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Protein

Group 10 secretory phospholipase A2

Gene

Pla2g10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Calcium; via carbonyl oxygenBy similarity1
Metal bindingi56Calcium; via carbonyl oxygenBy similarity1
Metal bindingi58Calcium; via carbonyl oxygenBy similarity1
Active sitei74By similarity1
Metal bindingi75CalciumBy similarity1
Active sitei119By similarity1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • phospholipase A2 activity Source: UniProtKB-EC
  • phospholipase activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1482788. Acyl chain remodelling of PC.
R-MMU-1482801. Acyl chain remodelling of PS.
R-MMU-1482839. Acyl chain remodelling of PE.
R-MMU-1482922. Acyl chain remodelling of PI.
R-MMU-1482925. Acyl chain remodelling of PG.
R-MMU-1483166. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Group 10 secretory phospholipase A2 (EC:3.1.1.4)
Alternative name(s):
Group X secretory phospholipase A2
Short name:
GX sPLA2
Short name:
sPLA2-X
Phosphatidylcholine 2-acylhydrolase 10
Gene namesi
Name:Pla2g10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1347522. Pla2g10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000002276618 – 28Add BLAST11
ChainiPRO_000002276729 – 151Group 10 secretory phospholipase A2Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 97By similarity
Disulfide bondi53 ↔ 143By similarity
Disulfide bondi55 ↔ 71By similarity
Disulfide bondi70 ↔ 125By similarity
Disulfide bondi76 ↔ 150By similarity
Disulfide bondi77 ↔ 118By similarity
Disulfide bondi86 ↔ 111By similarity
Disulfide bondi104 ↔ 116By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9QXX3.
PRIDEiQ9QXX3.

Expressioni

Tissue specificityi

Expressed in various tissues including the lung, thymus, and spleen.

Gene expression databases

BgeeiENSMUSG00000022683.
CleanExiMM_PLA2G10.
ExpressionAtlasiQ9QXX3. baseline and differential.
GenevisibleiQ9QXX3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023364.

Chemistry databases

BindingDBiQ9QXX3.

Structurei

3D structure databases

ProteinModelPortaliQ9QXX3.
SMRiQ9QXX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiQ9QXX3.
KOiK01047.
OMAiQELLCKC.
OrthoDBiEOG091G0UZ3.
PhylomeDBiQ9QXX3.
TreeFamiTF319283.

Family and domain databases

CDDicd00125. PLA2c. 1 hit.
Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLLLLL GPGPGFSEAT RRSHVYKRGL LELAGTLDCV GPRSPMAYMN
60 70 80 90 100
YGCYCGLGGH GEPRDAIDWC CYHHDCCYSR AQDAGCSPKL DRYPWKCMDH
110 120 130 140 150
HILCGPAENK CQELLCRCDE ELAYCLAGTE YHLKYLFFPS ILCEKDSPKC

N
Length:151
Mass (Da):17,005
Last modified:May 1, 2000 - v1
Checksum:i05D15E70BC2C9294
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151N → D in AAG43522 (PubMed:11019817).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166097 mRNA. Translation: AAF04498.2.
AF210429 mRNA. Translation: AAG43522.1.
CCDSiCCDS27967.1.
RefSeqiNP_036117.1. NM_011987.4.
UniGeneiMm.4214.

Genome annotation databases

EnsembliENSMUST00000023364; ENSMUSP00000023364; ENSMUSG00000022683.
GeneIDi26565.
KEGGimmu:26565.
UCSCiuc007ygh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166097 mRNA. Translation: AAF04498.2.
AF210429 mRNA. Translation: AAG43522.1.
CCDSiCCDS27967.1.
RefSeqiNP_036117.1. NM_011987.4.
UniGeneiMm.4214.

3D structure databases

ProteinModelPortaliQ9QXX3.
SMRiQ9QXX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023364.

Chemistry databases

BindingDBiQ9QXX3.
ChEMBLiCHEMBL4200.

Proteomic databases

PaxDbiQ9QXX3.
PRIDEiQ9QXX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023364; ENSMUSP00000023364; ENSMUSG00000022683.
GeneIDi26565.
KEGGimmu:26565.
UCSCiuc007ygh.2. mouse.

Organism-specific databases

CTDi8399.
MGIiMGI:1347522. Pla2g10.

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiQ9QXX3.
KOiK01047.
OMAiQELLCKC.
OrthoDBiEOG091G0UZ3.
PhylomeDBiQ9QXX3.
TreeFamiTF319283.

Enzyme and pathway databases

ReactomeiR-MMU-1482788. Acyl chain remodelling of PC.
R-MMU-1482801. Acyl chain remodelling of PS.
R-MMU-1482839. Acyl chain remodelling of PE.
R-MMU-1482922. Acyl chain remodelling of PI.
R-MMU-1482925. Acyl chain remodelling of PG.
R-MMU-1483166. Synthesis of PA.

Miscellaneous databases

PROiQ9QXX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022683.
CleanExiMM_PLA2G10.
ExpressionAtlasiQ9QXX3. baseline and differential.
GenevisibleiQ9QXX3. MM.

Family and domain databases

CDDicd00125. PLA2c. 1 hit.
Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPA2GX_MOUSE
AccessioniPrimary (citable) accession number: Q9QXX3
Secondary accession number(s): Q9EQK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.