Unconventional myosin-IXb - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Unconventional myosin-IXb

Alternative name(s):
Unconventional myosin-9b

Gene names

Name:	Myo9b
Synonyms:	Myr5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2114 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho.
Subcellular location	Cytoplasm › cell cortex By similarity. Cytoplasm › perinuclear region By similarity. Cytoplasm › cytoskeleton By similarity. Note: In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region By similarity.
Tissue specificity	Expressed in the brain, heart, muscle and inner ear.
Sequence similarities	Contains 4 IQ domains. Contains 1 myosin head-like domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Ras-associating domain. Contains 1 Rho-GAP domain.
Caution	Represents a unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat Zinc-finger
Ligand	ATP-binding Actin-binding Calmodulin-binding Metal-binding Nucleotide-binding Zinc
Molecular function	GTPase activation Motor protein Myosin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Rho protein signal transduction Inferred from mutant phenotype PubMed 20566876. Source: MGI establishment of cell polarity Inferred from mutant phenotype PubMed 20566876. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: InterPro lamellipodium morphogenesis Inferred from mutant phenotype PubMed 20566876. Source: MGI macrophage chemotaxis Inferred from mutant phenotype PubMed 20566876. Source: MGI monocyte chemotaxis Inferred from mutant phenotype PubMed 20566876. Source: MGI positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC
Cellular_component	cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell filopodium tip Inferred from direct assay PubMed 17314409. Source: MGI lamellipodium Inferred from direct assay PubMed 17314409. Source: MGI myosin complex Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell ruffle Inferred from direct assay PubMed 17314409. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW Rho GTPase activator activity Inferred from direct assay PubMed 17314409. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW microfilament motor activity Inferred from direct assay PubMed 17314409. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9QY06-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9QY06-2) Also known as: Q; The sequence of this isoform differs from the canonical sequence as follows: 740-740: R → RCTGLDFSFERSEELDVNAFEDIMAFYESR

Isoform 3 (identifier: Q9QY06-3) Also known as: C; The sequence of this isoform differs from the canonical sequence as follows: 1875-1890: Missing. 1977-2114: GPPAPALPCP...LPPSSGQANG → E

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2114

2114

Unconventional myosin-IXb

PRO_0000123470

Regions

Domain

1 – 939

939

Myosin head-like

Domain

15 – 114

100

Ras-associating

Domain

957 – 977

21

IQ 1

Domain

979 – 1000

22

IQ 2

Domain

1001 – 1023

23

IQ 3

Domain

1024 – 1053

30

IQ 4

Domain

1661 – 1846

186

Rho-GAP

Nucleotide binding

239 – 246

8

ATP Potential

Zinc finger

1590 – 1639

50

Phorbol-ester/DAG-type

Region

844 – 855

12

Actin-binding

Region

940 – 1044

105

Neck or regulatory domain

Region

1045 – 2114

1070

Tail

Coiled coil

1562 – 1592

31

Potential

Coiled coil

1839 – 1859

21

Potential

Coiled coil

1915 – 1945

31

Potential

Amino acid modifications

Modified residue

716

1

Phosphoserine By similarity

Modified residue

1175

1

Phosphoserine Ref.3 Ref.4

Modified residue

1218

1

Phosphoserine Ref.5

Modified residue

1241

1

Phosphoserine By similarity

Modified residue

1264

1

Phosphoserine By similarity

Modified residue

1317

1

Phosphothreonine By similarity

Modified residue

1319

1

Phosphothreonine Ref.2

Modified residue

1325

1

Phosphoserine Ref.3

Modified residue

1371

1

Phosphoserine By similarity

Modified residue

1949

1

Phosphoserine Ref.2

Natural variations

Alternative sequence

740

1

R → RCTGLDFSFERSEELDVNAF EDIMAFYESR in isoform 2.

VSP_003363

Alternative sequence

1875 – 1890

16

Missing in isoform 3.

VSP_003364

Alternative sequence

1977 – 2114

138

GPPAP…GQANG → E in isoform 3.

VSP_003365

Natural variant

1243

1

L → LEVSPVLPSSSL Only in strain C57BL/6; contains an in-frame 33 bp imperfect duplication.

Natural variant

2083

1

A → P.

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: D774D4B1B2788045 Show »	FASTA	2,114	238,834
10 20 30 40 50 60 MSAHEAGSSG RRQQATYHLH IYPQLSSAGS QTSCRVTATK DSTTSDVIQD VVASLHLDGS 70 80 90 100 110 120 KHYVLVEVKE SGGEEWVLDA SDSPVHRVLL WPRRAQDEHP QEDGYYFLLQ ERNADGSIQY 130 140 150 160 170 180 LPIQLLAQPT AACRLVERGL LPRPQADFDD LCNLPELTEA NLLQNLKLRF MQQKIYTYAG 190 200 210 220 230 240 SILVAINPFK FLPIYNPKYV KMYENQQLGK LEPHVFALAD VAYYAMLRKH VNQCIVISGE 250 260 270 280 290 300 SGSGKTQSTN FLIHCLTALS QKGYASGVER TILGAGPVLE AFGNAKTAHN NNSSRFGKFI 310 320 330 340 350 360 QVNYLENGIV RGAVVEKYLL EKSRLVSQEK DERNYHVFYY LLLGVSEEER LEFQLKQPQD 370 380 390 400 410 420 YFYLNQHNLN IEDGEDLKHD FERLQQAMEM VGFLPATKKQ IFSVLSAILY LGNVTYKKRA 430 440 450 460 470 480 TGRDEGLEVG PPEVLDTLSQ LLKVKRETLV EVLTKRKTVT VNDKLILPYS LSEAITARDS 490 500 510 520 530 540 MAKSLYSALF DWIVLRINHA LLNKKDMEEA VSCLSIGVLD IFGFEDFERN SFEQFCINYA 550 560 570 580 590 600 NEQLQYYFTQ HIFKLEQEEY QGEGISWHNI DYTDNVGCIH LISKKPTGLF YLLDEESNFP 610 620 630 640 650 660 HATSHTLLAK FKQQHEDNKY FLGTPVLEPA FIIQHFAGRV KYQIKDFREK NMDYMRPDIV 670 680 690 700 710 720 ALLRGSDSSY VRQLIGMDPV AVFRWAVLRA AIRAMAVLRE AGRLRAERAE KAAGISSPAT 730 740 750 760 770 780 RSHMEELPRG ASTPSEKLYR DLHNQIIKSL KGLPWQGEDP RRLLQSLSLL QKPRTSFLKS 790 800 810 820 830 840 KGIKQKQIIP KNLLDSKSLR LIISMTLHDR TTKSLLHLHK KKKPPSISAQ FQTSLNKLLE 850 860 870 880 890 900 ALGKAEPFFI RCIRSNAEKK ELCFDDELVL QQLRYTGMLE TVRIRRSGYS AKYTFQDFTE 910 920 930 940 950 960 QFQVLLPKDV QPCREAIAAL LEKLQVDRQN YQIGKTKVFL KETERQTLQE KLHGEVLRRI 970 980 990 1000 1010 1020 LQLQSWFRMV LERKHFVQMK HAALTIQACW RSYRVRRALE RTQAAVYLQA AWRGYLQRQA 1030 1040 1050 1060 1070 1080 YHHQRHSIIR LQSLCRGHLQ RRSFSQMVSE KQKAEQAREA AGGKLSEGEP GPVAAGEQLS 1090 1100 1110 1120 1130 1140 EHPVEDPESL GVEAETWMNK SPDGMSPKKE TPSPEMETAA QKTVPAESHE KVSSSREKRE 1150 1160 1170 1180 1190 1200 SRRQRGLEHV ERQNKHIQSC REESSTHREP SRRASLEIGE SFPEGTKGPR EDGLEAWTET 1210 1220 1230 1240 1250 1260 TAPSSSKQAQ VVGDPPGSPS PVQRPTTLAL DSRVSPMLPS SSLESPKDKD KDESSTKAQD 1270 1280 1290 1300 1310 1320 KPESPSGSTQ IQRYQHPDTE RLATAVEIWR GKKLASAVLS QSLDLSEKHR ATGAALTPTE 1330 1340 1350 1360 1370 1380 ERRISFSTSD ISKLSPVKTS AEIDGDFSSK KPSIHKKKSG DPSAGPDAGL SPGSQGDSKS 1390 1400 1410 1420 1430 1440 AFKRLFLHKA KDKKPSLEGV EETESNGGQA AQETPARKTL DVPSSQQHRH TTGEKPLKGK 1450 1460 1470 1480 1490 1500 KNRNRKVGQI TVSEKWRESV FRKITNANEL KFLDEFLLNK VNDLRSQKTP IESLFIEATE 1510 1520 1530 1540 1550 1560 