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Q9QY17 (PACN2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase C and casein kinase substrate in neurons 2 protein
Alternative name(s):
Synaptic dynamin-associated protein II
Syndapin 2
Syndapin-II
Short name=SdpII
Gene names
Name:Pacsin2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in endocytosis. Ref.1

Subunit structure

May form homo- and heterooligomers with other PACSINs By similarity. Interacts with DNM1, SYN1, SYNJ1 and WASL through its SH3 domain. Ref.1

Subcellular location

Cytoplasm. Note: Endocytic vesicle-like distribution. Ref.1

Tissue specificity

Widely expressed (at protein level). Isoforms 1/3 are predominantly expressed in heart and in PC-12 cells, a pheochromocytoma cell line (at protein level). Isoforms 2/4 are widely expressed with highest levels in muscle, testis and brain (at protein level). Ref.1

Post-translational modification

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) By similarity.

Sequence similarities

Belongs to the PACSIN family.

Contains 1 FCH domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
SH3 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of endocytosis

Inferred from electronic annotation. Source: Compara

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Ehd1Q641Z62EBI-491201,EBI-492911
Ehd4Q9EQP24EBI-491201,EBI-491022From a different organism.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QY17-1)

Also known as: Aa; SdpII-l;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QY17-2)

Also known as: Ab;

The sequence of this isoform differs from the canonical sequence as follows:
     346-386: Missing.
Isoform 3 (identifier: Q9QY17-3)

Also known as: Ba;

The sequence of this isoform differs from the canonical sequence as follows:
     302-303: Missing.
Isoform 4 (identifier: Q9QY17-4)

Also known as: Bb; SdpII-s;

The sequence of this isoform differs from the canonical sequence as follows:
     302-303: Missing.
     346-386: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Protein kinase C and casein kinase substrate in neurons 2 protein
PRO_0000161797

Regions

Domain11 – 7565FCH
Domain428 – 48861SH3
Coiled coil184 – 23956 Potential

Natural variations

Alternative sequence302 – 3032Missing in isoform 3 and isoform 4.
VSP_004518
Alternative sequence346 – 38641Missing in isoform 2 and isoform 4.
VSP_004519

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Aa) (SdpII-l) [UniParc].

Last modified August 13, 2002. Version 2.
Checksum: B2975012EF0FDF56

FASTA48855,978
        10         20         30         40         50         60 
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCGD LMNCLHERAR IEKAYAQQLT 

        70         80         90        100        110        120 
EWARRWRQLV EKGPQYGTVE KAWMAVMSEA ERVSELHLEV KASLMNEDFE KIKNWQKEAF 

       130        140        150        160        170        180 
HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVDAAKKAHH TACKEEKLAV SREANSKADP 

       190        200        210        220        230        240 
SLNPEQLKKL QDKIEKCKQD VLKTKDKYEK ALKELDQTTP QYMENMEQVF EQCQQFEEKR 

       250        260        270        280        290        300 
LRFFREVLLE VQKHLDLSNV ASYKGIYREL EQSIKAADAV EDLRWFRANH GPGMAMNWPQ 

       310        320        330        340        350        360 
FEDEEWSADL NRTLSRREKK KAADGVTLTG INQTGDQSGQ NKPSSNLSVP SNPAQSTQLQ 

       370        380        390        400        410        420 
SSYNPFEDED DTGSSVSEKE DIKAKNVSSY EKTQNYPADW SDDESNNPFS STDANGDSNP 

       430        440        450        460        470        480 
FDEDTTSGTE VRVRALYDYE GQEHDELSFK AGDELTKIED EDEQGWCKGR LDSGQVGLYP 


ANYVEAIQ

« Hide

Isoform 2 (Ab) [UniParc].

Checksum: B202B81D7D48E6D1
Show »

FASTA44751,538
Isoform 3 (Ba) [UniParc].

Checksum: B140F324EF11E29B
Show »

FASTA48655,734
Isoform 4 (Bb) (SdpII-s) [UniParc].

Checksum: 99512F063951F4A6
Show »

FASTA44551,294

References

[1]"Syndapin isoforms participate in receptor-mediated endocytosis and actin organization."
Qualmann B., Kelly R.B.
J. Cell Biol. 148:1047-1062(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, INTERACTION WITH DNM1; SYN1; SYNJ1 AND WASL, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF139492 mRNA. Translation: AAF22211.1.
AF139493 mRNA. Translation: AAF22212.1.
AF139494 mRNA. Translation: AAF22213.1.
AF139495 mRNA. Translation: AAF22214.1.
IPIIPI00213498.
IPI00231215.
IPI00231216.
IPI00231217.
RefSeqNP_570096.2. NM_130740.2.
UniGeneRn.17106.

3D structure databases

ProteinModelPortalQ9QY17.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9QY17. 2 interactions.
MINTMINT-4567486.
STRING10116.ENSRNOP00000013398.

PTM databases

PhosphoSiteQ9QY17.

Proteomic databases

PaxDbQ9QY17.
PRIDEQ9QY17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013398; ENSRNOP00000013398; ENSRNOG00000009756.
GeneID124461.
KEGGrno:124461.

Organism-specific databases

CTD11252.
RGD69411. Pacsin2.

Phylogenomic databases

eggNOGNOG283356.
GeneTreeENSGT00510000046376.
HOGENOMHOG000007245.
HOVERGENHBG053486.
InParanoidQ9QY17.

Gene expression databases

ArrayExpressQ9QY17.
GenevestigatorQ9QY17.
GermOnlineENSRNOG00000009756. Rattus norvegicus.

Family and domain databases

InterProIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SH3. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620467.

Entry information

Entry namePACN2_RAT
AccessionPrimary (citable) accession number: Q9QY17
Secondary accession number(s): Q9QY18, Q9QY19, Q9QY20
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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