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Q9QY14 (FOXE3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein E3
Gene names
Name:Foxe3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor essential for lens epithelial proliferation and closure of the lens vesicle.

Subcellular location

Nucleus.

Developmental stage

Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins.

Involvement in disease

Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcamera-type eye development

Inferred from mutant phenotype PubMed 11309658. Source: MGI

cell development

Inferred from mutant phenotype PubMed 16199865. Source: MGI

embryonic organ morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

eye development

Inferred from mutant phenotype Ref.1. Source: MGI

hair follicle morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

hard palate development

Inferred from Biological aspect of Ancestor. Source: RefGenome

lens morphogenesis in camera-type eye

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 16199865. Source: MGI

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

soft palate development

Inferred from Biological aspect of Ancestor. Source: RefGenome

thyroid gland development

Inferred from Biological aspect of Ancestor. Source: RefGenome

thyroid hormone generation

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from sequence orthology Ref.1. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from sequence orthology Ref.1. Source: MGI

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from sequence orthology Ref.1. Source: MGI

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Forkhead box protein E3
PRO_0000091830

Regions

DNA binding63 – 15492Fork-head
Compositional bias55 – 584Poly-Arg
Compositional bias166 – 17611Poly-Pro
Compositional bias179 – 1868Poly-Pro
Compositional bias229 – 2324Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q9QY14 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 16425926F3E466C5

FASTA28830,541
        10         20         30         40         50         60 
MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP GPGKRRRRPL 

        70         80         90        100        110        120 
QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF YRDSPRKWQN SIRHNLTLND 

       130        140        150        160        170        180 
CFVKVPREPG NPGKGNYWTL DPAAADMFDN GSFLRRRKRF KRAELPAPPP PPPPFPYAPF 

       190        200        210        220        230        240 
PPPPAPASAP PARLFRLDSL LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA 

       250        260        270        280 
SERLGLPAPL PAQPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL 

« Hide

References

[1]"A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle."
Blixt A., Mahlapuu M., Aitola M., Pelto-Huikko M., Enerbaeck S., Carlsson P.
Genes Dev. 14:245-254(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN DYL.
Strain: 129/Sv.
Tissue: Lens.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF142647 Genomic DNA. Translation: AAF15997.1.
RefSeqNP_056573.1. NM_015758.2.
UniGeneMm.377122.

3D structure databases

ProteinModelPortalQ9QY14.
SMRQ9QY14. Positions 64-159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206001. 2 interactions.
STRING10090.ENSMUSP00000050445.

PTM databases

PhosphoSiteQ9QY14.

Proteomic databases

PRIDEQ9QY14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
GeneID30923.
KEGGmmu:30923.
UCSCuc008uef.1. mouse.

Organism-specific databases

CTD2301.
MGIMGI:1353569. Foxe3.

Phylogenomic databases

eggNOGCOG5025.
GeneTreeENSGT00740000115067.
HOGENOMHOG000231286.
HOVERGENHBG051642.
InParanoidQ9QY14.
KOK09398.
OMAPEPPCCA.
OrthoDBEOG7KWSK8.
PhylomeDBQ9QY14.
TreeFamTF316127.

Gene expression databases

BgeeQ9QY14.
CleanExMM_FOXE3.
GenevestigatorQ9QY14.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307312.
PROQ9QY14.
SOURCESearch...

Entry information

Entry nameFOXE3_MOUSE
AccessionPrimary (citable) accession number: Q9QY14
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot