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Q9QXX0

- JAG1_MOUSE

UniProt

Q9QXX0 - JAG1_MOUSE

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Protein

Protein jagged-1

Gene
Jag1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation By similarity. May regulate fibroblast growth factor-induced angiogenesis.

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. Notch binding Source: UniProtKB
  3. protein binding Source: MGI

GO - Biological processi

  1. aorta morphogenesis Source: BHF-UCL
  2. auditory receptor cell differentiation Source: MGI
  3. blood vessel remodeling Source: MGI
  4. camera-type eye development Source: MGI
  5. cardiac neural crest cell development involved in outflow tract morphogenesis Source: BHF-UCL
  6. cardiac right ventricle morphogenesis Source: BHF-UCL
  7. cardiac septum morphogenesis Source: BHF-UCL
  8. ciliary body morphogenesis Source: MGI
  9. distal tubule development Source: UniProtKB
  10. endocardial cushion cell development Source: BHF-UCL
  11. inner ear development Source: UniProtKB
  12. loop of Henle development Source: UniProtKB
  13. morphogenesis of an epithelial sheet Source: MGI
  14. negative regulation of cell differentiation Source: MGI
  15. negative regulation of fat cell differentiation Source: MGI
  16. negative regulation of neuron differentiation Source: MGI
  17. negative regulation of stem cell differentiation Source: Ensembl
  18. neuronal stem cell maintenance Source: Ensembl
  19. Notch signaling involved in heart development Source: BHF-UCL
  20. Notch signaling pathway Source: UniProtKB
  21. organ morphogenesis Source: MGI
  22. positive regulation of myeloid cell differentiation Source: MGI
  23. positive regulation of Notch signaling pathway Source: MGI
  24. positive regulation of osteoblast differentiation Source: MGI
  25. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  26. pulmonary artery morphogenesis Source: BHF-UCL
  27. pulmonary valve morphogenesis Source: BHF-UCL
  28. response to muramyl dipeptide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-1
Short name:
Jagged1
Alternative name(s):
CD_antigen: CD339
Gene namesi
Name:Jag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1095416. Jag1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 10671034Extracellular Reviewed predictionAdd
BLAST
Transmembranei1068 – 109326Helical; Reviewed predictionAdd
BLAST
Topological domaini1094 – 1218125Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 12181185Protein jagged-1PRO_0000007626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi187 ↔ 196 By similarity
Disulfide bondi200 ↔ 212 By similarity
Glycosylationi217 – 2171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi220 ↔ 229 By similarity
Disulfide bondi234 ↔ 245 By similarity
Disulfide bondi238 ↔ 251 By similarity
Disulfide bondi253 ↔ 262 By similarity
Disulfide bondi265 ↔ 276 By similarity
Disulfide bondi271 ↔ 282 By similarity
Disulfide bondi284 ↔ 293 By similarity
Disulfide bondi300 ↔ 312 By similarity
Disulfide bondi306 ↔ 322 By similarity
Disulfide bondi324 ↔ 333 By similarity
Disulfide bondi340 ↔ 351 By similarity
Disulfide bondi345 ↔ 360 By similarity
Disulfide bondi362 ↔ 371 By similarity
Disulfide bondi378 ↔ 389 By similarity
Glycosylationi382 – 3821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi383 ↔ 398 By similarity
Disulfide bondi400 ↔ 409 By similarity
Disulfide bondi416 ↔ 427 By similarity
Disulfide bondi421 ↔ 436 By similarity
Disulfide bondi438 ↔ 447 By similarity
Disulfide bondi454 ↔ 464 By similarity
Disulfide bondi458 ↔ 473 By similarity
Disulfide bondi475 ↔ 484 By similarity
Disulfide bondi491 ↔ 502 By similarity
Disulfide bondi496 ↔ 511 By similarity
Disulfide bondi513 ↔ 522 By similarity
Disulfide bondi529 ↔ 540 By similarity
Disulfide bondi534 ↔ 549 By similarity
Disulfide bondi551 ↔ 560 By similarity
Glycosylationi559 – 5591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi578 ↔ 605 By similarity
Disulfide bondi599 ↔ 615 By similarity
Disulfide bondi617 ↔ 626 By similarity
Disulfide bondi633 ↔ 644 By similarity
Disulfide bondi638 ↔ 653 By similarity
Disulfide bondi655 ↔ 664 By similarity
Disulfide bondi671 ↔ 682 By similarity
Disulfide bondi676 ↔ 691 By similarity
Disulfide bondi693 ↔ 702 By similarity
Disulfide bondi709 ↔ 720 By similarity
Disulfide bondi714 ↔ 729 By similarity
Disulfide bondi731 ↔ 740 By similarity
Glycosylationi745 – 7451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi748 ↔ 759 By similarity
Disulfide bondi753 ↔ 768 By similarity
Disulfide bondi770 ↔ 779 By similarity
Disulfide bondi786 ↔ 797 By similarity
Disulfide bondi791 ↔ 806 By similarity
Disulfide bondi808 ↔ 817 By similarity
Disulfide bondi824 ↔ 835 By similarity
Disulfide bondi829 ↔ 844 By similarity
Disulfide bondi846 ↔ 855 By similarity
Glycosylationi960 – 9601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi991 – 9911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1045 – 10451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1064 – 10641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QXX0.
PRIDEiQ9QXX0.

