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Protein

Protein jagged-1

Gene

Jag1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.By similarity

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • Notch binding Source: UniProtKB
  • phospholipid binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • aorta morphogenesis Source: BHF-UCL
  • blood vessel remodeling Source: MGI
  • camera-type eye development Source: MGI
  • cardiac neural crest cell development involved in outflow tract morphogenesis Source: BHF-UCL
  • cardiac right ventricle morphogenesis Source: BHF-UCL
  • cardiac septum morphogenesis Source: BHF-UCL
  • ciliary body morphogenesis Source: MGI
  • distal tubule development Source: UniProtKB
  • endocardial cushion cell development Source: BHF-UCL
  • glomerular visceral epithelial cell development Source: UniProtKB
  • inner ear auditory receptor cell differentiation Source: MGI
  • inner ear development Source: UniProtKB
  • loop of Henle development Source: UniProtKB
  • morphogenesis of an epithelial sheet Source: MGI
  • negative regulation of cell-cell adhesion Source: Ensembl
  • negative regulation of cell differentiation Source: MGI
  • negative regulation of cell-matrix adhesion Source: Ensembl
  • negative regulation of cell migration Source: Ensembl
  • negative regulation of endothelial cell differentiation Source: BHF-UCL
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of stem cell differentiation Source: MGI
  • nephron development Source: UniProtKB
  • neuronal stem cell population maintenance Source: Ensembl
  • Notch signaling involved in heart development Source: BHF-UCL
  • Notch signaling pathway Source: MGI
  • positive regulation of myeloid cell differentiation Source: MGI
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • pulmonary artery morphogenesis Source: BHF-UCL
  • pulmonary valve morphogenesis Source: BHF-UCL
  • regulation of cell proliferation Source: MGI
  • response to muramyl dipeptide Source: BHF-UCL
  • T cell mediated immunity Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-1980150 Signaling by NOTCH4
R-MMU-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-1
Short name:
Jagged1
Alternative name(s):
CD_antigen: CD339
Gene namesi
Name:Jag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1095416 Jag1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 1067ExtracellularSequence analysisAdd BLAST1034
Transmembranei1068 – 1093HelicalSequence analysisAdd BLAST26
Topological domaini1094 – 1218CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000762634 – 1218Protein jagged-1Add BLAST1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi187 ↔ 196By similarity
Disulfide bondi200 ↔ 212By similarity
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi234 ↔ 245By similarity
Disulfide bondi238 ↔ 251By similarity
Disulfide bondi253 ↔ 262By similarity
Disulfide bondi265 ↔ 276By similarity
Disulfide bondi271 ↔ 282By similarity
Disulfide bondi284 ↔ 293By similarity
Disulfide bondi300 ↔ 312By similarity
Disulfide bondi306 ↔ 322By similarity
Disulfide bondi324 ↔ 333By similarity
Disulfide bondi340 ↔ 351By similarity
Disulfide bondi345 ↔ 360By similarity
Disulfide bondi362 ↔ 371By similarity
Disulfide bondi378 ↔ 389By similarity
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi383 ↔ 398By similarity
Disulfide bondi400 ↔ 409By similarity
Disulfide bondi416 ↔ 427By similarity
Disulfide bondi421 ↔ 436By similarity
Disulfide bondi438 ↔ 447By similarity
Disulfide bondi454 ↔ 464By similarity
Disulfide bondi458 ↔ 473By similarity
Disulfide bondi475 ↔ 484By similarity
Disulfide bondi491 ↔ 502By similarity
Disulfide bondi496 ↔ 511By similarity
Disulfide bondi513 ↔ 522By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi534 ↔ 549By similarity
Disulfide bondi551 ↔ 560By similarity
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi578 ↔ 605By similarity
Disulfide bondi599 ↔ 615By similarity
Disulfide bondi617 ↔ 626By similarity
Disulfide bondi633 ↔ 644By similarity
Disulfide bondi638 ↔ 653By similarity
Disulfide bondi655 ↔ 664By similarity
Disulfide bondi671 ↔ 682By similarity
Disulfide bondi676 ↔ 691By similarity
Disulfide bondi693 ↔ 702By similarity
Disulfide bondi709 ↔ 720By similarity
Disulfide bondi714 ↔ 729By similarity
Disulfide bondi731 ↔ 740By similarity
Glycosylationi745N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi748 ↔ 759By similarity
Disulfide bondi753 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi786 ↔ 797By similarity
Disulfide bondi791 ↔ 806By similarity
Disulfide bondi808 ↔ 817By similarity
Disulfide bondi824 ↔ 835By similarity
Disulfide bondi829 ↔ 844By similarity
Disulfide bondi846 ↔ 855By similarity
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi991N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1045N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1064N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QXX0
PaxDbiQ9QXX0
PRIDEiQ9QXX0

PTM databases

iPTMnetiQ9QXX0
PhosphoSitePlusiQ9QXX0
SwissPalmiQ9QXX0

Expressioni

Tissue specificityi

Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus.1 Publication

Developmental stagei

At 8.75-9.75 dpc expression was detected in structures that include those destined to contribute to the cardiovascular system of the adult heart. Expression was also detected in the mesencephalon and rhombencephalon.

