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Protein

Prosaposin receptor GPR37

Gene

Gpr37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  • dopamine biosynthetic process Source: MGI
  • locomotion involved in locomotory behavior Source: MGI
  • negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
  • positive regulation of dopamine metabolic process Source: MGI
  • positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prosaposin receptor GPR37
Alternative name(s):
G-protein coupled receptor 37
Gene namesi
Name:Gpr37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1313297. Gpr37.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 252226ExtracellularSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini274 – 28613CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini308 – 32215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei323 – 34321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini344 – 36623CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei367 – 38721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini388 – 43043ExtracellularSequence AnalysisAdd
BLAST
Transmembranei431 – 45121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini452 – 48029CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei481 – 50121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini502 – 51817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei519 – 53921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini540 – 60061CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 600574Prosaposin receptor GPR37PRO_0000012800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi321 ↔ 406PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated by PARK2 in the presence of ubiquitin-conjugating enzymes in the endoplasmic reticulum.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ9QY42.

PTM databases

PhosphoSiteiQ9QY42.

Expressioni

Gene expression databases

BgeeiQ9QY42.
CleanExiMM_GPR37.
GenevisibleiQ9QY42. MM.

Interactioni

Subunit structurei

Forms a complex with PARK2, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052185.

Structurei

3D structure databases

ProteinModelPortaliQ9QY42.
SMRiQ9QY42. Positions 230-547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi538 – 55821Cys-richAdd
BLAST
Compositional biasi550 – 5556Poly-Cys

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ9QY42.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG79SDX9.
PhylomeDBiQ9QY42.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QY42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPARGAPLSR TSRLLLLLLF KVSVSAALSF VPEPRNGTCL GESCSPLIQR
60 70 80 90 100
RSRDARGPGN SAKDALRVHV PREKLEAEVR GATSWDLPPP RGGDTGVIEE
110 120 130 140 150
AAAAGPLGPP TKPPSAWRWK SAQGKEPSGH LRRRDPTDPQ LFFPTSEGGE
160 170 180 190 200
MSSKRDGIPQ SRQEHSVKTE PRDLFYWPRR TGQLQDSQHR PSAVHEGRTL
210 220 230 240 250
APPGRALPQN GSADDWVPDQ GGPRRGNTTR RVRLKNPFYP LTQESYGAYA
260 270 280 290 300
VMCLSVVIFG TGIIGNLAVM CIVCHNYYMR SISNSLLANL AFWDFLIIFF
310 320 330 340 350
CLPLVIFHEL TKKWLLEDFS CKIVPYIEVA SLGVTTFTLC ALCIDRFRAA
360 370 380 390 400
TNVQMYYEMI ENCSSTTAKL AVIWVGALLL ALPEVVLRQL SKEDLGFSGQ
410 420 430 440 450
APAERCVIKI SPDLPDTIYV LALTYDGARL WWYFGCYFCL PTLFTITCSL
460 470 480 490 500
VTARKIRKAE KASTRGNKRQ IHLESQMNCT VVALTILYGF CIIPENICNI
510 520 530 540 550
VTAYMATGVS QQTMDLLNII SQFLLFFKSC VTPVLLFCLC RPFSRAFMEC
560 570 580 590 600
CCCCCEECIQ KSSTVTSDDN DNEYTTELEL SPFSTIRREM STFASVGTHC
Length:600
Mass (Da):66,775
Last modified:May 1, 2000 - v1
Checksum:i5F92E65984746B30
GO
Isoform 2 (identifier: Q9QY42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.

Show »
Length:349
Mass (Da):39,278
Checksum:i4064D99EE7258E42
GO
Isoform 3 (identifier: Q9QY42-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-440: IYVLALTYDGARLWWYFGCYFCL → VQVERDCFIKIRTRNHWIRLSHL
     441-600: Missing.

