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Q9QXX0

- JAG1_MOUSE

UniProt

Q9QXX0 - JAG1_MOUSE

Protein

Protein jagged-1

Gene

Jag1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation By similarity. May regulate fibroblast growth factor-induced angiogenesis.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. Notch binding Source: UniProtKB
    3. protein binding Source: MGI

    GO - Biological processi

    1. aorta morphogenesis Source: BHF-UCL
    2. auditory receptor cell differentiation Source: MGI
    3. blood vessel remodeling Source: MGI
    4. camera-type eye development Source: MGI
    5. cardiac neural crest cell development involved in outflow tract morphogenesis Source: BHF-UCL
    6. cardiac right ventricle morphogenesis Source: BHF-UCL
    7. cardiac septum morphogenesis Source: BHF-UCL
    8. ciliary body morphogenesis Source: MGI
    9. distal tubule development Source: UniProtKB
    10. endocardial cushion cell development Source: BHF-UCL
    11. inner ear development Source: UniProtKB
    12. loop of Henle development Source: UniProtKB
    13. morphogenesis of an epithelial sheet Source: MGI
    14. negative regulation of cell differentiation Source: MGI
    15. negative regulation of fat cell differentiation Source: MGI
    16. negative regulation of neuron differentiation Source: MGI
    17. negative regulation of stem cell differentiation Source: Ensembl
    18. neuronal stem cell maintenance Source: Ensembl
    19. Notch signaling involved in heart development Source: BHF-UCL
    20. Notch signaling pathway Source: UniProtKB
    21. organ morphogenesis Source: MGI
    22. positive regulation of myeloid cell differentiation Source: MGI
    23. positive regulation of Notch signaling pathway Source: MGI
    24. positive regulation of osteoblast differentiation Source: MGI
    25. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    26. pulmonary artery morphogenesis Source: BHF-UCL
    27. pulmonary valve morphogenesis Source: BHF-UCL
    28. response to muramyl dipeptide Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Notch signaling pathway

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein jagged-1
    Short name:
    Jagged1
    Alternative name(s):
    CD_antigen: CD339
    Gene namesi
    Name:Jag1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1095416. Jag1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 12181185Protein jagged-1PRO_0000007626Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi187 ↔ 196By similarity
    Disulfide bondi200 ↔ 212By similarity
    Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi220 ↔ 229By similarity
    Disulfide bondi234 ↔ 245By similarity
    Disulfide bondi238 ↔ 251By similarity
    Disulfide bondi253 ↔ 262By similarity
    Disulfide bondi265 ↔ 276By similarity
    Disulfide bondi271 ↔ 282By similarity
    Disulfide bondi284 ↔ 293By similarity
    Disulfide bondi300 ↔ 312By similarity
    Disulfide bondi306 ↔ 322By similarity
    Disulfide bondi324 ↔ 333By similarity
    Disulfide bondi340 ↔ 351By similarity
    Disulfide bondi345 ↔ 360By similarity
    Disulfide bondi362 ↔ 371By similarity
    Disulfide bondi378 ↔ 389By similarity
    Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi383 ↔ 398By similarity
    Disulfide bondi400 ↔ 409By similarity
    Disulfide bondi416 ↔ 427By similarity
    Disulfide bondi421 ↔ 436By similarity
    Disulfide bondi438 ↔ 447By similarity
    Disulfide bondi454 ↔ 464By similarity
    Disulfide bondi458 ↔ 473By similarity
    Disulfide bondi475 ↔ 484By similarity
    Disulfide bondi491 ↔ 502By similarity
    Disulfide bondi496 ↔ 511By similarity
    Disulfide bondi513 ↔ 522By similarity
    Disulfide bondi529 ↔ 540By similarity
    Disulfide bondi534 ↔ 549By similarity
    Disulfide bondi551 ↔ 560By similarity
    Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi578 ↔ 605By similarity
    Disulfide bondi599 ↔ 615By similarity
    Disulfide bondi617 ↔ 626By similarity
    Disulfide bondi633 ↔ 644By similarity
    Disulfide bondi638 ↔ 653By similarity
    Disulfide bondi655 ↔ 664By similarity
    Disulfide bondi671 ↔ 682By similarity
    Disulfide bondi676 ↔ 691By similarity
    Disulfide bondi693 ↔ 702By similarity
    Disulfide bondi709 ↔ 720By similarity
    Disulfide bondi714 ↔ 729By similarity
    Disulfide bondi731 ↔ 740By similarity
    Glycosylationi745 – 7451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi748 ↔ 759By similarity
    Disulfide bondi753 ↔ 768By similarity
    Disulfide bondi770 ↔ 779By similarity
    Disulfide bondi786 ↔ 797By similarity
    Disulfide bondi791 ↔ 806By similarity
    Disulfide bondi808 ↔ 817By similarity
    Disulfide bondi824 ↔ 835By similarity
    Disulfide bondi829 ↔ 844By similarity
    Disulfide bondi846 ↔ 855By similarity
    Glycosylationi960 – 9601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi991 – 9911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1045 – 10451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1064 – 10641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9QXX0.
    PRIDEiQ9QXX0.

