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Protein

Inhibitor of growth protein 1

Gene

Ing1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei212Histone H3K4me3By similarity1
Metal bindingi213Zinc 1By similarity1
Metal bindingi215Zinc 1By similarity1
Binding sitei223Histone H3K4me3By similarity1
Metal bindingi226Zinc 2By similarity1
Binding sitei227Histone H3K4me3By similarity1
Metal bindingi231Zinc 2By similarity1
Binding sitei235Histone H3K4me3By similarity1
Metal bindingi237Zinc 1; via pros nitrogenBy similarity1
Metal bindingi240Zinc 1By similarity1
Metal bindingi253Zinc 2By similarity1
Metal bindingi256Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri210 – 259PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chromatin organization Source: InterPro
  • negative regulation of cell proliferation Source: InterPro
  • positive regulation of transcription, DNA-templated Source: MGI
  • protein import into nucleus Source: MGI
  • regulation of cell death Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 1
Gene namesi
Name:Ing1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1349481. Ing1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126621 – 279Inhibitor of growth protein 1Add BLAST279

Proteomic databases

EPDiQ9QXV3.
PaxDbiQ9QXV3.
PeptideAtlasiQ9QXV3.
PRIDEiQ9QXV3.

PTM databases

PhosphoSitePlusiQ9QXV3.

Expressioni

Tissue specificityi

In the adult, widely expressed with highest levels in thymus and testis.1 Publication

Developmental stagei

Expressed throughout the whole embryo at all stages of development examined. At day 10, highest expression is found in the yolk sac while at day 16 and 18, higher levels are found in inner compartments of bone. In the embryo, highest expression of isoform 1 is found at day 11 while highest expression of isoform 2 is found at day 7.1 Publication

Gene expression databases

BgeeiENSMUSG00000045969.
CleanExiMM_ING1.
ExpressionAtlasiQ9QXV3. baseline and differential.
GenevisibleiQ9QXV3. MM.

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Isoform 2 interacts with RSL1D1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204916. 1 interactor.
STRINGi10090.ENSMUSP00000062593.

Structurei

3D structure databases

ProteinModelPortaliQ9QXV3.
SMRiQ9QXV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni262 – 279PBRBy similarityAdd BLAST18

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.By similarity
The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).By similarity

Sequence similaritiesi

Belongs to the ING family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri210 – 259PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1973. Eukaryota.
COG5034. LUCA.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239724.
HOVERGENiHBG006607.
InParanoidiQ9QXV3.
KOiK19197.
OMAiIDAKCVH.
OrthoDBiEOG091G0J8Y.
PhylomeDBiQ9QXV3.
TreeFamiTF352014.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N_histone_binding.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamiPF12998. ING. 1 hit.
[Graphical view]
SMARTiSM01408. ING. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QXV3-1) [UniParc]FASTAAdd to basket
Also known as: 1b, p37

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPANGEQI HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE
60 70 80 90 100
LDDYYEKFKR ETDGTQKRRV LHCIQRALIR SQELGDEKIQ IVSQMVELVE
110 120 130 140 150
NRSRQVDSHV ELFEAHQDIS DGTGGSGKAG QDKSKSEAIT QADKPNNKRS
160 170 180 190 200
RRQRNNENRE NASNNHDHDD ITSGTPKEKK AKTSKKKKRS KAKAEREASP
210 220 230 240 250
ADLPIDPNEP TYCLCNQVSY GEMIGCDNDE CPIEWFHFSC VGLNHKPKGK
260 270
WYCPKCRGES EKTMDKALEK SKKERAYNR
Length:279
Mass (Da):32,109
Last modified:May 1, 2000 - v1
Checksum:i6765C984EEF179F4
GO
Isoform 2 (identifier: Q9QXV3-2) [UniParc]FASTAAdd to basket
Also known as: 1a, 1c, p31

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:185
Mass (Da):20,968
Checksum:i3C855D1C6AB3EC3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203L → F in AAF09183 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0503781 – 94Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177753 Genomic DNA. Translation: AAF16911.1.
AF177755 mRNA. Translation: AAF16908.1.
AF177756 mRNA. Translation: AAF16909.1.
AF177757 mRNA. Translation: AAF16910.1.
AF149820 mRNA. Translation: AAF09183.1.
BC016573 mRNA. Translation: AAH16573.1.
BC147770 mRNA. Translation: AAI47771.1.
BC147784 mRNA. Translation: AAI47785.1.
CCDSiCCDS22097.1. [Q9QXV3-1]
RefSeqiNP_001289386.1. NM_001302457.1. [Q9QXV3-2]
NP_001289387.1. NM_001302458.1. [Q9QXV3-2]
NP_001289388.1. NM_001302459.1. [Q9QXV3-2]
NP_001289389.1. NM_001302460.1. [Q9QXV3-2]
NP_036049.2. NM_011919.5. [Q9QXV3-1]
UniGeneiMm.25709.

Genome annotation databases

EnsembliENSMUST00000054399; ENSMUSP00000062593; ENSMUSG00000045969. [Q9QXV3-1]
ENSMUST00000209565; ENSMUSP00000147892; ENSMUSG00000045969. [Q9QXV3-2]
ENSMUST00000210041; ENSMUSP00000147270; ENSMUSG00000045969. [Q9QXV3-2]
ENSMUST00000210740; ENSMUSP00000147476; ENSMUSG00000045969. [Q9QXV3-2]
ENSMUST00000211007; ENSMUSP00000148030; ENSMUSG00000045969. [Q9QXV3-2]
GeneIDi26356.
KEGGimmu:26356.
UCSCiuc009kvk.2. mouse. [Q9QXV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177753 Genomic DNA. Translation: AAF16911.1.
AF177755 mRNA. Translation: AAF16908.1.
AF177756 mRNA. Translation: AAF16909.1.
AF177757 mRNA. Translation: AAF16910.1.
AF149820 mRNA. Translation: AAF09183.1.
BC016573 mRNA. Translation: AAH16573.1.
BC147770 mRNA. Translation: AAI47771.1.
BC147784 mRNA. Translation: AAI47785.1.
CCDSiCCDS22097.1. [Q9QXV3-1]
RefSeqiNP_001289386.1. NM_001302457.1. [Q9QXV3-2]
NP_001289387.1. NM_001302458.1. [Q9QXV3-2]
NP_001289388.1. NM_001302459.1. [Q9QXV3-2]
NP_001289389.1. NM_001302460.1. [Q9QXV3-2]
NP_036049.2. NM_011919.5. [Q9QXV3-1]
UniGeneiMm.25709.

3D structure databases

ProteinModelPortaliQ9QXV3.
SMRiQ9QXV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204916. 1 interactor.
STRINGi10090.ENSMUSP00000062593.

PTM databases

PhosphoSitePlusiQ9QXV3.

Proteomic databases

EPDiQ9QXV3.
PaxDbiQ9QXV3.
PeptideAtlasiQ9QXV3.
PRIDEiQ9QXV3.

Protocols and materials databases

DNASUi26356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054399; ENSMUSP00000062593; ENSMUSG00000045969. [Q9QXV3-1]
ENSMUST00000209565; ENSMUSP00000147892; ENSMUSG00000045969. [Q9QXV3-2]
ENSMUST00000210041; ENSMUSP00000147270; ENSMUSG00000045969. [Q9QXV3-2]
ENSMUST00000210740; ENSMUSP00000147476; ENSMUSG00000045969. [Q9QXV3-2]
ENSMUST00000211007; ENSMUSP00000148030; ENSMUSG00000045969. [Q9QXV3-2]
GeneIDi26356.
KEGGimmu:26356.
UCSCiuc009kvk.2. mouse. [Q9QXV3-1]

Organism-specific databases

CTDi3621.
MGIiMGI:1349481. Ing1.

Phylogenomic databases

eggNOGiKOG1973. Eukaryota.
COG5034. LUCA.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239724.
HOVERGENiHBG006607.
InParanoidiQ9QXV3.
KOiK19197.
OMAiIDAKCVH.
OrthoDBiEOG091G0J8Y.
PhylomeDBiQ9QXV3.
TreeFamiTF352014.

Miscellaneous databases

PROiQ9QXV3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045969.
CleanExiMM_ING1.
ExpressionAtlasiQ9QXV3. baseline and differential.
GenevisibleiQ9QXV3. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N_histone_binding.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamiPF12998. ING. 1 hit.
[Graphical view]
SMARTiSM01408. ING. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiING1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXV3
Secondary accession number(s): B2RWH0
, Q9QUP8, Q9QXV4, Q9QZX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.