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Protein

Olfactory receptor 154

Gene

Olfr154

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential odorant receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 154
Alternative name(s):
Olfactory receptor 175-1
Gene namesi
Name:Olfr154
Synonyms:Mor175-1, Olfr4-3, Or912-93, Or93
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1351316. Olfr154.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 567CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9316ExtracellularSequence analysisAdd
BLAST
Transmembranei94 – 11421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini115 – 14430CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini166 – 19833ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27111ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31826CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 154PRO_0000150829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QY00.
PRIDEiQ9QY00.

Expressioni

Gene expression databases

CleanExiMM_OLFR154.
GenevisibleiQ9QY00. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097502.

Structurei

3D structure databases

ProteinModelPortaliQ9QY00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITSH. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9QY00.
KOiK04257.
OrthoDBiEOG71K63J.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QY00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMHRNQTVVT EFFFTGLTSS FHLQIVLFLT FLCVYLATLL GNLGMIILIH
60 70 80 90 100
LDTRLHIPMY FFLSHLSFVD ACSSSVISPK MLSDMFVDKK VISFLGCAIQ
110 120 130 140 150
LCLFSQFVVT ECFLLASMAY DRYVAICKPL LYTLIMSQRV CVQLVIGPYS
160 170 180 190 200
IGFVSTMVHI ISAFVLPYCG PNLINHFFCD LLPVLSLACA NTQMKKRLLF
210 220 230 240 250
IVAGILGVFS GIIILVSYVY IAITILKISS ADGRRKAFST CSSHLTAVSI
260 270 280 290 300
LYGTLFFIYV RPSSSFSLDI NKVVSLFYTT VIPMLNPFIY SLRNKEVKDA
310
LIRTFEKQFC YSFQDKIL
Length:318
Mass (Da):35,901
Last modified:July 27, 2011 - v2
Checksum:iC348CFAFAC8F880B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541V → I in AAF20365 (PubMed:10594242).Curated
Sequence conflicti154 – 1541V → I in AAL61186 (PubMed:11875048).Curated
Sequence conflicti154 – 1541V → I in AAP71458 (PubMed:11875048).Curated
Sequence conflicti154 – 1541V → I in AAI20643 (PubMed:15489334).Curated
Sequence conflicti154 – 1541V → I in AAI20645 (PubMed:15489334).Curated
Sequence conflicti195 – 1951K → N in AAF20365 (PubMed:10594242).Curated
Sequence conflicti195 – 1951K → N in AAL61186 (PubMed:11875048).Curated
Sequence conflicti195 – 1951K → N in AAP71458 (PubMed:11875048).Curated
Sequence conflicti195 – 1951K → N in AAI20643 (PubMed:15489334).Curated
Sequence conflicti195 – 1951K → N in AAI20645 (PubMed:15489334).Curated
Sequence conflicti313 – 3131F → L in AAF20365 (PubMed:10594242).Curated
Sequence conflicti313 – 3131F → L in AAL61186 (PubMed:11875048).Curated
Sequence conflicti313 – 3131F → L in AAI20643 (PubMed:15489334).Curated
Sequence conflicti313 – 3131F → L in AAI20645 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146372 Genomic DNA. Translation: AAF20365.1.
AY073523 Genomic DNA. Translation: AAL61186.1.
AY318199 Genomic DNA. Translation: AAP71458.1.
AL773585 Genomic DNA. Translation: CAM16169.1.
BC120642 mRNA. Translation: AAI20643.1.
BC120644 mRNA. Translation: AAI20645.1.
CCDSiCCDS16213.1.
RefSeqiNP_038756.2. NM_013728.2.
UniGeneiMm.377120.

Genome annotation databases

EnsembliENSMUST00000099918; ENSMUSP00000097502; ENSMUSG00000075212.
GeneIDi27216.
KEGGimmu:27216.
UCSCiuc008kko.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146372 Genomic DNA. Translation: AAF20365.1.
AY073523 Genomic DNA. Translation: AAL61186.1.
AY318199 Genomic DNA. Translation: AAP71458.1.
AL773585 Genomic DNA. Translation: CAM16169.1.
BC120642 mRNA. Translation: AAI20643.1.
BC120644 mRNA. Translation: AAI20645.1.
CCDSiCCDS16213.1.
RefSeqiNP_038756.2. NM_013728.2.
UniGeneiMm.377120.

3D structure databases

ProteinModelPortaliQ9QY00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097502.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9QY00.
PRIDEiQ9QY00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099918; ENSMUSP00000097502; ENSMUSG00000075212.
GeneIDi27216.
KEGGimmu:27216.
UCSCiuc008kko.2. mouse.

Organism-specific databases

CTDi27216.
MGIiMGI:1351316. Olfr154.

Phylogenomic databases

eggNOGiENOG410ITSH. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9QY00.
KOiK04257.
OrthoDBiEOG71K63J.
TreeFamiTF352753.

Miscellaneous databases

PROiQ9QY00.
SOURCEiSearch...

Gene expression databases

CleanExiMM_OLFR154.
GenevisibleiQ9QY00. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and chromosomal localization of the mouse ortholog of the human olfactory receptor gene 912-93."
    Rouquier S., Stubbs L., Gaillard-Sanchez I., Giorgi D.G.
    Mamm. Genome 10:1172-1174(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The olfactory receptor gene superfamily of the mouse."
    Zhang X., Firestein S.
    Nat. Neurosci. 5:124-133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Different evolutionary processes shaped the mouse and human olfactory receptor gene families."
    Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., Trask B.J.
    Hum. Mol. Genet. 11:535-546(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Erratum
    Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., Trask B.J.
    Hum. Mol. Genet. 11:1683-1683(2002)
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 228-236, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiOL154_MOUSE
AccessioniPrimary (citable) accession number: Q9QY00
Secondary accession number(s): A2ALD1, Q0VBG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.