RFRSNIKTMY SVPNGKIHVG YKDLMENYQI VVSNLAAERG EKDTNLVLNV FQSLLDEFTR 1570 1580 1590 1600 1610 1620 SYNKTDFERA KSKAQKKKRK QERAVQEHNG HVFASYQVNI PQSCEQCLSY IWLMDKALLC 1630 1640 1650 1660 1670 1680 SVCKMTCHKK CVHKIQSYCS YTGRRKSELG AEPGHFGVCV DSLTSDKASV PIVLEKLLEH 1690 1700 1710 1720 1730 1740 VEMHGLYTEG LYRKSGAANR TRELRQALQT DPAAVKLEDF PIHAITGVLK QWLRELPEPL 1750 1760 1770 1780 1790 1800 MTFAQYGDFL RAVELPEKQE QLSAIYAVLD HLPEANHTSL ERLIFHLVKV ALLEDVNRMS 1810 1820 1830 1840 1850 1860 PGALAIIFAP CLLRCPDNSD PLTSMKDVLK ITTCVEMLIK EQMRKYKMKM EEINHLEAAE 1870 1880 1890 1900 1910 1920 SIAFRRLSLL RQNAPWPLKL GFSSPYEGVR IKSPRTPVVQ DLELGALSEE AAGGDEDREK 1930 1940 1950 1960 1970 1980 EILMERIQSI KEEKEDITYR LPELDPRGSD EENLDSETSA STESLLEERG VRGAVEGPPA 1990 2000 2010 2020 2030 2040 PALPCPISPT LSPLPEAAAP PRGRPTSFVT VRVKTPRRTP IMPMANIKLP PGLPLHLTSW 2050 2060 2070 2080 2090 2100 APALQEAVVP VKRREPPARR QDQVHSVYIA PGADLPSQST LIALDHDTIL PGTKRRYSDP 2110 PTYCLPPSSG QANG « Hide
Isoform 2 (Q) [UniParc]. Checksum: 842A3BEEE32F48E7 Show »	FASTA	2,143	242,238
10 20 30 40 50 60 MSAHEAGSSG RRQQATYHLH IYPQLSSAGS QTSCRVTATK DSTTSDVIQD VVASLHLDGS 70 80 90 100 110 120 KHYVLVEVKE SGGEEWVLDA SDSPVHRVLL WPRRAQDEHP QEDGYYFLLQ ERNADGSIQY 130 140 150 160 170 180 LPIQLLAQPT AACRLVERGL LPRPQADFDD LCNLPELTEA NLLQNLKLRF MQQKIYTYAG 190 200 210 220 230 240 SILVAINPFK FLPIYNPKYV KMYENQQLGK LEPHVFALAD VAYYAMLRKH VNQCIVISGE 250 260 270 280 290 300 SGSGKTQSTN FLIHCLTALS QKGYASGVER TILGAGPVLE AFGNAKTAHN NNSSRFGKFI 310 320 330 340 350 360 QVNYLENGIV RGAVVEKYLL EKSRLVSQEK DERNYHVFYY LLLGVSEEER LEFQLKQPQD 370 380 390 400 410 420 YFYLNQHNLN IEDGEDLKHD FERLQQAMEM VGFLPATKKQ IFSVLSAILY LGNVTYKKRA 430 440 450 460 470 480 TGRDEGLEVG PPEVLDTLSQ LLKVKRETLV EVLTKRKTVT VNDKLILPYS LSEAITARDS 490 500 510 520 530 540 MAKSLYSALF DWIVLRINHA LLNKKDMEEA VSCLSIGVLD IFGFEDFERN SFEQFCINYA 550 560 570 580 590 600 NEQLQYYFTQ HIFKLEQEEY QGEGISWHNI DYTDNVGCIH LISKKPTGLF YLLDEESNFP 610 620 630 640 650 660 HATSHTLLAK FKQQHEDNKY FLGTPVLEPA FIIQHFAGRV KYQIKDFREK NMDYMRPDIV 670 680 690 700 710 720 ALLRGSDSSY VRQLIGMDPV AVFRWAVLRA AIRAMAVLRE AGRLRAERAE KAAGISSPAT 730 740 750 760 770 780 RSHMEELPRG ASTPSEKLYR CTGLDFSFER SEELDVNAFE DIMAFYESRD LHNQIIKSLK 790 800 810 820 830 840 GLPWQGEDPR RLLQSLSLLQ KPRTSFLKSK GIKQKQIIPK NLLDSKSLRL IISMTLHDRT 850 860 870 880 890 900 TKSLLHLHKK KKPPSISAQF QTSLNKLLEA LGKAEPFFIR CIRSNAEKKE LCFDDELVLQ 910 920 930 940 950 960 QLRYTGMLET VRIRRSGYSA KYTFQDFTEQ FQVLLPKDVQ PCREAIAALL EKLQVDRQNY 970 980 990 1000 1010 1020 QIGKTKVFLK ETERQTLQEK LHGEVLRRIL QLQSWFRMVL ERKHFVQMKH AALTIQACWR 1030 1040 1050 1060 1070 1080 SYRVRRALER TQAAVYLQAA WRGYLQRQAY HHQRHSIIRL QSLCRGHLQR RSFSQMVSEK 1090 1100 1110 1120 1130 1140 QKAEQAREAA GGKLSEGEPG PVAAGEQLSE HPVEDPESLG VEAETWMNKS PDGMSPKKET 1150 1160 1170 1180 1190 1200 PSPEMETAAQ KTVPAESHEK VSSSREKRES RRQRGLEHVE RQNKHIQSCR EESSTHREPS 1210 1220 1230 1240 1250 1260 RRASLEIGES FPEGTKGPRE DGLEAWTETT APSSSKQAQV VGDPPGSPSP VQRPTTLALD 1270 1280 1290 1300 1310 1320 SRVSPMLPSS SLESPKDKDK DESSTKAQDK PESPSGSTQI QRYQHPDTER LATAVEIWRG 1330 1340 1350 1360 1370 1380 KKLASAVLSQ SLDLSEKHRA TGAALTPTEE RRISFSTSDI SKLSPVKTSA EIDGDFSSKK 1390 1400 1410 1420 1430 1440 PSIHKKKSGD PSAGPDAGLS PGSQGDSKSA FKRLFLHKAK DKKPSLEGVE ETESNGGQAA 1450 1460 1470 1480 1490 1500 QETPARKTLD VPSSQQHRHT TGEKPLKGKK NRNRKVGQIT VSEKWRESVF RKITNANELK 1510 1520 1530 1540 1550 1560 FLDEFLLNKV NDLRSQKTPI ESLFIEATER FRSNIKTMYS VPNGKIHVGY KDLMENYQIV 1570 1580 1590 1600 1610 1620 VSNLAAERGE KDTNLVLNVF QSLLDEFTRS YNKTDFERAK SKAQKKKRKQ ERAVQEHNGH 1630 1640 1650 1660 1670 1680 VFASYQVNIP QSCEQCLSYI WLMDKALLCS VCKMTCHKKC VHKIQSYCSY TGRRKSELGA 1690 1700 1710 1720 1730 1740 EPGHFGVCVD SLTSDKASVP IVLEKLLEHV EMHGLYTEGL YRKSGAANRT RELRQALQTD 1750 1760 1770 1780 1790 1800 PAAVKLEDFP IHAITGVLKQ WLRELPEPLM TFAQYGDFLR AVELPEKQEQ LSAIYAVLDH 1810 1820 1830 1840 1850 1860 LPEANHTSLE RLIFHLVKVA LLEDVNRMSP GALAIIFAPC LLRCPDNSDP LTSMKDVLKI 1870 1880 1890 1900 1910 1920 TTCVEMLIKE QMRKYKMKME EINHLEAAES IAFRRLSLLR QNAPWPLKLG FSSPYEGVRI 1930 1940 1950 1960 1970 1980 KSPRTPVVQD LELGALSEEA AGGDEDREKE ILMERIQSIK EEKEDITYRL PELDPRGSDE 1990 2000 2010 2020 2030 2040 ENLDSETSAS TESLLEERGV RGAVEGPPAP ALPCPISPTL SPLPEAAAPP RGRPTSFVTV 2050 2060 2070 2080 2090 2100 RVKTPRRTPI MPMANIKLPP GLPLHLTSWA PALQEAVVPV KRREPPARRQ DQVHSVYIAP 2110 2120 2130 2140 GADLPSQSTL IALDHDTILP GTKRRYSDPP TYCLPPSSGQ ANG « Hide
Isoform 3 (C) [UniParc]. Checksum: AEC7450E4B7307BF Show »	FASTA	1,961	222,444
10 20 30 40 50 60 MSAHEAGSSG RRQQATYHLH IYPQLSSAGS QTSCRVTATK DSTTSDVIQD VVASLHLDGS 70 80 90 100 110 120 KHYVLVEVKE SGGEEWVLDA SDSPVHRVLL WPRRAQDEHP QEDGYYFLLQ ERNADGSIQY 130 140 150 160 170 180 LPIQLLAQPT AACRLVERGL LPRPQADFDD LCNLPELTEA NLLQNLKLRF MQQKIYTYAG 190 200 210 220 230 240 SILVAINPFK FLPIYNPKYV KMYENQQLGK LEPHVFALAD VAYYAMLRKH VNQCIVISGE 250 260 270 280 290 300 SGSGKTQSTN FLIHCLTALS