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Q9QXY8

- CCL7_RAT

UniProt

Q9QXY8 - CCL7_RAT

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Protein
C-C motif chemokine 7
Gene
Ccl7, Mcp3, Scya7
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity By similarity.

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to ethanol Source: RGD
  2. cytoskeleton organization Source: Ensembl
  3. eosinophil chemotaxis Source: Ensembl
  4. immune response Source: InterPro
  5. inflammatory response Source: UniProtKB-KW
  6. positive regulation of natural killer cell chemotaxis Source: Ensembl
  7. regulation of cell shape Source: Ensembl
  8. response to gamma radiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 7
Alternative name(s):
Monocyte chemoattractant protein 3
Monocyte chemotactic protein 3
Short name:
MCP-3
Small-inducible cytokine A7
Gene namesi
Name:Ccl7
Synonyms:Mcp3, Scya7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1359152. Ccl7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 9774C-C motif chemokine 7
PRO_0000005185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid By similarity
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Gene expression databases

GenevestigatoriQ9QXY8.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000256.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140372.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ9QXY8.
KOiK05509.
OMAiGDMNSAS.
OrthoDBiEOG7673DP.
PhylomeDBiQ9QXY8.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXY8-1 [UniParc]FASTAAdd to Basket

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MQISAALLCV LLTAAAFTVH VWAQPDGTNS STCCYVKKQK IPKRNLKSYR   50
KITSSRCPWE AVIFKTKKGM EVCAEAHQKW VEEAIAYLDM KTSTPKP 97
Length:97
Mass (Da):10,906
Last modified:May 1, 2000 - v1
Checksum:iAEDBB7BD9288F0C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154245 Genomic DNA. Translation: AAF24172.1.
RefSeqiNP_001007613.1. NM_001007612.1.
UniGeneiRn.26815.

Genome annotation databases

EnsembliENSRNOT00000000256; ENSRNOP00000000256; ENSRNOG00000000239.
GeneIDi287561.
KEGGirno:287561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154245 Genomic DNA. Translation: AAF24172.1 .
RefSeqi NP_001007613.1. NM_001007612.1.
UniGenei Rn.26815.

3D structure databases

ProteinModelPortali Q9QXY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000256 ; ENSRNOP00000000256 ; ENSRNOG00000000239 .
GeneIDi 287561.
KEGGi rno:287561.

Organism-specific databases

CTDi 6354.
RGDi 1359152. Ccl7.

Phylogenomic databases

eggNOGi NOG140372.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi Q9QXY8.
KOi K05509.
OMAi GDMNSAS.
OrthoDBi EOG7673DP.
PhylomeDBi Q9QXY8.
TreeFami TF334888.

Miscellaneous databases

NextBioi 626523.
PROi Q9QXY8.

Gene expression databases

Genevestigatori Q9QXY8.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: a possible role in stroke."
    Wang X., Li X., Yaish-Ohad S., Sarau H.M., Barone F.C., Feuerstein G.Z.
    Brain Res. Mol. Brain Res. 71:304-312(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCL7_RAT
AccessioniPrimary (citable) accession number: Q9QXY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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