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Protein

Protein sprouty homolog 1

Gene

Spry1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

GO - Biological processi

  • bud elongation involved in lung branching Source: MGI
  • establishment of mitotic spindle orientation Source: MGI
  • metanephros development Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  • negative regulation of GTPase activity Source: MGI
  • negative regulation of MAP kinase activity Source: MGI
  • negative regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • negative regulation of Ras protein signal transduction Source: MGI
  • organ induction Source: MGI
  • ureteric bud development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiR-MMU-182971. EGFR downregulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 1
Short name:
Spry-1
Gene namesi
Name:Spry1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1345139. Spry1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Protein sprouty homolog 1PRO_0000076899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QXV9.
PaxDbiQ9QXV9.
PRIDEiQ9QXV9.

PTM databases

iPTMnetiQ9QXV9.
PhosphoSiteiQ9QXV9.

Expressioni

Tissue specificityi

Expressed in the embryo and adult tissues including heart, brain, lung, kidney, and skeletal muscle.

Developmental stagei

At E8.5 expressed in the primitive streak, rostral forebrain, cells lateral to the posterior hindbrain, anterior hindbrain and developing midbrain. At E9.5 continues to be expressed in the rostral forebrain and primitive streak, and is also detected in the branchial arches and the forelimb bud. At E10.5 expressed in the somites, frontonasal processes, tailbud, and hindlimb bud.

Inductioni

By FGF signaling.

Gene expression databases

BgeeiQ9QXV9.
CleanExiMM_SPRY1.
ExpressionAtlasiQ9QXV9. baseline and differential.
GenevisibleiQ9QXV9. MM.

Interactioni

Protein-protein interaction databases

BioGridi204876. 7 interactions.
STRINGi10090.ENSMUSP00000049292.

Structurei

3D structure databases

ProteinModelPortaliQ9QXV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini177 – 289113SPRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi116 – 12510Poly-Ser
Compositional biasi175 – 304130Cys-richAdd
BLAST

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJJB. Eukaryota.
ENOG410Z8F4. LUCA.
GeneTreeiENSGT00390000003535.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiQ9QXV9.
KOiK04704.
OMAiNNYEHRP.
OrthoDBiEOG7G4QDV.
PhylomeDBiQ9QXV9.
TreeFamiTF325070.

Family and domain databases

InterProiIPR007875. Sprouty.
IPR030783. SPRY1.
[Graphical view]
PANTHERiPTHR12365:SF10. PTHR12365:SF10. 1 hit.
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPSQHGSH TSLVVIQPPA VEGRQRLDYD RDTQPATILS LDQIKAIRGS
60 70 80 90 100
NEYTEGPSVA RRPAPRTAPR PEKQERTHEI IPANVNSSYE HRPASHPGNA
110 120 130 140 150
RGSVLSRSTS TGSAASSGSS SSVSSEQGLL GRSPPTRPIP GHRSDRVIRT
160 170 180 190 200
QPKQLLVEDL KASLKEDPTQ HKFICEQCGK CKCGECTAPR ALPSCLACDR
210 220 230 240 250
QCLCSAESMV EYGTCMCLVK GIFYHCSNDD DGGSYSDNPC SCSQSHCCSR
260 270 280 290 300
YLCMGALSLC LPCLLCYPPA KGCLKLCRGC YDWTHRPGCR CRNSNTVYCK
310
LESCPSRAQG KLS
Length:313
Mass (Da):34,004
Last modified:May 1, 2000 - v1
Checksum:iCD3C27F7022C0B99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176903 mRNA. Translation: AAD56004.1.
BC053428 mRNA. Translation: AAH53428.1.
BC069914 mRNA. Translation: AAH69914.1.
CCDSiCCDS17322.1.
RefSeqiNP_001292369.1. NM_001305440.1.
NP_001292370.1. NM_001305441.1.
NP_001292371.1. NM_001305442.1.
NP_036026.1. NM_011896.3.
UniGeneiMm.330986.

Genome annotation databases

EnsembliENSMUST00000038569; ENSMUSP00000049292; ENSMUSG00000037211.
ENSMUST00000108107; ENSMUSP00000103742; ENSMUSG00000037211.
ENSMUST00000108109; ENSMUSP00000103744; ENSMUSG00000037211.
GeneIDi24063.
KEGGimmu:24063.
UCSCiuc008pax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176903 mRNA. Translation: AAD56004.1.
BC053428 mRNA. Translation: AAH53428.1.
BC069914 mRNA. Translation: AAH69914.1.
CCDSiCCDS17322.1.
RefSeqiNP_001292369.1. NM_001305440.1.
NP_001292370.1. NM_001305441.1.
NP_001292371.1. NM_001305442.1.
NP_036026.1. NM_011896.3.
UniGeneiMm.330986.

3D structure databases

ProteinModelPortaliQ9QXV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204876. 7 interactions.
STRINGi10090.ENSMUSP00000049292.

PTM databases

iPTMnetiQ9QXV9.
PhosphoSiteiQ9QXV9.

Proteomic databases

MaxQBiQ9QXV9.
PaxDbiQ9QXV9.
PRIDEiQ9QXV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038569; ENSMUSP00000049292; ENSMUSG00000037211.
ENSMUST00000108107; ENSMUSP00000103742; ENSMUSG00000037211.
ENSMUST00000108109; ENSMUSP00000103744; ENSMUSG00000037211.
GeneIDi24063.
KEGGimmu:24063.
UCSCiuc008pax.2. mouse.

Organism-specific databases

CTDi10252.
MGIiMGI:1345139. Spry1.

Phylogenomic databases

eggNOGiENOG410IJJB. Eukaryota.
ENOG410Z8F4. LUCA.
GeneTreeiENSGT00390000003535.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiQ9QXV9.
KOiK04704.
OMAiNNYEHRP.
OrthoDBiEOG7G4QDV.
PhylomeDBiQ9QXV9.
TreeFamiTF325070.

Enzyme and pathway databases

ReactomeiR-MMU-182971. EGFR downregulation.

Miscellaneous databases

PROiQ9QXV9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXV9.
CleanExiMM_SPRY1.
ExpressionAtlasiQ9QXV9. baseline and differential.
GenevisibleiQ9QXV9. MM.

Family and domain databases

InterProiIPR007875. Sprouty.
IPR030783. SPRY1.
[Graphical view]
PANTHERiPTHR12365:SF10. PTHR12365:SF10. 1 hit.
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Vertebrate sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed."
    Minowada G., Jarvis L.A., Chi C.L., Neubueser A., Sun X., Hacohen N., Krasnow M.A., Martin G.R.
    Development 126:4465-4475(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb and Mammary gland.

Entry informationi

Entry nameiSPY1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.