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Protein

Tetraspanin-3

Gene

Tspan3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-3
Short name:
Tspan-3
Alternative name(s):
OSP-associated protein 1
Short name:
OAP-1
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
Gene namesi
Name:Tspan3
Synonyms:Tm4sf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1928098. Tspan3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 50ExtracellularSequence analysisAdd BLAST18
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 85CytoplasmicSequence analysisAdd BLAST14
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 212ExtracellularSequence analysisAdd BLAST106
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192401 – 253Tetraspanin-3Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QY33.
PRIDEiQ9QY33.

PTM databases

iPTMnetiQ9QY33.
PhosphoSitePlusiQ9QY33.
SwissPalmiQ9QY33.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032324.
CleanExiMM_TSPAN3.
ExpressionAtlasiQ9QY33. baseline and differential.
GenevisibleiQ9QY33. MM.

Interactioni

Subunit structurei

Interacts with claudin-11/CLDN11 and integrins.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034876.

Structurei

3D structure databases

ProteinModelPortaliQ9QY33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230654.
HOVERGENiHBG104967.
InParanoidiQ9QY33.
KOiK17293.
OMAiDLYSEGC.
OrthoDBiEOG091G0INM.
PhylomeDBiQ9QY33.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT
60 70 80 90 100
LFPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVFIL LLVFVTEVVV
110 120 130 140 150
VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN SDAASRAIDY VQRQLHCCGI
160 170 180 190 200
HNYSDWENTD WFKETKNQSV PLSCCRETAK SCNGSLANPS DLYAEGCEAL
210 220 230 240 250
VVKKLQEILM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG

TYA
Length:253
Mass (Da):28,049
Last modified:May 1, 2000 - v1
Checksum:i8A7378F76263019A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220A → R in AAG49145 (PubMed:11309411).Curated1
Sequence conflicti226G → A in AAG49145 (PubMed:11309411).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133427 mRNA. Translation: AAF15362.1.
AF242591 mRNA. Translation: AAG49145.1.
CCDSiCCDS23207.1.
RefSeqiNP_062767.3. NM_019793.3.
UniGeneiMm.28484.

Genome annotation databases

EnsembliENSMUST00000034876; ENSMUSP00000034876; ENSMUSG00000032324.
GeneIDi56434.
KEGGimmu:56434.
UCSCiuc009psx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133427 mRNA. Translation: AAF15362.1.
AF242591 mRNA. Translation: AAG49145.1.
CCDSiCCDS23207.1.
RefSeqiNP_062767.3. NM_019793.3.
UniGeneiMm.28484.

3D structure databases

ProteinModelPortaliQ9QY33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034876.

PTM databases

iPTMnetiQ9QY33.
PhosphoSitePlusiQ9QY33.
SwissPalmiQ9QY33.

Proteomic databases

PaxDbiQ9QY33.
PRIDEiQ9QY33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034876; ENSMUSP00000034876; ENSMUSG00000032324.
GeneIDi56434.
KEGGimmu:56434.
UCSCiuc009psx.2. mouse.

Organism-specific databases

CTDi10099.
MGIiMGI:1928098. Tspan3.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230654.
HOVERGENiHBG104967.
InParanoidiQ9QY33.
KOiK17293.
OMAiDLYSEGC.
OrthoDBiEOG091G0INM.
PhylomeDBiQ9QY33.
TreeFamiTF316345.

Miscellaneous databases

ChiTaRSiTspan3. mouse.
PROiQ9QY33.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032324.
CleanExiMM_TSPAN3.
ExpressionAtlasiQ9QY33. baseline and differential.
GenevisibleiQ9QY33. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY33
Secondary accession number(s): Q9EQG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.