Q9QY14 (FOXE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein E3

Gene names

Name:

Foxe3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor essential for lens epithelial proliferation and closure of the lens vesicle.
Subcellular location	Nucleus.
Developmental stage	Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins.
Involvement in disease	Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell development Inferred from mutant phenotype PubMed 16199865. Source: MGI cell migration Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic organ morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome enteric nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome hair follicle morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome hard palate development Inferred from Biological aspect of Ancestor. Source: RefGenome lens morphogenesis in camera-type eye Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome peripheral nervous system development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 16199865. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome soft palate development Inferred from Biological aspect of Ancestor. Source: RefGenome thyroid gland development Inferred from Biological aspect of Ancestor. Source: RefGenome thyroid hormone generation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from sequence orthology Ref.1. Source: MGI
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Forkhead box protein E3		PRO_0000091830
Regions
	DNA binding	63 – 154	92	Fork-head
	Compositional bias	55 – 58	4	Poly-Arg
	Compositional bias	166 – 176	11	Poly-Pro
	Compositional bias	179 – 186	8	Poly-Pro
	Compositional bias	229 – 232	4	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q9QY14 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 16425926F3E466C5	FASTA	288	30,541
	10 20 30 40 50 60 MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP GPGKRRRRPL 70 80 90 100 110 120 QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF YRDSPRKWQN SIRHNLTLND 130 140 150 160 170 180 CFVKVPREPG NPGKGNYWTL DPAAADMFDN GSFLRRRKRF KRAELPAPPP PPPPFPYAPF 190 200 210 220 230 240 PPPPAPASAP PARLFRLDSL LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA 250 260 270 280 SERLGLPAPL PAQPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL

References

[1]	"A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle." Blixt A., Mahlapuu M., Aitola M., Pelto-Huikko M., Enerbaeck S., Carlsson P. Genes Dev. 14:245-254(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN DYL. Strain: 129/Sv. Tissue: Lens.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF142647 Genomic DNA. Translation: AAF15997.1.
IPI	IPI00135416.
RefSeq	NP_056573.1. NM_015758.2.
UniGene	Mm.377122.
3D structure databases
ProteinModelPortal	Q9QY14.
SMR	Q9QY14. Positions 64-159.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000050445.
PTM databases
PhosphoSite	Q9QY14.
Proteomic databases
PRIDE	Q9QY14.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
GeneID	30923.
KEGG	mmu:30923.
Organism-specific databases
CTD	2301.
MGI	MGI:1353569. Foxe3.
Phylogenomic databases
eggNOG	COG5025.
GeneTree	ENSGT00700000104135.
HOGENOM	HOG000231286.
HOVERGEN	HBG051642.
InParanoid	Q9QY14.
KO	K09398.
OMA	FPYAPFP.
OrthoDB	EOG4001JR.
Gene expression databases
ArrayExpress	Q9QY14.
Bgee	Q9QY14.
CleanEx	MM_FOXE3.
Genevestigator	Q9QY14.
GermOnline	ENSMUSG00000044518. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	307312.
SOURCE	Search...

Entry information

Entry name

FOXE3_MOUSE

Accession

Primary (citable) accession number: Q9QY14

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program