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Q9QY30 (ABCBB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein
Gene names
Name:Abcb11
Synonyms:Bsep, Spgp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1321 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Subunit structure

Interacts with HAX1 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Domain

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13211321Bile salt export pump
PRO_0000093297

Regions

Topological domain1 – 6262Cytoplasmic Potential
Transmembrane63 – 8321Helical; Potential
Topological domain84 – 14764Extracellular Potential
Transmembrane148 – 16821Helical; Potential
Topological domain169 – 21547Cytoplasmic Potential
Transmembrane216 – 23621Helical; Potential
Topological domain237 – 2404Extracellular Potential
Transmembrane241 – 26121Helical; Potential
Topological domain262 – 31958Cytoplasmic Potential
Transmembrane320 – 34021Helical; Potential
Topological domain341 – 35313Extracellular Potential
Transmembrane354 – 37421Helical; Potential
Topological domain375 – 755381Cytoplasmic Potential
Transmembrane756 – 77621Helical; Potential
Topological domain777 – 79418Extracellular Potential
Transmembrane795 – 81521Helical; Potential
Topological domain816 – 86954Cytoplasmic Potential
Transmembrane870 – 89021Helical; Potential
Transmembrane891 – 91121Helical; Potential
Topological domain912 – 97968Cytoplasmic Potential
Transmembrane980 – 100021Helical; Potential
Topological domain1001 – 101111Extracellular Potential
Transmembrane1012 – 103221Helical; Potential
Topological domain1033 – 1321289Cytoplasmic Potential
Domain62 – 385324ABC transmembrane type-1 1
Domain420 – 656237ABC transporter 1
Domain755 – 1043289ABC transmembrane type-1 2
Domain1078 – 1316239ABC transporter 2
Nucleotide binding455 – 4628ATP 1 Potential
Nucleotide binding1113 – 11208ATP 2 Potential
Region651 – 67424Interaction with HAX1 By similarity

Amino acid modifications

Modified residue6921Phosphoserine Ref.5
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1041E → G in AAF14372. Ref.1
Sequence conflict4811L → P in AAD56419. Ref.3
Sequence conflict6331T → V in AAD56419. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9QY30 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: C71F8D3D0A352BA8

FASTA1,321146,749
        10         20         30         40         50         60 
MSDSVILRSV KKFGEENHAF ESDGFHNNDK KSRLQDKKKG EGARVGFFEL FRFSSSKDNW 

        70         80         90        100        110        120 
LMFMGSVCAL LHGMAQPGMI IVFGILTDIF VEYDIERQEL SIPEKVCMNN TIVWINSSFN 

       130        140        150        160        170        180 
QNMTNGTSCG LVDINSEVIK FSGIYAGVGV AVLILGYFQI RLWVITGARQ IRKMRKFYFR 

       190        200        210        220        230        240 
RIMRMEIGWF DCTSVGELNS RFSDDINKID EAIADQMALF LQRLSTALSG LLLGFYRGWK 

       250        260        270        280        290        300 
LTLVILAVSP LIGIGAAVIG LSVAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE 

       310        320        330        340        350        360 
VERYEKNLMF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSRLVLD EGEYTPGTLI 

       370        380        390        400        410        420 
QIFLCVIIAA MNIGNASSCL EIFSTGCSAA SSIFQTIDRQ PVMDCMSGDG YKLDRIKGEI 

       430        440        450        460        470        480 
EFHNVTFHYP SRPEVKILNN LSMVIKPGET TAFVGSSGAG KSTALQLIQR FYDPCEGMVT 

       490        500        510        520        530        540 
LDGHDIRSLN IRWLRDQIGI VEQEPVLFST TIAENIRLGR EEATMEDIVQ AAKDANAYNF 

       550        560        570        580        590        600 
IMALPQQFDT LVGEGGGQMS GGQKQRVAIA RALIRKPKIL LLDMATSALD NESEAKVQGA 

