity

Post-translational modificationi

Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ9QY42.

PTM databases

PhosphoSiteiQ9QY42.

Expressioni

Gene expression databases

BgeeiQ9QY42.
CleanExiMM_GPR37.
GenevestigatoriQ9QY42.

Interactioni

Subunit structurei

Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9QY42.
SMRiQ9QY42. Positions 230-547.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi538 – 55821Cys-rich
Add
BLAST
Compositional biasi550 – 5556Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00690000101856.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ9QY42.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG79SDX9.
PhylomeDBiQ9QY42.
TreeFamiTF331292.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QY42-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPARGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIQR    50
RSRDARGPGN SAKDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE 100
AAAAGPLGPP TKPPSAWRWK SAQGKEPSGH LRRRDPTDPQ LFFPTSEGGE 150
MSSKRDGIPQ SRQEHSVKTE PRDLFYWPRR TGQLQDSQHR PSAVHEGRTL 200
APPGRALPQN GSADDWVPDQ GGPRRGNTTR RVRLKNPFYP LTQESYGAYA 250
VMCLSVVIFG TGIIGNLAVM CIVCHNYYMR SISNSLLANL AFWDFLIIFF 300
CLPLVIFHEL TKKWLLEDFS CKIVPYIEVA SLGVTTFTLC ALCIDRFRAA 350
TNVQMYYEMI ENCSSTTAKL AVIWVGALLL ALPEVVLRQL SKEDLGFSGQ 400
APAERCVIKI SPDLPDTIYV LALTYDGARL WWYFGCYFCL PTLFTITCSL 450
VTARKIRKAE KASTRGNKRQ IHLESQMNCT VVALTILYGF CIIPENICNI 500
VTAYMATGVS QQTMDLLNII SQFLLFFKSC VTPVLLFCLC RPFSRAFMEC 550
CCCCCEECIQ KSSTVTSDDN DNEYTTELEL SPFSTIRREM STFASVGTHC 600
Length:600
Mass (Da):66,775
Last modified:May 1, 2000 - v1
Checksum:i5F92E65984746B30
GO
Isoform 2 (identifier: Q9QY42-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.

Show »
Length:349
Mass (Da):39,278
Checksum:i4064D99EE7258E42
GO
Isoform 3 (identifier: Q9QY42-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-440: IYVLALTYDGARLWWYFGCYFCL → VQVERDCFIKIRTRNHWIRLSHL
     441-600: Missing.

Show »
Length:440
Mass (Da):48,926
Checksum:i45B9B3940948FB76
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 251251Missing in isoform 2.
VSP_011762Add
BLAST
Alternative sequencei418 – 44023IYVLA…CYFCL → VQVERDCFIKIRTRNHWIRL SHL in isoform 3.
VSP_011763Add
BLAST
Alternative sequencei441 – 600160Missing in isoform 3.
VSP_011764Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051R → M in BAC27911. 1 Publication
Sequence conflicti224 – 2241R → P in CAA11247. 1 Publication
Sequence conflicti224 – 2241R → P in CAA11579. 1 Publication
Sequence conflicti228 – 2281T → P in CAA11247. 1 Publication
Sequence conflicti228 – 2281T → P in CAA11579. 1 Publication
Sequence conflicti326 – 3261Y → N in BAC27911. 1 Publication
Sequence conflicti399 – 3991G → V in BAC31956. 1 Publication
Sequence conflicti551 – 5511C → Y in BAC27911. 1 Publication
Sequence conflicti598 – 5981T → N in BAC27911. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223305 mRNA. Translation: CAA11247.1.
AJ223834, AJ223835 Genomic DNA. Translation: CAA11579.1.
AF132039 Genomic DNA. Translation: AAF22144.1.
AK032525 mRNA. Translation: BAC27911.1.
AK044508 mRNA. Translation: BAC31956.1.
AK053287 mRNA. Translation: BAC35333.1.
BC031918 mRNA. Translation: AAH31918.1.
CCDSiCCDS19949.1. [Q9QY42-1]
RefSeqiNP_034468.2. NM_010338.2. [Q9QY42-1]
UniGeneiMm.409670.

Genome annotation databases

EnsembliENSMUST00000054867; ENSMUSP00000052185; ENSMUSG00000039904. [Q9QY42-1]
GeneIDi14763.
KEGGimmu:14763.
UCSCiuc009bcd.2. mouse. [Q9QY42-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ223305 mRNA. Translation: CAA11247.1 .
AJ223834 , AJ223835 Genomic DNA. Translation: CAA11579.1 .
AF132039 Genomic DNA. Translation: AAF22144.1 .
AK032525 mRNA. Translation: BAC27911.1 .
AK044508 mRNA. Translation: BAC31956.1 .
AK053287 mRNA. Translation: BAC35333.1 .
BC031918 mRNA. Translation: AAH31918.1 .
CCDSi CCDS19949.1. [Q9QY42-1 ]
RefSeqi NP_034468.2. NM_010338.2. [Q9QY42-1 ]
UniGenei Mm.409670.

3D structure databases

ProteinModelPortali Q9QY42.
SMRi Q9QY42. Positions 230-547.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QY42.

Proteomic databases

PRIDEi Q9QY42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054867 ; ENSMUSP00000052185 ; ENSMUSG00000039904 . [Q9QY42-1 ]
GeneIDi 14763.
KEGGi mmu:14763.
UCSCi uc009bcd.2. mouse. [Q9QY42-1 ]

Organism-specific databases

CTDi 2861.
MGIi MGI:1313297. Gpr37.

Phylogenomic databases

eggNOGi NOG291459.
GeneTreei ENSGT00690000101856.
HOGENOMi HOG000252922.
HOVERGENi HBG051808.
InParanoidi Q9QY42.
KOi K04243.
OMAi IQRRSRD.
OrthoDBi EOG79SDX9.
PhylomeDBi Q9QY42.
TreeFami TF331292.

Miscellaneous databases

NextBioi 286843.
PROi Q9QY42.
SOURCEi Search...

Gene expression databases

Bgeei Q9QY42.
CleanExi MM_GPR37.
Genevestigatori Q9QY42.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis."
    Marazziti D., Gallo A., Golini E., Matteoni R., Tocchini-Valentini G.P.
    Genomics 53:315-324(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Brain and Liver.
  2. "Genomic structure of the murine G protein-coupled receptor 37 on chromosome 6."
    Platzer M., Zhao W., Herman G.E., Rosenthal A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Eye, Olfactory bulb and Retina.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.

Entry informationi

Entry nameiGPR37_MOUSE
AccessioniPrimary (citable) accession number: Q9QY42
Secondary accession number(s): Q8BKF8
, Q8BXP9, Q8C022, Q9Z0G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi