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Protein

Nuclear fragile X mental retardation-interacting protein 1

Gene

Nufip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds RNA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fragile X mental retardation-interacting protein 1
Alternative name(s):
Nuclear FMRP-interacting protein 1
Gene namesi
Name:Nufip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1351474. Nufip1.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Distributed in the nucleus in a dot-like pattern.

GO - Cellular componenti

  • cytosolic ribosome Source: HGNC
  • nuclear matrix Source: HGNC
  • nucleolus Source: HGNC
  • nucleus Source: MGI
  • perichromatin fibrils Source: HGNC
  • pre-snoRNP complex Source: MGI
  • presynaptic active zone Source: HGNC
  • protein complex Source: MGI
  • transcription elongation factor complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455191 – 484Nuclear fragile X mental retardation-interacting protein 1Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329PhosphoserineBy similarity1
Modified residuei331PhosphoserineBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei394PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QXX8.
MaxQBiQ9QXX8.
PaxDbiQ9QXX8.
PeptideAtlasiQ9QXX8.
PRIDEiQ9QXX8.

PTM databases

iPTMnetiQ9QXX8.
PhosphoSitePlusiQ9QXX8.

Expressioni

Tissue specificityi

Expressed in the brain; in neurons and not in glial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000022009.
GenevisibleiQ9QXX8. MM.

Interactioni

Subunit structurei

Interacts with FMR1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-110119.
STRINGi10090.ENSMUSP00000022586.

Structurei

3D structure databases

ProteinModelPortaliQ9QXX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi234 – 250Bipartite nuclear localization signalAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 92Pro-richAdd BLAST89

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ6R. Eukaryota.
ENOG4111GKG. LUCA.
GeneTreeiENSGT00390000003758.
HOGENOMiHOG000113888.
HOVERGENiHBG059841.
InParanoidiQ9QXX8.
OMAiKEPVFHY.
OrthoDBiEOG091G0OE9.
PhylomeDBiQ9QXX8.
TreeFamiTF329804.

Family and domain databases

InterProiIPR019496. NUFIP1_cons_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF10453. NUFIP1. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPAPAVWP SAPDLTPAPG TPSEAAPPRD NWVYWAMLPP PPPPLSSPVA
60 70 80 90 100
GSEQSRKGQP HVLPQPPSGA LPPFDAQILP AAQPPFDAQA PPDAQSQFSG
110 120 130 140 150
QQAWNLQAST PWYWGLSPNG FSTYHTSYQS PVTHSYFPRS HDAKFNLPQN
160 170 180 190 200
RKQKTKKRKE PVFHFFCDTC DRGFKNQEKY DTHMSEHTKC PEVDCSFSAH
210 220 230 240 250
EKIVQFHWRN MHAPGMKKIK LDTPEEIARW REERRKNYPT LANIERKKKL
260 270 280 290 300
QLEKAKRGEV LTTTQYGKMK GMSRHSQMAK IRSPGKHHKW RRGGARQRAV
310 320 330 340 350
VGLGNHARDS KPEVPSKANV DPLGALIHSD SESDKEEKAQ RTVVPKEVTP
360 370 380 390 400
ALCSLMSSYG DVSGSDSEPE EAPIKTEAEV LAENHVLHSS PPKSPKQNVQ
410 420 430 440 450
TTGRTVSRSK WENQRNGLRK ISLKRKKSHC HPLFEPRTHH PYLLEMLLAP
460 470 480
DIRHERNVIL QCVRYIIKKD FFGLNTDSVK TEEV
Length:484
Mass (Da):54,713
Last modified:May 1, 2000 - v1
Checksum:iD17E4B099F4EA579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032324 mRNA. Translation: BAC27815.1.
AK009260 mRNA. Translation: BAB26177.1.
AK156205 mRNA. Translation: BAE33625.1.
AF159549 mRNA. Translation: AAF15316.1.
BC056192 mRNA. Translation: AAH56192.1.
CCDSiCCDS27284.1.
RefSeqiNP_038773.1. NM_013745.5.
UniGeneiMm.21138.

Genome annotation databases

EnsembliENSMUST00000022586; ENSMUSP00000022586; ENSMUSG00000022009.
GeneIDi27275.
KEGGimmu:27275.
UCSCiuc007ure.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032324 mRNA. Translation: BAC27815.1.
AK009260 mRNA. Translation: BAB26177.1.
AK156205 mRNA. Translation: BAE33625.1.
AF159549 mRNA. Translation: AAF15316.1.
BC056192 mRNA. Translation: AAH56192.1.
CCDSiCCDS27284.1.
RefSeqiNP_038773.1. NM_013745.5.
UniGeneiMm.21138.

3D structure databases

ProteinModelPortaliQ9QXX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-110119.
STRINGi10090.ENSMUSP00000022586.

PTM databases

iPTMnetiQ9QXX8.
PhosphoSitePlusiQ9QXX8.

Proteomic databases

EPDiQ9QXX8.
MaxQBiQ9QXX8.
PaxDbiQ9QXX8.
PeptideAtlasiQ9QXX8.
PRIDEiQ9QXX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022586; ENSMUSP00000022586; ENSMUSG00000022009.
GeneIDi27275.
KEGGimmu:27275.
UCSCiuc007ure.1. mouse.

Organism-specific databases

CTDi26747.
MGIiMGI:1351474. Nufip1.

Phylogenomic databases

eggNOGiENOG410IJ6R. Eukaryota.
ENOG4111GKG. LUCA.
GeneTreeiENSGT00390000003758.
HOGENOMiHOG000113888.
HOVERGENiHBG059841.
InParanoidiQ9QXX8.
OMAiKEPVFHY.
OrthoDBiEOG091G0OE9.
PhylomeDBiQ9QXX8.
TreeFamiTF329804.

Miscellaneous databases

PROiQ9QXX8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022009.
GenevisibleiQ9QXX8. MM.

Family and domain databases

InterProiIPR019496. NUFIP1_cons_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF10453. NUFIP1. 1 hit.
PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUFP1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXX8
Secondary accession number(s): Q9CV69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.