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Q9QY33

- TSN3_MOUSE

UniProt

Q9QY33 - TSN3_MOUSE

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Protein
Tetraspanin-3
Gene
Tspan3, Tm4sf8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-3
Short name:
Tspan-3
Alternative name(s):
OSP-associated protein 1
Short name:
OAP-1
Tetraspanin TM4-A
Transmembrane 4 superfamily member 8
Gene namesi
Name:Tspan3
Synonyms:Tm4sf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1928098. Tspan3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei12 – 3221Helical; Reviewed prediction
Add
BLAST
Topological domaini33 – 5018Extracellular Reviewed prediction
Add
BLAST
Transmembranei51 – 7121Helical; Reviewed prediction
Add
BLAST
Topological domaini72 – 8514Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Topological domaini107 – 212106Extracellular Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Topological domaini234 – 25320Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Tetraspanin-3
PRO_0000219240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9QY33.

PTM databases

PhosphoSiteiQ9QY33.

Expressioni

Gene expression databases

ArrayExpressiQ9QY33.
BgeeiQ9QY33.
CleanExiMM_TSPAN3.
GenevestigatoriQ9QY33.

Interactioni

Subunit structurei

Interacts with claudin-11/CLDN11 and integrins.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9QY33.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG317438.
GeneTreeiENSGT00740000115083.
HOGENOMiHOG000230654.
HOVERGENiHBG104967.
KOiK17293.
OMAiYVIWAAL.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ9QY33.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY33-1 [UniParc]FASTAAdd to Basket

« Hide

MGQCGITSSK TVLVFLNLIF WGAAGILCYV GAYVFITYDD YDHFFEDVYT    50
LFPAVVIIAV GALLFIIGLI GCCATIRESR CGLATFVFIL LLVFVTEVVV 100
VVLGYVYRAK VENEVDRSIQ KVYKTYNGTN SDAASRAIDY VQRQLHCCGI 150
HNYSDWENTD WFKETKNQSV PLSCCRETAK SCNGSLANPS DLYAEGCEAL 200
VVKKLQEILM HVIWAALAFA AIQLLGMLCA CIVLCRRSRD PAYELLITGG 250
TYA 253
Length:253
Mass (Da):28,049
Last modified:May 1, 2000 - v1
Checksum:i8A7378F76263019A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201A → R in AAG49145. 1 Publication
Sequence conflicti226 – 2261G → A in AAG49145. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133427 mRNA. Translation: AAF15362.1.
AF242591 mRNA. Translation: AAG49145.1.
CCDSiCCDS23207.1.
RefSeqiNP_062767.3. NM_019793.3.
UniGeneiMm.28484.

Genome annotation databases

EnsembliENSMUST00000034876; ENSMUSP00000034876; ENSMUSG00000032324.
GeneIDi56434.
KEGGimmu:56434.
UCSCiuc009psx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133427 mRNA. Translation: AAF15362.1 .
AF242591 mRNA. Translation: AAG49145.1 .
CCDSi CCDS23207.1.
RefSeqi NP_062767.3. NM_019793.3.
UniGenei Mm.28484.

3D structure databases

ProteinModelPortali Q9QY33.
ModBasei Search...

PTM databases

PhosphoSitei Q9QY33.

Proteomic databases

PRIDEi Q9QY33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034876 ; ENSMUSP00000034876 ; ENSMUSG00000032324 .
GeneIDi 56434.
KEGGi mmu:56434.
UCSCi uc009psx.2. mouse.

Organism-specific databases

CTDi 10099.
MGIi MGI:1928098. Tspan3.

Phylogenomic databases

eggNOGi NOG317438.
GeneTreei ENSGT00740000115083.
HOGENOMi HOG000230654.
HOVERGENi HBG104967.
KOi K17293.
OMAi YVIWAAL.
OrthoDBi EOG7PGDRZ.
PhylomeDBi Q9QY33.
TreeFami TF316345.

Miscellaneous databases

ChiTaRSi TSPAN3. mouse.
NextBioi 312614.
PROi Q9QY33.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QY33.
Bgeei Q9QY33.
CleanExi MM_TSPAN3.
Genevestigatori Q9QY33.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The molecular characterisation of mouse tspan-3."
    Puls K.L., Wright M.D.
    DNA Seq. 11:271-275(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes."
    Tiwari-Woodruff S.K., Buznikov A.G., Vu T.Q., Micevych P.E., Chen K., Kornblum H.I., Bronstein J.M.
    J. Cell Biol. 153:295-306(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CLDN11.
    Strain: C57BL/6.

Entry informationi

Entry nameiTSN3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY33
Secondary accession number(s): Q9EQG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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