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Q9QXY8

- CCL7_RAT

UniProt

Q9QXY8 - CCL7_RAT

Protein

C-C motif chemokine 7

Gene

Ccl7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to ethanol Source: RGD
    2. cytoskeleton organization Source: Ensembl
    3. eosinophil chemotaxis Source: Ensembl
    4. immune response Source: InterPro
    5. inflammatory response Source: UniProtKB-KW
    6. positive regulation of natural killer cell chemotaxis Source: Ensembl
    7. regulation of cell shape Source: Ensembl
    8. response to gamma radiation Source: RGD

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 7
    Alternative name(s):
    Monocyte chemoattractant protein 3
    Monocyte chemotactic protein 3
    Short name:
    MCP-3
    Small-inducible cytokine A7
    Gene namesi
    Name:Ccl7
    Synonyms:Mcp3, Scya7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1359152. Ccl7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9774C-C motif chemokine 7PRO_0000005185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QXY8.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG140372.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ9QXY8.
    KOiK05509.
    OMAiGDMNSAS.
    OrthoDBiEOG7673DP.
    PhylomeDBiQ9QXY8.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QXY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQISAALLCV LLTAAAFTVH VWAQPDGTNS STCCYVKKQK IPKRNLKSYR   50
    KITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTSTPKP 97
    Length:97
    Mass (Da):10,906
    Last modified:May 1, 2000 - v1
    Checksum:iAEDBB7BD9288F0C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154245 Genomic DNA. Translation: AAF24172.1.
    RefSeqiNP_001007613.1. NM_001007612.1.
    UniGeneiRn.26815.

    Genome annotation databases

    EnsembliENSRNOT00000000256; ENSRNOP00000000256; ENSRNOG00000000239.
    GeneIDi287561.
    KEGGirno:287561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154245 Genomic DNA. Translation: AAF24172.1 .
    RefSeqi NP_001007613.1. NM_001007612.1.
    UniGenei Rn.26815.

    3D structure databases

    ProteinModelPortali Q9QXY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000256 ; ENSRNOP00000000256 ; ENSRNOG00000000239 .
    GeneIDi 287561.
    KEGGi rno:287561.

    Organism-specific databases

    CTDi 6354.
    RGDi 1359152. Ccl7.

    Phylogenomic databases

    eggNOGi NOG140372.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q9QXY8.
    KOi K05509.
    OMAi GDMNSAS.
    OrthoDBi EOG7673DP.
    PhylomeDBi Q9QXY8.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 626523.
    PROi Q9QXY8.

    Gene expression databases

    Genevestigatori Q9QXY8.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: a possible role in stroke."
      Wang X., Li X., Yaish-Ohad S., Sarau H.M., Barone F.C., Feuerstein G.Z.
      Brain Res. Mol. Brain Res. 71:304-312(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCCL7_RAT
    AccessioniPrimary (citable) accession number: Q9QXY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3