ID   TSN3_MOUSE              Reviewed;         253 AA.
AC   Q9QY33; Q9EQG4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Tetraspanin-3;
DE            Short=Tspan-3;
DE   AltName: Full=OSP-associated protein 1;
DE            Short=OAP-1;
DE   AltName: Full=Tetraspanin TM4-A;
DE   AltName: Full=Transmembrane 4 superfamily member 8;
GN   Name=Tspan3; Synonyms=Tm4sf8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RX   PubMed=11092739; DOI=10.3109/10425170009033242;
RA   Puls K.L., Wright M.D.;
RT   "The molecular characterisation of mouse tspan-3.";
RL   DNA Seq. 11:271-275(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH CLDN11.
RC   STRAIN=C57BL/6J;
RX   PubMed=11309411; DOI=10.1083/jcb.153.2.295;
RA   Tiwari-Woodruff S.K., Buznikov A.G., Vu T.Q., Micevych P.E., Chen K.,
RA   Kornblum H.I., Bronstein J.M.;
RT   "OSP/claudin-11 forms a complex with a novel member of the tetraspanin
RT   super family and beta1 integrin and regulates proliferation and migration
RT   of oligodendrocytes.";
RL   J. Cell Biol. 153:295-306(2001).
CC   -!- FUNCTION: Regulates the proliferation and migration of
CC       oligodendrocytes, a process essential for normal myelination and
CC       repair.
CC   -!- SUBUNIT: Interacts with claudin-11/CLDN11 and integrins.
CC       {ECO:0000269|PubMed:11309411}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; AF133427; AAF15362.1; -; mRNA.
DR   EMBL; AF242591; AAG49145.1; -; mRNA.
DR   CCDS; CCDS23207.1; -.
DR   RefSeq; NP_062767.3; NM_019793.3.
DR   AlphaFoldDB; Q9QY33; -.
DR   SMR; Q9QY33; -.
DR   CORUM; Q9QY33; -.
DR   STRING; 10090.ENSMUSP00000034876; -.
DR   GlyConnect; 2761; 13 N-Linked glycans (1 site).
DR   GlyCosmos; Q9QY33; 4 sites, 13 glycans.
DR   GlyGen; Q9QY33; 4 sites, 13 N-linked glycans (1 site).
DR   iPTMnet; Q9QY33; -.
DR   PhosphoSitePlus; Q9QY33; -.
DR   SwissPalm; Q9QY33; -.
DR   PaxDb; 10090-ENSMUSP00000034876; -.
DR   ProteomicsDB; 297665; -.
DR   Pumba; Q9QY33; -.
DR   Antibodypedia; 3085; 186 antibodies from 20 providers.
DR   DNASU; 56434; -.
DR   Ensembl; ENSMUST00000034876.10; ENSMUSP00000034876.9; ENSMUSG00000032324.12.
DR   GeneID; 56434; -.
DR   KEGG; mmu:56434; -.
DR   UCSC; uc009psx.2; mouse.
DR   AGR; MGI:1928098; -.
DR   CTD; 10099; -.
DR   MGI; MGI:1928098; Tspan3.
DR   VEuPathDB; HostDB:ENSMUSG00000032324; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000154954; -.
DR   HOGENOM; CLU_055524_5_2_1; -.
DR   InParanoid; Q9QY33; -.
DR   OMA; ISCCKIA; -.
DR   OrthoDB; 2913577at2759; -.
DR   PhylomeDB; Q9QY33; -.
DR   TreeFam; TF316345; -.
DR   BioGRID-ORCS; 56434; 1 hit in 78 CRISPR screens.
DR   ChiTaRS; Tspan3; mouse.
DR   PRO; PR:Q9QY33; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q9QY33; Protein.
DR   Bgee; ENSMUSG00000032324; Expressed in vestibular epithelium and 256 other cell types or tissues.
DR   ExpressionAtlas; Q9QY33; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd03163; TM4SF8_like_LEL; 1.
DR   Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; TETRASPANIN; 1.
DR   PANTHER; PTHR19282:SF48; TETRASPANIN-3; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   Genevisible; Q9QY33; MM.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..253
FT                   /note="Tetraspanin-3"
FT                   /id="PRO_0000219240"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..50
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..253
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        167
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        220
FT                   /note="A -> R (in Ref. 2; AAG49145)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        226
FT                   /note="G -> A (in Ref. 2; AAG49145)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   253 AA;  28049 MW;  8A7378F76263019A CRC64;
     MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT LFPAVVIIAV
     GALLFIIGLI GCCATIRESR CGLATFVFIL LLVFVTEVVV VVLGYVYRAK VENEVDRSIQ
     KVYKTYNGTN SDAASRAIDY VQRQLHCCGI HNYSDWENTD WFKETKNQSV PLSCCRETAK
     SCNGSLANPS DLYAEGCEAL VVKKLQEILM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD
     PAYELLITGG TYA
//