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Q9QY14

- FOXE3_MOUSE

UniProt

Q9QY14 - FOXE3_MOUSE

Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Transcription factor essential for lens epithelial proliferation and closure of the lens vesicle.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi63 – 15492Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. camera-type eye development Source: MGI
    2. cell development Source: MGI
    3. eye development Source: MGI
    4. positive regulation of epithelial cell proliferation Source: MGI
    5. transcription from RNA polymerase II promoter Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein E3
    Gene namesi
    Name:Foxe3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1353569. Foxe3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Forkhead box protein E3PRO_0000091830Add
    BLAST

    Proteomic databases

    PRIDEiQ9QY14.

    PTM databases

    PhosphoSiteiQ9QY14.

    Expressioni

    Developmental stagei

    Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins.

    Gene expression databases

    BgeeiQ9QY14.
    CleanExiMM_FOXE3.
    GenevestigatoriQ9QY14.

    Interactioni

    Protein-protein interaction databases

    BioGridi206001. 2 interactions.
    STRINGi10090.ENSMUSP00000050445.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QY14.
    SMRiQ9QY14. Positions 64-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 584Poly-Arg
    Compositional biasi166 – 17611Poly-ProAdd
    BLAST
    Compositional biasi179 – 1868Poly-Pro
    Compositional biasi229 – 2324Poly-Ala

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00740000115067.
    HOGENOMiHOG000231286.
    HOVERGENiHBG051642.
    InParanoidiQ9QY14.
    KOiK09398.
    OMAiYRDNPRK.
    OrthoDBiEOG7KWSK8.
    PhylomeDBiQ9QY14.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QY14-1 [UniParc]FASTAAdd to Basket

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    MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP    50
    GPGKRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF 100
    YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN 150
    GSFLRRRKRF KRAELPAPPP PPPPFPYAPF PPPPAPASAP PARLFRLDSL 200
    LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA SERLGLPAPL 250
    PAQPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL 288
    Length:288
    Mass (Da):30,541
    Last modified:May 1, 2000 - v1
    Checksum:i16425926F3E466C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142647 Genomic DNA. Translation: AAF15997.1.
    CCDSiCCDS18483.1.
    RefSeqiNP_056573.1. NM_015758.2.
    UniGeneiMm.377122.

    Genome annotation databases

    EnsembliENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
    GeneIDi30923.
    KEGGimmu:30923.
    UCSCiuc008uef.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142647 Genomic DNA. Translation: AAF15997.1 .
    CCDSi CCDS18483.1.
    RefSeqi NP_056573.1. NM_015758.2.
    UniGenei Mm.377122.

    3D structure databases

    ProteinModelPortali Q9QY14.
    SMRi Q9QY14. Positions 64-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206001. 2 interactions.
    STRINGi 10090.ENSMUSP00000050445.

    PTM databases

    PhosphoSitei Q9QY14.

    Proteomic databases

    PRIDEi Q9QY14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050940 ; ENSMUSP00000050445 ; ENSMUSG00000044518 .
    GeneIDi 30923.
    KEGGi mmu:30923.
    UCSCi uc008uef.1. mouse.

    Organism-specific databases

    CTDi 2301.
    MGIi MGI:1353569. Foxe3.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00740000115067.
    HOGENOMi HOG000231286.
    HOVERGENi HBG051642.
    InParanoidi Q9QY14.
    KOi K09398.
    OMAi YRDNPRK.
    OrthoDBi EOG7KWSK8.
    PhylomeDBi Q9QY14.
    TreeFami TF316127.

    Miscellaneous databases

    NextBioi 307312.
    PROi Q9QY14.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QY14.
    CleanExi MM_FOXE3.
    Genevestigatori Q9QY14.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle."
      Blixt A., Mahlapuu M., Aitola M., Pelto-Huikko M., Enerbaeck S., Carlsson P.
      Genes Dev. 14:245-254(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN DYL.
      Strain: 129/Sv.
      Tissue: Lens.

    Entry informationi

    Entry nameiFOXE3_MOUSE
    AccessioniPrimary (citable) accession number: Q9QY14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3