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Q9QXX3

- PA2GX_MOUSE

UniProt

Q9QXX3 - PA2GX_MOUSE

Protein

Group 10 secretory phospholipase A2

Gene

Pla2g10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids.

    Catalytic activityi

    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Calcium; via carbonyl oxygenBy similarity
    Metal bindingi56 – 561Calcium; via carbonyl oxygenBy similarity
    Metal bindingi58 – 581Calcium; via carbonyl oxygenBy similarity
    Active sitei74 – 741By similarity
    Metal bindingi75 – 751CalciumBy similarity
    Active sitei119 – 1191By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phospholipase A2 activity Source: UniProtKB-EC
    3. phospholipase activity Source: BHF-UCL

    GO - Biological processi

    1. axon guidance Source: MGI
    2. cholesterol homeostasis Source: BHF-UCL
    3. lipid catabolic process Source: UniProtKB-KW
    4. lysophospholipid transport Source: MGI
    5. negative regulation of cholesterol efflux Source: BHF-UCL
    6. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    7. phospholipid metabolic process Source: InterPro
    8. positive regulation of arachidonic acid secretion Source: BHF-UCL
    9. positive regulation of cellular protein metabolic process Source: Ensembl
    10. positive regulation of lipid storage Source: Ensembl
    11. positive regulation of prostaglandin secretion Source: Ensembl
    12. regulation of macrophage activation Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_188640. Synthesis of PA.
    REACT_199024. Acyl chain remodelling of PI.
    REACT_199027. Acyl chain remodelling of PE.
    REACT_199030. Acyl chain remodelling of PS.
    REACT_199038. Acyl chain remodelling of PC.
    REACT_199039. Acyl chain remodelling of PG.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Group 10 secretory phospholipase A2 (EC:3.1.1.4)
    Alternative name(s):
    Group X secretory phospholipase A2
    Short name:
    GX sPLA2
    Short name:
    sPLA2-X
    Phosphatidylcholine 2-acylhydrolase 10
    Gene namesi
    Name:Pla2g10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1347522. Pla2g10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Propeptidei18 – 2811PRO_0000022766Add
    BLAST
    Chaini29 – 151123Group 10 secretory phospholipase A2PRO_0000022767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi39 ↔ 97By similarity
    Disulfide bondi53 ↔ 143By similarity
    Disulfide bondi55 ↔ 71By similarity
    Disulfide bondi70 ↔ 125By similarity
    Disulfide bondi76 ↔ 150By similarity
    Disulfide bondi77 ↔ 118By similarity
    Disulfide bondi86 ↔ 111By similarity
    Disulfide bondi104 ↔ 116By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ9QXX3.

    Expressioni

    Tissue specificityi

    Expressed in various tissues including the lung, thymus, and spleen.

    Gene expression databases

    ArrayExpressiQ9QXX3.
    BgeeiQ9QXX3.
    CleanExiMM_PLA2G10.
    GenevestigatoriQ9QXX3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023364.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXX3.
    SMRiQ9QXX3. Positions 29-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phospholipase A2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284162.
    GeneTreeiENSGT00710000106605.
    HOGENOMiHOG000231749.
    HOVERGENiHBG008137.
    InParanoidiQ9QXX3.
    KOiK01047.
    OMAiCDEELAY.
    PhylomeDBiQ9QXX3.
    TreeFamiTF319283.

    Family and domain databases

    Gene3Di1.20.90.10. 1 hit.
    InterProiIPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view]
    PANTHERiPTHR11716. PTHR11716. 1 hit.
    PfamiPF00068. Phospholip_A2_1. 1 hit.
    [Graphical view]
    PRINTSiPR00389. PHPHLIPASEA2.
    SMARTiSM00085. PA2c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48619. SSF48619. 1 hit.
    PROSITEiPS00119. PA2_ASP. 1 hit.
    PS00118. PA2_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QXX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLLLLLLL GPGPGFSEAT RRSHVYKRGL LELAGTLDCV GPRSPMAYMN    50
    YGCYCGLGGH GEPRDAIDWC CYHHDCCYSR AQDAGCSPKL DRYPWKCMDH 100
    HILCGPAENK CQELLCRCDE ELAYCLAGTE YHLKYLFFPS ILCEKDSPKC 150
    N 151
    Length:151
    Mass (Da):17,005
    Last modified:May 1, 2000 - v1
    Checksum:i05D15E70BC2C9294
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511N → D in AAG43522. (PubMed:11019817)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF166097 mRNA. Translation: AAF04498.2.
    AF210429 mRNA. Translation: AAG43522.1.
    CCDSiCCDS27967.1.
    RefSeqiNP_036117.1. NM_011987.3.
    UniGeneiMm.4214.

    Genome annotation databases

    EnsembliENSMUST00000023364; ENSMUSP00000023364; ENSMUSG00000022683.
    GeneIDi26565.
    KEGGimmu:26565.
    UCSCiuc007ygh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF166097 mRNA. Translation: AAF04498.2 .
    AF210429 mRNA. Translation: AAG43522.1 .
    CCDSi CCDS27967.1.
    RefSeqi NP_036117.1. NM_011987.3.
    UniGenei Mm.4214.

    3D structure databases

    ProteinModelPortali Q9QXX3.
    SMRi Q9QXX3. Positions 29-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000023364.

    Chemistry

    BindingDBi Q9QXX3.
    ChEMBLi CHEMBL4200.

    Proteomic databases

    PRIDEi Q9QXX3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023364 ; ENSMUSP00000023364 ; ENSMUSG00000022683 .
    GeneIDi 26565.
    KEGGi mmu:26565.
    UCSCi uc007ygh.1. mouse.

    Organism-specific databases

    CTDi 8399.
    MGIi MGI:1347522. Pla2g10.

    Phylogenomic databases

    eggNOGi NOG284162.
    GeneTreei ENSGT00710000106605.
    HOGENOMi HOG000231749.
    HOVERGENi HBG008137.
    InParanoidi Q9QXX3.
    KOi K01047.
    OMAi CDEELAY.
    PhylomeDBi Q9QXX3.
    TreeFami TF319283.

    Enzyme and pathway databases

    Reactomei REACT_188640. Synthesis of PA.
    REACT_199024. Acyl chain remodelling of PI.
    REACT_199027. Acyl chain remodelling of PE.
    REACT_199030. Acyl chain remodelling of PS.
    REACT_199038. Acyl chain remodelling of PC.
    REACT_199039. Acyl chain remodelling of PG.

    Miscellaneous databases

    NextBioi 304643.
    PROi Q9QXX3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QXX3.
    Bgeei Q9QXX3.
    CleanExi MM_PLA2G10.
    Genevestigatori Q9QXX3.

    Family and domain databases

    Gene3Di 1.20.90.10. 1 hit.
    InterProi IPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view ]
    PANTHERi PTHR11716. PTHR11716. 1 hit.
    Pfami PF00068. Phospholip_A2_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00389. PHPHLIPASEA2.
    SMARTi SM00085. PA2c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48619. SSF48619. 1 hit.
    PROSITEi PS00119. PA2_ASP. 1 hit.
    PS00118. PA2_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "On the diversity of secreted phospholipases A2. Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes."
      Valentin E., Ghomashchi F., Gelb M.H., Lazdunski M., Lambeau G.
      J. Biol. Chem. 274:31195-31202(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor."
      Morioka Y., Saiga A., Yokota Y., Suzuki N., Ikeda M., Ono T., Nakano K., Fujii N., Ishizaki J., Arita H., Hanasaki K.
      Arch. Biochem. Biophys. 381:31-42(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-30, CHARACTERIZATION.
      Strain: BALB/c.

    Entry informationi

    Entry nameiPA2GX_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXX3
    Secondary accession number(s): Q9EQK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3