PTM databases

PhosphoSiteiQ9QXX0.

Expressioni

Tissue specificityi

Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus.1 Publication

Developmental stagei

At 8.75-9.75 dpc expression was detected in structures that include those destined to contribute to the cardiovascular system of the adult heart. Expression was also detected in the mesencephalon and rhombencephalon.

Gene expression databases

ArrayExpressiQ9QXX0.
BgeeiQ9QXX0.
CleanExiMM_JAG1.
GenevestigatoriQ9QXX0.

Interactioni

Subunit structurei

Interacts with NOTCH1, NOTCH2 and NOTCH3.1 Publication

Protein-protein interaction databases

BioGridi200854. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9QXX0.
SMRiQ9QXX0. Positions 32-858.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 22945DSLAdd
BLAST
Domaini230 – 26334EGF-like 1Add
BLAST
Domaini264 – 29431EGF-like 2; atypicalAdd
BLAST
Domaini296 – 33439EGF-like 3Add
BLAST
Domaini336 – 37237EGF-like 4Add
BLAST
Domaini374 – 41037EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini412 – 44837EGF-like 6; calcium-binding Reviewed predictionAdd
BLAST
Domaini450 – 48536EGF-like 7; calcium-binding Reviewed predictionAdd
BLAST
Domaini487 – 52337EGF-like 8; calcium-binding Reviewed predictionAdd
BLAST
Domaini525 – 56137EGF-like 9Add
BLAST
Domaini586 – 62742EGF-like 10Add
BLAST
Domaini629 – 66537EGF-like 11; calcium-binding Reviewed predictionAdd
BLAST
Domaini667 – 70337EGF-like 12; calcium-binding Reviewed predictionAdd
BLAST
Domaini705 – 74137EGF-like 13Add
BLAST
Domaini744 – 78037EGF-like 14Add
BLAST
Domaini782 – 81837EGF-like 15; calcium-binding Reviewed predictionAdd
BLAST
Domaini820 – 85637EGF-like 16; calcium-binding Reviewed predictionAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2079Important for interaction with NOTCH1 By similarity

Domaini

The DSL domain is indispensable and sufficient for binding to NOTCH2.

Sequence similaritiesi

Contains 1 DSL domain.
Contains 16 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00740000114998.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ9QXX0.
KOiK06052.
OMAiHPNWTNK.
OrthoDBiEOG7BKCSS.
PhylomeDBiQ9QXX0.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 11 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXX0-1 [UniParc]FASTAAdd to Basket

« Hide

MRSPRTRGRP GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ     50
NGNCCGGVRN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP 100
VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTIQPDS 150
IIEKASHSGM INPSRQWQTL KQNTGIAHFE YQIRVTCDDH YYGFGCNKFC 200
RPRDDFFGHY ACDQNGNKTC MEGWMGPDCN KAICRQGCSP KHGSCKLPGD 250
CRCQYGWQGL YCDKCIPHPG CVHGTCNEPW QCLCETNWGG QLCDKDLNYC 300
GTHQPCLNRG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS 350
CKETSSGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC 400
PPQWTGKTCQ LDANECEAKP CVNARSCKNL IASYYCDCLP GWMGQNCDIN 450
INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG 500
HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK 550
CPEDYEGKNC SHLKDHCRTT TCEVIDSCTV AMASNDTPEG VRYISSNVCG 600
PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCKN GGTCIDGVNS 650
YKCICSDGWE GAHCENNIND CSQNPCHYGG TCRDLVNDFY CDCKNGWKGK 700
TCHSRDSQCD EATCNNGGTC YDEVDTFKCM CPGGWEGTTC NIARNSSCLP 750
NPCHNGGTCV VNGDSFTCVC KEGWEGPICT QNTNDCSPHP CYNSGTCVDG 800
DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYQCICPPGH 850
SGAKCHEVSG RSCITMGRVI LDGAKWDDDC NTCQCLNGRV ACSKVWCGPR 900
PCRLHKSHNE CPSGQSCIPV LDDQCFVRPC TGVGECRSSS LQPVKTKCTS 950
DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI 1000
ACEPSLSANN EIHVAISAED IRDDGNPVKE ITDKIIDLVS KRDGNSSLIA 1050
AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WVCCLVTAFY WCVRKRRKPS 1100
SHTHSAPEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR 1150
THNSEVEEDD MDKHQQKVRF AKQPVYTLVD REEKAPSGTP TKHPNWTNKQ 1200
DNRDLESAQS LNRMEYIV 1218
Length:1,218
Mass (Da):134,164
Last modified:May 1, 2000 - v1
Checksum:i77739F8928BB793C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171092 mRNA. Translation: AAF15505.1.
BC058675 mRNA. Translation: AAH58675.1.
CCDSiCCDS16797.1.
RefSeqiNP_038850.1. NM_013822.5.
UniGeneiMm.22398.

Genome annotation databases

EnsembliENSMUST00000028735; ENSMUSP00000028735; ENSMUSG00000027276.
GeneIDi16449.
KEGGimmu:16449.
UCSCiuc008moz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171092 mRNA. Translation: AAF15505.1 .
BC058675 mRNA. Translation: AAH58675.1 .
CCDSi CCDS16797.1.
RefSeqi NP_038850.1. NM_013822.5.
UniGenei Mm.22398.

3D structure databases

ProteinModelPortali Q9QXX0.
SMRi Q9QXX0. Positions 32-858.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200854. 1 interaction.

PTM databases

PhosphoSitei Q9QXX0.

Proteomic databases

PaxDbi Q9QXX0.
PRIDEi Q9QXX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028735 ; ENSMUSP00000028735 ; ENSMUSG00000027276 .
GeneIDi 16449.
KEGGi mmu:16449.
UCSCi uc008moz.2. mouse.

Organism-specific databases

CTDi 182.
MGIi MGI:1095416. Jag1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00740000114998.
HOGENOMi HOG000113124.
HOVERGENi HBG031645.
InParanoidi Q9QXX0.
KOi K06052.
OMAi HPNWTNK.
OrthoDBi EOG7BKCSS.
PhylomeDBi Q9QXX0.
TreeFami TF351835.

Enzyme and pathway databases

Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Miscellaneous databases

ChiTaRSi JAG1. mouse.
NextBioi 289705.
PROi Q9QXX0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QXX0.
Bgeei Q9QXX0.
CleanExi MM_JAG1.
Genevestigatori Q9QXX0.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 11 hits.
PF07645. EGF_CA. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view ]
PRINTSi PR02059. JAGGEDFAMILY.
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 10 hits.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Jagged1 physically interacts with Notch2 and other Notch receptors: assessment by quantitative methods."
    Shimizu K., Chiba S., Kumano K., Hosoya N., Takahashi T., Kanda Y., Hamada Y., Yazaki Y., Hirai H.
    J. Biol. Chem. 274:32961-32969(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION.
    Strain: Swiss Webster / NIH.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome."
    Loomes K.M., Underkoffler L.A., Morabito J., Gottlieb S., Piccoli D.A., Spinner N.B., Baldwin H.S., Oakey R.J.
    Hum. Mol. Genet. 8:2443-2449(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiJAG1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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