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Q9QXY9

- PEX3_MOUSE

UniProt

Q9QXY9 - PEX3_MOUSE

Protein

Peroxisomal biogenesis factor 3

Gene

Pex3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.

    GO - Molecular functioni

    1. lipid binding Source: Ensembl

    GO - Biological processi

    1. peroxisome membrane biogenesis Source: Ensembl
    2. protein import into peroxisome membrane Source: Ensembl

    Keywords - Biological processi

    Peroxisome biogenesis

    Enzyme and pathway databases

    ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal biogenesis factor 3
    Alternative name(s):
    Peroxin-3
    Peroxisomal assembly protein PEX3
    Gene namesi
    Name:Pex3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1929646. Pex3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. endoplasmic reticulum Source: Ensembl
    3. integral component of peroxisomal membrane Source: Ensembl
    4. integral component of plasma membrane Source: MGI
    5. nucleus Source: Ensembl
    6. protein complex Source: Ensembl
    7. protein-lipid complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Peroxisomal biogenesis factor 3PRO_0000208739Add
    BLAST

    Proteomic databases

    MaxQBiQ9QXY9.
    PaxDbiQ9QXY9.
    PRIDEiQ9QXY9.

    PTM databases

    PhosphoSiteiQ9QXY9.

    Expressioni

    Tissue specificityi

    Identified in all tissues analyzed, with the strongest expression in liver and in testis.

    Gene expression databases

    ArrayExpressiQ9QXY9.
    BgeeiQ9QXY9.
    CleanExiMM_PEX3.
    GenevestigatoriQ9QXY9.

    Interactioni

    Subunit structurei

    Interacts with PEX19.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXY9.
    SMRiQ9QXY9. Positions 52-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 11680PeroxisomalSequence AnalysisAdd
    BLAST
    Topological domaini141 – 372232CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 14024HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4545Targeting to peroxisomesBy similarityAdd
    BLAST
    Regioni120 – 13617Binding to PEX19By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxin-3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259038.
    GeneTreeiENSGT00390000008481.
    HOGENOMiHOG000007212.
    HOVERGENiHBG000467.
    InParanoidiQ9QXY9.
    KOiK13336.
    OMAiARRQFHF.
    PhylomeDBiQ9QXY9.
    TreeFamiTF352826.

    Family and domain databases

    InterProiIPR006966. Peroxin-3.
    [Graphical view]
    PfamiPF04882. Peroxin-3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QXY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRSMWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA    50
    QARRQYHFES NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKSRPSNK 100
    LEIWEDLKII SFTRSIVAVY STCMLVVLLR VQLNIIGGYI YLDNATVGKN 150
    GTTVLAPPDV QQQYLSSIQH LLGDGLTELV TVIKQAVQRI LGSVSLKHSL 200
    SLLDLEQKLK EIRILVEQHQ SSWNDKDVSR SSLCQYMMPD EETPLAAQAY 250
    GLSHRDITTI KLLNETRDML ESPDFSTVLN TCLNRGFSRL LDNMAEFFRP 300
    TEQDLQHGNS INSLSSVSLP LAKIIPIVNG QIHSVCSETP SHFVQDLLMM 350
    EQVKDFAANV YEAFSTPQQL EK 372
    Length:372
    Mass (Da):42,224
    Last modified:May 1, 2000 - v1
    Checksum:i77AA9590A53FAB77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152996 mRNA. Translation: AAF14524.1.
    AF162896
    , AF162890, AF162891, AF162892, AF162893, AF162894, AF162895 Genomic DNA. Translation: AAG24507.1.
    BC033415 mRNA. Translation: AAH33415.1.
    BC037606 mRNA. Translation: AAH37606.1.
    CCDSiCCDS23702.1.
    RefSeqiNP_064345.1. NM_019961.3.
    UniGeneiMm.282711.

    Genome annotation databases

    EnsembliENSMUST00000019945; ENSMUSP00000019945; ENSMUSG00000019809.
    GeneIDi56535.
    KEGGimmu:56535.
    UCSCiuc007eky.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152996 mRNA. Translation: AAF14524.1 .
    AF162896
    , AF162890 , AF162891 , AF162892 , AF162893 , AF162894 , AF162895 Genomic DNA. Translation: AAG24507.1 .
    BC033415 mRNA. Translation: AAH33415.1 .
    BC037606 mRNA. Translation: AAH37606.1 .
    CCDSi CCDS23702.1.
    RefSeqi NP_064345.1. NM_019961.3.
    UniGenei Mm.282711.

    3D structure databases

    ProteinModelPortali Q9QXY9.
    SMRi Q9QXY9. Positions 52-367.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QXY9.

    Proteomic databases

    MaxQBi Q9QXY9.
    PaxDbi Q9QXY9.
    PRIDEi Q9QXY9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019945 ; ENSMUSP00000019945 ; ENSMUSG00000019809 .
    GeneIDi 56535.
    KEGGi mmu:56535.
    UCSCi uc007eky.2. mouse.

    Organism-specific databases

    CTDi 8504.
    MGIi MGI:1929646. Pex3.

    Phylogenomic databases

    eggNOGi NOG259038.
    GeneTreei ENSGT00390000008481.
    HOGENOMi HOG000007212.
    HOVERGENi HBG000467.
    InParanoidi Q9QXY9.
    KOi K13336.
    OMAi ARRQFHF.
    PhylomeDBi Q9QXY9.
    TreeFami TF352826.

    Enzyme and pathway databases

    Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

    Miscellaneous databases

    NextBioi 312898.
    PROi Q9QXY9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QXY9.
    Bgeei Q9QXY9.
    CleanExi MM_PEX3.
    Genevestigatori Q9QXY9.

    Family and domain databases

    InterProi IPR006966. Peroxin-3.
    [Graphical view ]
    Pfami PF04882. Peroxin-3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein."
      Muntau A.C., Mayerhofer P.U., Albet S., Schmid T.E., Bugaut M., Roscher A.A., Kammerer S.
      Biol. Chem. 381:337-342(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/Ola.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland and Retina.

    Entry informationi

    Entry nameiPEX3_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3