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Protein

Bile salt export pump

Gene

Abcb11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi455 – 462ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1113 – 1120ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts
R-MMU-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein
Gene namesi
Name:Abcb11
Synonyms:Bsep, Spgp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1351619 Abcb11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicSequence analysisAdd BLAST62
Transmembranei63 – 83HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini84 – 147ExtracellularSequence analysisAdd BLAST64
Transmembranei148 – 168HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini169 – 215CytoplasmicSequence analysisAdd BLAST47
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini237 – 240ExtracellularSequence analysis4
Transmembranei241 – 261HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini262 – 319CytoplasmicSequence analysisAdd BLAST58
Transmembranei320 – 340HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini341 – 353ExtracellularSequence analysisAdd BLAST13
Transmembranei354 – 374HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini375 – 755CytoplasmicSequence analysisAdd BLAST381
Transmembranei756 – 776HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini777 – 794ExtracellularSequence analysisAdd BLAST18
Transmembranei795 – 815HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini816 – 869CytoplasmicSequence analysisAdd BLAST54
Transmembranei870 – 890HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei891 – 911HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini912 – 979CytoplasmicSequence analysisAdd BLAST68
Transmembranei980 – 1000HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1001 – 1011ExtracellularSequence analysisAdd BLAST11
Transmembranei1012 – 1032HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1033 – 1321CytoplasmicSequence analysisAdd BLAST289

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073695

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000932971 – 1321Bile salt export pumpAdd BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei586PhosphothreonineBy similarity1
Modified residuei587PhosphoserineBy similarity1
Modified residuei692PhosphoserineCombined sources1
Modified residuei703PhosphoserineBy similarity1
Modified residuei706PhosphoserineBy similarity1
Modified residuei1321PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9QY30
PaxDbiQ9QY30
PRIDEiQ9QY30

PTM databases

iPTMnetiQ9QY30
PhosphoSitePlusiQ9QY30
SwissPalmiQ9QY30

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Gene expression databases

BgeeiENSMUSG00000027048
ExpressionAtlasiQ9QY30 baseline and differential
GenevisibleiQ9QY30 MM

Interactioni

Subunit structurei

Interacts with HAX1.By similarity

Protein-protein interaction databases

IntActiQ9QY30, 1 interactor
MINTiQ9QY30
STRINGi10090.ENSMUSP00000099770

Structurei

3D structure databases

ProteinModelPortaliQ9QY30
SMRiQ9QY30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 385ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST324
Domaini420 – 656ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini755 – 1043ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini1078 – 1316ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 674Interaction with HAX1By similarityAdd BLAST24

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00530000062896
HOVERGENiHBG080809
InParanoidiQ9QY30
KOiK05664
OMAiVDCKFTY
TreeFamiTF105193

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030278 BSEP
IPR027417 P-loop_NTPase
PANTHERiPTHR24221:SF165 PTHR24221:SF165, 3 hits
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 3 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9QY30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSVILRSV KKFGEENHAF ESDGFHNNDK KSRLQDKKKG EGARVGFFEL
60 70 80 90 100
FRFSSSKDNW LMFMGSVCAL LHGMAQPGMI IVFGILTDIF VEYDIERQEL
110 120 130 140 150
SIPEKVCMNN TIVWINSSFN QNMTNGTSCG LVDINSEVIK FSGIYAGVGV
160 170 180 190 200
AVLILGYFQI RLWVITGARQ IRKMRKFYFR RIMRMEIGWF DCTSVGELNS
210 220 230 240 250
RFSDDINKID EAIADQMALF LQRLSTALSG LLLGFYRGWK LTLVILAVSP
260 270 280 290 300
LIGIGAAVIG LSVAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE
310 320 330 340 350
VERYEKNLMF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSRLVLD
360 370 380 390 400
EGEYTPGTLI QIFLCVIIAA MNIGNASSCL EIFSTGCSAA SSIFQTIDRQ
410 420 430 440 450
PVMDCMSGDG YKLDRIKGEI EFHNVTFHYP SRPEVKILNN LSMVIKPGET
460 470 480 490 500
TAFVGSSGAG KSTALQLIQR FYDPCEGMVT LDGHDIRSLN IRWLRDQIGI
510 520 530 540 550
VEQEPVLFST TIAENIRLGR EEATMEDIVQ AAKDANAYNF IMALPQQFDT
560 570 580 590 600
LVGEGGGQMS GGQKQRVAIA RALIRKPKIL LLDMATSALD NESEAKVQGA
610 620 630 640 650
LNKIQHGHTI ISVAHRLSTV RSADVIIGFE HGTAVERGTH EELLERKGVY
660 670 680 690 700
FMLVTLQSQE DNTHKETGIK GKDTTEGDTP ERTFSRGSYQ DSLRASIRQR
710 720 730 740 750
SKSQLSHLSH EPPLAIGDHK SSYEDRKDND VLVEEVEPAP VRRILKYNIS
760 770 780 790 800
EWPYILVGAL CAAINGAVTP IYSLLFSQIL KTFSLVDKEQ QRSEIYSMCL
810 820 830 840 850
FFVILGCVSL FTQFLQGYNF AKSGELLTKR LRKFGFKAML RQDIGWFDDL
860 870 880 890 900
KNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIFVAV LIAFLFNWKL
910 920 930 940 950
SLVISVFFPF LALSGAVQTK MLTGFASQDK EILEKAGQIT NEALSNIRTV
960 970 980 990 1000
AGIGVEGRFI KAFEVELEKS YKTAIRKANV YGLCYAFSQG ISFLANSAAY
1010 1020 1030 1040 1050
RYGGYLIVYE DLNFSYVFRV VSSIAMSATA VGRTFSYTPS YAKAKISAAR
1060 1070 1080 1090 1100
FFQLLDRKPP IDVYSGAGEK WDNFQGKIDF IDCKFTYPSR PDIQVLNGLS
1110 1120 1130 1140 1150
VSVDPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID GHDSKKVNVQ
1160 1170 1180 1190 1200
FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF
1210 1220 1230 1240 1250
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD
1260 1270 1280 1290 1300
TESEKTVQLA LDKAREGRTC IVIAHRLSTI QNSDIIAVMS QGVVIEKGTH
1310 1320
KKLMDQKGAY YKLVITGAPI S
Length:1,321
Mass (Da):146,749
Last modified:June 28, 2011 - v2
Checksum:iC71F8D3D0A352BA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104E → G in AAF14372 (PubMed:10607905).Curated1
Sequence conflicti481L → P in AAD56419 (Ref. 3) Curated1
Sequence conflicti633T → V in AAD56419 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133903 mRNA Translation: AAF14372.1
AL929170 Genomic DNA Translation: CAM24720.1
CH466519 Genomic DNA Translation: EDL27032.1
AF186585 mRNA Translation: AAD56419.1
CCDSiCCDS16090.1
RefSeqiNP_066302.2, NM_021022.3
XP_006499732.1, XM_006499669.3
UniGeneiMm.439855

Genome annotation databases

EnsembliENSMUST00000102709; ENSMUSP00000099770; ENSMUSG00000027048
ENSMUST00000102710; ENSMUSP00000099771; ENSMUSG00000027048
GeneIDi27413
KEGGimmu:27413
UCSCiuc008jya.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABCBB_MOUSE
AccessioniPrimary (citable) accession number: Q9QY30
Secondary accession number(s): A2AUN4, Q9QZE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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