    PTM databases

    PhosphoSiteiQ9QXX0.

    Expressioni

    Tissue specificityi

    Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus.1 Publication

    Developmental stagei

    At 8.75-9.75 dpc expression was detected in structures that include those destined to contribute to the cardiovascular system of the adult heart. Expression was also detected in the mesencephalon and rhombencephalon.

    Gene expression databases

    ArrayExpressiQ9QXX0.
    BgeeiQ9QXX0.
    CleanExiMM_JAG1.
    GenevestigatoriQ9QXX0.

    Interactioni

    Subunit structurei

    Interacts with NOTCH1, NOTCH2 and NOTCH3.

    Protein-protein interaction databases

    BioGridi200854. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXX0.
    SMRiQ9QXX0. Positions 32-858.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 10671034ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1094 – 1218125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1068 – 109326HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini185 – 22945DSLPROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 26334EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini264 – 29431EGF-like 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini296 – 33439EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini336 – 37237EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini374 – 41037EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini412 – 44837EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini450 – 48536EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini487 – 52337EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini525 – 56137EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini586 – 62742EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini629 – 66537EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini667 – 70337EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini705 – 74137EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini744 – 78037EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini782 – 81837EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini820 – 85637EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni199 – 2079Important for interaction with NOTCH1By similarity

    Domaini

    The DSL domain is indispensable and sufficient for binding to NOTCH2.

    Sequence similaritiesi

    Contains 1 DSL domain.PROSITE-ProRule annotation
    Contains 16 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00740000114998.
    HOGENOMiHOG000113124.
    HOVERGENiHBG031645.
    InParanoidiQ9QXX0.
    KOiK06052.
    OMAiHPNWTNK.
    OrthoDBiEOG7BKCSS.
    PhylomeDBiQ9QXX0.
    TreeFamiTF351835.

    Family and domain databases

    InterProiIPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF01414. DSL. 1 hit.
    PF00008. EGF. 11 hits.
    PF07645. EGF_CA. 1 hit.
    PF07657. MNNL. 1 hit.
    [Graphical view]
    PRINTSiPR02059. JAGGEDFAMILY.
    SMARTiSM00051. DSL. 1 hit.
    SM00181. EGF. 6 hits.
    SM00179. EGF_CA. 10 hits.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 3 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 12 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QXX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSPRTRGRP GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ     50
    NGNCCGGVRN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP 100
    VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTIQPDS 150
    IIEKASHSGM INPSRQWQTL KQNTGIAHFE YQIRVTCDDH YYGFGCNKFC 200
    RPRDDFFGHY ACDQNGNKTC MEGWMGPDCN KAICRQGCSP KHGSCKLPGD 250
    CRCQYGWQGL YCDKCIPHPG CVHGTCNEPW QCLCETNWGG QLCDKDLNYC 300
    GTHQPCLNRG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS 350
    CKETSSGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC 400
    PPQWTGKTCQ LDANECEAKP CVNARSCKNL IASYYCDCLP GWMGQNCDIN 450
    INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG 500
    HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK 550
    CPEDYEGKNC SHLKDHCRTT TCEVIDSCTV AMASNDTPEG VRYISSNVCG 600
    PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCKN GGTCIDGVNS 650
    YKCICSDGWE GAHCENNIND CSQNPCHYGG TCRDLVNDFY CDCKNGWKGK 700
    TCHSRDSQCD EATCNNGGTC YDEVDTFKCM CPGGWEGTTC NIARNSSCLP 750
    NPCHNGGTCV VNGDSFTCVC KEGWEGPICT QNTNDCSPHP CYNSGTCVDG 800
    DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYQCICPPGH 850
    SGAKCHEVSG RSCITMGRVI LDGAKWDDDC NTCQCLNGRV ACSKVWCGPR 900
    PCRLHKSHNE CPSGQSCIPV LDDQCFVRPC TGVGECRSSS LQPVKTKCTS 950
    DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI 1000
    ACEPSLSANN EIHVAISAED IRDDGNPVKE ITDKIIDLVS KRDGNSSLIA 1050
    AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WVCCLVTAFY WCVRKRRKPS 1100
    SHTHSAPEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR 1150
    THNSEVEEDD MDKHQQKVRF AKQPVYTLVD REEKAPSGTP TKHPNWTNKQ 1200
    DNRDLESAQS LNRMEYIV 1218
    Length:1,218
    Mass (Da):134,164
    Last modified:May 1, 2000 - v1
    Checksum:i77739F8928BB793C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171092 mRNA. Translation: AAF15505.1.
    BC058675 mRNA. Translation: AAH58675.1.
    CCDSiCCDS16797.1.
    RefSeqiNP_038850.1. NM_013822.5.
    UniGeneiMm.22398.

