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Protein

SRC kinase signaling inhibitor 1

Gene

Srcin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.2 Publications

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein kinase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
SRC kinase signaling inhibitor 1
Alternative name(s):
SNAP-25-interacting protein
Short name:
SNIP
p130Cas-associated protein
p140Cap
Gene namesi
Name:Srcin1
Synonyms:P140, Snip
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi708439. Srcin1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: RGD
  • axon Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • filopodium Source: RGD
  • lamellipodium Source: RGD
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-KW
  • synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11971197SRC kinase signaling inhibitor 1PRO_0000072013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471PhosphoserineBy similarity
Modified residuei52 – 521PhosphoserineBy similarity
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity
Modified residuei98 – 981PhosphoserineCombined sources
Modified residuei178 – 1781PhosphoserineCombined sources
Modified residuei200 – 2001PhosphoserineCombined sources
Modified residuei204 – 2041PhosphoserineCombined sources
Modified residuei214 – 2141PhosphoserineBy similarity
Modified residuei260 – 2601PhosphoserineCombined sources
Modified residuei276 – 2761PhosphotyrosineBy similarity
Modified residuei333 – 3331PhosphoserineBy similarity
Modified residuei342 – 3421PhosphoserineBy similarity
Modified residuei359 – 3591PhosphoserineBy similarity
Modified residuei378 – 3781PhosphoserineCombined sources
Modified residuei397 – 3971PhosphoserineBy similarity
Modified residuei399 – 3991PhosphoserineBy similarity
Modified residuei431 – 4311PhosphotyrosineBy similarity
Modified residuei527 – 5271PhosphoserineBy similarity
Modified residuei530 – 5301PhosphoserineBy similarity
Modified residuei534 – 5341PhosphoserineBy similarity
Modified residuei537 – 5371PhosphoserineBy similarity
Modified residuei547 – 5471PhosphoserineCombined sources
Modified residuei549 – 5491PhosphoserineBy similarity
Modified residuei551 – 5511PhosphoserineBy similarity
Modified residuei556 – 5561PhosphoserineCombined sources
Modified residuei631 – 6311PhosphoserineBy similarity
Modified residuei655 – 6551PhosphoserineBy similarity
Modified residuei658 – 6581PhosphothreonineBy similarity
Modified residuei671 – 6711PhosphothreonineBy similarity
Modified residuei878 – 8781PhosphoserineBy similarity
Modified residuei900 – 9001PhosphoserineCombined sources
Modified residuei918 – 9181PhosphothreonineBy similarity
Modified residuei1021 – 10211PhosphoserineCombined sources
Modified residuei1077 – 10771PhosphoserineCombined sources
Modified residuei1094 – 10941PhosphoserineBy similarity

Post-translational modificationi

Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QXY2.
PRIDEiQ9QXY2.

PTM databases

iPTMnetiQ9QXY2.
PhosphoSiteiQ9QXY2.
SwissPalmiQ9QXY2.

Expressioni

Tissue specificityi

Expressed exclusively in brain. Abundant in telencephalon and expressed moderately in cerebellum, hypothalamus, thalamus, superior and inferior colliculi, and olfactory bulb. No expression detected in medulla oblongata, spinal cord or pituitary gland. Enriched in the neuropil rather than soma in the thalamus, corpus striatum and cerebral cortex. Detected in astrocytes.2 Publications

Developmental stagei

In the embryo, expression increases dramatically between E14.5 and E18.5 (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000011475.
GenevisibleiQ9QXY2. RN.

Interactioni

Subunit structurei

Interacts with BCAR1/p130Cas through its C-terminal domain and with CSK, CTTN and SRC (By similarity). Also interacts with MAPRE3/EB3, SORBS3/vinexin and the N-terminal coiled-coil region of SNAP25.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Snap25P608813EBI-1394088,EBI-1027214

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi248555. 3 interactions.
IntActiQ9QXY2. 5 interactions.
MINTiMINT-139008.
STRINGi10116.ENSRNOP00000016070.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni681 – 73151Interaction with SNAP25Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili594 – 62128Sequence analysisAdd
BLAST
Coiled coili685 – 70824Sequence analysisAdd
BLAST
Coiled coili750 – 81263Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi990 – 104859Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SRCIN1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHFG. Eukaryota.
ENOG410XTBA. LUCA.
GeneTreeiENSGT00390000012399.
HOVERGENiHBG019587.
InParanoidiQ9QXY2.
KOiK19930.
OMAiAQQPNYW.
OrthoDBiEOG091G00Q1.
PhylomeDBiQ9QXY2.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026727. Srcin1.
[Graphical view]
PANTHERiPTHR22741:SF5. PTHR22741:SF5. 1 hit.
PfamiPF03915. AIP3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9QXY2-1) [UniParc]FASTAAdd to basket
Also known as: SNIP-b1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPWQCLRRF ALAWWERTAE GRARSPREEV GPRDPGGRGE PDPERSSPPM
60 70 80 90 100
LSADDAEYPR EYRTLGGGGS GGSGGRRFSN VGLVHTSERR HTVIAAQSLE
110 120 130 140 150
ALSGLQKADA DRKRDAFMDH LKSKYPQHAL ALRGQQDRMR EQQPNYWSFK
160 170 180 190 200
TRSSRHTQGA QPGLADQAAK LSYASAESLE TMSEAELPLG FSRMNRFRQS
210 220 230 240 250
LPLSRSASQT KLRSPGVLFL QFGEETRRVH ITHEVSSLDT LHALIAHMFP
260 270 280 290 300
QKLTMGMLKS PNTAILIKDE ARNVFYELED VRDIQDRSII KIYRKEPLYA
310 320 330 340 350
AFPGSHLTNG DLRREMVYAS RESSPTRRLN NLSPASHLAS SSPPPGLPSG
360 370 380 390 400
LPSGLPSGSP SRSRLSYAGG RPPSYAGSPV HHAAERLGGA PTSQGVSPSP
410 420 430 440 450
SAILERRDVK PDEDLAGKAG GMVLVKGEGL YADPYGLLHE GRLSLAAAAG
460 470 480 490 500
DPFAYPGAGG LYKRGSVRSL STYSAAALQS DLEDSLYKAG AGGPLYGDGY
510 520 530 540 550
GFRLPPSSPQ KLADVSAPSG GPPPPHSPYS GPPSRGSPVR QSFRKDSGSS
560 570 580 590 600
SVFAESPGGK ARSTGASTAG APPSELFPGP GERSLVGFGP PVPAKDTETR
610 620 630 640 650
ERMEAMEKQI ASLTGLVQSA LLRGSEPETP SEKIEGSNGA ATPSAPVCGS
660 670 680 690 700
GSRSSGATPV SGPPPPAVSS TPAGQPTAVS RLQMQMHLRG LQNSASDLRG
710 720 730 740 750
QLQQLRKLQL QNQESVRALL KRTEAELSMR VSEAARRQED PLQRQRTLVE
760 770 780 790 800
EERLRYLNDE ELITQQLNDL EKSVEKIQRD VAHNHRLVPG PELEEKALVL
810 820 830 840 850
KQLGETLTEL KAHFPGLQSK MRVVLRVEVE AVKFLKEEPQ RLDGLLKRCR
860 870 880 890 900
VVTDTLAQIR RQVDEGVWPP PNNLLNQSPK KVAAETDFSK GLDFEIPPPS
910 920 930 940 950
PPLNLHELSG PAEGTPLTPK SGNPTKGLDA PSKRNMDKAV SVEAAERDWE
960 970 980 990 1000
EKRAALTQYS AKDINRLLEE TQAELLKAIP DLDCASKTHP GPTPTPDHKP
1010 1020 1030 1040 1050
PKAPHGQKAA PRTEPSGRRG SDELTVPRYR TEKPSKSPPP PPPRRSFPSS
1060 1070 1080 1090 1100
HGLTTTRTGE VVVTSKKDSV FIKKAESEEL EIQKPQVKLR RAVSEVVRPA
1110 1120 1130 1140 1150
STPPIMASAI KDEDDEERII AELESGGGSV PPMKVVTPGA SRLKAAQGPA
1160 1170 1180 1190
GSPDKGKHGK QRTEYMRIQA QQQVRVGYQA PRPLEGCTPR LCYMPLS
Length:1,197
Mass (Da):129,744
Last modified:May 1, 2000 - v1
Checksum:i8C9A2E630FB31C33
GO
Isoform 21 Publication (identifier: Q9QXY2-2) [UniParc]FASTAAdd to basket
Also known as: SNIP-a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1174-1197: Missing.

Show »
Length:1,173
Mass (Da):127,055
Checksum:iB6DF0EEC27B69080
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1174 – 119724Missing in isoform 2. 1 PublicationVSP_050633Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156981 mRNA. Translation: AAF25003.1.
AF156982 mRNA. Translation: AAF25004.1.
RefSeqiNP_062251.1. NM_019378.1. [Q9QXY2-1]
UniGeneiRn.207205.

Genome annotation databases

EnsembliENSRNOT00000016070; ENSRNOP00000016070; ENSRNOG00000011475. [Q9QXY2-1]
GeneIDi56029.
KEGGirno:56029.
UCSCiRGD:708439. rat. [Q9QXY2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156981 mRNA. Translation: AAF25003.1.
AF156982 mRNA. Translation: AAF25004.1.
RefSeqiNP_062251.1. NM_019378.1. [Q9QXY2-1]
UniGeneiRn.207205.

3D structure databases

ProteinModelPortaliQ9QXY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248555. 3 interactions.
IntActiQ9QXY2. 5 interactions.
MINTiMINT-139008.
STRINGi10116.ENSRNOP00000016070.

PTM databases

iPTMnetiQ9QXY2.
PhosphoSiteiQ9QXY2.
SwissPalmiQ9QXY2.

Proteomic databases

PaxDbiQ9QXY2.
PRIDEiQ9QXY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016070; ENSRNOP00000016070; ENSRNOG00000011475. [Q9QXY2-1]
GeneIDi56029.
KEGGirno:56029.
UCSCiRGD:708439. rat. [Q9QXY2-1]

Organism-specific databases

CTDi80725.
RGDi708439. Srcin1.

Phylogenomic databases

eggNOGiENOG410IHFG. Eukaryota.
ENOG410XTBA. LUCA.
GeneTreeiENSGT00390000012399.
HOVERGENiHBG019587.
InParanoidiQ9QXY2.
KOiK19930.
OMAiAQQPNYW.
OrthoDBiEOG091G00Q1.
PhylomeDBiQ9QXY2.

Miscellaneous databases

PROiQ9QXY2.

Gene expression databases

BgeeiENSRNOG00000011475.
GenevisibleiQ9QXY2. RN.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026727. Srcin1.
[Graphical view]
PANTHERiPTHR22741:SF5. PTHR22741:SF5. 1 hit.
PfamiPF03915. AIP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRCN1_RAT
AccessioniPrimary (citable) accession number: Q9QXY2
Secondary accession number(s): Q9QXY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.