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Protein

Plakophilin-3

Gene

Pkp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in junctional plaques.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-3
Gene namesi
Name:Pkp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891830. Pkp3.

Subcellular locationi

GO - Cellular componenti

  • desmosome Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • spot adherens junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 797797Plakophilin-3PRO_0000064288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231PhosphoserineCombined sources
Modified residuei180 – 1801PhosphoserineCombined sources
Modified residuei183 – 1831PhosphoserineBy similarity
Modified residuei240 – 2401PhosphoserineBy similarity
Modified residuei250 – 2501PhosphothreonineBy similarity
Modified residuei313 – 3131PhosphoserineBy similarity
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei331 – 3311PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QY23.
PaxDbiQ9QY23.
PeptideAtlasiQ9QY23.
PRIDEiQ9QY23.

PTM databases

iPTMnetiQ9QY23.
PhosphoSiteiQ9QY23.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054065.
CleanExiMM_PKP3.
ExpressionAtlasiQ9QY23. baseline and differential.
GenevisibleiQ9QY23. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101654.

Structurei

3D structure databases

ProteinModelPortaliQ9QY23.
SMRiQ9QY23. Positions 318-781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati305 – 34844ARM 1Add
BLAST
Repeati351 – 39040ARM 2Add
BLAST
Repeati393 – 43240ARM 3Add
BLAST
Repeati449 – 48739ARM 4Add
BLAST
Repeati491 – 53646ARM 5Add
BLAST
Repeati596 – 63742ARM 6Add
BLAST
Repeati645 – 68440ARM 7Add
BLAST
Repeati689 – 73042ARM 8Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 8 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000115567.
HOVERGENiHBG106682.
InParanoidiQ9QY23.
OMAiNARNKDE.
OrthoDBiEOG091G01WL.
PhylomeDBiQ9QY23.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028434. Plakophilin-3.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF1. PTHR10372:SF1. 1 hit.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QY23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQEGNFLLSA LQPETGVCSL ALPSDLQLDR RGAEGPEADR LRAARVQEQV
60 70 80 90 100
RARLLQLGQQ SRHNGSAELD GSAESARGMP RGQYHTMQTG FSSRSQGMSG
110 120 130 140 150
DKTSTFRPIA KPAYSPASWS SRSAVDLTCS RRLSSAHNGG SAFGAVGYGG
160 170 180 190 200
TQPTPPMPTR PVSFHERGGA ASRADYDTLS LRSLRLGPGG LDDRYSVVSE
210 220 230 240 250
QLEPAAASTY RAYAYERQAS SGSSRAGGLD WPEATEGPPS RTIRAPAMRT
260 270 280 290 300
LQRFQSSHRS RGGTGSVSGA GLEPVARAPS VRSLSLSLAD SGHLPDVRGL
310 320 330 340 350
DSYTGHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHRCYSD
360 370 380 390 400
AAAKKQARSL QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNVDNKLALV
410 420 430 440 450
EENGIFELLR TLREQDDELR KNVTGILWNL SSSDHLKDRL ARDTLEQLTD
460 470 480 490 500
LVLSPLSGAG GPPLIQQNAS EAEIFYNATG FLRNLSSASQ ATRQKMRECH
510 520 530 540 550
GLVDALVTYI NHALDVGKCE DKSVENAVCV LRNLSYRLYD EMPPSALQRL
560 570 580 590 600
EGRGRRDMAG APPGEMVGCF TPQSRRLREL PLTADALTFA EVSKDPKGLE
610 620 630 640 650
WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA
660 670 680 690 700
LEQERILNPL LDRVRTADHN QLRSLTGLIR NLSRNARNKD EMSTKVVSHL
710 720 730 740 750
IEKLPGSVGE KCPPAEVLVN IIAVLNNLVV ASPIAARDLL YFDGLRKLVF
760 770 780 790
IKKKRDSPDS EKSSRAASSL LANLWQYSKL HRDFRAKGYR KEDFLGP
Length:797
Mass (Da):87,333
Last modified:June 12, 2007 - v2
Checksum:iC2ECF73BDE7323B1
GO
Isoform 2 (identifier: Q9QY23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MQEGNFLLSALQ → MEPTAGSRTRMEPRRNCPTAGTSRMSQGASGGQTSGK

Note: No experimental confirmation available.
Show »
Length:822
Mass (Da):89,822
Checksum:i2FF8611C988EB4D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821R → P in AAD55892 (PubMed:10381383).Curated
Sequence conflicti216 – 2161E → K in AAD55892 (PubMed:10381383).Curated
Sequence conflicti459 – 4591A → P in AAD55892 (PubMed:10381383).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212MQEGN…LSALQ → MEPTAGSRTRMEPRRNCPTA GTSRMSQGASGGQTSGK in isoform 2. 1 PublicationVSP_026139Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136719 mRNA. Translation: AAD55892.1.
BC090668 mRNA. Translation: AAH90668.1.
BC106141 mRNA. Translation: AAI06142.1.
BC139775 mRNA. Translation: AAI39776.1.
CCDSiCCDS21999.1. [Q9QY23-1]
CCDS52437.1. [Q9QY23-2]
RefSeqiNP_001156396.1. NM_001162924.1. [Q9QY23-2]
NP_062736.2. NM_019762.2. [Q9QY23-1]
UniGeneiMm.350037.

Genome annotation databases

EnsembliENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065. [Q9QY23-1]
ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065. [Q9QY23-2]
GeneIDi56460.
KEGGimmu:56460.
UCSCiuc009kjh.2. mouse. [Q9QY23-2]
uc009kji.2. mouse. [Q9QY23-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136719 mRNA. Translation: AAD55892.1.
BC090668 mRNA. Translation: AAH90668.1.
BC106141 mRNA. Translation: AAI06142.1.
BC139775 mRNA. Translation: AAI39776.1.
CCDSiCCDS21999.1. [Q9QY23-1]
CCDS52437.1. [Q9QY23-2]
RefSeqiNP_001156396.1. NM_001162924.1. [Q9QY23-2]
NP_062736.2. NM_019762.2. [Q9QY23-1]
UniGeneiMm.350037.

3D structure databases

ProteinModelPortaliQ9QY23.
SMRiQ9QY23. Positions 318-781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101654.

PTM databases

iPTMnetiQ9QY23.
PhosphoSiteiQ9QY23.

Proteomic databases

MaxQBiQ9QY23.
PaxDbiQ9QY23.
PeptideAtlasiQ9QY23.
PRIDEiQ9QY23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066873; ENSMUSP00000069961; ENSMUSG00000054065. [Q9QY23-1]
ENSMUST00000106039; ENSMUSP00000101654; ENSMUSG00000054065. [Q9QY23-2]
GeneIDi56460.
KEGGimmu:56460.
UCSCiuc009kjh.2. mouse. [Q9QY23-2]
uc009kji.2. mouse. [Q9QY23-1]

Organism-specific databases

CTDi11187.
MGIiMGI:1891830. Pkp3.

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000115567.
HOVERGENiHBG106682.
InParanoidiQ9QY23.
OMAiNARNKDE.
OrthoDBiEOG091G01WL.
PhylomeDBiQ9QY23.
TreeFamiTF321877.

Miscellaneous databases

ChiTaRSiPkp3. mouse.
PROiQ9QY23.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054065.
CleanExiMM_PKP3.
ExpressionAtlasiQ9QY23. baseline and differential.
GenevisibleiQ9QY23. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028434. Plakophilin-3.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF1. PTHR10372:SF1. 1 hit.
PfamiPF00514. Arm. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKP3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY23
Secondary accession number(s): A4QPD8, Q0VGP3, Q3KQL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 12, 2007
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.