    Genome annotation databases

    EnsembliENSMUST00000028735; ENSMUSP00000028735; ENSMUSG00000027276.
    GeneIDi16449.
    KEGGimmu:16449.
    UCSCiuc008moz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171092 mRNA. Translation: AAF15505.1 .
    BC058675 mRNA. Translation: AAH58675.1 .
    CCDSi CCDS16797.1.
    RefSeqi NP_038850.1. NM_013822.5.
    UniGenei Mm.22398.

    3D structure databases

    ProteinModelPortali Q9QXX0.
    SMRi Q9QXX0. Positions 32-858.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200854. 1 interaction.

    PTM databases

    PhosphoSitei Q9QXX0.

    Proteomic databases

    PaxDbi Q9QXX0.
    PRIDEi Q9QXX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028735 ; ENSMUSP00000028735 ; ENSMUSG00000027276 .
    GeneIDi 16449.
    KEGGi mmu:16449.
    UCSCi uc008moz.2. mouse.

    Organism-specific databases

    CTDi 182.
    MGIi MGI:1095416. Jag1.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00740000114998.
    HOGENOMi HOG000113124.
    HOVERGENi HBG031645.
    InParanoidi Q9QXX0.
    KOi K06052.
    OMAi HPNWTNK.
    OrthoDBi EOG7BKCSS.
    PhylomeDBi Q9QXX0.
    TreeFami TF351835.

    Enzyme and pathway databases

    Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.

    Miscellaneous databases

    ChiTaRSi JAG1. mouse.
    NextBioi 289705.
    PROi Q9QXX0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QXX0.
    Bgeei Q9QXX0.
    CleanExi MM_JAG1.
    Genevestigatori Q9QXX0.

    Family and domain databases

    InterProi IPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF01414. DSL. 1 hit.
    PF00008. EGF. 11 hits.
    PF07645. EGF_CA. 1 hit.
    PF07657. MNNL. 1 hit.
    [Graphical view ]
    PRINTSi PR02059. JAGGEDFAMILY.
    SMARTi SM00051. DSL. 1 hit.
    SM00181. EGF. 6 hits.
    SM00179. EGF_CA. 10 hits.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 3 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 12 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Jagged1 physically interacts with Notch2 and other Notch receptors: assessment by quantitative methods."
      Shimizu K., Chiba S., Kumano K., Hosoya N., Takahashi T., Kanda Y., Hamada Y., Yazaki Y., Hirai H.
      J. Biol. Chem. 274:32961-32969(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION.
      Strain: Swiss Webster / NIH.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome."
      Loomes K.M., Underkoffler L.A., Morabito J., Gottlieb S., Piccoli D.A., Spinner N.B., Baldwin H.S., Oakey R.J.
      Hum. Mol. Genet. 8:2443-2449(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiJAG1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3