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Q9QXY9 (PEX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal biogenesis factor 3
Alternative name(s):
Peroxin-3
Peroxisomal assembly protein PEX3
Gene names
Name:Pex3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.

Subunit structure

Interacts with PEX19 By similarity.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein.

Tissue specificity

Identified in all tissues analyzed, with the strongest expression in liver and in testis.

Sequence similarities

Belongs to the peroxin-3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Peroxisomal biogenesis factor 3
PRO_0000208739

Regions

Topological domain1 – 1515Cytoplasmic Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 11680Peroxisomal Potential
Transmembrane117 – 14024Helical; Potential
Topological domain141 – 372232Cytoplasmic Potential
Region1 – 4545Targeting to peroxisomes By similarity
Region120 – 13617Binding to PEX19 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QXY9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 77AA9590A53FAB77

FASTA37242,224
        10         20         30         40         50         60 
MLRSMWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA QARRQYHFES 

        70         80         90        100        110        120 
NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKSRPSNK LEIWEDLKII SFTRSIVAVY 

       130        140        150        160        170        180 
STCMLVVLLR VQLNIIGGYI YLDNATVGKN GTTVLAPPDV QQQYLSSIQH LLGDGLTELV 

       190        200        210        220        230        240 
TVIKQAVQRI LGSVSLKHSL SLLDLEQKLK EIRILVEQHQ SSWNDKDVSR SSLCQYMMPD 

       250        260        270        280        290        300 
EETPLAAQAY GLSHRDITTI KLLNETRDML ESPDFSTVLN TCLNRGFSRL LDNMAEFFRP 

       310        320        330        340        350        360 
TEQDLQHGNS INSLSSVSLP LAKIIPIVNG QIHSVCSETP SHFVQDLLMM EQVKDFAANV 

       370 
YEAFSTPQQL EK 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein."
Muntau A.C., Mayerhofer P.U., Albet S., Schmid T.E., Bugaut M., Roscher A.A., Kammerer S.
Biol. Chem. 381:337-342(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Ola.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland and Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152996 mRNA. Translation: AAF14524.1.
AF162896 expand/collapse EMBL AC list , AF162890, AF162891, AF162892, AF162893, AF162894, AF162895 Genomic DNA. Translation: AAG24507.1.
BC033415 mRNA. Translation: AAH33415.1.
BC037606 mRNA. Translation: AAH37606.1.
RefSeqNP_064345.1. NM_019961.3.
UniGeneMm.282711.

3D structure databases

ProteinModelPortalQ9QXY9.
SMRQ9QXY9. Positions 52-367.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QXY9.

Proteomic databases

PaxDbQ9QXY9.
PRIDEQ9QXY9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019945; ENSMUSP00000019945; ENSMUSG00000019809.
GeneID56535.
KEGGmmu:56535.
UCSCuc007eky.2. mouse.

Organism-specific databases

CTD8504.
MGIMGI:1929646. Pex3.

Phylogenomic databases

eggNOGNOG259038.
GeneTreeENSGT00390000008481.
HOGENOMHOG000007212.
HOVERGENHBG000467.
InParanoidQ9QXY9.
KOK13336.
OMAARRQFHF.
PhylomeDBQ9QXY9.
TreeFamTF352826.

Gene expression databases

ArrayExpressQ9QXY9.
BgeeQ9QXY9.
CleanExMM_PEX3.
GenevestigatorQ9QXY9.

Family and domain databases

InterProIPR006966. Peroxin-3.
[Graphical view]
PfamPF04882. Peroxin-3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio312898.
PROQ9QXY9.
SOURCESearch...

Entry information

Entry namePEX3_MOUSE
AccessionPrimary (citable) accession number: Q9QXY9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot