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Q9QXV3

- ING1_MOUSE

UniProt

Q9QXV3 - ING1_MOUSE

Protein

Inhibitor of growth protein 1

Gene

Ing1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei212 – 2121Histone H3K4me3By similarity
    Binding sitei223 – 2231Histone H3K4me3By similarity
    Binding sitei227 – 2271Histone H3K4me3By similarity
    Binding sitei235 – 2351Histone H3K4me3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri210 – 25950PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. chromatin modification Source: InterPro
    3. negative regulation of cell proliferation Source: InterPro
    4. positive regulation of transcription, DNA-templated Source: MGI
    5. protein import into nucleus Source: MGI
    6. regulation of cell death Source: MGI

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inhibitor of growth protein 1
    Gene namesi
    Name:Ing1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1349481. Ing1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Inhibitor of growth protein 1PRO_0000212662Add
    BLAST

    Proteomic databases

    PRIDEiQ9QXV3.

    PTM databases

    PhosphoSiteiQ9QXV3.

    Expressioni

    Tissue specificityi

    In the adult, widely expressed with highest levels in thymus and testis.1 Publication

    Developmental stagei

    Expressed throughout the whole embryo at all stages of development examined. At day 10, highest expression is found in the yolk sac while at day 16 and 18, higher levels are found in inner compartments of bone. In the embryo, highest expression of isoform 1 is found at day 11 while highest expression of isoform 2 is found at day 7.1 Publication

    Gene expression databases

    ArrayExpressiQ9QXV3.
    BgeeiQ9QXV3.
    CleanExiMM_ING1.
    GenevestigatoriQ9QXV3.

    Interactioni

    Subunit structurei

    Interacts with H3K4me3 and to a lesser extent with H3K4me2.By similarity

    Protein-protein interaction databases

    BioGridi204916. 1 interaction.
    STRINGi10090.ENSMUSP00000062593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXV3.
    SMRiQ9QXV3. Positions 15-108, 209-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni262 – 27918PBRBy similarityAdd
    BLAST

    Domaini

    The PHD-type zinc finger mediates the binding to H3K4me3.By similarity
    The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).By similarity

    Sequence similaritiesi

    Belongs to the ING family.Curated
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri210 – 25950PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5034.
    GeneTreeiENSGT00550000074538.
    HOGENOMiHOG000239724.
    HOVERGENiHBG006607.
    InParanoidiB2RWH0.
    OMAiFETCQET.
    OrthoDBiEOG7RBZ9T.
    PhylomeDBiQ9QXV3.
    TreeFamiTF352014.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR028643. ING1.
    IPR028651. ING_fam.
    IPR024610. ING_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR10333. PTHR10333. 1 hit.
    PTHR10333:SF38. PTHR10333:SF38. 1 hit.
    PfamiPF12998. ING. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QXV3-1) [UniParc]FASTAAdd to Basket

    Also known as: 1b, p37

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSPANGEQI HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE    50
    LDDYYEKFKR ETDGTQKRRV LHCIQRALIR SQELGDEKIQ IVSQMVELVE 100
    NRSRQVDSHV ELFEAHQDIS DGTGGSGKAG QDKSKSEAIT QADKPNNKRS 150
    RRQRNNENRE NASNNHDHDD ITSGTPKEKK AKTSKKKKRS KAKAEREASP 200
    ADLPIDPNEP TYCLCNQVSY GEMIGCDNDE CPIEWFHFSC VGLNHKPKGK 250
    WYCPKCRGES EKTMDKALEK SKKERAYNR 279
    Length:279
    Mass (Da):32,109
    Last modified:May 1, 2000 - v1
    Checksum:i6765C984EEF179F4
    GO
    Isoform 2 (identifier: Q9QXV3-2) [UniParc]FASTAAdd to Basket

    Also known as: 1a, 1c, p31

    The sequence of this isoform differs from the canonical sequence as follows:
         1-94: Missing.