Gene expression databases

BgeeiENSMUSG00000027276
CleanExiMM_JAG1
ExpressionAtlasiQ9QXX0 baseline and differential
GenevisibleiQ9QXX0 MM

Interactioni

Subunit structurei

Interacts with NOTCH1, NOTCH2 and NOTCH3.1 Publication

GO - Molecular functioni

  • Notch binding Source: UniProtKB

Protein-protein interaction databases

BioGridi200854, 1 interactor
STRINGi10090.ENSMUSP00000028735

Structurei

3D structure databases

ProteinModelPortaliQ9QXX0
SMRiQ9QXX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 229DSLPROSITE-ProRule annotationAdd BLAST45
Domaini230 – 263EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini264 – 294EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini296 – 334EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini336 – 372EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini374 – 410EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini412 – 448EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini450 – 485EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini487 – 523EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini525 – 561EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini586 – 627EGF-like 10PROSITE-ProRule annotationAdd BLAST42
Domaini629 – 665EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini667 – 703EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini705 – 741EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini744 – 780EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini782 – 818EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini820 – 856EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 207Important for interaction with NOTCH1By similarity9

Domaini

The DSL domain is indispensable and sufficient for binding to NOTCH2.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00810000125346
HOGENOMiHOG000113124
HOVERGENiHBG031645
InParanoidiQ9QXX0
KOiK06052
OMAiCLCETNW
OrthoDBiEOG091G0A88
PhylomeDBiQ9QXX0
TreeFamiTF351835

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 11 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 1 hit
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 16 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSPRTRGRP GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ
60 70 80 90 100
NGNCCGGVRN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP
110 120 130 140 150
VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTIQPDS
160 170 180 190 200
IIEKASHSGM INPSRQWQTL KQNTGIAHFE YQIRVTCDDH YYGFGCNKFC
210 220 230 240 250
RPRDDFFGHY ACDQNGNKTC MEGWMGPDCN KAICRQGCSP KHGSCKLPGD
260 270 280 290 300
CRCQYGWQGL YCDKCIPHPG CVHGTCNEPW QCLCETNWGG QLCDKDLNYC
310 320 330 340 350
GTHQPCLNRG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS
360 370 380 390 400
CKETSSGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC
410 420 430 440 450
PPQWTGKTCQ LDANECEAKP CVNARSCKNL IASYYCDCLP GWMGQNCDIN
460 470 480 490 500
INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG
510 520 530 540 550
HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK
560 570 580 590 600
CPEDYEGKNC SHLKDHCRTT TCEVIDSCTV AMASNDTPEG VRYISSNVCG
610 620 630 640 650
PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCKN GGTCIDGVNS
660 670 680 690 700
YKCICSDGWE GAHCENNIND CSQNPCHYGG TCRDLVNDFY CDCKNGWKGK
710 720 730 740 750
TCHSRDSQCD EATCNNGGTC YDEVDTFKCM CPGGWEGTTC NIARNSSCLP
760 770 780 790 800
NPCHNGGTCV VNGDSFTCVC KEGWEGPICT QNTNDCSPHP CYNSGTCVDG
810 820 830 840 850
DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYQCICPPGH
860 870 880 890 900
SGAKCHEVSG RSCITMGRVI LDGAKWDDDC NTCQCLNGRV ACSKVWCGPR
910 920 930 940 950
PCRLHKSHNE CPSGQSCIPV LDDQCFVRPC TGVGECRSSS LQPVKTKCTS
960 970 980 990 1000
DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI
1010 1020 1030 1040 1050
ACEPSLSANN EIHVAISAED IRDDGNPVKE ITDKIIDLVS KRDGNSSLIA
1060 1070 1080 1090 1100
AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WVCCLVTAFY WCVRKRRKPS
1110 1120 1130 1140 1150
SHTHSAPEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR
1160 1170 1180 1190 1200
THNSEVEEDD MDKHQQKVRF AKQPVYTLVD REEKAPSGTP TKHPNWTNKQ
1210
DNRDLESAQS LNRMEYIV
Length:1,218
Mass (Da):134,164
Last modified:May 1, 2000 - v1
Checksum:i77739F8928BB793C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171092 mRNA Translation: AAF15505.1
BC058675 mRNA Translation: AAH58675.1
CCDSiCCDS16797.1
RefSeqiNP_038850.1, NM_013822.5
UniGeneiMm.22398

Genome annotation databases

EnsembliENSMUST00000028735; ENSMUSP00000028735; ENSMUSG00000027276
GeneIDi16449
KEGGimmu:16449
UCSCiuc008moz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiJAG1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health