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Protein

Peroxisomal biogenesis factor 3

Gene

Pex3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 3
Alternative name(s):
Peroxin-3
Peroxisomal assembly protein PEX3
Gene namesi
Name:Pex3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1929646 Pex3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 116PeroxisomalSequence analysisAdd BLAST80
Transmembranei117 – 140HelicalSequence analysisAdd BLAST24
Topological domaini141 – 372CytoplasmicSequence analysisAdd BLAST232

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087391 – 372Peroxisomal biogenesis factor 3Add BLAST372

Proteomic databases

EPDiQ9QXY9
MaxQBiQ9QXY9
PaxDbiQ9QXY9
PRIDEiQ9QXY9

PTM databases

iPTMnetiQ9QXY9
PhosphoSitePlusiQ9QXY9

Expressioni

Tissue specificityi

Identified in all tissues analyzed, with the strongest expression in liver and in testis.

Gene expression databases

BgeeiENSMUSG00000019809
CleanExiMM_PEX3
ExpressionAtlasiQ9QXY9 baseline and differential
GenevisibleiQ9QXY9 MM

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019945

Structurei

3D structure databases

ProteinModelPortaliQ9QXY9
SMRiQ9QXY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Targeting to peroxisomesBy similarityAdd BLAST45
Regioni120 – 136Binding to PEX19By similarityAdd BLAST17

Sequence similaritiesi

Belongs to the peroxin-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4444 Eukaryota
ENOG41101IY LUCA
GeneTreeiENSGT00390000008481
HOGENOMiHOG000007212
HOVERGENiHBG000467
InParanoidiQ9QXY9
KOiK13336
OMAiWSLQMAI
OrthoDBiEOG091G1027
PhylomeDBiQ9QXY9
TreeFamiTF352826

Family and domain databases

InterProiView protein in InterPro
IPR006966 Peroxin-3
PANTHERiPTHR28080 PTHR28080, 1 hit
PfamiView protein in Pfam
PF04882 Peroxin-3, 2 hits

Sequencei

Sequence statusi: Complete.

Q9QXY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSMWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA
60 70 80 90 100
QARRQYHFES NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKSRPSNK
110 120 130 140 150
LEIWEDLKII SFTRSIVAVY STCMLVVLLR VQLNIIGGYI YLDNATVGKN
160 170 180 190 200
GTTVLAPPDV QQQYLSSIQH LLGDGLTELV TVIKQAVQRI LGSVSLKHSL
210 220 230 240 250
SLLDLEQKLK EIRILVEQHQ SSWNDKDVSR SSLCQYMMPD EETPLAAQAY
260 270 280 290 300
GLSHRDITTI KLLNETRDML ESPDFSTVLN TCLNRGFSRL LDNMAEFFRP
310 320 330 340 350
TEQDLQHGNS INSLSSVSLP LAKIIPIVNG QIHSVCSETP SHFVQDLLMM
360 370
EQVKDFAANV YEAFSTPQQL EK
Length:372
Mass (Da):42,224
Last modified:May 1, 2000 - v1
Checksum:i77AA9590A53FAB77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152996 mRNA Translation: AAF14524.1
AF162896
, AF162890, AF162891, AF162892, AF162893, AF162894, AF162895 Genomic DNA Translation: AAG24507.1
BC033415 mRNA Translation: AAH33415.1
BC037606 mRNA Translation: AAH37606.1
CCDSiCCDS23702.1
RefSeqiNP_064345.1, NM_019961.3
UniGeneiMm.282711

Genome annotation databases

EnsembliENSMUST00000019945; ENSMUSP00000019945; ENSMUSG00000019809
GeneIDi56535
KEGGimmu:56535
UCSCiuc007eky.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPEX3_MOUSE
AccessioniPrimary (citable) accession number: Q9QXY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health