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Protein

C-C motif chemokine 7

Gene

Ccl7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
Small-inducible cytokine A7
Gene namesi
Name:Ccl7
Synonyms:Mcp3, Scya7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359152. Ccl7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000518524 – 97C-C motif chemokine 7Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9QXY8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000239.
GenevisibleiQ9QXY8. RN.

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000256.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9QXY8.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG091G14KV.
PhylomeDBiQ9QXY8.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQISAALLCV LLTAAAFTVH VWAQPDGTNS STCCYVKKQK IPKRNLKSYR
60 70 80 90
KITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTSTPKP
Length:97
Mass (Da):10,906
Last modified:May 1, 2000 - v1
Checksum:iAEDBB7BD9288F0C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154245 Genomic DNA. Translation: AAF24172.1.
RefSeqiNP_001007613.1. NM_001007612.1.
UniGeneiRn.26815.

Genome annotation databases

EnsembliENSRNOT00000000256; ENSRNOP00000000256; ENSRNOG00000000239.
GeneIDi287561.
KEGGirno:287561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154245 Genomic DNA. Translation: AAF24172.1.
RefSeqiNP_001007613.1. NM_001007612.1.
UniGeneiRn.26815.

3D structure databases

ProteinModelPortaliQ9QXY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000256.

Proteomic databases

PaxDbiQ9QXY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000256; ENSRNOP00000000256; ENSRNOG00000000239.
GeneIDi287561.
KEGGirno:287561.

Organism-specific databases

CTDi6354.
RGDi1359152. Ccl7.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9QXY8.
KOiK05509.
OMAiTTCCYRF.
OrthoDBiEOG091G14KV.
PhylomeDBiQ9QXY8.
TreeFamiTF334888.

Miscellaneous databases

PROiQ9QXY8.

Gene expression databases

BgeeiENSRNOG00000000239.
GenevisibleiQ9QXY8. RN.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL7_RAT
AccessioniPrimary (citable) accession number: Q9QXY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.