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Protein

Plakophilin-3

Gene

Pkp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in junctional plaques.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-3
Gene namesi
Name:Pkp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891830. Pkp3.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • desmosome Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • spot adherens junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642881 – 797Plakophilin-3Add BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Omega-N-methylarginineBy similarity1
Modified residuei123PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei183PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei250PhosphothreonineBy similarity1
Modified residuei261Omega-N-methylarginineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei331PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QY23.
PeptideAtlasiQ9QY23.
PRIDEiQ9QY23.

PTM databases

iPTMnetiQ9QY23.
PhosphoSitePlusiQ9QY23.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054065.
CleanExiMM_PKP3.
ExpressionAtlasiQ9QY23. baseline and differential.
GenevisibleiQ9QY23. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101654.

Structurei

3D structure databases

ProteinModelPortaliQ9QY23.
SMRiQ9QY23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati305 – 348ARM 1Add BLAST44
Repeati351 – 390ARM 2Add BLAST40
Repeati393 – 432ARM 3Add BLAST40
Repeati449 – 487ARM 4Add BLAST39
Repeati491 – 536ARM 5Add BLAST46
Repeati596 – 637ARM 6Add BLAST42
Repeati645 – 684ARM 7Add BLAST40
Repeati689 – 730ARM 8Add BLAST42

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 8 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000115567.
HOVERGENiHBG106682.
InParanoidiQ9QY23.
OMAiNARNKDE.
OrthoDBiEOG091G01WL.
PhylomeDBiQ9QY23.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028434. Plakophilin-3.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF1. PTHR10372:SF1. 1 hit.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QY23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQEGNFLLSA LQPETGVCSL ALPSDLQLDR RGAEGPEADR LRAARVQEQV
60 70 80 90 100
RARLLQLGQQ SRHNGSAELD GSAESARGMP RGQYHTMQTG FSSRSQGMSG
110 120 130 140 150
DKTSTFRPIA KPAYSPASWS SRSAVDLTCS RRLSSAHNGG SAFGAVGYGG
160 170 180 190 200
TQPTPPMPTR PVSFHERGGA ASRADYDTLS LRSLRLGPGG LDDRYSVVSE
210 220 230 240 250
QLEPAAASTY RAYAYERQAS SGSSRAGGLD WPEATEGPPS RTIRAPAMRT
260 270 280 290 300
LQRFQSSHRS RGGTGSVSGA GLEPVARAPS VRSLSLSLAD SGHLPDVRGL
310 320 330 340 350
DSYTGHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHRCYSD
360 370 380 390 400
AAAKKQARSL QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNVDNKLALV
410 420 430 440 450
EENGIFELLR TLREQDDELR KNVTGILWNL SSSDHLKDRL ARDTLEQLTD
460 470 480 490 500
LVLSPLSGAG GPPLIQQNAS EAEIFYNATG FLRNLSSASQ ATRQKMRECH
510 520 530 540 550
GLVDALVTYI NHALDVGKCE DKSVENAVCV LRNLSYRLYD EMPPSALQRL
560 570 580 590 600
EGRGRRDMAG APPGEMVGCF TPQSRRLREL PLTADALTFA EVSKDPKGLE
610 620 630 640 650
WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA
660 670 680 690 700
LEQERILNPL LDRVRTADHN QLRSLTGLIR NLSRNARNKD EMSTKVVSHL
710 720 730 740 750
IEKLPGSVGE KCPPAEVLVN IIAVLNNLVV ASPIAARDLL YFDGLRKLVF
760 770 780 790
IKKKRDSPDS EKSSRAASSL LANLWQYSKL HRDFRAKGYR KEDFLGP
Length:797
Mass (Da):87,333
Last modified:June 12, 2007 - v2
Checksum:iC2ECF73BDE7323B1
GO
Isoform 2 (identifier: Q9QY23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MQEGNFLLSALQ → MEPTAGSRTRMEPRRNCPTAGTSRMSQGASGGQTSGK

Note: No experimental confirmation available.
Show »
Length:822
Mass (Da):89,822
Checksum:i2FF8611C988EB4D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182R → P in AAD55892 (PubMed:10381383).Curated1
Sequence conflicti216E → K in AAD55892 (PubMed:10381383).Curated1
Sequence conflicti459A → P in AAD55892 (PubMed:10381383).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0261391 – 12MQEGN…LSALQ → MEPTAGSRTRMEPRRNCPTA GTSRMSQGASGGQTSGK in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136719 mRNA. Translation: AAD55892.1.
BC090668 mRNA. Translation: AAH90668.1.
BC106141 mRNA. Translation: AAI06142.1.
BC139775 mRNA. Translation: AAI39776.1.
CCDSiCCDS21999.1. [Q9QY23-1]
CCDS52437.1. [Q9QY23-2]
RefSeqiNP_001156396.1. NM_001162924.1. [Q9QY23-2]
NP_062736.2. NM_019762.2. [Q9QY23-1]
UniGeneiMm.350037.

Genome annotation databases

EnsembliENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065. [Q9QY23-1]
ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065. [Q9QY23-2]
GeneIDi56460.
KEGGimmu:56460.
UCSCiuc009kjh.2. mouse. [Q9QY23-2]
uc009kji.2. mouse. [Q9QY23-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136719 mRNA. Translation: AAD55892.1.
BC090668 mRNA. Translation: AAH90668.1.
BC106141 mRNA. Translation: AAI06142.1.
BC139775 mRNA. Translation: AAI39776.1.
CCDSiCCDS21999.1. [Q9QY23-1]
CCDS52437.1. [Q9QY23-2]
RefSeqiNP_001156396.1. NM_001162924.1. [Q9QY23-2]
NP_062736.2. NM_019762.2. [Q9QY23-1]
UniGeneiMm.350037.

3D structure databases

ProteinModelPortaliQ9QY23.
SMRiQ9QY23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101654.

PTM databases

iPTMnetiQ9QY23.
PhosphoSitePlusiQ9QY23.

Proteomic databases

PaxDbiQ9QY23.
PeptideAtlasiQ9QY23.
PRIDEiQ9QY23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065. [Q9QY23-1]
ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065. [Q9QY23-2]
GeneIDi56460.
KEGGimmu:56460.
UCSCiuc009kjh.2. mouse. [Q9QY23-2]
uc009kji.2. mouse. [Q9QY23-1]

Organism-specific databases

CTDi11187.
MGIiMGI:1891830. Pkp3.

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000115567.
HOVERGENiHBG106682.
InParanoidiQ9QY23.
OMAiNARNKDE.
OrthoDBiEOG091G01WL.
PhylomeDBiQ9QY23.
TreeFamiTF321877.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiPkp3. mouse.
PROiQ9QY23.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054065.
CleanExiMM_PKP3.
ExpressionAtlasiQ9QY23. baseline and differential.
GenevisibleiQ9QY23. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028434. Plakophilin-3.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF1. PTHR10372:SF1. 1 hit.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKP3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY23
Secondary accession number(s): A4QPD8, Q0VGP3, Q3KQL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.