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Q9QY30

- ABCBB_MOUSE

UniProt

Q9QY30 - ABCBB_MOUSE

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Protein

Bile salt export pump

Gene
Abcb11, Bsep, Spgp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi455 – 4628ATP 1 Reviewed prediction
Nucleotide bindingi1113 – 11208ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. canalicular bile acid transmembrane transporter activity Source: RefGenome

GO - Biological processi

  1. canalicular bile acid transport Source: RefGenome
  2. transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_203193. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein
Gene namesi
Name:Abcb11
Synonyms:Bsep, Spgp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1351619. Abcb11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei63 – 8321Helical; Reviewed predictionAdd
BLAST
Topological domaini84 – 14764Extracellular Reviewed predictionAdd
BLAST
Transmembranei148 – 16821Helical; Reviewed predictionAdd
BLAST
Topological domaini169 – 21547Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei216 – 23621Helical; Reviewed predictionAdd
BLAST
Topological domaini237 – 2404Extracellular Reviewed prediction
Transmembranei241 – 26121Helical; Reviewed predictionAdd
BLAST
Topological domaini262 – 31958Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei320 – 34021Helical; Reviewed predictionAdd
BLAST
Topological domaini341 – 35313Extracellular Reviewed predictionAdd
BLAST
Transmembranei354 – 37421Helical; Reviewed predictionAdd
BLAST
Topological domaini375 – 755381Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei756 – 77621Helical; Reviewed predictionAdd
BLAST
Topological domaini777 – 79418Extracellular Reviewed predictionAdd
BLAST
Transmembranei795 – 81521Helical; Reviewed predictionAdd
BLAST
Topological domaini816 – 86954Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei870 – 89021Helical; Reviewed predictionAdd
BLAST
Transmembranei891 – 91121Helical; Reviewed predictionAdd
BLAST
Topological domaini912 – 97968Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei980 – 100021Helical; Reviewed predictionAdd
BLAST
Topological domaini1001 – 101111Extracellular Reviewed predictionAdd
BLAST
Transmembranei1012 – 103221Helical; Reviewed predictionAdd
BLAST
Topological domaini1033 – 1321289Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. integral component of membrane Source: RefGenome
  3. intercellular canaliculus Source: MGI
  4. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13211321Bile salt export pumpPRO_0000093297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Modified residuei692 – 6921Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9QY30.
PaxDbiQ9QY30.
PRIDEiQ9QY30.

PTM databases

PhosphoSiteiQ9QY30.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Gene expression databases

BgeeiQ9QY30.
GenevestigatoriQ9QY30.

Interactioni

Subunit structurei

Interacts with HAX1 By similarity.

Protein-protein interaction databases

IntActiQ9QY30. 1 interaction.
MINTiMINT-1865476.

Structurei

3D structure databases

ProteinModelPortaliQ9QY30.
SMRiQ9QY30. Positions 45-660, 754-1316.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 385324ABC transmembrane type-1 1Add
BLAST
Domaini420 – 656237ABC transporter 1Add
BLAST
Domaini755 – 1043289ABC transmembrane type-1 2Add
BLAST
Domaini1078 – 1316239ABC transporter 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni651 – 67424Interaction with HAX1 By similarityAdd
BLAST

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiA2AUN4.
KOiK05664.
OMAiXITNEAL.
OrthoDBiEOG7Z3F4H.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY30-1 [UniParc]FASTAAdd to Basket

« Hide

MSDSVILRSV KKFGEENHAF ESDGFHNNDK KSRLQDKKKG EGARVGFFEL     50
FRFSSSKDNW LMFMGSVCAL LHGMAQPGMI IVFGILTDIF VEYDIERQEL 100
SIPEKVCMNN TIVWINSSFN QNMTNGTSCG LVDINSEVIK FSGIYAGVGV 150
AVLILGYFQI RLWVITGARQ IRKMRKFYFR RIMRMEIGWF DCTSVGELNS 200
RFSDDINKID EAIADQMALF LQRLSTALSG LLLGFYRGWK LTLVILAVSP 250
LIGIGAAVIG LSVAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE 300
VERYEKNLMF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSRLVLD 350
EGEYTPGTLI QIFLCVIIAA MNIGNASSCL EIFSTGCSAA SSIFQTIDRQ 400
PVMDCMSGDG YKLDRIKGEI EFHNVTFHYP SRPEVKILNN LSMVIKPGET 450
TAFVGSSGAG KSTALQLIQR FYDPCEGMVT LDGHDIRSLN IRWLRDQIGI 500
VEQEPVLFST TIAENIRLGR EEATMEDIVQ AAKDANAYNF IMALPQQFDT 550
LVGEGGGQMS GGQKQRVAIA RALIRKPKIL LLDMATSALD NESEAKVQGA 600
LNKIQHGHTI ISVAHRLSTV RSADVIIGFE HGTAVERGTH EELLERKGVY 650
FMLVTLQSQE DNTHKETGIK GKDTTEGDTP ERTFSRGSYQ DSLRASIRQR 700
SKSQLSHLSH EPPLAIGDHK SSYEDRKDND VLVEEVEPAP VRRILKYNIS 750
EWPYILVGAL CAAINGAVTP IYSLLFSQIL KTFSLVDKEQ QRSEIYSMCL 800
FFVILGCVSL FTQFLQGYNF AKSGELLTKR LRKFGFKAML RQDIGWFDDL 850
KNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIFVAV LIAFLFNWKL 900
SLVISVFFPF LALSGAVQTK MLTGFASQDK EILEKAGQIT NEALSNIRTV 950
AGIGVEGRFI KAFEVELEKS YKTAIRKANV YGLCYAFSQG ISFLANSAAY 1000
RYGGYLIVYE DLNFSYVFRV VSSIAMSATA VGRTFSYTPS YAKAKISAAR 1050
FFQLLDRKPP IDVYSGAGEK WDNFQGKIDF IDCKFTYPSR PDIQVLNGLS 1100
VSVDPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID GHDSKKVNVQ 1150
FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF 1200
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD 1250
TESEKTVQLA LDKAREGRTC IVIAHRLSTI QNSDIIAVMS QGVVIEKGTH 1300
KKLMDQKGAY YKLVITGAPI S 1321
Length:1,321
Mass (Da):146,749
Last modified:June 28, 2011 - v2
Checksum:iC71F8D3D0A352BA8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041E → G in AAF14372. 1 Publication
Sequence conflicti481 – 4811L → P in AAD56419. 1 Publication
Sequence conflicti633 – 6331T → V in AAD56419. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133903 mRNA. Translation: AAF14372.1.
AL929170 Genomic DNA. Translation: CAM24720.1.
CH466519 Genomic DNA. Translation: EDL27032.1.
AF186585 mRNA. Translation: AAD56419.1.
CCDSiCCDS16090.1.
RefSeqiNP_066302.2. NM_021022.3.
XP_006499732.1. XM_006499669.1.
UniGeneiMm.439855.

Genome annotation databases

EnsembliENSMUST00000102709; ENSMUSP00000099770; ENSMUSG00000027048.
ENSMUST00000102710; ENSMUSP00000099771; ENSMUSG00000027048.
GeneIDi27413.
KEGGimmu:27413.
UCSCiuc008jya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133903 mRNA. Translation: AAF14372.1 .
AL929170 Genomic DNA. Translation: CAM24720.1 .
CH466519 Genomic DNA. Translation: EDL27032.1 .
AF186585 mRNA. Translation: AAD56419.1 .
CCDSi CCDS16090.1.
RefSeqi NP_066302.2. NM_021022.3.
XP_006499732.1. XM_006499669.1.
UniGenei Mm.439855.

3D structure databases

ProteinModelPortali Q9QY30.
SMRi Q9QY30. Positions 45-660, 754-1316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QY30. 1 interaction.
MINTi MINT-1865476.

Chemistry

ChEMBLi CHEMBL2073695.

PTM databases

PhosphoSitei Q9QY30.

Proteomic databases

MaxQBi Q9QY30.
PaxDbi Q9QY30.
PRIDEi Q9QY30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102709 ; ENSMUSP00000099770 ; ENSMUSG00000027048 .
ENSMUST00000102710 ; ENSMUSP00000099771 ; ENSMUSG00000027048 .
GeneIDi 27413.
KEGGi mmu:27413.
UCSCi uc008jya.1. mouse.

Organism-specific databases

CTDi 8647.
MGIi MGI:1351619. Abcb11.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00530000062896.
HOVERGENi HBG080809.
InParanoidi A2AUN4.
KOi K05664.
OMAi XITNEAL.
OrthoDBi EOG7Z3F4H.
TreeFami TF105193.

Enzyme and pathway databases

Reactomei REACT_203193. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

Miscellaneous databases

NextBioi 305442.
PROi Q9QY30.
SOURCEi Search...

Gene expression databases

Bgeei Q9QY30.
Genevestigatori Q9QY30.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the murine bile salt export pump."
    Green R.M., Hoda F., Ward K.L.
    Gene 241:117-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Molecular cloning of mouse liver bile salt export pump (bsep)."
    Salkar R., Suchy F.J., Ananthanarayanan M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 463-635.
    Strain: C57BL/6.
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiABCBB_MOUSE
AccessioniPrimary (citable) accession number: Q9QY30
Secondary accession number(s): A2AUN4, Q9QZE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi