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Protein

Peroxisomal biogenesis factor 3

Gene

Pex3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

ReactomeiREACT_346149. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 3
Alternative name(s):
Peroxin-3
Peroxisomal assembly protein PEX3
Gene namesi
Name:Pex3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1929646. Pex3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 11680PeroxisomalSequence AnalysisAdd
BLAST
Transmembranei117 – 14024HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 372232CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Peroxisomal biogenesis factor 3PRO_0000208739Add
BLAST

Proteomic databases

MaxQBiQ9QXY9.
PaxDbiQ9QXY9.
PRIDEiQ9QXY9.

PTM databases

PhosphoSiteiQ9QXY9.

Expressioni

Tissue specificityi

Identified in all tissues analyzed, with the strongest expression in liver and in testis.

Gene expression databases

BgeeiQ9QXY9.
CleanExiMM_PEX3.
ExpressionAtlasiQ9QXY9. baseline and differential.
GenevestigatoriQ9QXY9.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QXY9.
SMRiQ9QXY9. Positions 52-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4545Targeting to peroxisomesBy similarityAdd
BLAST
Regioni120 – 13617Binding to PEX19By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peroxin-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259038.
GeneTreeiENSGT00390000008481.
HOGENOMiHOG000007212.
HOVERGENiHBG000467.
InParanoidiQ9QXY9.
KOiK13336.
OMAiARRQFHF.
PhylomeDBiQ9QXY9.
TreeFamiTF352826.

Family and domain databases

InterProiIPR006966. Peroxin-3.
[Graphical view]
PfamiPF04882. Peroxin-3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSMWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA
60 70 80 90 100
QARRQYHFES NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKSRPSNK
110 120 130 140 150
LEIWEDLKII SFTRSIVAVY STCMLVVLLR VQLNIIGGYI YLDNATVGKN
160 170 180 190 200
GTTVLAPPDV QQQYLSSIQH LLGDGLTELV TVIKQAVQRI LGSVSLKHSL
210 220 230 240 250
SLLDLEQKLK EIRILVEQHQ SSWNDKDVSR SSLCQYMMPD EETPLAAQAY
260 270 280 290 300
GLSHRDITTI KLLNETRDML ESPDFSTVLN TCLNRGFSRL LDNMAEFFRP
310 320 330 340 350
TEQDLQHGNS INSLSSVSLP LAKIIPIVNG QIHSVCSETP SHFVQDLLMM
360 370
EQVKDFAANV YEAFSTPQQL EK
Length:372
Mass (Da):42,224
Last modified:May 1, 2000 - v1
Checksum:i77AA9590A53FAB77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152996 mRNA. Translation: AAF14524.1.
AF162896
, AF162890, AF162891, AF162892, AF162893, AF162894, AF162895 Genomic DNA. Translation: AAG24507.1.
BC033415 mRNA. Translation: AAH33415.1.
BC037606 mRNA. Translation: AAH37606.1.
CCDSiCCDS23702.1.
RefSeqiNP_064345.1. NM_019961.3.
UniGeneiMm.282711.

Genome annotation databases

EnsembliENSMUST00000019945; ENSMUSP00000019945; ENSMUSG00000019809.
GeneIDi56535.
KEGGimmu:56535.
UCSCiuc007eky.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152996 mRNA. Translation: AAF14524.1.
AF162896
, AF162890, AF162891, AF162892, AF162893, AF162894, AF162895 Genomic DNA. Translation: AAG24507.1.
BC033415 mRNA. Translation: AAH33415.1.
BC037606 mRNA. Translation: AAH37606.1.
CCDSiCCDS23702.1.
RefSeqiNP_064345.1. NM_019961.3.
UniGeneiMm.282711.

3D structure databases

ProteinModelPortaliQ9QXY9.
SMRiQ9QXY9. Positions 52-367.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9QXY9.

Proteomic databases

MaxQBiQ9QXY9.
PaxDbiQ9QXY9.
PRIDEiQ9QXY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019945; ENSMUSP00000019945; ENSMUSG00000019809.
GeneIDi56535.
KEGGimmu:56535.
UCSCiuc007eky.2. mouse.

Organism-specific databases

CTDi8504.
MGIiMGI:1929646. Pex3.

Phylogenomic databases

eggNOGiNOG259038.
GeneTreeiENSGT00390000008481.
HOGENOMiHOG000007212.
HOVERGENiHBG000467.
InParanoidiQ9QXY9.
KOiK13336.
OMAiARRQFHF.
PhylomeDBiQ9QXY9.
TreeFamiTF352826.

Enzyme and pathway databases

ReactomeiREACT_346149. ABCA transporters in lipid homeostasis.

Miscellaneous databases

NextBioi312898.
PROiQ9QXY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXY9.
CleanExiMM_PEX3.
ExpressionAtlasiQ9QXY9. baseline and differential.
GenevestigatoriQ9QXY9.

Family and domain databases

InterProiIPR006966. Peroxin-3.
[Graphical view]
PfamiPF04882. Peroxin-3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein."
    Muntau A.C., Mayerhofer P.U., Albet S., Schmid T.E., Bugaut M., Roscher A.A., Kammerer S.
    Biol. Chem. 381:337-342(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Ola.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Retina.

Entry informationi

Entry nameiPEX3_MOUSE
AccessioniPrimary (citable) accession number: Q9QXY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.