Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SRC kinase signaling inhibitor 1

Gene

Srcin1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.2 Publications

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein kinase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
SRC kinase signaling inhibitor 1
Alternative name(s):
SNAP-25-interacting protein
Short name:
SNIP
p130Cas-associated protein
p140Cap
Gene namesi
Name:Srcin1
Synonyms:P140, Snip
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi708439. Srcin1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: RGD
  • axon Source: UniProtKB
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • filopodium Source: RGD
  • lamellipodium Source: RGD
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • postsynaptic density Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB-KW
  • synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720131 – 1197SRC kinase signaling inhibitor 1Add BLAST1197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei98PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei214PhosphoserineBy similarity1
Modified residuei260PhosphoserineCombined sources1
Modified residuei276PhosphotyrosineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei364Omega-N-methylarginineBy similarity1
Modified residuei371Omega-N-methylarginineBy similarity1
Modified residuei378PhosphoserineCombined sources1
Modified residuei397PhosphoserineBy similarity1
Modified residuei399PhosphoserineBy similarity1
Modified residuei431PhosphotyrosineBy similarity1
Modified residuei527PhosphoserineBy similarity1
Modified residuei530PhosphoserineBy similarity1
Modified residuei534PhosphoserineBy similarity1
Modified residuei535Omega-N-methylarginineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei547PhosphoserineCombined sources1
Modified residuei549PhosphoserineBy similarity1
Modified residuei551PhosphoserineBy similarity1
Modified residuei556PhosphoserineCombined sources1
Modified residuei631PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1
Modified residuei658PhosphothreonineBy similarity1
Modified residuei671PhosphothreonineBy similarity1
Modified residuei878PhosphoserineBy similarity1
Modified residuei900PhosphoserineCombined sources1
Modified residuei918PhosphothreonineBy similarity1
Modified residuei1021PhosphoserineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1094PhosphoserineBy similarity1

Post-translational modificationi

Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QXY2.
PRIDEiQ9QXY2.

PTM databases

iPTMnetiQ9QXY2.
PhosphoSitePlusiQ9QXY2.
SwissPalmiQ9QXY2.

Expressioni

Tissue specificityi

Expressed exclusively in brain. Abundant in telencephalon and expressed moderately in cerebellum, hypothalamus, thalamus, superior and inferior colliculi, and olfactory bulb. No expression detected in medulla oblongata, spinal cord or pituitary gland. Enriched in the neuropil rather than soma in the thalamus, corpus striatum and cerebral cortex. Detected in astrocytes.2 Publications

Developmental stagei

In the embryo, expression increases dramatically between E14.5 and E18.5 (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000011475.
GenevisibleiQ9QXY2. RN.

Interactioni

Subunit structurei

Interacts with BCAR1/p130Cas through its C-terminal domain and with CSK, CTTN and SRC (By similarity). Also interacts with MAPRE3/EB3, SORBS3/vinexin and the N-terminal coiled-coil region of SNAP25.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Snap25P608813EBI-1394088,EBI-1027214

GO - Molecular functioni

  • protein domain specific binding Source: RGD
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi248555. 3 interactors.
IntActiQ9QXY2. 5 interactors.
MINTiMINT-139008.
STRINGi10116.ENSRNOP00000016070.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni681 – 731Interaction with SNAP251 PublicationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili594 – 621Sequence analysisAdd BLAST28
Coiled coili685 – 708Sequence analysisAdd BLAST24
Coiled coili750 – 812Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi990 – 1048Pro-richAdd BLAST59

