ID   CCL7_RAT                Reviewed;          97 AA.
AC   Q9QXY8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 141.
DE   RecName: Full=C-C motif chemokine 7;
DE   AltName: Full=Monocyte chemoattractant protein 3;
DE   AltName: Full=Monocyte chemotactic protein 3;
DE            Short=MCP-3;
DE   AltName: Full=Small-inducible cytokine A7;
DE   Flags: Precursor;
GN   Name=Ccl7; Synonyms=Mcp3, Scya7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10521584; DOI=10.1016/s0169-328x(99)00203-x;
RA   Wang X., Li X., Yaish-Ohad S., Sarau H.M., Barone F.C., Feuerstein G.Z.;
RT   "Molecular cloning and expression of the rat monocyte chemotactic protein-3
RT   gene: a possible role in stroke.";
RL   Brain Res. Mol. Brain Res. 71:304-312(1999).
CC   -!- FUNCTION: Chemotactic factor that attracts monocytes and eosinophils,
CC       but not neutrophils. Augments monocyte anti-tumor activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with TNFAIP6 (via Link domain).
CC       {ECO:0000250|UniProtKB:P80098}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF154245; AAF24172.1; -; Genomic_DNA.
DR   RefSeq; NP_001007613.1; NM_001007612.1.
DR   AlphaFoldDB; Q9QXY8; -.
DR   SMR; Q9QXY8; -.
DR   STRING; 10116.ENSRNOP00000000256; -.
DR   GlyCosmos; Q9QXY8; 1 site, No reported glycans.
DR   GlyGen; Q9QXY8; 1 site.
DR   PaxDb; 10116-ENSRNOP00000000256; -.
DR   Ensembl; ENSRNOT00000000256.5; ENSRNOP00000000256.2; ENSRNOG00000000239.5.
DR   Ensembl; ENSRNOT00055044216; ENSRNOP00055036174; ENSRNOG00055025633.
DR   Ensembl; ENSRNOT00060033438; ENSRNOP00060027363; ENSRNOG00060019349.
DR   Ensembl; ENSRNOT00065033005; ENSRNOP00065026377; ENSRNOG00065019603.
DR   GeneID; 287561; -.
DR   KEGG; rno:287561; -.
DR   AGR; RGD:1359152; -.
DR   CTD; 6354; -.
DR   RGD; 1359152; Ccl7.
DR   eggNOG; ENOG502S6ZP; Eukaryota.
DR   GeneTree; ENSGT01100000263482; -.
DR   HOGENOM; CLU_141716_1_0_1; -.
DR   InParanoid; Q9QXY8; -.
DR   OMA; QKWVQEF; -.
DR   OrthoDB; 4265193at2759; -.
DR   PhylomeDB; Q9QXY8; -.
DR   TreeFam; TF334888; -.
DR   Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR   PRO; PR:Q9QXY8; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000000239; Expressed in stomach and 17 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0031726; F:CCR1 chemokine receptor binding; ISO:RGD.
DR   GO; GO:0031727; F:CCR2 chemokine receptor binding; ISO:RGD.
DR   GO; GO:0008009; F:chemokine activity; ISO:RGD.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0071361; P:cellular response to ethanol; IDA:RGD.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; ISO:RGD.
DR   GO; GO:0048245; P:eosinophil chemotaxis; ISO:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:RGD.
DR   GO; GO:0008360; P:regulation of cell shape; ISO:RGD.
DR   GO; GO:0010332; P:response to gamma radiation; IEP:RGD.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF197; C-C MOTIF CHEMOKINE 7; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
DR   Genevisible; Q9QXY8; RN.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Glycoprotein; Heparin-binding;
KW   Inflammatory response; Pyrrolidone carboxylic acid; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..97
FT                   /note="C-C motif chemokine 7"
FT                   /id="PRO_0000005185"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P80098"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        33..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   97 AA;  10906 MW;  AEDBB7BD9288F0C4 CRC64;
     MQISAALLCV LLTAAAFTVH VWAQPDGTNS STCCYVKKQK IPKRNLKSYR KITSSRCPWE
     AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTSTPKP
//