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Protein

Tight junction protein ZO-3

Gene

Tjp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • regulation of G1/S transition of mitotic cell cycle Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction protein ZO-3
Alternative name(s):
Tight junction protein 3
Zona occludens protein 3
Zonula occludens protein 3
Gene namesi
Name:Tjp3
Synonyms:Zo3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351650. Tjp3.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • bicellular tight junction Source: MGI
  • cell surface Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905Tight junction protein ZO-3PRO_0000094547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111PhosphoserineBy similarity
Modified residuei128 – 1281PhosphoserineBy similarity
Modified residuei156 – 1561PhosphoserineCombined sources
Modified residuei157 – 1571PhosphoserineCombined sources
Modified residuei161 – 1611PhosphoserineCombined sources
Modified residuei195 – 1951PhosphoserineBy similarity
Modified residuei311 – 3111PhosphoserineCombined sources
Modified residuei317 – 3171PhosphothreonineBy similarity
Modified residuei319 – 3191PhosphoserineBy similarity
Modified residuei343 – 3431PhosphoserineCombined sources
Modified residuei359 – 3591PhosphoserineBy similarity
Modified residuei584 – 5841PhosphoserineBy similarity
Modified residuei891 – 8911PhosphoserineCombined sources
Modified residuei892 – 8921PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QXY1.
PaxDbiQ9QXY1.
PRIDEiQ9QXY1.

PTM databases

iPTMnetiQ9QXY1.
PhosphoSiteiQ9QXY1.

Expressioni

Gene expression databases

CleanExiMM_TJP3.

Interactioni

Subunit structurei

Interacts with INADL and UBN1 (By similarity). Interacts with occludin, claudins and ZO-1. Interacts with FASLG (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-113222.
STRINGi10090.ENSMUSP00000036438.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY1.
SMRiQ9QXY1. Positions 1-107, 188-264, 367-765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9383PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini187 – 26478PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini368 – 43467PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini467 – 54074SH3Add
BLAST
Domaini573 – 754182Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiQ9QXY1.
PhylomeDBiQ9QXY1.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005420. ZO-3.
[Graphical view]
PANTHERiPTHR13865:SF11. PTHR13865:SF11. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELTIWEQH TATLYKDPRR GFGIAVSGGH DRASGSVVVS DVVPGSPAEG
60 70 80 90 100
RLRTGDHIVM VNGVSVENVT SAFAIQILKT CTKTANVTVK RPRRVQLPAT
110 120 130 140 150
KASPASGHQL SDQEEADHGR GYEGDSSSGS GRSWGERSRR SRAGRRGRVG
160 170 180 190 200
SHGRRSSGGG SEANGLDLVS GYKRLPKQDV LMRPLKSVLV KRRNSEEFGV
210 220 230 240 250
KLGSQIFIKH ITESGLAARN HGLQEGDLIL QINGVSSANL SLSDTRRLIE
260 270 280 290 300
KSEGELTLLV LRDSGQFLVN IPPAVSDSDS SLMEDISDLT SELSQAPPSH
310 320 330 340 350
VPPPPLKGQR SPEDSQTDSP VETPQPRRRE RSVNSRAIAE PESPGESRYD
360 370 380 390 400
IYRVPSRQSL EDRGYSPDTR VVSFPKGASI GLRLAGGNDV GIFVSGVQAG
410 420 430 440 450
SPADGQGIQE GDEILQVNGM PFRNLTREEA VQFLLGLPPG EDMELVTQSK
460 470 480 490 500
TGHSLRRWSQ SRVGDSFYIR THFELEPSPP YGLGFTRGDV FHVVDTLYPG
510 520 530 540 550
SGPGHGHSSH GGLWLAARMG RDLREQERGV IPNQSRAEQL ASLEAAQRAA
560 570 580 590 600
GVGPGASVGS NPRAEFWRLR SLRRGTKKAS TQRSREDLSA LTRQGHYPPY
610 620 630 640 650
ERVVLREASF KRPVVILGPV ADIAMKKLTT EMPEEFEIAE SMSRTDSPSK
660 670 680 690 700
IIKLDTVRVI AERDKHALLD VTPSAIERLN YVQYYPIVIF CAPESRPALK
710 720 730 740 750
ALREWLAPAS RRSSRRLYAQ AQKLQKHSGH LFTATIPLHG TSDSWYQEVK
760 770 780 790 800
AVIQQQQARP IWTAEDQLNS SSEDLDLTGH GLAASSGDLS CDSRTNSDYE
810 820 830 840 850
DTDGEGAYTD REGGPQDVDE EVAPTALARS SEPVWVDDHQ GLMGHGTTIT
860 870 880 890 900
DKWETQADSH YTQDQRRQDS MRTYKHEALR KKFTRARDVE SSDDEGYDWG

PATDL
Length:905
Mass (Da):99,324
Last modified:May 1, 2000 - v1
Checksum:iB787BA1592661FEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157006 mRNA. Translation: AAF24175.1.
UniGeneiMm.27984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157006 mRNA. Translation: AAF24175.1.
UniGeneiMm.27984.

3D structure databases

ProteinModelPortaliQ9QXY1.
SMRiQ9QXY1. Positions 1-107, 188-264, 367-765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-113222.
STRINGi10090.ENSMUSP00000036438.

PTM databases

iPTMnetiQ9QXY1.
PhosphoSiteiQ9QXY1.

Proteomic databases

MaxQBiQ9QXY1.
PaxDbiQ9QXY1.
PRIDEiQ9QXY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1351650. Tjp3.

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiQ9QXY1.
PhylomeDBiQ9QXY1.

Miscellaneous databases

PROiQ9QXY1.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TJP3.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005420. ZO-3.
[Graphical view]
PANTHERiPTHR13865:SF11. PTHR13865:SF11. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZO3_MOUSE
AccessioniPrimary (citable) accession number: Q9QXY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.