       610        620        630        640        650        660 
LNKIQHGHTI ISVAHRLSTV RSADVIIGFE HGTAVERGTH EELLERKGVY FMLVTLQSQE 

       670        680        690        700        710        720 
DNTHKETGIK GKDTTEGDTP ERTFSRGSYQ DSLRASIRQR SKSQLSHLSH EPPLAIGDHK 

       730        740        750        760        770        780 
SSYEDRKDND VLVEEVEPAP VRRILKYNIS EWPYILVGAL CAAINGAVTP IYSLLFSQIL 

       790        800        810        820        830        840 
KTFSLVDKEQ QRSEIYSMCL FFVILGCVSL FTQFLQGYNF AKSGELLTKR LRKFGFKAML 

       850        860        870        880        890        900 
RQDIGWFDDL KNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIFVAV LIAFLFNWKL 

       910        920        930        940        950        960 
SLVISVFFPF LALSGAVQTK MLTGFASQDK EILEKAGQIT NEALSNIRTV AGIGVEGRFI 

       970        980        990       1000       1010       1020 
KAFEVELEKS YKTAIRKANV YGLCYAFSQG ISFLANSAAY RYGGYLIVYE DLNFSYVFRV 

      1030       1040       1050       1060       1070       1080 
VSSIAMSATA VGRTFSYTPS YAKAKISAAR FFQLLDRKPP IDVYSGAGEK WDNFQGKIDF 

      1090       1100       1110       1120       1130       1140 
IDCKFTYPSR PDIQVLNGLS VSVDPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID 

      1150       1160       1170       1180       1190       1200 
GHDSKKVNVQ FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF 

      1210       1220       1230       1240       1250       1260 
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQLA 

      1270       1280       1290       1300       1310       1320 
LDKAREGRTC IVIAHRLSTI QNSDIIAVMS QGVVIEKGTH KKLMDQKGAY YKLVITGAPI 


S 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the murine bile salt export pump."
Green R.M., Hoda F., Ward K.L.
Gene 241:117-123(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Molecular cloning of mouse liver bile salt export pump (bsep)."
Salkar R., Suchy F.J., Ananthanarayanan M.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 463-635.
Strain: C57BL/6.
Tissue: Liver.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF133903 mRNA. Translation: AAF14372.1.
AL929170 Genomic DNA. Translation: CAM24720.1.
CH466519 Genomic DNA. Translation: EDL27032.1.
AF186585 mRNA. Translation: AAD56419.1.
RefSeqNP_066302.2. NM_021022.3.
XP_006499732.1. XM_006499669.1.
UniGeneMm.439855.

3D structure databases

ProteinModelPortalQ9QY30.
SMRQ9QY30. Positions 45-660, 754-1316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9QY30. 1 interaction.
MINTMINT-1865476.

Chemistry

ChEMBLCHEMBL2073695.

PTM databases

PhosphoSiteQ9QY30.

Proteomic databases

PaxDbQ9QY30.
PRIDEQ9QY30.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102709; ENSMUSP00000099770; ENSMUSG00000027048.
ENSMUST00000102710; ENSMUSP00000099771; ENSMUSG00000027048.
GeneID27413.
KEGGmmu:27413.
UCSCuc008jya.1. mouse.

Organism-specific databases

CTD8647.
MGIMGI:1351619. Abcb11.

Phylogenomic databases

eggNOGCOG1132.
GeneTreeENSGT00530000062896.
HOVERGENHBG080809.
InParanoidA2AUN4.
KOK05664.
OMAVRTININ.
OrthoDBEOG7Z3F4H.
TreeFamTF105193.

Gene expression databases

BgeeQ9QY30.
GenevestigatorQ9QY30.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio305442.
PROQ9QY30.
SOURCESearch...

Entry information

Entry nameABCBB_MOUSE
AccessionPrimary (citable) accession number: Q9QY30
Secondary accession number(s): A2AUN4, Q9QZE8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot