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Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor essential for lens epithelial proliferation and closure of the lens vesicle.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi63 – 15492Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. camera-type eye development Source: MGI
  2. cell development Source: MGI
  3. eye development Source: MGI
  4. positive regulation of epithelial cell proliferation Source: MGI
  5. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  6. transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E3
Gene namesi
Name:Foxe3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1353569. Foxe3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: GO_Central
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Forkhead box protein E3PRO_0000091830Add
BLAST

Proteomic databases

PRIDEiQ9QY14.

PTM databases

PhosphoSiteiQ9QY14.

Expressioni

Developmental stagei

Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins.

Gene expression databases

BgeeiQ9QY14.
CleanExiMM_FOXE3.
GenevestigatoriQ9QY14.

Interactioni

Protein-protein interaction databases

BioGridi206001. 2 interactions.
STRINGi10090.ENSMUSP00000050445.

Structurei

3D structure databases

ProteinModelPortaliQ9QY14.
SMRiQ9QY14. Positions 64-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 584Poly-Arg
Compositional biasi166 – 17611Poly-ProAdd
BLAST
Compositional biasi179 – 1868Poly-Pro
Compositional biasi229 – 2324Poly-Ala

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiQ9QY14.
KOiK09398.
OMAiPEPPCCA.
OrthoDBiEOG7KWSK8.
PhylomeDBiQ9QY14.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP
60 70 80 90 100
GPGKRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF
110 120 130 140 150
YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN
160 170 180 190 200
GSFLRRRKRF KRAELPAPPP PPPPFPYAPF PPPPAPASAP PARLFRLDSL
210 220 230 240 250
LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA SERLGLPAPL
260 270 280
PAQPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL
Length:288
Mass (Da):30,541
Last modified:May 1, 2000 - v1
Checksum:i16425926F3E466C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142647 Genomic DNA. Translation: AAF15997.1.
CCDSiCCDS18483.1.
RefSeqiNP_056573.1. NM_015758.2.
UniGeneiMm.377122.

Genome annotation databases

EnsembliENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
GeneIDi30923.
KEGGimmu:30923.
UCSCiuc008uef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142647 Genomic DNA. Translation: AAF15997.1.
CCDSiCCDS18483.1.
RefSeqiNP_056573.1. NM_015758.2.
UniGeneiMm.377122.

3D structure databases

ProteinModelPortaliQ9QY14.
SMRiQ9QY14. Positions 64-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206001. 2 interactions.
STRINGi10090.ENSMUSP00000050445.

PTM databases

PhosphoSiteiQ9QY14.

Proteomic databases

PRIDEiQ9QY14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
GeneIDi30923.
KEGGimmu:30923.
UCSCiuc008uef.1. mouse.

Organism-specific databases

CTDi2301.
MGIiMGI:1353569. Foxe3.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiQ9QY14.
KOiK09398.
OMAiPEPPCCA.
OrthoDBiEOG7KWSK8.
PhylomeDBiQ9QY14.
TreeFamiTF316127.

Miscellaneous databases

NextBioi307312.
PROiQ9QY14.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QY14.
CleanExiMM_FOXE3.
GenevestigatoriQ9QY14.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle."
    Blixt A., Mahlapuu M., Aitola M., Pelto-Huikko M., Enerbaeck S., Carlsson P.
    Genes Dev. 14:245-254(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN DYL.
    Strain: 129/Sv.
    Tissue: Lens.

Entry informationi

Entry nameiFOXE3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.