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Q9QXX0

- JAG1_MOUSE

UniProt

Q9QXX0 - JAG1_MOUSE

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Protein

Protein jagged-1

Gene

Jag1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. Notch binding Source: UniProtKB

GO - Biological processi

  1. aorta morphogenesis Source: BHF-UCL
  2. auditory receptor cell differentiation Source: MGI
  3. blood vessel remodeling Source: MGI
  4. camera-type eye development Source: MGI
  5. cardiac neural crest cell development involved in outflow tract morphogenesis Source: BHF-UCL
  6. cardiac right ventricle morphogenesis Source: BHF-UCL
  7. cardiac septum morphogenesis Source: BHF-UCL
  8. ciliary body morphogenesis Source: MGI
  9. distal tubule development Source: UniProtKB
  10. endocardial cushion cell development Source: BHF-UCL
  11. inner ear development Source: UniProtKB
  12. loop of Henle development Source: UniProtKB
  13. morphogenesis of an epithelial sheet Source: MGI
  14. negative regulation of cell differentiation Source: MGI
  15. negative regulation of fat cell differentiation Source: MGI
  16. negative regulation of neuron differentiation Source: MGI
  17. negative regulation of stem cell differentiation Source: Ensembl
  18. neuronal stem cell maintenance Source: Ensembl
  19. Notch signaling involved in heart development Source: BHF-UCL
  20. Notch signaling pathway Source: UniProtKB
  21. organ morphogenesis Source: MGI
  22. positive regulation of myeloid cell differentiation Source: MGI
  23. positive regulation of Notch signaling pathway Source: MGI
  24. positive regulation of osteoblast differentiation Source: MGI
  25. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  26. pulmonary artery morphogenesis Source: BHF-UCL
  27. pulmonary valve morphogenesis Source: BHF-UCL
  28. response to muramyl dipeptide Source: BHF-UCL
  29. T cell mediated immunity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-1
Short name:
Jagged1
Alternative name(s):
CD_antigen: CD339
Gene namesi
Name:Jag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1095416. Jag1.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 12181185Protein jagged-1PRO_0000007626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi187 ↔ 196By similarity
Disulfide bondi200 ↔ 212By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi234 ↔ 245By similarity
Disulfide bondi238 ↔ 251By similarity
Disulfide bondi253 ↔ 262By similarity
Disulfide bondi265 ↔ 276By similarity
Disulfide bondi271 ↔ 282By similarity
Disulfide bondi284 ↔ 293By similarity
Disulfide bondi300 ↔ 312By similarity
Disulfide bondi306 ↔ 322By similarity
Disulfide bondi324 ↔ 333By similarity
Disulfide bondi340 ↔ 351By similarity
Disulfide bondi345 ↔ 360By similarity
Disulfide bondi362 ↔ 371By similarity
Disulfide bondi378 ↔ 389By similarity
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi383 ↔ 398By similarity
Disulfide bondi400 ↔ 409By similarity
Disulfide bondi416 ↔ 427By similarity
Disulfide bondi421 ↔ 436By similarity
Disulfide bondi438 ↔ 447By similarity
Disulfide bondi454 ↔ 464By similarity
Disulfide bondi458 ↔ 473By similarity
Disulfide bondi475 ↔ 484By similarity
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi496 ↔ 511By similarity
Disulfide bondi513 ↔ 522By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi534 ↔ 549By similarity
Disulfide bondi551 ↔ 560By similarity
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi578 ↔ 605By similarity
Disulfide bondi599 ↔ 615By similarity
Disulfide bondi617 ↔ 626By similarity
Disulfide bondi633 ↔ 644By similarity
Disulfide bondi638 ↔ 653By similarity
Disulfide bondi655 ↔ 664By similarity
Disulfide bondi671 ↔ 682By similarity
Disulfide bondi676 ↔ 691By similarity
Disulfide bondi693 ↔ 702By similarity
Disulfide bondi709 ↔ 720By similarity
Disulfide bondi714 ↔ 729By similarity
Disulfide bondi731 ↔ 740By similarity
Glycosylationi745 – 7451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi748 ↔ 759By similarity
Disulfide bondi753 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi786 ↔ 797By similarity
Disulfide bondi791 ↔ 806By similarity
Disulfide bondi808 ↔ 817By similarity
Disulfide bondi824 ↔ 835By similarity
Disulfide bondi829 ↔ 844By similarity
Disulfide bondi846 ↔ 855By similarity
Glycosylationi960 – 9601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi991 – 9911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1045 – 10451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1064 – 10641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QXX0.
PaxDbiQ9QXX0.
PRIDEiQ9QXX0.

PTM databases

PhosphoSiteiQ9QXX0.

Expressioni

Tissue specificityi

Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus.1 Publication

Developmental stagei

At 8.75-9.75 dpc expression was detected in structures that include those destined to contribute to the cardiovascular system of the adult heart. Expression was also detected in the mesencephalon and rhombencephalon.

Gene expression databases

BgeeiQ9QXX0.
CleanExiMM_JAG1.
ExpressionAtlasiQ9QXX0. baseline and differential.
GenevestigatoriQ9QXX0.

Interactioni

Subunit structurei

Interacts with NOTCH1, NOTCH2 and NOTCH3.

Protein-protein interaction databases

BioGridi200854. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9QXX0.
SMRiQ9QXX0. Positions 32-897.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 10671034ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1094 – 1218125CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1068 – 109326HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 22945DSLPROSITE-ProRule annotationAdd
BLAST
Domaini230 – 26334EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini264 – 29431EGF-like 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini296 – 33439EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini336 – 37237EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 41037EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini412 – 44837EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini450 – 48536EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini487 – 52337EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini525 – 56137EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini586 – 62742EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini629 – 66537EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini667 – 70337EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini705 – 74137EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini744 – 78037EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 81837EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini820 – 85637EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2079Important for interaction with NOTCH1By similarity

Domaini

The DSL domain is indispensable and sufficient for binding to NOTCH2.

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 16 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ9QXX0.
KOiK06052.
OMAiHPNWTNK.
OrthoDBiEOG7BKCSS.
PhylomeDBiQ9QXX0.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 11 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXX0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSPRTRGRP GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ
60 70 80 90 100
NGNCCGGVRN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP
110 120 130 140 150
VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTIQPDS
160 170 180 190 200
IIEKASHSGM INPSRQWQTL KQNTGIAHFE YQIRVTCDDH YYGFGCNKFC
210 220 230 240 250
RPRDDFFGHY ACDQNGNKTC MEGWMGPDCN KAICRQGCSP KHGSCKLPGD
260 270 280 290 300
CRCQYGWQGL YCDKCIPHPG CVHGTCNEPW QCLCETNWGG QLCDKDLNYC
310 320 330 340 350
GTHQPCLNRG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS
360 370 380 390 400
CKETSSGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC
410 420 430 440 450
PPQWTGKTCQ LDANECEAKP CVNARSCKNL IASYYCDCLP GWMGQNCDIN
460 470 480 490 500
INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG
510 520 530 540 550
HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK
560 570 580 590 600
CPEDYEGKNC SHLKDHCRTT TCEVIDSCTV AMASNDTPEG VRYISSNVCG
610 620 630 640 650
PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCKN GGTCIDGVNS
660 670 680 690 700
YKCICSDGWE GAHCENNIND CSQNPCHYGG TCRDLVNDFY CDCKNGWKGK
710 720 730 740 750
TCHSRDSQCD EATCNNGGTC YDEVDTFKCM CPGGWEGTTC NIARNSSCLP
760 770 780 790 800
NPCHNGGTCV VNGDSFTCVC KEGWEGPICT QNTNDCSPHP CYNSGTCVDG
810 820 830 840 850
DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYQCICPPGH
860 870 880 890 900
SGAKCHEVSG RSCITMGRVI LDGAKWDDDC NTCQCLNGRV ACSKVWCGPR
910 920 930 940 950
PCRLHKSHNE CPSGQSCIPV LDDQCFVRPC TGVGECRSSS LQPVKTKCTS
960 970 980 990 1000
DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI
1010 1020 1030 1040 1050
ACEPSLSANN EIHVAISAED IRDDGNPVKE ITDKIIDLVS KRDGNSSLIA
1060 1070 1080 1090 1100
AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WVCCLVTAFY WCVRKRRKPS
1110 1120 1130 1140 1150
SHTHSAPEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR
1160 1170 1180 1190 1200
THNSEVEEDD MDKHQQKVRF AKQPVYTLVD REEKAPSGTP TKHPNWTNKQ
1210
DNRDLESAQS LNRMEYIV
Length:1,218
Mass (Da):134,164
Last modified:May 1, 2000 - v1
Checksum:i77739F8928BB793C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171092 mRNA. Translation: AAF15505.1.
BC058675 mRNA. Translation: AAH58675.1.
CCDSiCCDS16797.1.
RefSeqiNP_038850.1. NM_013822.5.
UniGeneiMm.22398.

Genome annotation databases

EnsembliENSMUST00000028735; ENSMUSP00000028735; ENSMUSG00000027276.
GeneIDi16449.
KEGGimmu:16449.
UCSCiuc008moz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171092 mRNA. Translation: AAF15505.1 .
BC058675 mRNA. Translation: AAH58675.1 .
CCDSi CCDS16797.1.
RefSeqi NP_038850.1. NM_013822.5.
UniGenei Mm.22398.

3D structure databases

ProteinModelPortali Q9QXX0.
SMRi Q9QXX0. Positions 32-897.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200854. 1 interaction.

PTM databases

PhosphoSitei Q9QXX0.

Proteomic databases

MaxQBi Q9QXX0.
PaxDbi Q9QXX0.
PRIDEi Q9QXX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028735 ; ENSMUSP00000028735 ; ENSMUSG00000027276 .
GeneIDi 16449.
KEGGi mmu:16449.
UCSCi uc008moz.2. mouse.

Organism-specific databases

CTDi 182.
MGIi MGI:1095416. Jag1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118786.
HOGENOMi HOG000113124.
HOVERGENi HBG031645.
InParanoidi Q9QXX0.
KOi K06052.
OMAi HPNWTNK.
OrthoDBi EOG7BKCSS.
PhylomeDBi Q9QXX0.
TreeFami TF351835.

Enzyme and pathway databases

Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Miscellaneous databases

ChiTaRSi JAG1. mouse.
NextBioi 289705.
PROi Q9QXX0.
SOURCEi Search...

Gene expression databases

Bgeei Q9QXX0.
CleanExi MM_JAG1.
ExpressionAtlasi Q9QXX0. baseline and differential.
Genevestigatori Q9QXX0.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 11 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view ]
PRINTSi PR02059. JAGGEDFAMILY.
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Jagged1 physically interacts with Notch2 and other Notch receptors: assessment by quantitative methods."
    Shimizu K., Chiba S., Kumano K., Hosoya N., Takahashi T., Kanda Y., Hamada Y., Yazaki Y., Hirai H.
    J. Biol. Chem. 274:32961-32969(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION.
    Strain: Swiss Webster / NIH.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome."
    Loomes K.M., Underkoffler L.A., Morabito J., Gottlieb S., Piccoli D.A., Spinner N.B., Baldwin H.S., Oakey R.J.
    Hum. Mol. Genet. 8:2443-2449(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiJAG1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3