Show »
Length:440
Mass (Da):48,926
Checksum:i45B9B3940948FB76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051R → M in BAC27911 (PubMed:16141072).Curated
Sequence conflicti224 – 2241R → P in CAA11247 (PubMed:9799598).Curated
Sequence conflicti224 – 2241R → P in CAA11579 (PubMed:9799598).Curated
Sequence conflicti228 – 2281T → P in CAA11247 (PubMed:9799598).Curated
Sequence conflicti228 – 2281T → P in CAA11579 (PubMed:9799598).Curated
Sequence conflicti326 – 3261Y → N in BAC27911 (PubMed:16141072).Curated
Sequence conflicti399 – 3991G → V in BAC31956 (PubMed:16141072).Curated
Sequence conflicti551 – 5511C → Y in BAC27911 (PubMed:16141072).Curated
Sequence conflicti598 – 5981T → N in BAC27911 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 251251Missing in isoform 2. 1 PublicationVSP_011762Add
BLAST
Alternative sequencei418 – 44023IYVLA…CYFCL → VQVERDCFIKIRTRNHWIRL SHL in isoform 3. 1 PublicationVSP_011763Add
BLAST
Alternative sequencei441 – 600160Missing in isoform 3. 1 PublicationVSP_011764Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223305 mRNA. Translation: CAA11247.1.
AJ223834, AJ223835 Genomic DNA. Translation: CAA11579.1.
AF132039 Genomic DNA. Translation: AAF22144.1.
AK032525 mRNA. Translation: BAC27911.1.
AK044508 mRNA. Translation: BAC31956.1.
AK053287 mRNA. Translation: BAC35333.1.
BC031918 mRNA. Translation: AAH31918.1.
CCDSiCCDS19949.1. [Q9QY42-1]
RefSeqiNP_034468.2. NM_010338.2. [Q9QY42-1]
UniGeneiMm.409670.

Genome annotation databases

EnsembliENSMUST00000054867; ENSMUSP00000052185; ENSMUSG00000039904. [Q9QY42-1]
GeneIDi14763.
KEGGimmu:14763.
UCSCiuc009bcd.2. mouse. [Q9QY42-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223305 mRNA. Translation: CAA11247.1.
AJ223834, AJ223835 Genomic DNA. Translation: CAA11579.1.
AF132039 Genomic DNA. Translation: AAF22144.1.
AK032525 mRNA. Translation: BAC27911.1.
AK044508 mRNA. Translation: BAC31956.1.
AK053287 mRNA. Translation: BAC35333.1.
BC031918 mRNA. Translation: AAH31918.1.
CCDSiCCDS19949.1. [Q9QY42-1]
RefSeqiNP_034468.2. NM_010338.2. [Q9QY42-1]
UniGeneiMm.409670.

3D structure databases

ProteinModelPortaliQ9QY42.
SMRiQ9QY42. Positions 230-547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052185.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9QY42.

Proteomic databases

PRIDEiQ9QY42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054867; ENSMUSP00000052185; ENSMUSG00000039904. [Q9QY42-1]
GeneIDi14763.
KEGGimmu:14763.
UCSCiuc009bcd.2. mouse. [Q9QY42-1]

Organism-specific databases

CTDi2861.
MGIiMGI:1313297. Gpr37.

Phylogenomic databases

eggNOGiNOG291459.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000252922.
HOVERGENiHBG051808.
InParanoidiQ9QY42.
KOiK04243.
OMAiIQRRSRD.
OrthoDBiEOG79SDX9.
PhylomeDBiQ9QY42.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi286843.
PROiQ9QY42.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QY42.
CleanExiMM_GPR37.
GenevisibleiQ9QY42. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003909. GPR37_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01421. GPR37ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis."
    Marazziti D., Gallo A., Golini E., Matteoni R., Tocchini-Valentini G.P.
    Genomics 53:315-324(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Brain and Liver.
  2. "Genomic structure of the murine G protein-coupled receptor 37 on chromosome 6."
    Platzer M., Zhao W., Herman G.E., Rosenthal A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Eye, Olfactory bulb and Retina.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.

Entry informationi

Entry nameiGPR37_MOUSE
AccessioniPrimary (citable) accession number: Q9QY42
Secondary accession number(s): Q8BKF8
, Q8BXP9, Q8C022, Q9Z0G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.