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Q9QY33

- TSN3_MOUSE

UniProt

Q9QY33 - TSN3_MOUSE

Protein

Tetraspanin-3

Gene

Tspan3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-3
    Short name:
    Tspan-3
    Alternative name(s):
    OSP-associated protein 1
    Short name:
    OAP-1
    Tetraspanin TM4-A
    Transmembrane 4 superfamily member 8
    Gene namesi
    Name:Tspan3
    Synonyms:Tm4sf8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1928098. Tspan3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Tetraspanin-3PRO_0000219240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9QY33.

    PTM databases

    PhosphoSiteiQ9QY33.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QY33.
    BgeeiQ9QY33.
    CleanExiMM_TSPAN3.
    GenevestigatoriQ9QY33.

    Interactioni

    Subunit structurei

    Interacts with claudin-11/CLDN11 and integrins.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QY33.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 5018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 8514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 212106ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini234 – 25320CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG317438.
    GeneTreeiENSGT00740000115083.
    HOGENOMiHOG000230654.
    HOVERGENiHBG104967.
    KOiK17293.
    OMAiYVIWAAL.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiQ9QY33.
    TreeFamiTF316345.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QY33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT    50
    LFPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVFIL LLVFVTEVVV 100
    VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN SDAASRAIDY VQRQLHCCGI 150
    HNYSDWENTD WFKETKNQSV PLSCCRETAK SCNGSLANPS DLYAEGCEAL 200
    VVKKLQEILM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG 250
    TYA 253
    Length:253
    Mass (Da):28,049
    Last modified:May 1, 2000 - v1
    Checksum:i8A7378F76263019A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti220 – 2201A → R in AAG49145. (PubMed:11309411)Curated
    Sequence conflicti226 – 2261G → A in AAG49145. (PubMed:11309411)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133427 mRNA. Translation: AAF15362.1.
    AF242591 mRNA. Translation: AAG49145.1.
    CCDSiCCDS23207.1.
    RefSeqiNP_062767.3. NM_019793.3.
    UniGeneiMm.28484.

    Genome annotation databases

    EnsembliENSMUST00000034876; ENSMUSP00000034876; ENSMUSG00000032324.
    GeneIDi56434.
    KEGGimmu:56434.
    UCSCiuc009psx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133427 mRNA. Translation: AAF15362.1 .
    AF242591 mRNA. Translation: AAG49145.1 .
    CCDSi CCDS23207.1.
    RefSeqi NP_062767.3. NM_019793.3.
    UniGenei Mm.28484.

    3D structure databases

    ProteinModelPortali Q9QY33.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QY33.

    Proteomic databases

    PRIDEi Q9QY33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034876 ; ENSMUSP00000034876 ; ENSMUSG00000032324 .
    GeneIDi 56434.
    KEGGi mmu:56434.
    UCSCi uc009psx.2. mouse.

    Organism-specific databases

    CTDi 10099.
    MGIi MGI:1928098. Tspan3.

    Phylogenomic databases

    eggNOGi NOG317438.
    GeneTreei ENSGT00740000115083.
    HOGENOMi HOG000230654.
    HOVERGENi HBG104967.
    KOi K17293.
    OMAi YVIWAAL.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi Q9QY33.
    TreeFami TF316345.

    Miscellaneous databases

    ChiTaRSi TSPAN3. mouse.
    NextBioi 312614.
    PROi Q9QY33.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QY33.
    Bgeei Q9QY33.
    CleanExi MM_TSPAN3.
    Genevestigatori Q9QY33.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The molecular characterisation of mouse tspan-3."
      Puls K.L., Wright M.D.
      DNA Seq. 11:271-275(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes."
      Tiwari-Woodruff S.K., Buznikov A.G., Vu T.Q., Micevych P.E., Chen K., Kornblum H.I., Bronstein J.M.
      J. Cell Biol. 153:295-306(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CLDN11.
      Strain: C57BL/6.

    Entry informationi

    Entry nameiTSN3_MOUSE
    AccessioniPrimary (citable) accession number: Q9QY33
    Secondary accession number(s): Q9EQG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3