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Q9QXY9

- PEX3_MOUSE

UniProt

Q9QXY9 - PEX3_MOUSE

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Protein

Peroxisomal biogenesis factor 3

Gene

Pex3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.

GO - Molecular functioni

  1. lipid binding Source: Ensembl

GO - Biological processi

  1. peroxisome membrane biogenesis Source: Ensembl
  2. protein import into peroxisome membrane Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 3
Alternative name(s):
Peroxin-3
Peroxisomal assembly protein PEX3
Gene namesi
Name:Pex3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1929646. Pex3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. integral component of peroxisomal membrane Source: Ensembl
  4. integral component of plasma membrane Source: MGI
  5. nucleus Source: Ensembl
  6. protein complex Source: Ensembl
  7. protein-lipid complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Peroxisomal biogenesis factor 3PRO_0000208739Add
BLAST

Proteomic databases

MaxQBiQ9QXY9.
PaxDbiQ9QXY9.
PRIDEiQ9QXY9.

PTM databases

PhosphoSiteiQ9QXY9.

Expressioni

Tissue specificityi

Identified in all tissues analyzed, with the strongest expression in liver and in testis.

Gene expression databases

BgeeiQ9QXY9.
CleanExiMM_PEX3.
ExpressionAtlasiQ9QXY9. baseline and differential.
GenevestigatoriQ9QXY9.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QXY9.
SMRiQ9QXY9. Positions 52-367.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini37 – 11680PeroxisomalSequence AnalysisAdd
BLAST
Topological domaini141 – 372232CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei117 – 14024HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4545Targeting to peroxisomesBy similarityAdd
BLAST
Regioni120 – 13617Binding to PEX19By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peroxin-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259038.
GeneTreeiENSGT00390000008481.
HOGENOMiHOG000007212.
HOVERGENiHBG000467.
InParanoidiQ9QXY9.
KOiK13336.
OMAiARRQFHF.
PhylomeDBiQ9QXY9.
TreeFamiTF352826.

Family and domain databases

InterProiIPR006966. Peroxin-3.
[Graphical view]
PfamiPF04882. Peroxin-3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXY9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRSMWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA
60 70 80 90 100
QARRQYHFES NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKSRPSNK
110 120 130 140 150
LEIWEDLKII SFTRSIVAVY STCMLVVLLR VQLNIIGGYI YLDNATVGKN
160 170 180 190 200
GTTVLAPPDV QQQYLSSIQH LLGDGLTELV TVIKQAVQRI LGSVSLKHSL
210 220 230 240 250
SLLDLEQKLK EIRILVEQHQ SSWNDKDVSR SSLCQYMMPD EETPLAAQAY
260 270 280 290 300
GLSHRDITTI KLLNETRDML ESPDFSTVLN TCLNRGFSRL LDNMAEFFRP
310 320 330 340 350
TEQDLQHGNS INSLSSVSLP LAKIIPIVNG QIHSVCSETP SHFVQDLLMM
360 370
EQVKDFAANV YEAFSTPQQL EK
Length:372
Mass (Da):42,224
Last modified:May 1, 2000 - v1
Checksum:i77AA9590A53FAB77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152996 mRNA. Translation: AAF14524.1.
AF162896
, AF162890, AF162891, AF162892, AF162893, AF162894, AF162895 Genomic DNA. Translation: AAG24507.1.
BC033415 mRNA. Translation: AAH33415.1.
BC037606 mRNA. Translation: AAH37606.1.
CCDSiCCDS23702.1.
RefSeqiNP_064345.1. NM_019961.3.
UniGeneiMm.282711.

Genome annotation databases

EnsembliENSMUST00000019945; ENSMUSP00000019945; ENSMUSG00000019809.
GeneIDi56535.
KEGGimmu:56535.
UCSCiuc007eky.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152996 mRNA. Translation: AAF14524.1 .
AF162896
, AF162890 , AF162891 , AF162892 , AF162893 , AF162894 , AF162895 Genomic DNA. Translation: AAG24507.1 .
BC033415 mRNA. Translation: AAH33415.1 .
BC037606 mRNA. Translation: AAH37606.1 .
CCDSi CCDS23702.1.
RefSeqi NP_064345.1. NM_019961.3.
UniGenei Mm.282711.

3D structure databases

ProteinModelPortali Q9QXY9.
SMRi Q9QXY9. Positions 52-367.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QXY9.

Proteomic databases

MaxQBi Q9QXY9.
PaxDbi Q9QXY9.
PRIDEi Q9QXY9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019945 ; ENSMUSP00000019945 ; ENSMUSG00000019809 .
GeneIDi 56535.
KEGGi mmu:56535.
UCSCi uc007eky.2. mouse.

Organism-specific databases

CTDi 8504.
MGIi MGI:1929646. Pex3.

Phylogenomic databases

eggNOGi NOG259038.
GeneTreei ENSGT00390000008481.
HOGENOMi HOG000007212.
HOVERGENi HBG000467.
InParanoidi Q9QXY9.
KOi K13336.
OMAi ARRQFHF.
PhylomeDBi Q9QXY9.
TreeFami TF352826.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

NextBioi 312898.
PROi Q9QXY9.
SOURCEi Search...

Gene expression databases

Bgeei Q9QXY9.
CleanExi MM_PEX3.
ExpressionAtlasi Q9QXY9. baseline and differential.
Genevestigatori Q9QXY9.

Family and domain databases

InterProi IPR006966. Peroxin-3.
[Graphical view ]
Pfami PF04882. Peroxin-3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein."
    Muntau A.C., Mayerhofer P.U., Albet S., Schmid T.E., Bugaut M., Roscher A.A., Kammerer S.
    Biol. Chem. 381:337-342(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Ola.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Retina.

Entry informationi

Entry nameiPEX3_MOUSE
AccessioniPrimary (citable) accession number: Q9QXY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3