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Protein

Bile salt export pump

Gene

Abcb11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi455 – 4628ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1113 – 11208ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  2. ATP binding Source: UniProtKB-KW
  3. canalicular bile acid transmembrane transporter activity Source: GO_Central

GO - Biological processi

  1. canalicular bile acid transport Source: GO_Central
  2. transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_300927. Recycling of bile acids and salts.
REACT_325766. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein
Gene namesi
Name:Abcb11
Synonyms:Bsep, Spgp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1351619. Abcb11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini84 – 14764ExtracellularSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini169 – 21547CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini237 – 2404ExtracellularSequence Analysis
Transmembranei241 – 26121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini262 – 31958CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini341 – 35313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei354 – 37421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini375 – 755381CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei756 – 77621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini777 – 79418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei795 – 81521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini816 – 86954CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei870 – 89021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei891 – 91121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini912 – 97968CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei980 – 100021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1001 – 101111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1012 – 103221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini1033 – 1321289CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. integral component of membrane Source: GO_Central
  4. intercellular canaliculus Source: MGI
  5. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13211321Bile salt export pumpPRO_0000093297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Modified residuei586 – 5861PhosphothreonineBy similarity
Modified residuei587 – 5871PhosphoserineBy similarity
Modified residuei692 – 6921Phosphoserine1 Publication
Modified residuei706 – 7061PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9QY30.
PaxDbiQ9QY30.
PRIDEiQ9QY30.

PTM databases

PhosphoSiteiQ9QY30.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Gene expression databases

BgeeiQ9QY30.
ExpressionAtlasiQ9QY30. baseline and differential.
GenevestigatoriQ9QY30.

Interactioni

Subunit structurei

Interacts with HAX1.By similarity

Protein-protein interaction databases

IntActiQ9QY30. 1 interaction.
MINTiMINT-1865476.

Structurei

3D structure databases

ProteinModelPortaliQ9QY30.
SMRiQ9QY30. Positions 45-660, 754-1316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 385324ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini420 – 656237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini755 – 1043289ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1078 – 1316239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni651 – 67424Interaction with HAX1By similarityAdd
BLAST

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiQ9QY30.
KOiK05664.
OMAiKYNISEW.
OrthoDBiEOG7Z3F4H.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030278. BSEP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF165. PTHR24221:SF165. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSVILRSV KKFGEENHAF ESDGFHNNDK KSRLQDKKKG EGARVGFFEL
60 70 80 90 100
FRFSSSKDNW LMFMGSVCAL LHGMAQPGMI IVFGILTDIF VEYDIERQEL
110 120 130 140 150
SIPEKVCMNN TIVWINSSFN QNMTNGTSCG LVDINSEVIK FSGIYAGVGV
160 170 180 190 200
AVLILGYFQI RLWVITGARQ IRKMRKFYFR RIMRMEIGWF DCTSVGELNS
210 220 230 240 250
RFSDDINKID EAIADQMALF LQRLSTALSG LLLGFYRGWK LTLVILAVSP
260 270 280 290 300
LIGIGAAVIG LSVAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE
310 320 330 340 350
VERYEKNLMF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSRLVLD
360 370 380 390 400
EGEYTPGTLI QIFLCVIIAA MNIGNASSCL EIFSTGCSAA SSIFQTIDRQ
410 420 430 440 450
PVMDCMSGDG YKLDRIKGEI EFHNVTFHYP SRPEVKILNN LSMVIKPGET
460 470 480 490 500
TAFVGSSGAG KSTALQLIQR FYDPCEGMVT LDGHDIRSLN IRWLRDQIGI
510 520 530 540 550
VEQEPVLFST TIAENIRLGR EEATMEDIVQ AAKDANAYNF IMALPQQFDT
560 570 580 590 600
LVGEGGGQMS GGQKQRVAIA RALIRKPKIL LLDMATSALD NESEAKVQGA
610 620 630 640 650
LNKIQHGHTI ISVAHRLSTV RSADVIIGFE HGTAVERGTH EELLERKGVY
660 670 680 690 700
FMLVTLQSQE DNTHKETGIK GKDTTEGDTP ERTFSRGSYQ DSLRASIRQR
710 720 730 740 750
SKSQLSHLSH EPPLAIGDHK SSYEDRKDND VLVEEVEPAP VRRILKYNIS
760 770 780 790 800
EWPYILVGAL CAAINGAVTP IYSLLFSQIL KTFSLVDKEQ QRSEIYSMCL
810 820 830 840 850
FFVILGCVSL FTQFLQGYNF AKSGELLTKR LRKFGFKAML RQDIGWFDDL
860 870 880 890 900
KNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIFVAV LIAFLFNWKL
910 920 930 940 950
SLVISVFFPF LALSGAVQTK MLTGFASQDK EILEKAGQIT NEALSNIRTV
960 970 980 990 1000
AGIGVEGRFI KAFEVELEKS YKTAIRKANV YGLCYAFSQG ISFLANSAAY
1010 1020 1030 1040 1050
RYGGYLIVYE DLNFSYVFRV VSSIAMSATA VGRTFSYTPS YAKAKISAAR
1060 1070 1080 1090 1100
FFQLLDRKPP IDVYSGAGEK WDNFQGKIDF IDCKFTYPSR PDIQVLNGLS
1110 1120 1130 1140 1150
VSVDPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID GHDSKKVNVQ
1160 1170 1180 1190 1200
FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF
1210 1220 1230 1240 1250
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD
1260 1270 1280 1290 1300
TESEKTVQLA LDKAREGRTC IVIAHRLSTI QNSDIIAVMS QGVVIEKGTH
1310 1320
KKLMDQKGAY YKLVITGAPI S
Length:1,321
Mass (Da):146,749
Last modified:June 28, 2011 - v2
Checksum:iC71F8D3D0A352BA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041E → G in AAF14372 (PubMed:10607905).Curated
Sequence conflicti481 – 4811L → P in AAD56419 (Ref. 3) Curated
Sequence conflicti633 – 6331T → V in AAD56419 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133903 mRNA. Translation: AAF14372.1.
AL929170 Genomic DNA. Translation: CAM24720.1.
CH466519 Genomic DNA. Translation: EDL27032.1.
AF186585 mRNA. Translation: AAD56419.1.
CCDSiCCDS16090.1.
RefSeqiNP_066302.2. NM_021022.3.
XP_006499732.1. XM_006499669.2.
UniGeneiMm.439855.

