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Protein

Insulin-like peptide INSL6

Gene

Insl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in sperm development and fertilization.

GO - Molecular functioni

GO - Biological processi

  • fertilization Source: MGI
  • flagellated sperm motility Source: MGI
  • male gonad development Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • spermatid development Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like peptide INSL6
Short name:
Insulin-like peptide 6
Cleaved into the following 2 chains:
Gene namesi
Name:Insl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1351595. Insl6.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001617723 – 191Insulin-like peptide INSL6Add BLAST169
PeptideiPRO_000001617823 – 51Insulin-like peptide INSL6 B chainSequence analysisAdd BLAST29
PropeptideiPRO_000001617953 – 161Connecting peptideSequence analysisAdd BLAST109
PeptideiPRO_0000016180166 – 191Insulin-like peptide INSL6 A chainSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 172By similarity
Disulfide bondi45 ↔ 185By similarity
Disulfide bondi171 ↔ 176By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9QY05.
PRIDEiQ9QY05.

PTM databases

iPTMnetiQ9QY05.
PhosphoSitePlusiQ9QY05.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050957.
CleanExiMM_INSL6.
ExpressionAtlasiQ9QY05. baseline and differential.
GenevisibleiQ9QY05. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054488.

Structurei

3D structure databases

ProteinModelPortaliQ9QY05.
SMRiQ9QY05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9YE. Eukaryota.
ENOG41117BC. LUCA.
GeneTreeiENSGT00510000049111.
HOGENOMiHOG000113078.
HOVERGENiHBG052136.
InParanoidiQ9QY05.
KOiK05255.
OMAiFWGNHPQ.
OrthoDBiEOG091G0SQ8.
PhylomeDBiQ9QY05.
TreeFamiTF343788.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016179. Insulin-like.
IPR017100. Insulin-like_pep_6.
IPR022353. Insulin_CS.
PANTHERiPTHR12004:SF7. PTHR12004:SF7. 1 hit.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PIRSFiPIRSF037062. Insulin-like_peptide_6. 1 hit.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QY05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQLCCSCLL WLGLLLTPFS REEEEESRPR KLCGRHLLIE VIKLCGQSDW
60 70 80 90 100
SRFEMEEQSP MTQFFPHYSR KGKAFNPHPS SSAWRRFTNP VPAGVSQKKG
110 120 130 140 150
THTWEPQSLP DYQFEKTELL PKARVFSYHS GKPYVKSVQL QKKSTNKMNT
160 170 180 190
FRSLFWGNHS QRKRRGFADK CCVIGCTKEE MAVACLPFVD F
Length:191
Mass (Da):22,215
Last modified:May 1, 2000 - v1
Checksum:iB47FFE245F031190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143807 mRNA. Translation: AAD30158.2.
BC028752 mRNA. Translation: AAH28752.1.
CCDSiCCDS29732.1.
RefSeqiNP_038782.1. NM_013754.1.
UniGeneiMm.306511.

Genome annotation databases

EnsembliENSMUST00000052380; ENSMUSP00000054488; ENSMUSG00000050957.
GeneIDi27356.
KEGGimmu:27356.
UCSCiuc008hdd.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiINSL6_MOUSE
AccessioniPrimary (citable) accession number: Q9QY05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families