Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box/LRR-repeat protein 6

Gene

Fbxl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 6
Alternative name(s):
F-box and leucine-rich repeat protein 6
F-box protein FBL6
Gene namesi
Name:Fbxl6
Synonyms:Fbl6
ORF Names:MNCb-1275
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1354705. Fbxl6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198481 – 535F-box/LRR-repeat protein 6Add BLAST535

Proteomic databases

PaxDbiQ9QXW0.
PeptideAtlasiQ9QXW0.
PRIDEiQ9QXW0.

PTM databases

iPTMnetiQ9QXW0.
PhosphoSitePlusiQ9QXW0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022559.
CleanExiMM_FBXL6.
GenevisibleiQ9QXW0. MM.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023219.

Structurei

3D structure databases

ProteinModelPortaliQ9QXW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 106F-boxAdd BLAST53
Repeati169 – 195LRR 1Add BLAST27
Repeati196 – 221LRR 2Add BLAST26
Repeati222 – 247LRR 3Add BLAST26
Repeati273 – 299LRR 4Add BLAST27
Repeati304 – 329LRR 5Add BLAST26
Repeati330 – 357LRR 6Add BLAST28
Repeati360 – 385LRR 7Add BLAST26
Repeati386 – 411LRR 8Add BLAST26
Repeati415 – 441LRR 9Add BLAST27
Repeati474 – 499LRR 10Add BLAST26

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00390000009358.
HOGENOMiHOG000112552.
HOVERGENiHBG051590.
InParanoidiQ9QXW0.
KOiK10272.
OMAiLEEVQWC.
OrthoDBiEOG091G0ABY.
PhylomeDBiQ9QXW0.
TreeFamiTF324422.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QXW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPVASRRVR RRVRSSKRPD ARGRSAEDWW WDRLAPRGSG YHLLQADSML
60 70 80 90 100
LVLPDLEPPR ARAHRRARRR APRSLARGPT AVAKPRTKPR PEPSLDQGLD
110 120 130 140 150
SGWGDRIPLE VLVHIFGLLV AAHGPMPFLG RAARVCRHWH EATSHPSLWH
160 170 180 190 200
TVTLSPSLVG RAGKGNLKGE KKLLACLEWL VPNRFSQLQS LTLIHWKSQV
210 220 230 240 250
HSVLELVSKF CPRLTFLKLS DCHTVTAETL VMLARACCQL HSLDLHHSMV
260 270 280 290 300
ESTAVVSFLE EAGSRMRKLW LTYSSQTTAI LGALLDNCCP QLQVLQVSTG
310 320 330 340 350
MNCNNTPLQL PVEALQKGCP QLQVLRLLNL IWLPKPCGRG VPQGPGFPSL
360 370 380 390 400
EELCLAGSTC NFVSNEVLGR LLHRSPKLRM LDLRGCARVT PSGLCHLPCQ
410 420 430 440 450
ELEQLYLGLY GISDGLTLAK DGSPLLTRKW YHTLRELDFS GQGFSEKDLE
460 470 480 490 500
QALAVFSGTP GGLHPALCSL NLRGTRVTPS TVSSVISGCP GLLYLNLESC
510 520 530
RCLPRGLKRV YRGLEEVQWC LEQLLTSPPS AKEPT
Length:535
Mass (Da):59,268
Last modified:October 3, 2003 - v2
Checksum:iAEF85C18AD3A80FC
GO
Isoform 2 (identifier: Q9QXW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-238: Missing.

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):53,386
Checksum:iEC5C8DAF20FCFBDC
GO
Isoform 3 (identifier: Q9QXW0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-231: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):33,239
Checksum:iD899364F263571FB
GO

Sequence cautioni

The sequence AAF22828 differs from that shown. Reason: Frameshift at position 8.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0084991 – 231Missing in isoform 3. 1 PublicationAdd BLAST231
Alternative sequenceiVSP_008500187 – 238Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176522 mRNA. Translation: AAF22828.1. Frameshift.
AB041571 mRNA. Translation: BAA95055.1.
BC054377 mRNA. Translation: AAH54377.1.
CCDSiCCDS49653.1. [Q9QXW0-1]
RefSeqiNP_038937.2. NM_013909.2. [Q9QXW0-1]
UniGeneiMm.275279.

Genome annotation databases

EnsembliENSMUST00000023219; ENSMUSP00000023219; ENSMUSG00000022559. [Q9QXW0-1]
GeneIDi30840.
KEGGimmu:30840.
UCSCiuc007wkp.2. mouse. [Q9QXW0-1]
uc007wks.2. mouse. [Q9QXW0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176522 mRNA. Translation: AAF22828.1. Frameshift.
AB041571 mRNA. Translation: BAA95055.1.
BC054377 mRNA. Translation: AAH54377.1.
CCDSiCCDS49653.1. [Q9QXW0-1]
RefSeqiNP_038937.2. NM_013909.2. [Q9QXW0-1]
UniGeneiMm.275279.

3D structure databases

ProteinModelPortaliQ9QXW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023219.

PTM databases

iPTMnetiQ9QXW0.
PhosphoSitePlusiQ9QXW0.

Proteomic databases

PaxDbiQ9QXW0.
PeptideAtlasiQ9QXW0.
PRIDEiQ9QXW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023219; ENSMUSP00000023219; ENSMUSG00000022559. [Q9QXW0-1]
GeneIDi30840.
KEGGimmu:30840.
UCSCiuc007wkp.2. mouse. [Q9QXW0-1]
uc007wks.2. mouse. [Q9QXW0-3]

Organism-specific databases

CTDi26233.
MGIiMGI:1354705. Fbxl6.

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
GeneTreeiENSGT00390000009358.
HOGENOMiHOG000112552.
HOVERGENiHBG051590.
InParanoidiQ9QXW0.
KOiK10272.
OMAiLEEVQWC.
OrthoDBiEOG091G0ABY.
PhylomeDBiQ9QXW0.
TreeFamiTF324422.

Miscellaneous databases

PROiQ9QXW0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022559.
CleanExiMM_FBXL6.
GenevisibleiQ9QXW0. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 3 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL6_MOUSE
AccessioniPrimary (citable) accession number: Q9QXW0
Secondary accession number(s): Q9JJD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.