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Q9QY14

- FOXE3_MOUSE

UniProt

Q9QY14 - FOXE3_MOUSE

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Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor essential for lens epithelial proliferation and closure of the lens vesicle.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi63 – 15492Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. camera-type eye development Source: MGI
  2. cell development Source: MGI
  3. eye development Source: MGI
  4. positive regulation of epithelial cell proliferation Source: MGI
  5. transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E3
Gene namesi
Name:Foxe3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1353569. Foxe3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Forkhead box protein E3PRO_0000091830Add
BLAST

Proteomic databases

PRIDEiQ9QY14.

PTM databases

PhosphoSiteiQ9QY14.

Expressioni

Developmental stagei

Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins.

Gene expression databases

BgeeiQ9QY14.
CleanExiMM_FOXE3.
GenevestigatoriQ9QY14.

Interactioni

Protein-protein interaction databases

BioGridi206001. 2 interactions.
STRINGi10090.ENSMUSP00000050445.

Structurei

3D structure databases

ProteinModelPortaliQ9QY14.
SMRiQ9QY14. Positions 64-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 584Poly-Arg
Compositional biasi166 – 17611Poly-ProAdd
BLAST
Compositional biasi179 – 1868Poly-Pro
Compositional biasi229 – 2324Poly-Ala

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiQ9QY14.
KOiK09398.
OMAiYRDNPRK.
OrthoDBiEOG7KWSK8.
PhylomeDBiQ9QY14.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP
60 70 80 90 100
GPGKRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF
110 120 130 140 150
YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN
160 170 180 190 200
GSFLRRRKRF KRAELPAPPP PPPPFPYAPF PPPPAPASAP PARLFRLDSL
210 220 230 240 250
LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA SERLGLPAPL
260 270 280
PAQPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL
Length:288
Mass (Da):30,541
Last modified:May 1, 2000 - v1
Checksum:i16425926F3E466C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142647 Genomic DNA. Translation: AAF15997.1.
CCDSiCCDS18483.1.
RefSeqiNP_056573.1. NM_015758.2.
UniGeneiMm.377122.

Genome annotation databases

EnsembliENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
GeneIDi30923.
KEGGimmu:30923.
UCSCiuc008uef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142647 Genomic DNA. Translation: AAF15997.1 .
CCDSi CCDS18483.1.
RefSeqi NP_056573.1. NM_015758.2.
UniGenei Mm.377122.

3D structure databases

ProteinModelPortali Q9QY14.
SMRi Q9QY14. Positions 64-159.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206001. 2 interactions.
STRINGi 10090.ENSMUSP00000050445.

PTM databases

PhosphoSitei Q9QY14.

Proteomic databases

PRIDEi Q9QY14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050940 ; ENSMUSP00000050445 ; ENSMUSG00000044518 .
GeneIDi 30923.
KEGGi mmu:30923.
UCSCi uc008uef.1. mouse.

Organism-specific databases

CTDi 2301.
MGIi MGI:1353569. Foxe3.

Phylogenomic databases

eggNOGi COG5025.
GeneTreei ENSGT00760000118904.
HOGENOMi HOG000231286.
HOVERGENi HBG051642.
InParanoidi Q9QY14.
KOi K09398.
OMAi YRDNPRK.
OrthoDBi EOG7KWSK8.
PhylomeDBi Q9QY14.
TreeFami TF316127.

Miscellaneous databases

NextBioi 307312.
PROi Q9QY14.
SOURCEi Search...

Gene expression databases

Bgeei Q9QY14.
CleanExi MM_FOXE3.
Genevestigatori Q9QY14.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle."
    Blixt A., Mahlapuu M., Aitola M., Pelto-Huikko M., Enerbaeck S., Carlsson P.
    Genes Dev. 14:245-254(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INVOLVEMENT IN DYL.
    Strain: 129/Sv.
    Tissue: Lens.

Entry informationi

Entry nameiFOXE3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3