Sequence similaritiesi

Belongs to the SRCIN1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHFG. Eukaryota.
ENOG410XTBA. LUCA.
GeneTreeiENSGT00390000012399.
HOVERGENiHBG019587.
InParanoidiQ9QXY2.
KOiK19930.
OMAiAQQPNYW.
OrthoDBiEOG091G00Q1.
PhylomeDBiQ9QXY2.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026727. Srcin1.
[Graphical view]
PANTHERiPTHR22741:SF5. PTHR22741:SF5. 1 hit.
PfamiPF03915. AIP3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9QXY2-1) [UniParc]FASTAAdd to basket
Also known as: SNIP-b1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPWQCLRRF ALAWWERTAE GRARSPREEV GPRDPGGRGE PDPERSSPPM
60 70 80 90 100
LSADDAEYPR EYRTLGGGGS GGSGGRRFSN VGLVHTSERR HTVIAAQSLE
110 120 130 140 150
ALSGLQKADA DRKRDAFMDH LKSKYPQHAL ALRGQQDRMR EQQPNYWSFK
160 170 180 190 200
TRSSRHTQGA QPGLADQAAK LSYASAESLE TMSEAELPLG FSRMNRFRQS
210 220 230 240 250
LPLSRSASQT KLRSPGVLFL QFGEETRRVH ITHEVSSLDT LHALIAHMFP
260 270 280 290 300
QKLTMGMLKS PNTAILIKDE ARNVFYELED VRDIQDRSII KIYRKEPLYA
310 320 330 340 350
AFPGSHLTNG DLRREMVYAS RESSPTRRLN NLSPASHLAS SSPPPGLPSG
360 370 380 390 400
LPSGLPSGSP SRSRLSYAGG RPPSYAGSPV HHAAERLGGA PTSQGVSPSP
410 420 430 440 450
SAILERRDVK PDEDLAGKAG GMVLVKGEGL YADPYGLLHE GRLSLAAAAG
460 470 480 490 500
DPFAYPGAGG LYKRGSVRSL STYSAAALQS DLEDSLYKAG AGGPLYGDGY
510 520 530 540 550
GFRLPPSSPQ KLADVSAPSG GPPPPHSPYS GPPSRGSPVR QSFRKDSGSS
560 570 580 590 600
SVFAESPGGK ARSTGASTAG APPSELFPGP GERSLVGFGP PVPAKDTETR
610 620 630 640 650
ERMEAMEKQI ASLTGLVQSA LLRGSEPETP SEKIEGSNGA ATPSAPVCGS
660 670 680 690 700
GSRSSGATPV SGPPPPAVSS TPAGQPTAVS RLQMQMHLRG LQNSASDLRG
710 720 730 740 750
QLQQLRKLQL QNQESVRALL KRTEAELSMR VSEAARRQED PLQRQRTLVE
760 770 780 790 800
EERLRYLNDE ELITQQLNDL EKSVEKIQRD VAHNHRLVPG PELEEKALVL
810 820 830 840 850
KQLGETLTEL KAHFPGLQSK MRVVLRVEVE AVKFLKEEPQ RLDGLLKRCR
860 870 880 890 900
VVTDTLAQIR RQVDEGVWPP PNNLLNQSPK KVAAETDFSK GLDFEIPPPS
910 920 930 940 950
PPLNLHELSG PAEGTPLTPK SGNPTKGLDA PSKRNMDKAV SVEAAERDWE
960 970 980 990 1000
EKRAALTQYS AKDINRLLEE TQAELLKAIP DLDCASKTHP GPTPTPDHKP
1010 1020 1030 1040 1050
PKAPHGQKAA PRTEPSGRRG SDELTVPRYR TEKPSKSPPP PPPRRSFPSS
1060 1070 1080 1090 1100
HGLTTTRTGE VVVTSKKDSV FIKKAESEEL EIQKPQVKLR RAVSEVVRPA
1110 1120 1130 1140 1150
STPPIMASAI KDEDDEERII AELESGGGSV PPMKVVTPGA SRLKAAQGPA
1160 1170 1180 1190
GSPDKGKHGK QRTEYMRIQA QQQVRVGYQA PRPLEGCTPR LCYMPLS
Length:1,197
Mass (Da):129,744
Last modified:May 1, 2000 - v1
Checksum:i8C9A2E630FB31C33
GO
Isoform 21 Publication (identifier: Q9QXY2-2) [UniParc]FASTAAdd to basket
Also known as: SNIP-a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1174-1197: Missing.

Show »
Length:1,173
Mass (Da):127,055
Checksum:iB6DF0EEC27B69080
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0506331174 – 1197Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156981 mRNA. Translation: AAF25003.1.
AF156982 mRNA. Translation: AAF25004.1.
RefSeqiNP_062251.1. NM_019378.1. [Q9QXY2-1]
UniGeneiRn.207205.

Genome annotation databases

EnsembliENSRNOT00000016070; ENSRNOP00000016070; ENSRNOG00000011475. [Q9QXY2-1]
GeneIDi56029.
KEGGirno:56029.
UCSCiRGD:708439. rat. [Q9QXY2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156981 mRNA. Translation: AAF25003.1.
AF156982 mRNA. Translation: AAF25004.1.
RefSeqiNP_062251.1. NM_019378.1. [Q9QXY2-1]
UniGeneiRn.207205.

3D structure databases

ProteinModelPortaliQ9QXY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248555. 3 interactors.
IntActiQ9QXY2. 5 interactors.
MINTiMINT-139008.
STRINGi10116.ENSRNOP00000016070.

PTM databases

iPTMnetiQ9QXY2.
PhosphoSitePlusiQ9QXY2.
SwissPalmiQ9QXY2.

Proteomic databases

PaxDbiQ9QXY2.
PRIDEiQ9QXY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016070; ENSRNOP00000016070; ENSRNOG00000011475. [Q9QXY2-1]
GeneIDi56029.
KEGGirno:56029.
UCSCiRGD:708439. rat. [Q9QXY2-1]

Organism-specific databases

CTDi80725.
RGDi708439. Srcin1.

Phylogenomic databases

eggNOGiENOG410IHFG. Eukaryota.
ENOG410XTBA. LUCA.
GeneTreeiENSGT00390000012399.
HOVERGENiHBG019587.
InParanoidiQ9QXY2.
KOiK19930.
OMAiAQQPNYW.
OrthoDBiEOG091G00Q1.
PhylomeDBiQ9QXY2.

Miscellaneous databases

PROiQ9QXY2.

Gene expression databases

BgeeiENSRNOG00000011475.
GenevisibleiQ9QXY2. RN.

Family and domain databases

InterProiIPR022782. AIP3_C.
IPR026727. Srcin1.
[Graphical view]
PANTHERiPTHR22741:SF5. PTHR22741:SF5. 1 hit.
PfamiPF03915. AIP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRCN1_RAT
AccessioniPrimary (citable) accession number: Q9QXY2
Secondary accession number(s): Q9QXY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.