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Protein

Tight junction protein ZO-3

Gene

Tjp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • regulation of G1/S transition of mitotic cell cycle Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction protein ZO-3
Alternative name(s):
Tight junction protein 3
Zona occludens protein 3
Zonula occludens protein 3
Gene namesi
Name:Tjp3
Synonyms:Zo3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351650. Tjp3.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • bicellular tight junction Source: MGI
  • cell surface Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945471 – 905Tight junction protein ZO-3Add BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei156PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei195PhosphoserineBy similarity1
Modified residuei311PhosphoserineCombined sources1
Modified residuei317PhosphothreonineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei359PhosphoserineBy similarity1
Modified residuei584PhosphoserineBy similarity1
Modified residuei891PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QXY1.
PaxDbiQ9QXY1.
PRIDEiQ9QXY1.

PTM databases

iPTMnetiQ9QXY1.
PhosphoSitePlusiQ9QXY1.

Expressioni

Gene expression databases

CleanExiMM_TJP3.

Interactioni

Subunit structurei

Interacts with PATJ and UBN1 (By similarity). Interacts with occludin, claudins and ZO-1. Interacts with FASLG (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-113222.
STRINGi10090.ENSMUSP00000036438.

Structurei

3D structure databases

ProteinModelPortaliQ9QXY1.
SMRiQ9QXY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 93PDZ 1PROSITE-ProRule annotationAdd BLAST83
Domaini187 – 264PDZ 2PROSITE-ProRule annotationAdd BLAST78
Domaini368 – 434PDZ 3PROSITE-ProRule annotationAdd BLAST67
Domaini467 – 540SH3Add BLAST74
Domaini573 – 754Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST182

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiQ9QXY1.
PhylomeDBiQ9QXY1.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005420. ZO-3.
[Graphical view]
PANTHERiPTHR13865:SF11. PTHR13865:SF11. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELTIWEQH TATLYKDPRR GFGIAVSGGH DRASGSVVVS DVVPGSPAEG
60 70 80 90 100
RLRTGDHIVM VNGVSVENVT SAFAIQILKT CTKTANVTVK RPRRVQLPAT
110 120 130 140 150
KASPASGHQL SDQEEADHGR GYEGDSSSGS GRSWGERSRR SRAGRRGRVG
160 170 180 190 200
SHGRRSSGGG SEANGLDLVS GYKRLPKQDV LMRPLKSVLV KRRNSEEFGV
210 220 230 240 250
KLGSQIFIKH ITESGLAARN HGLQEGDLIL QINGVSSANL SLSDTRRLIE
260 270 280 290 300
KSEGELTLLV LRDSGQFLVN IPPAVSDSDS SLMEDISDLT SELSQAPPSH
310 320 330 340 350
VPPPPLKGQR SPEDSQTDSP VETPQPRRRE RSVNSRAIAE PESPGESRYD
360 370 380 390 400
IYRVPSRQSL EDRGYSPDTR VVSFPKGASI GLRLAGGNDV GIFVSGVQAG
410 420 430 440 450
SPADGQGIQE GDEILQVNGM PFRNLTREEA VQFLLGLPPG EDMELVTQSK
460 470 480 490 500
TGHSLRRWSQ SRVGDSFYIR THFELEPSPP YGLGFTRGDV FHVVDTLYPG
510 520 530 540 550
SGPGHGHSSH GGLWLAARMG RDLREQERGV IPNQSRAEQL ASLEAAQRAA
560 570 580 590 600
GVGPGASVGS NPRAEFWRLR SLRRGTKKAS TQRSREDLSA LTRQGHYPPY
610 620 630 640 650
ERVVLREASF KRPVVILGPV ADIAMKKLTT EMPEEFEIAE SMSRTDSPSK
660 670 680 690 700
IIKLDTVRVI AERDKHALLD VTPSAIERLN YVQYYPIVIF CAPESRPALK
710 720 730 740 750
ALREWLAPAS RRSSRRLYAQ AQKLQKHSGH LFTATIPLHG TSDSWYQEVK
760 770 780 790 800
AVIQQQQARP IWTAEDQLNS SSEDLDLTGH GLAASSGDLS CDSRTNSDYE
810 820 830 840 850
DTDGEGAYTD REGGPQDVDE EVAPTALARS SEPVWVDDHQ GLMGHGTTIT
860 870 880 890 900
DKWETQADSH YTQDQRRQDS MRTYKHEALR KKFTRARDVE SSDDEGYDWG

PATDL
Length:905
Mass (Da):99,324
Last modified:May 1, 2000 - v1
Checksum:iB787BA1592661FEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157006 mRNA. Translation: AAF24175.1.
UniGeneiMm.27984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157006 mRNA. Translation: AAF24175.1.
UniGeneiMm.27984.

3D structure databases

ProteinModelPortaliQ9QXY1.
SMRiQ9QXY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-113222.
STRINGi10090.ENSMUSP00000036438.

PTM databases

iPTMnetiQ9QXY1.
PhosphoSitePlusiQ9QXY1.

Proteomic databases

MaxQBiQ9QXY1.
PaxDbiQ9QXY1.
PRIDEiQ9QXY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1351650. Tjp3.

Phylogenomic databases

eggNOGiKOG3580. Eukaryota.
ENOG410XQP3. LUCA.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiQ9QXY1.
PhylomeDBiQ9QXY1.

Miscellaneous databases

PROiQ9QXY1.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TJP3.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZO.
IPR005420. ZO-3.
[Graphical view]
PANTHERiPTHR13865:SF11. PTHR13865:SF11. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZO3_MOUSE
AccessioniPrimary (citable) accession number: Q9QXY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.