SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9QXV3

- ING1_MOUSE

UniProt

Q9QXV3 - ING1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Inhibitor of growth protein 1

Gene
Ing1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121Histone H3K4me3 By similarity
Binding sitei223 – 2231Histone H3K4me3 By similarity
Binding sitei227 – 2271Histone H3K4me3 By similarity
Binding sitei235 – 2351Histone H3K4me3 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri210 – 25950PHD-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. chromatin modification Source: InterPro
  3. negative regulation of cell proliferation Source: InterPro
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. protein import into nucleus Source: MGI
  6. regulation of cell death Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 1
Gene namesi
Name:Ing1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1349481. Ing1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Inhibitor of growth protein 1PRO_0000212662Add
BLAST

Proteomic databases

PRIDEiQ9QXV3.

PTM databases

PhosphoSiteiQ9QXV3.

Expressioni

Tissue specificityi

In the adult, widely expressed with highest levels in thymus and testis.1 Publication

Developmental stagei

Expressed throughout the whole embryo at all stages of development examined. At day 10, highest expression is found in the yolk sac while at day 16 and 18, higher levels are found in inner compartments of bone. In the embryo, highest expression of isoform 1 is found at day 11 while highest expression of isoform 2 is found at day 7.1 Publication

Gene expression databases

ArrayExpressiQ9QXV3.
BgeeiQ9QXV3.
CleanExiMM_ING1.
GenevestigatoriQ9QXV3.

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2 By similarity.

Protein-protein interaction databases

BioGridi204916. 1 interaction.
STRINGi10090.ENSMUSP00000062593.

Structurei

3D structure databases

ProteinModelPortaliQ9QXV3.
SMRiQ9QXV3. Positions 15-108, 209-259.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 27918PBR By similarityAdd
BLAST

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3 By similarity.
The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P) By similarity.

Sequence similaritiesi

Belongs to the ING family.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri210 – 25950PHD-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5034.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239724.
HOVERGENiHBG006607.
InParanoidiB2RWH0.
OMAiFETCQET.
OrthoDBiEOG7RBZ9T.
PhylomeDBiQ9QXV3.
TreeFamiTF352014.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamiPF12998. ING. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QXV3-1) [UniParc]FASTAAdd to Basket

Also known as: 1b, p37

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLSPANGEQI HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE    50
LDDYYEKFKR ETDGTQKRRV LHCIQRALIR SQELGDEKIQ IVSQMVELVE 100
NRSRQVDSHV ELFEAHQDIS DGTGGSGKAG QDKSKSEAIT QADKPNNKRS 150
RRQRNNENRE NASNNHDHDD ITSGTPKEKK AKTSKKKKRS KAKAEREASP 200
ADLPIDPNEP TYCLCNQVSY GEMIGCDNDE CPIEWFHFSC VGLNHKPKGK 250
WYCPKCRGES EKTMDKALEK SKKERAYNR 279
Length:279
Mass (Da):32,109
Last modified:May 1, 2000 - v1
Checksum:i6765C984EEF179F4
GO
Isoform 2 (identifier: Q9QXV3-2) [UniParc]FASTAAdd to Basket

Also known as: 1a, 1c, p31

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:185
Mass (Da):20,968
Checksum:i3C855D1C6AB3EC3A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2. VSP_050378Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031L → F in AAF09183. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177753 Genomic DNA. Translation: AAF16911.1.
AF177755 mRNA. Translation: AAF16908.1.
AF177756 mRNA. Translation: AAF16909.1.
AF177757 mRNA. Translation: AAF16910.1.
AF149820 mRNA. Translation: AAF09183.1.
BC016573 mRNA. Translation: AAH16573.1.
BC147770 mRNA. Translation: AAI47771.1.
BC147784 mRNA. Translation: AAI47785.1.
CCDSiCCDS22097.1. [Q9QXV3-1]
RefSeqiNP_036049.2. NM_011919.4. [Q9QXV3-1]
XP_006508865.1. XM_006508802.1. [Q9QXV3-2]
XP_006508866.1. XM_006508803.1. [Q9QXV3-2]
XP_006508867.1. XM_006508804.1. [Q9QXV3-2]
UniGeneiMm.25709.

Genome annotation databases

EnsembliENSMUST00000054399; ENSMUSP00000062593; ENSMUSG00000045969. [Q9QXV3-1]
GeneIDi26356.
KEGGimmu:26356.
UCSCiuc009kvk.1. mouse. [Q9QXV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177753 Genomic DNA. Translation: AAF16911.1 .
AF177755 mRNA. Translation: AAF16908.1 .
AF177756 mRNA. Translation: AAF16909.1 .
AF177757 mRNA. Translation: AAF16910.1 .
AF149820 mRNA. Translation: AAF09183.1 .
BC016573 mRNA. Translation: AAH16573.1 .
BC147770 mRNA. Translation: AAI47771.1 .
BC147784 mRNA. Translation: AAI47785.1 .
CCDSi CCDS22097.1. [Q9QXV3-1 ]
RefSeqi NP_036049.2. NM_011919.4. [Q9QXV3-1 ]
XP_006508865.1. XM_006508802.1. [Q9QXV3-2 ]
XP_006508866.1. XM_006508803.1. [Q9QXV3-2 ]
XP_006508867.1. XM_006508804.1. [Q9QXV3-2 ]
UniGenei Mm.25709.

3D structure databases

ProteinModelPortali Q9QXV3.
SMRi Q9QXV3. Positions 15-108, 209-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204916. 1 interaction.
STRINGi 10090.ENSMUSP00000062593.

PTM databases

PhosphoSitei Q9QXV3.

Proteomic databases

PRIDEi Q9QXV3.

Protocols and materials databases

DNASUi 26356.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054399 ; ENSMUSP00000062593 ; ENSMUSG00000045969 . [Q9QXV3-1 ]
GeneIDi 26356.
KEGGi mmu:26356.
UCSCi uc009kvk.1. mouse. [Q9QXV3-1 ]

Organism-specific databases

CTDi 3621.
MGIi MGI:1349481. Ing1.

Phylogenomic databases

eggNOGi COG5034.
GeneTreei ENSGT00550000074538.
HOGENOMi HOG000239724.
HOVERGENi HBG006607.
InParanoidi B2RWH0.
OMAi FETCQET.
OrthoDBi EOG7RBZ9T.
PhylomeDBi Q9QXV3.
TreeFami TF352014.

Miscellaneous databases

NextBioi 304199.
PROi Q9QXV3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QXV3.
Bgeei Q9QXV3.
CleanExi MM_ING1.
Genevestigatori Q9QXV3.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
Pfami PF12998. ING. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two PHD finger proteins that have opposite effects on p53 function."
    Zeremski M., Hill J.E., Kwek S.S.S., Grigorian I.A., Gurova K.V., Garkavtsev I.V., Diatchenko L., Koonin E.V., Gudkov A.V.
    J. Biol. Chem. 274:32172-32181(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/SvJ.
    Tissue: Brain, Embryonic fibroblast and Spleen.
  2. "Structural organization and expression pattern of the murine ING1 gene."
    Rancourt D., Garkavtsev I.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiING1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXV3
Secondary accession number(s): B2RWH0
, Q9QUP8, Q9QXV4, Q9QZX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi