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Q9QY30

- ABCBB_MOUSE

UniProt

Q9QY30 - ABCBB_MOUSE

Protein

Bile salt export pump

Gene

Abcb11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi455 – 4628ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1113 – 11208ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
    2. ATP binding Source: UniProtKB-KW
    3. canalicular bile acid transmembrane transporter activity Source: RefGenome

    GO - Biological processi

    1. canalicular bile acid transport Source: RefGenome
    2. transmembrane transport Source: RefGenome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_203193. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bile salt export pump
    Alternative name(s):
    ATP-binding cassette sub-family B member 11
    Sister of P-glycoprotein
    Gene namesi
    Name:Abcb11
    Synonyms:Bsep, Spgp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1351619. Abcb11.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: MGI
    2. integral component of membrane Source: RefGenome
    3. intercellular canaliculus Source: MGI
    4. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13211321Bile salt export pumpPRO_0000093297Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Modified residuei692 – 6921Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QY30.
    PaxDbiQ9QY30.
    PRIDEiQ9QY30.

    PTM databases

    PhosphoSiteiQ9QY30.

    Expressioni

    Tissue specificityi

    Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

    Gene expression databases

    BgeeiQ9QY30.
    GenevestigatoriQ9QY30.

    Interactioni

    Subunit structurei

    Interacts with HAX1.By similarity

    Protein-protein interaction databases

    IntActiQ9QY30. 1 interaction.
    MINTiMINT-1865476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QY30.
    SMRiQ9QY30. Positions 45-660, 754-1316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6262CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini84 – 14764ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini169 – 21547CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini237 – 2404ExtracellularSequence Analysis
    Topological domaini262 – 31958CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini341 – 35313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini375 – 755381CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini777 – 79418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini816 – 86954CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini912 – 97968CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1001 – 101111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1033 – 1321289CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei148 – 16821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei216 – 23621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei241 – 26121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei320 – 34021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei354 – 37421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei756 – 77621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei795 – 81521HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei870 – 89021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei891 – 91121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei980 – 100021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1012 – 103221HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 385324ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 656237ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini755 – 1043289ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1078 – 1316239ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni651 – 67424Interaction with HAX1By similarityAdd
    BLAST

    Domaini

    Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00530000062896.
    HOVERGENiHBG080809.
    InParanoidiA2AUN4.
    KOiK05664.
    OMAiXITNEAL.
    OrthoDBiEOG7Z3F4H.
    TreeFamiTF105193.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 3 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QY30-1 [UniParc]FASTAAdd to Basket

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    MSDSVILRSV KKFGEENHAF ESDGFHNNDK KSRLQDKKKG EGARVGFFEL     50
    FRFSSSKDNW LMFMGSVCAL LHGMAQPGMI IVFGILTDIF VEYDIERQEL 100
    SIPEKVCMNN TIVWINSSFN QNMTNGTSCG LVDINSEVIK FSGIYAGVGV 150
    AVLILGYFQI RLWVITGARQ IRKMRKFYFR RIMRMEIGWF DCTSVGELNS 200
    RFSDDINKID EAIADQMALF LQRLSTALSG LLLGFYRGWK LTLVILAVSP 250
    LIGIGAAVIG LSVAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE 300
    VERYEKNLMF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSRLVLD 350
    EGEYTPGTLI QIFLCVIIAA MNIGNASSCL EIFSTGCSAA SSIFQTIDRQ 400
    PVMDCMSGDG YKLDRIKGEI EFHNVTFHYP SRPEVKILNN LSMVIKPGET 450
    TAFVGSSGAG KSTALQLIQR FYDPCEGMVT LDGHDIRSLN IRWLRDQIGI 500
    VEQEPVLFST TIAENIRLGR EEATMEDIVQ AAKDANAYNF IMALPQQFDT 550
    LVGEGGGQMS GGQKQRVAIA RALIRKPKIL LLDMATSALD NESEAKVQGA 600
    LNKIQHGHTI ISVAHRLSTV RSADVIIGFE HGTAVERGTH EELLERKGVY 650
    FMLVTLQSQE DNTHKETGIK GKDTTEGDTP ERTFSRGSYQ DSLRASIRQR 700
    SKSQLSHLSH EPPLAIGDHK SSYEDRKDND VLVEEVEPAP VRRILKYNIS 750
    EWPYILVGAL CAAINGAVTP IYSLLFSQIL KTFSLVDKEQ QRSEIYSMCL 800
    FFVILGCVSL FTQFLQGYNF AKSGELLTKR LRKFGFKAML RQDIGWFDDL 850
    KNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIFVAV LIAFLFNWKL 900
    SLVISVFFPF LALSGAVQTK MLTGFASQDK EILEKAGQIT NEALSNIRTV 950
    AGIGVEGRFI KAFEVELEKS YKTAIRKANV YGLCYAFSQG ISFLANSAAY 1000
    RYGGYLIVYE DLNFSYVFRV VSSIAMSATA VGRTFSYTPS YAKAKISAAR 1050
    FFQLLDRKPP IDVYSGAGEK WDNFQGKIDF IDCKFTYPSR PDIQVLNGLS 1100
    VSVDPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID GHDSKKVNVQ 1150
    FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF 1200
    VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD 1250
    TESEKTVQLA LDKAREGRTC IVIAHRLSTI QNSDIIAVMS QGVVIEKGTH 1300
    KKLMDQKGAY YKLVITGAPI S 1321
    Length:1,321
    Mass (Da):146,749
    Last modified:June 28, 2011 - v2
    Checksum:iC71F8D3D0A352BA8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041E → G in AAF14372. (PubMed:10607905)Curated
    Sequence conflicti481 – 4811L → P in AAD56419. 1 PublicationCurated
    Sequence conflicti633 – 6331T → V in AAD56419. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133903 mRNA. Translation: AAF14372.1.
    AL929170 Genomic DNA. Translation: CAM24720.1.
    CH466519 Genomic DNA. Translation: EDL27032.1.
    AF186585 mRNA. Translation: AAD56419.1.
    CCDSiCCDS16090.1.
    RefSeqiNP_066302.2. NM_021022.3.
    XP_006499732.1. XM_006499669.1.
    UniGeneiMm.439855.

    Genome annotation databases

    EnsembliENSMUST00000102709; ENSMUSP00000099770; ENSMUSG00000027048.
    ENSMUST00000102710; ENSMUSP00000099771; ENSMUSG00000027048.
    GeneIDi27413.
    KEGGimmu:27413.
    UCSCiuc008jya.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133903 mRNA. Translation: AAF14372.1 .
    AL929170 Genomic DNA. Translation: CAM24720.1 .
    CH466519 Genomic DNA. Translation: EDL27032.1 .
    AF186585 mRNA. Translation: AAD56419.1 .
    CCDSi CCDS16090.1.
    RefSeqi NP_066302.2. NM_021022.3.
    XP_006499732.1. XM_006499669.1.
    UniGenei Mm.439855.

    3D structure databases

    ProteinModelPortali Q9QY30.
    SMRi Q9QY30. Positions 45-660, 754-1316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QY30. 1 interaction.
    MINTi MINT-1865476.

    Chemistry

    ChEMBLi CHEMBL2073695.

    PTM databases

    PhosphoSitei Q9QY30.

    Proteomic databases

    MaxQBi Q9QY30.
    PaxDbi Q9QY30.
    PRIDEi Q9QY30.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102709 ; ENSMUSP00000099770 ; ENSMUSG00000027048 .
    ENSMUST00000102710 ; ENSMUSP00000099771 ; ENSMUSG00000027048 .
    GeneIDi 27413.
    KEGGi mmu:27413.
    UCSCi uc008jya.1. mouse.

    Organism-specific databases

    CTDi 8647.
    MGIi MGI:1351619. Abcb11.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00530000062896.
    HOVERGENi HBG080809.
    InParanoidi A2AUN4.
    KOi K05664.
    OMAi XITNEAL.
    OrthoDBi EOG7Z3F4H.
    TreeFami TF105193.

    Enzyme and pathway databases

    Reactomei REACT_203193. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

    Miscellaneous databases

    NextBioi 305442.
    PROi Q9QY30.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QY30.
    Genevestigatori Q9QY30.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 3 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the murine bile salt export pump."
      Green R.M., Hoda F., Ward K.L.
      Gene 241:117-123(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Molecular cloning of mouse liver bile salt export pump (bsep)."
      Salkar R., Suchy F.J., Ananthanarayanan M.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 463-635.
      Strain: C57BL/6.
      Tissue: Liver.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiABCBB_MOUSE
    AccessioniPrimary (citable) accession number: Q9QY30
    Secondary accession number(s): A2AUN4, Q9QZE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3