Genome annotation databases

EnsembliENSMUST00000102709; ENSMUSP00000099770; ENSMUSG00000027048.
ENSMUST00000102710; ENSMUSP00000099771; ENSMUSG00000027048.
GeneIDi27413.
KEGGimmu:27413.
UCSCiuc008jya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133903 mRNA. Translation: AAF14372.1.
AL929170 Genomic DNA. Translation: CAM24720.1.
CH466519 Genomic DNA. Translation: EDL27032.1.
AF186585 mRNA. Translation: AAD56419.1.
CCDSiCCDS16090.1.
RefSeqiNP_066302.2. NM_021022.3.
XP_006499732.1. XM_006499669.2.
UniGeneiMm.439855.

3D structure databases

ProteinModelPortaliQ9QY30.
SMRiQ9QY30. Positions 45-660, 754-1316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QY30. 1 interaction.
MINTiMINT-1865476.

Chemistry

ChEMBLiCHEMBL2073695.

PTM databases

PhosphoSiteiQ9QY30.

Proteomic databases

MaxQBiQ9QY30.
PaxDbiQ9QY30.
PRIDEiQ9QY30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102709; ENSMUSP00000099770; ENSMUSG00000027048.
ENSMUST00000102710; ENSMUSP00000099771; ENSMUSG00000027048.
GeneIDi27413.
KEGGimmu:27413.
UCSCiuc008jya.1. mouse.

Organism-specific databases

CTDi8647.
MGIiMGI:1351619. Abcb11.

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiQ9QY30.
KOiK05664.
OMAiKYNISEW.
OrthoDBiEOG7Z3F4H.
TreeFamiTF105193.

Enzyme and pathway databases

ReactomeiREACT_300927. Recycling of bile acids and salts.
REACT_325766. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

Miscellaneous databases

ChiTaRSiAbcb11. mouse.
NextBioi305442.
PROiQ9QY30.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QY30.
ExpressionAtlasiQ9QY30. baseline and differential.
GenevestigatoriQ9QY30.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030278. BSEP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF165. PTHR24221:SF165. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the murine bile salt export pump."
    Green R.M., Hoda F., Ward K.L.
    Gene 241:117-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Molecular cloning of mouse liver bile salt export pump (bsep)."
    Salkar R., Suchy F.J., Ananthanarayanan M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 463-635.
    Strain: C57BL/6.
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiABCBB_MOUSE
AccessioniPrimary (citable) accession number: Q9QY30
Secondary accession number(s): A2AUN4, Q9QZE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 28, 2011
Last modified: April 1, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.