    Show »
    Length:185
    Mass (Da):20,968
    Checksum:i3C855D1C6AB3EC3A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2031L → F in AAF09183. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_050378Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177753 Genomic DNA. Translation: AAF16911.1.
    AF177755 mRNA. Translation: AAF16908.1.
    AF177756 mRNA. Translation: AAF16909.1.
    AF177757 mRNA. Translation: AAF16910.1.
    AF149820 mRNA. Translation: AAF09183.1.
    BC016573 mRNA. Translation: AAH16573.1.
    BC147770 mRNA. Translation: AAI47771.1.
    BC147784 mRNA. Translation: AAI47785.1.
    CCDSiCCDS22097.1. [Q9QXV3-1]
    RefSeqiNP_036049.2. NM_011919.4. [Q9QXV3-1]
    XP_006508865.1. XM_006508802.1. [Q9QXV3-2]
    XP_006508866.1. XM_006508803.1. [Q9QXV3-2]
    XP_006508867.1. XM_006508804.1. [Q9QXV3-2]
    UniGeneiMm.25709.

    Genome annotation databases

    EnsembliENSMUST00000054399; ENSMUSP00000062593; ENSMUSG00000045969. [Q9QXV3-1]
    GeneIDi26356.
    KEGGimmu:26356.
    UCSCiuc009kvk.1. mouse. [Q9QXV3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177753 Genomic DNA. Translation: AAF16911.1 .
    AF177755 mRNA. Translation: AAF16908.1 .
    AF177756 mRNA. Translation: AAF16909.1 .
    AF177757 mRNA. Translation: AAF16910.1 .
    AF149820 mRNA. Translation: AAF09183.1 .
    BC016573 mRNA. Translation: AAH16573.1 .
    BC147770 mRNA. Translation: AAI47771.1 .
    BC147784 mRNA. Translation: AAI47785.1 .
    CCDSi CCDS22097.1. [Q9QXV3-1 ]
    RefSeqi NP_036049.2. NM_011919.4. [Q9QXV3-1 ]
    XP_006508865.1. XM_006508802.1. [Q9QXV3-2 ]
    XP_006508866.1. XM_006508803.1. [Q9QXV3-2 ]
    XP_006508867.1. XM_006508804.1. [Q9QXV3-2 ]
    UniGenei Mm.25709.

    3D structure databases

    ProteinModelPortali Q9QXV3.
    SMRi Q9QXV3. Positions 15-108, 209-259.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204916. 1 interaction.
    STRINGi 10090.ENSMUSP00000062593.

    PTM databases

    PhosphoSitei Q9QXV3.

    Proteomic databases

    PRIDEi Q9QXV3.

    Protocols and materials databases

    DNASUi 26356.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054399 ; ENSMUSP00000062593 ; ENSMUSG00000045969 . [Q9QXV3-1 ]
    GeneIDi 26356.
    KEGGi mmu:26356.
    UCSCi uc009kvk.1. mouse. [Q9QXV3-1 ]

    Organism-specific databases

    CTDi 3621.
    MGIi MGI:1349481. Ing1.

    Phylogenomic databases

    eggNOGi COG5034.
    GeneTreei ENSGT00550000074538.
    HOGENOMi HOG000239724.
    HOVERGENi HBG006607.
    InParanoidi B2RWH0.
    OMAi FETCQET.
    OrthoDBi EOG7RBZ9T.
    PhylomeDBi Q9QXV3.
    TreeFami TF352014.

    Miscellaneous databases

    NextBioi 304199.
    PROi Q9QXV3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QXV3.
    Bgeei Q9QXV3.
    CleanExi MM_ING1.
    Genevestigatori Q9QXV3.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR028643. ING1.
    IPR028651. ING_fam.
    IPR024610. ING_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR10333. PTHR10333. 1 hit.
    PTHR10333:SF38. PTHR10333:SF38. 1 hit.
    Pfami PF12998. ING. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two PHD finger proteins that have opposite effects on p53 function."
      Zeremski M., Hill J.E., Kwek S.S.S., Grigorian I.A., Gurova K.V., Garkavtsev I.V., Diatchenko L., Koonin E.V., Gudkov A.V.
      J. Biol. Chem. 274:32172-32181(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: 129/SvJ.
      Tissue: Brain, Embryonic fibroblast and Spleen.
    2. "Structural organization and expression pattern of the murine ING1 gene."
      Rancourt D., Garkavtsev I.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Mammary gland.

    Entry informationi

    Entry nameiING1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXV3
    Secondary accession number(s): B2RWH0
    , Q9QUP8, Q9QXV4, Q9QZX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3