Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Forkhead box protein E3

Gene

Foxe3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278). Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680).4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi64 – 15895Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • camera-type eye development Source: MGI
  • cell development Source: MGI
  • cell differentiation Source: GO_Central
  • ciliary body morphogenesis Source: UniProtKB
  • cornea development in camera-type eye Source: UniProtKB
  • eye development Source: MGI
  • iris morphogenesis Source: UniProtKB
  • lens development in camera-type eye Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell cycle arrest Source: UniProtKB
  • negative regulation of lens fiber cell differentiation Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of lens epithelial cell proliferation Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • trabecular meshwork development Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein E3
Gene namesi
Name:Foxe3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1353569. Foxe3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Foxe3 are the cause of the dysgenetic lens (dyl) phenotype. In mouse mutant dyl the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractous lens (PubMed:10652278).

Disruption phenotypei

Knockout mice homozygotes are viable and fertile and show eye abnormalities; in some cases the eyes never opened. Knockout mice homozygotes have much smaller eyes, the anterior chamber is not formed, and the pupil is markedly smaller. There is any abnormalities in brain development (PubMed:16199865).1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Forkhead box protein E3PRO_0000091830Add
BLAST

Proteomic databases

PRIDEiQ9QY14.

PTM databases

PhosphoSiteiQ9QY14.

Expressioni

Developmental stagei

Expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins (PubMed:10652278, PubMed:10890982).2 Publications

Inductioni

Head ectoderm expression is induced by RAX and lens expression is induced by PAX6 (PubMed:10890982).1 Publication

Gene expression databases

BgeeiQ9QY14.
CleanExiMM_FOXE3.
GenevisibleiQ9QY14. MM.

Interactioni

Protein-protein interaction databases

BioGridi206001. 2 interactions.
STRINGi10090.ENSMUSP00000050445.

Structurei

3D structure databases

ProteinModelPortaliQ9QY14.
SMRiQ9QY14. Positions 64-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi166 – 25489Pro-richPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiQ9QY14.
KOiK09398.
OMAiPEPPCCA.
OrthoDBiEOG7KWSK8.
PhylomeDBiQ9QY14.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP
60 70 80 90 100
GPGKRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF
110 120 130 140 150
YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN
160 170 180 190 200
GSFLRRRKRF KRAELPAPPP PPPPFPYAPF PPPPAPASAP PARLFRLDSL
210 220 230 240 250
LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA SERLGLPAPL
260 270 280
PAQPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL
Length:288
Mass (Da):30,541
Last modified:May 1, 2000 - v1
Checksum:i16425926F3E466C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti93 – 931F → L in dyl; negative regulation of lens epithelial cell proliferation; positive regulation of lens fiber cell differentiation; positive regulation of epithelial cell apoptotic process; loss of sequence-specific DNA binding. 3 Publications
Natural varianti98 – 981F → S in dyl; negative regulation of lens epithelial cell proliferation; positive regulation of lens fiber cell differentiation; positive regulation of epithelial cell apoptotic process; loss of sequence-specific DNA binding. 3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142647 Genomic DNA. Translation: AAF15997.1.
CCDSiCCDS18483.1.
RefSeqiNP_056573.1. NM_015758.2.
UniGeneiMm.377122.

Genome annotation databases

EnsembliENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
GeneIDi30923.
KEGGimmu:30923.
UCSCiuc008uef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142647 Genomic DNA. Translation: AAF15997.1.
CCDSiCCDS18483.1.
RefSeqiNP_056573.1. NM_015758.2.
UniGeneiMm.377122.

3D structure databases

ProteinModelPortaliQ9QY14.
SMRiQ9QY14. Positions 64-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206001. 2 interactions.
STRINGi10090.ENSMUSP00000050445.

PTM databases

PhosphoSiteiQ9QY14.

Proteomic databases

PRIDEiQ9QY14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050940; ENSMUSP00000050445; ENSMUSG00000044518.
GeneIDi30923.
KEGGimmu:30923.
UCSCiuc008uef.1. mouse.

Organism-specific databases

CTDi2301.
MGIiMGI:1353569. Foxe3.

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231286.
HOVERGENiHBG051642.
InParanoidiQ9QY14.
KOiK09398.
OMAiPEPPCCA.
OrthoDBiEOG7KWSK8.
PhylomeDBiQ9QY14.
TreeFamiTF316127.

Miscellaneous databases

NextBioi307312.
PROiQ9QY14.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QY14.
CleanExiMM_FOXE3.
GenevisibleiQ9QY14. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle."
    Blixt A., Mahlapuu M., Aitola M., Pelto-Huikko M., Enerbaeck S., Carlsson P.
    Genes Dev. 14:245-254(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, FUNCTION, INVOLVEMENT IN DYL, VARIANTS DYL LEU-93 AND SER-98, CHARACTERIZATION OF VARIANTS DYL LEU-93 AND SER-98.
    Strain: 129/Sv.
    Tissue: Lens.
  2. "Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation."
    Brownell I., Dirksen M., Jamrich M.
    Genesis 27:81-93(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, DEVELOPMENTAL STAGE, VARIANTS DYL LEU-93 AND SER-98.
  3. "Foxe3 haploinsufficiency in mice: a model for Peters' anomaly."
    Ormestad M., Blixt A., Churchill A., Martinsson T., Enerback S., Carlsson P.
    Invest. Ophthalmol. Vis. Sci. 43:1350-1357(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANTS DYL LEU-93 AND SER-98.
  4. "Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice."
    Medina-Martinez O., Brownell I., Amaya-Manzanares F., Hu Q., Behringer R.R., Jamrich M.
    Mol. Cell. Biol. 25:8854-8863(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage."
    Blixt A., Landgren H., Johansson B.R., Carlsson P.
    Dev. Biol. 302:218-229(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiFOXE3_MOUSE
AccessioniPrimary (citable) accession number: Q9QY14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.