QKGYASGVER TILGAGPVLE AFGNAKTAHN NNSSRFGKFI 310 320 330 340 350 360 QVNYLENGIV RGAVVEKYLL EKSRLVSQEK DERNYHVFYY LLLGVSEEER LEFQLKQPQD 370 380 390 400 410 420 YFYLNQHNLN IEDGEDLKHD FERLQQAMEM VGFLPATKKQ IFSVLSAILY LGNVTYKKRA 430 440 450 460 470 480 TGRDEGLEVG PPEVLDTLSQ LLKVKRETLV EVLTKRKTVT VNDKLILPYS LSEAITARDS 490 500 510 520 530 540 MAKSLYSALF DWIVLRINHA LLNKKDMEEA VSCLSIGVLD IFGFEDFERN SFEQFCINYA 550 560 570 580 590 600 NEQLQYYFTQ HIFKLEQEEY QGEGISWHNI DYTDNVGCIH LISKKPTGLF YLLDEESNFP 610 620 630 640 650 660 HATSHTLLAK FKQQHEDNKY FLGTPVLEPA FIIQHFAGRV KYQIKDFREK NMDYMRPDIV 670 680 690 700 710 720 ALLRGSDSSY VRQLIGMDPV AVFRWAVLRA AIRAMAVLRE AGRLRAERAE KAAGISSPAT 730 740 750 760 770 780 RSHMEELPRG ASTPSEKLYR DLHNQIIKSL KGLPWQGEDP RRLLQSLSLL QKPRTSFLKS 790 800 810 820 830 840 KGIKQKQIIP KNLLDSKSLR LIISMTLHDR TTKSLLHLHK KKKPPSISAQ FQTSLNKLLE 850 860 870 880 890 900 ALGKAEPFFI RCIRSNAEKK ELCFDDELVL QQLRYTGMLE TVRIRRSGYS AKYTFQDFTE 910 920 930 940 950 960 QFQVLLPKDV QPCREAIAAL LEKLQVDRQN YQIGKTKVFL KETERQTLQE KLHGEVLRRI 970 980 990 1000 1010 1020 LQLQSWFRMV LERKHFVQMK HAALTIQACW RSYRVRRALE RTQAAVYLQA AWRGYLQRQA 1030 1040 1050 1060 1070 1080 YHHQRHSIIR LQSLCRGHLQ RRSFSQMVSE KQKAEQAREA AGGKLSEGEP GPVAAGEQLS 1090 1100 1110 1120 1130 1140 EHPVEDPESL GVEAETWMNK SPDGMSPKKE TPSPEMETAA QKTVPAESHE KVSSSREKRE 1150 1160 1170 1180 1190 1200 SRRQRGLEHV ERQNKHIQSC REESSTHREP SRRASLEIGE SFPEGTKGPR EDGLEAWTET 1210 1220 1230 1240 1250 1260 TAPSSSKQAQ VVGDPPGSPS PVQRPTTLAL DSRVSPMLPS SSLESPKDKD KDESSTKAQD 1270 1280 1290 1300 1310 1320 KPESPSGSTQ IQRYQHPDTE RLATAVEIWR GKKLASAVLS QSLDLSEKHR ATGAALTPTE 1330 1340 1350 1360 1370 1380 ERRISFSTSD ISKLSPVKTS AEIDGDFSSK KPSIHKKKSG DPSAGPDAGL SPGSQGDSKS 1390 1400 1410 1420 1430 1440 AFKRLFLHKA KDKKPSLEGV EETESNGGQA AQETPARKTL DVPSSQQHRH TTGEKPLKGK 1450 1460 1470 1480 1490 1500 KNRNRKVGQI TVSEKWRESV FRKITNANEL KFLDEFLLNK VNDLRSQKTP IESLFIEATE 1510 1520 1530 1540 1550 1560 RFRSNIKTMY SVPNGKIHVG YKDLMENYQI VVSNLAAERG EKDTNLVLNV FQSLLDEFTR 1570 1580 1590 1600 1610 1620 SYNKTDFERA KSKAQKKKRK QERAVQEHNG HVFASYQVNI PQSCEQCLSY IWLMDKALLC 1630 1640 1650 1660 1670 1680 SVCKMTCHKK CVHKIQSYCS YTGRRKSELG AEPGHFGVCV DSLTSDKASV PIVLEKLLEH 1690 1700 1710 1720 1730 1740 VEMHGLYTEG LYRKSGAANR TRELRQALQT DPAAVKLEDF PIHAITGVLK QWLRELPEPL 1750 1760 1770 1780 1790 1800 MTFAQYGDFL RAVELPEKQE QLSAIYAVLD HLPEANHTSL ERLIFHLVKV ALLEDVNRMS 1810 1820 1830 1840 1850 1860 PGALAIIFAP CLLRCPDNSD PLTSMKDVLK ITTCVEMLIK EQMRKYKMKM EEINHLEAAE 1870 1880 1890 1900 1910 1920 SIAFRRLSLL RQNAIKSPRT PVVQDLELGA LSEEAAGGDE DREKEILMER IQSIKEEKED 1930 1940 1950 1960 ITYRLPELDP RGSDEENLDS ETSASTESLL EERGVRGAVE E « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing." Grewal P.K., Jones A.-M., Maconochie M., Lemmers R.J.F., Frants R.R., Hewitt J.E. Gene 240:389-398(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANTS. Strain: C57BL/6.
[2]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1319 AND SER-1949, MASS SPECTROMETRY. Tissue: Liver.
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1175 AND SER-1325, MASS SPECTROMETRY. Tissue: Melanoma.
[4]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1175, MASS SPECTROMETRY. Tissue: Macrophage.
[5]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1218, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF143687 Genomic DNA. Translation: AAF00122.1. AF143685 mRNA. Translation: AAF00120.1. AF143686 mRNA. Translation: AAF00121.1. Frameshift. AF143683 mRNA. Translation: AAF00118.1.
IPI	IPI00135379. IPI00229766. IPI00319697.
UniGene	Mm.33779.
3D structure databases
ProteinModelPortal	Q9QY06.
SMR	Q9QY06. Positions 141-1055, 1591-1842.
ModBase	Search...
PTM databases
PhosphoSite	Q9QY06.
Proteomic databases
PaxDb	Q9QY06.
PRIDE	Q9QY06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc009mcj.2. mouse. uc009mck.1. mouse.
Organism-specific databases
MGI	MGI:106624. Myo9b.
Phylogenomic databases
eggNOG	COG5022.
HOGENOM	HOG000113707.
HOVERGEN	HBG052558.
OrthoDB	EOG408N75.
Gene expression databases
CleanEx	MM_MYO9B.
Genevestigator	Q9QY06.
GermOnline	ENSMUSG00000004677. Mus musculus.
Family and domain databases
Gene3D	1.10.555.10. 1 hit.
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000159. Ras-assoc. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Pfam	PF00612. IQ. 4 hits. PF00063. Myosin_head. 1 hit. PF00788. RA. 1 hit. PF00620. RhoGAP. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00109. C1. 1 hit. SM00015. IQ. 4 hits. SM00242. MYSc. 1 hit. SM00314. RA. 1 hit. SM00324. RhoGAP. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50096. IQ. 3 hits. PS50200. RA. 1 hit. PS50238. RHOGAP. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

MYO9B_MOUSE

Accession

Primary (citable) accession number: Q9QY06
Secondary accession number(s): Q9QY07, Q9QY08, Q9QY09

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents