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Protein

Zinc finger protein SNAI3

Gene

Snai3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 169C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein SNAI3
Alternative name(s):
Protein snail homolog 3
Snail-related gene from muscle cells
Zinc finger protein 293
Gene namesi
Name:Snai3
Synonyms:Smuc, Zfp293
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1353563. Snai3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003300381 – 287Zinc finger protein SNAI3Add BLAST287

Proteomic databases

PaxDbiQ9QY31.
PRIDEiQ9QY31.

PTM databases

PhosphoSitePlusiQ9QY31.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and thymus. Lower expression in heart, lung and spleen.1 Publication

Developmental stagei

Expressed at E7, higher expression observed in stages E15 and E18.1 Publication

Gene expression databases

BgeeiENSMUSG00000006587.
GenevisibleiQ9QY31. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006762.

Structurei

3D structure databases

ProteinModelPortaliQ9QY31.
SMRiQ9QY31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Domaini

Binds E-box via C2H2-type zinc finger domain.

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri147 – 169C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ9QY31.
KOiK09217.
OMAiTHTLPCT.
OrthoDBiEOG091G0Q0V.
PhylomeDBiQ9QY31.
TreeFamiTF315515.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKTH SSHRVPNYGK LETLREANGS CSACKELAGS RHLPDEEAPC
60 70 80 90 100
NPSDPLQPWD STSAVACISL PLLPNHRETL GVSGPEPQET SWVGPRAAQA
110 120 130 140 150
PSVTLKDSFT LPPLLVLPTR WPPILGPDGA LNEHLRAEGT SRVPGSFECI
160 170 180 190 200
HCHRPYHTLA GLARHQQLHC HLPTGRAFTC RYCDKEYASL GALKMHIRTH
210 220 230 240 250
TLPCICKVCG KAFSRPWLLQ GHIRTHTGEK PYTCSHCSRA FADRSNLRAH
260 270 280
LQTHVGTKKY RCAVCPKAFS RMSLLARHEE AGCCPGP
Length:287
Mass (Da):31,636
Last modified:May 1, 2000 - v1
Checksum:i02E42A6FE8BAFD48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75N → S in AAI00727 (PubMed:15489334).Curated1
Sequence conflicti169H → Y in BAC40828 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133714 mRNA. Translation: AAF22956.1.
AF195655 mRNA. Translation: AAQ13827.1.
AK042234 mRNA. Translation: BAC31201.1.
AK089285 mRNA. Translation: BAC40828.1.
AK153633 mRNA. Translation: BAE32128.1.
AK154585 mRNA. Translation: BAE32693.1.
BC100724 mRNA. Translation: AAI00725.1.
BC100726 mRNA. Translation: AAI00727.1.
BC100727 mRNA. Translation: AAI00728.1.
CCDSiCCDS22739.1.
RefSeqiNP_038942.1. NM_013914.2.
UniGeneiMm.103673.

Genome annotation databases

EnsembliENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587.
GeneIDi30927.
KEGGimmu:30927.
UCSCiuc009nsw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133714 mRNA. Translation: AAF22956.1.
AF195655 mRNA. Translation: AAQ13827.1.
AK042234 mRNA. Translation: BAC31201.1.
AK089285 mRNA. Translation: BAC40828.1.
AK153633 mRNA. Translation: BAE32128.1.
AK154585 mRNA. Translation: BAE32693.1.
BC100724 mRNA. Translation: AAI00725.1.
BC100726 mRNA. Translation: AAI00727.1.
BC100727 mRNA. Translation: AAI00728.1.
CCDSiCCDS22739.1.
RefSeqiNP_038942.1. NM_013914.2.
UniGeneiMm.103673.

3D structure databases

ProteinModelPortaliQ9QY31.
SMRiQ9QY31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006762.

PTM databases

PhosphoSitePlusiQ9QY31.

Proteomic databases

PaxDbiQ9QY31.
PRIDEiQ9QY31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006762; ENSMUSP00000006762; ENSMUSG00000006587.
GeneIDi30927.
KEGGimmu:30927.
UCSCiuc009nsw.1. mouse.

Organism-specific databases

CTDi333929.
MGIiMGI:1353563. Snai3.

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ9QY31.
KOiK09217.
OMAiTHTLPCT.
OrthoDBiEOG091G0Q0V.
PhylomeDBiQ9QY31.
TreeFamiTF315515.

Miscellaneous databases

PROiQ9QY31.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006587.
GenevisibleiQ9QY31. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNAI3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY31
Secondary accession number(s): Q3U3U2, Q496S5, Q8C244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.