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Protein

Membrane transport protein XK

Gene

Xk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.By similarity

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • cellular calcium ion homeostasis Source: MGI
  • cellular magnesium ion homeostasis Source: MGI
  • myelination Source: MGI
  • regulation of axon diameter Source: MGI
  • regulation of cell size Source: MGI
  • skeletal muscle fiber development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane transport protein XK
Alternative name(s):
XK homolog
XK-related protein 1
Gene namesi
Name:Xk
Synonyms:Xkh, Xkr1, Xrg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:103569. Xk.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 37ExtracellularSequence analysisAdd BLAST14
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 140ExtracellularSequence analysisAdd BLAST51
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 171CytoplasmicSequence analysis10
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 208ExtracellularSequence analysisAdd BLAST16
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 235CytoplasmicSequence analysis6
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 277ExtracellularSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 317CytoplasmicSequence analysisAdd BLAST19
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 349ExtracellularSequence analysisAdd BLAST11
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 446CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907681 – 446Membrane transport protein XKAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineBy similarity1
Disulfide bondi347Interchain (with C-53 in Kell)By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9QXY7.
PRIDEiQ9QXY7.

PTM databases

PhosphoSitePlusiQ9QXY7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015342.
ExpressionAtlasiQ9QXY7. baseline and differential.
GenevisibleiQ9QXY7. MM.

Interactioni

Subunit structurei

Heterodimer with Kell; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015486.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ9QXY7.
KOiK19522.
OMAiAVYYMLR.
OrthoDBiEOG091G07Y7.
PhylomeDBiQ9QXY7.
TreeFamiTF331465.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPASVIAS VFLFVAETAA ALYLSSTYRS AGDRMWQVLT LLFSLMPCAL
60 70 80 90 100
VQFTLLFVHR DLSRDRPLAL LMHLLQLGPL YRCCEVFCIY CQSDQNEEPY
110 120 130 140 150
VSITKKRQMP KDGLSEEVEK EVGQAEGKLI THRSAFSRAS VIQAFLGSAP
160 170 180 190 200
QLTLQLYITV LEQNITTGRC FIMTLSLLSI VYGALRCNIL AIKIKYDEYE
210 220 230 240 250
VKVKPLAYVC IFLWRSFEIA TRVIVLVLFT SVLKIWVVAV ILVNFFSFFL
260 270 280 290 300
YPWIVFWCSG SPFPENIEKA LSRVGTTIVL CFLTLLYAGI NMFCWSAVQL
310 320 330 340 350
KIDNPELISK SQNWYRLLIY YMTRFIENSV LLLLWYFFKT DIYMYVCAPL
360 370 380 390 400
LILQLLIGYC TGILFMLVFY QFFHPCKKLF SSSVSESFRA LLRCACWSSL
410 420 430 440
RRKSSEPVGR IDTDLKACTE QDVMPTTSKV IPEATDIWTA VDLCSA
Length:446
Mass (Da):51,115
Last modified:May 1, 2000 - v1
Checksum:iD785FB7B9E28B98B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155511 mRNA. Translation: AAF14527.1.
AY534248 mRNA. Translation: AAT07097.1.
AK007734 mRNA. Translation: BAB25222.1.
CCDSiCCDS30008.1.
RefSeqiNP_075989.1. NM_023500.2.
UniGeneiMm.56468.

Genome annotation databases

EnsembliENSMUST00000015486; ENSMUSP00000015486; ENSMUSG00000015342.
GeneIDi22439.
KEGGimmu:22439.
UCSCiuc009spq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155511 mRNA. Translation: AAF14527.1.
AY534248 mRNA. Translation: AAT07097.1.
AK007734 mRNA. Translation: BAB25222.1.
CCDSiCCDS30008.1.
RefSeqiNP_075989.1. NM_023500.2.
UniGeneiMm.56468.

3D structure databases

ProteinModelPortaliQ9QXY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015486.

Chemistry databases

ChEMBLiCHEMBL2176802.

PTM databases

PhosphoSitePlusiQ9QXY7.

Proteomic databases

PaxDbiQ9QXY7.
PRIDEiQ9QXY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015486; ENSMUSP00000015486; ENSMUSG00000015342.
GeneIDi22439.
KEGGimmu:22439.
UCSCiuc009spq.1. mouse.

Organism-specific databases

CTDi7504.
MGIiMGI:103569. Xk.

Phylogenomic databases

eggNOGiENOG410IE7C. Eukaryota.
ENOG410XP4P. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ9QXY7.
KOiK19522.
OMAiAVYYMLR.
OrthoDBiEOG091G07Y7.
PhylomeDBiQ9QXY7.
TreeFamiTF331465.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Miscellaneous databases

PROiQ9QXY7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015342.
ExpressionAtlasiQ9QXY7. baseline and differential.
GenevisibleiQ9QXY7. MM.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXK_MOUSE
AccessioniPrimary (citable) accession number: Q9QXY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.