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Q9QY33 (TSN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-3

Short name=Tspan-3
Alternative name(s):
OSP-associated protein 1
Short name=OAP-1
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
Gene names
Name:Tspan3
Synonyms:Tm4sf8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Subunit structure

Interacts with claudin-11/CLDN11 and integrins. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Tetraspanin-3
PRO_0000219240

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Potential
Topological domain33 – 5018Extracellular Potential
Transmembrane51 – 7121Helical; Potential
Topological domain72 – 8514Cytoplasmic Potential
Transmembrane86 – 10621Helical; Potential
Topological domain107 – 212106Extracellular Potential
Transmembrane213 – 23321Helical; Potential
Topological domain234 – 25320Cytoplasmic Potential

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2201A → R in AAG49145. Ref.2
Sequence conflict2261G → A in AAG49145. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9QY33 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 8A7378F76263019A

FASTA25328,049
        10         20         30         40         50         60 
MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT LFPAVVIIAV 

        70         80         90        100        110        120 
GALLFIIGLI GCCATIRESR CGLATFVFIL LLVFVTEVVV VVLGYVYRAK VENEVDRSIQ 

       130        140        150        160        170        180 
KVYKTYNGTN SDAASRAIDY VQRQLHCCGI HNYSDWENTD WFKETKNQSV PLSCCRETAK 

       190        200        210        220        230        240 
SCNGSLANPS DLYAEGCEAL VVKKLQEILM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD 

       250 
PAYELLITGG TYA 

« Hide

References

[1]"The molecular characterisation of mouse tspan-3."
Puls K.L., Wright M.D.
DNA Seq. 11:271-275(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes."
Tiwari-Woodruff S.K., Buznikov A.G., Vu T.Q., Micevych P.E., Chen K., Kornblum H.I., Bronstein J.M.
J. Cell Biol. 153:295-306(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CLDN11.
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF133427 mRNA. Translation: AAF15362.1.
AF242591 mRNA. Translation: AAG49145.1.
CCDSCCDS23207.1.
RefSeqNP_062767.3. NM_019793.3.
UniGeneMm.28484.

3D structure databases

ProteinModelPortalQ9QY33.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QY33.

Proteomic databases

PRIDEQ9QY33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034876; ENSMUSP00000034876; ENSMUSG00000032324.
GeneID56434.
KEGGmmu:56434.
UCSCuc009psx.2. mouse.

Organism-specific databases

CTD10099.
MGIMGI:1928098. Tspan3.

Phylogenomic databases

eggNOGNOG317438.
GeneTreeENSGT00740000115083.
HOGENOMHOG000230654.
HOVERGENHBG104967.
KOK17293.
OMAYVIWAAL.
OrthoDBEOG7PGDRZ.
PhylomeDBQ9QY33.
TreeFamTF316345.

Gene expression databases

ArrayExpressQ9QY33.
BgeeQ9QY33.
CleanExMM_TSPAN3.
GenevestigatorQ9QY33.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTSPAN3. mouse.
NextBio312614.
PROQ9QY33.
SOURCESearch...

Entry information

Entry nameTSN3_MOUSE
AccessionPrimary (citable) accession number: Q9QY33
Secondary accession number(s): Q9EQG4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot