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Protein

Fibroblast growth factor-binding protein 1

Gene

Fgfbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity).By similarity

GO - Biological processi

  • cell-cell signaling Source: RGD
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor-binding protein 1
Short name:
FGF-BP
Short name:
FGF-BP1
Short name:
FGF-binding protein 1
Short name:
FGFBP-1
Short name:
Growth factor-binding protein 1
Gene namesi
Name:Fgfbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621211. Fgfbp1.

Subcellular locationi

  • Secretedextracellular space By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity

  • Note: Extracellular and plasma membrane-associated.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 238218Fibroblast growth factor-binding protein 1PRO_0000245514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 88By similarity
Disulfide bondi97 ↔ 130By similarity
Disulfide bondi106 ↔ 142By similarity
Glycosylationi164 – 1641O-linked (GalNAc...)By similarity
Disulfide bondi201 ↔ 238By similarity
Disulfide bondi218 ↔ 226By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QY10.
PRIDEiQ9QY10.

Expressioni

Tissue specificityi

Expressed in gut, eye, thymus, skin, lung, tongue, Purkinje cells and cerebral chorioid plexus (at protein level).1 Publication

Inductioni

Down-regulated by retinoids.1 Publication

Interactioni

Subunit structurei

Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004128.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni197 – 23842Sufficient for interaction with FGF2 and FGF2-induced effectsBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBN. Eukaryota.
ENOG4111SHY. LUCA.
HOGENOMiHOG000013097.
HOVERGENiHBG053095.
InParanoidiQ9QY10.
PhylomeDBiQ9QY10.

Family and domain databases

InterProiIPR010510. FGF1-bd.
[Graphical view]
PANTHERiPTHR15258. PTHR15258. 1 hit.
PfamiPF06473. FGF-BP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QY10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHGLILLS FLLLAAQVLS EKVRKTAKNV PDSTTEEDMS PSLGKARNKQ
60 70 80 90 100
RSRTSKSMTH GRFVTKDQAT CRWAVTEEEL GINLKVQCTR ADQEFSCVFA
110 120 130 140 150
GDPTGCLKYD KDQTYWKQVA RTLRKQKNIC ENSKSVLKTR VCRKKFPESN
160 170 180 190 200
LKVVNPRKEK AEVSPREHNK VQEAVSMEPN KVKVDITTSP AATVAVKDSE
210 220 230
CLEDPDVLTQ RKTALEFCGE SWSSFCTFFL NMLQATSC
Length:238
Mass (Da):26,887
Last modified:May 1, 2000 - v1
Checksum:iDF18D3720FA536CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142758 mRNA. Translation: AAF23079.1.
RefSeqiNP_072125.1. NM_022603.1.
UniGeneiRn.6346.

Genome annotation databases

GeneIDi64535.
KEGGirno:64535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142758 mRNA. Translation: AAF23079.1.
RefSeqiNP_072125.1. NM_022603.1.
UniGeneiRn.6346.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004128.

Proteomic databases

PaxDbiQ9QY10.
PRIDEiQ9QY10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64535.
KEGGirno:64535.

Organism-specific databases

CTDi9982.
RGDi621211. Fgfbp1.

Phylogenomic databases

eggNOGiENOG410IZBN. Eukaryota.
ENOG4111SHY. LUCA.
HOGENOMiHOG000013097.
HOVERGENiHBG053095.
InParanoidiQ9QY10.
PhylomeDBiQ9QY10.

Miscellaneous databases

PROiQ9QY10.

Family and domain databases

InterProiIPR010510. FGF1-bd.
[Graphical view]
PANTHERiPTHR15258. PTHR15258. 1 hit.
PfamiPF06473. FGF-BP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGFP1_RAT
AccessioniPrimary (citable) accession number: Q9QY10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.