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Protein

Membrane transport protein XK

Gene

Xk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.By similarity

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • cellular calcium ion homeostasis Source: MGI
  • cellular magnesium ion homeostasis Source: MGI
  • myelination Source: MGI
  • regulation of axon diameter Source: MGI
  • regulation of cell size Source: MGI
  • skeletal muscle fiber development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane transport protein XK
Alternative name(s):
XK homolog
XK-related protein 1
Gene namesi
Name:Xk
Synonyms:Xkh, Xkr1, Xrg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:103569. Xk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence analysis
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Topological domaini24 – 3714ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Topological domaini59 – 6810CytoplasmicSequence analysis
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 14051ExtracellularSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 17110CytoplasmicSequence analysis
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Topological domaini193 – 20816ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 2356CytoplasmicSequence analysis
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 27721ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST
Topological domaini299 – 31719CytoplasmicSequence analysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST
Topological domaini339 – 34911ExtracellularSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Topological domaini371 – 44676CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell Source: GOC
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Membrane transport protein XKPRO_0000190768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineBy similarity
Disulfide bondi347 – 347Interchain (with C-53 in Kell)By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9QXY7.
PaxDbiQ9QXY7.
PRIDEiQ9QXY7.

PTM databases

PhosphoSiteiQ9QXY7.

Expressioni

Gene expression databases

BgeeiQ9QXY7.
ExpressionAtlasiQ9QXY7. baseline and differential.
GenevisibleiQ9QXY7. MM.

Interactioni

Subunit structurei

Heterodimer with Kell; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015486.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ9QXY7.
KOiK19522.
OMAiAVYYMLR.
OrthoDBiEOG7034H1.
PhylomeDBiQ9QXY7.
TreeFamiTF331465.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPASVIAS VFLFVAETAA ALYLSSTYRS AGDRMWQVLT LLFSLMPCAL
60 70 80 90 100
VQFTLLFVHR DLSRDRPLAL LMHLLQLGPL YRCCEVFCIY CQSDQNEEPY
110 120 130 140 150
VSITKKRQMP KDGLSEEVEK EVGQAEGKLI THRSAFSRAS VIQAFLGSAP
160 170 180 190 200
QLTLQLYITV LEQNITTGRC FIMTLSLLSI VYGALRCNIL AIKIKYDEYE
210 220 230 240 250
VKVKPLAYVC IFLWRSFEIA TRVIVLVLFT SVLKIWVVAV ILVNFFSFFL
260 270 280 290 300
YPWIVFWCSG SPFPENIEKA LSRVGTTIVL CFLTLLYAGI NMFCWSAVQL
310 320 330 340 350
KIDNPELISK SQNWYRLLIY YMTRFIENSV LLLLWYFFKT DIYMYVCAPL
360 370 380 390 400
LILQLLIGYC TGILFMLVFY QFFHPCKKLF SSSVSESFRA LLRCACWSSL
410 420 430 440
RRKSSEPVGR IDTDLKACTE QDVMPTTSKV IPEATDIWTA VDLCSA
Length:446
Mass (Da):51,115
Last modified:May 1, 2000 - v1
Checksum:iD785FB7B9E28B98B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155511 mRNA. Translation: AAF14527.1.
AY534248 mRNA. Translation: AAT07097.1.
AK007734 mRNA. Translation: BAB25222.1.
CCDSiCCDS30008.1.
RefSeqiNP_075989.1. NM_023500.2.
UniGeneiMm.56468.

Genome annotation databases

EnsembliENSMUST00000015486; ENSMUSP00000015486; ENSMUSG00000015342.
GeneIDi22439.
KEGGimmu:22439.
UCSCiuc009spq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155511 mRNA. Translation: AAF14527.1.
AY534248 mRNA. Translation: AAT07097.1.
AK007734 mRNA. Translation: BAB25222.1.
CCDSiCCDS30008.1.
RefSeqiNP_075989.1. NM_023500.2.
UniGeneiMm.56468.

3D structure databases

ProteinModelPortaliQ9QXY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015486.

Chemistry

ChEMBLiCHEMBL2176802.

PTM databases

PhosphoSiteiQ9QXY7.

Proteomic databases

MaxQBiQ9QXY7.
PaxDbiQ9QXY7.
PRIDEiQ9QXY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015486; ENSMUSP00000015486; ENSMUSG00000015342.
GeneIDi22439.
KEGGimmu:22439.
UCSCiuc009spq.1. mouse.

Organism-specific databases

CTDi7504.
MGIiMGI:103569. Xk.

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ9QXY7.
KOiK19522.
OMAiAVYYMLR.
OrthoDBiEOG7034H1.
PhylomeDBiQ9QXY7.
TreeFamiTF331465.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi302893.
PROiQ9QXY7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXY7.
ExpressionAtlasiQ9QXY7. baseline and differential.
GenevisibleiQ9QXY7. MM.

Family and domain databases

InterProiIPR018629. XK_fam.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the mouse homologue of the XK gene."
    Collec E., Colin Y., Carbonnet F., Hattab C., Bertrand O., Cartron J.-P., Kim C.L.
    Immunogenetics 50:16-21(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Skeletal muscle.
  2. "A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates."
    Huang C.-H., Chen Y.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  4. "The mouse Kell blood group gene (Kel): cDNA sequence, genomic organization, expression, and enzymatic function."
    Lee S., Russo D.C., Pu J., Ho M., Redman C.M.
    Immunogenetics 52:53-62(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiXK_MOUSE
AccessioniPrimary (citable) accession number: Q9QXY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: May 1, 2000
Last modified: December 9, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.