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Protein

Inhibitor of growth protein 1

Gene

Ing1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121Histone H3K4me3By similarity
Binding sitei223 – 2231Histone H3K4me3By similarity
Binding sitei227 – 2271Histone H3K4me3By similarity
Binding sitei235 – 2351Histone H3K4me3By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri210 – 25950PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chromatin modification Source: InterPro
  • negative regulation of cell proliferation Source: InterPro
  • positive regulation of transcription, DNA-templated Source: MGI
  • protein import into nucleus Source: MGI
  • regulation of cell death Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 1
Gene namesi
Name:Ing1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1349481. Ing1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Inhibitor of growth protein 1PRO_0000212662Add
BLAST

Proteomic databases

PRIDEiQ9QXV3.

PTM databases

PhosphoSiteiQ9QXV3.

Expressioni

Tissue specificityi

In the adult, widely expressed with highest levels in thymus and testis.1 Publication

Developmental stagei

Expressed throughout the whole embryo at all stages of development examined. At day 10, highest expression is found in the yolk sac while at day 16 and 18, higher levels are found in inner compartments of bone. In the embryo, highest expression of isoform 1 is found at day 11 while highest expression of isoform 2 is found at day 7.1 Publication

Gene expression databases

BgeeiQ9QXV3.
CleanExiMM_ING1.
ExpressionAtlasiQ9QXV3. baseline and differential.
GenevestigatoriQ9QXV3.

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Isoform 2 interacts with RSL1D1.By similarity

Protein-protein interaction databases

BioGridi204916. 1 interaction.
STRINGi10090.ENSMUSP00000062593.

Structurei

3D structure databases

ProteinModelPortaliQ9QXV3.
SMRiQ9QXV3. Positions 15-108, 209-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 27918PBRBy similarityAdd
BLAST

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.By similarity
The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).By similarity

Sequence similaritiesi

Belongs to the ING family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri210 – 25950PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5034.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239724.
HOVERGENiHBG006607.
InParanoidiQ9QXV3.
OMAiFETCQET.
OrthoDBiEOG7RBZ9T.
PhylomeDBiQ9QXV3.
TreeFamiTF352014.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamiPF12998. ING. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QXV3-1) [UniParc]FASTAAdd to basket

Also known as: 1b, p37

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPANGEQI HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE
60 70 80 90 100
LDDYYEKFKR ETDGTQKRRV LHCIQRALIR SQELGDEKIQ IVSQMVELVE
110 120 130 140 150
NRSRQVDSHV ELFEAHQDIS DGTGGSGKAG QDKSKSEAIT QADKPNNKRS
160 170 180 190 200
RRQRNNENRE NASNNHDHDD ITSGTPKEKK AKTSKKKKRS KAKAEREASP
210 220 230 240 250
ADLPIDPNEP TYCLCNQVSY GEMIGCDNDE CPIEWFHFSC VGLNHKPKGK
260 270
WYCPKCRGES EKTMDKALEK SKKERAYNR
Length:279
Mass (Da):32,109
Last modified:May 1, 2000 - v1
Checksum:i6765C984EEF179F4
GO
Isoform 2 (identifier: Q9QXV3-2) [UniParc]FASTAAdd to basket

Also known as: 1a, 1c, p31

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:185
Mass (Da):20,968
Checksum:i3C855D1C6AB3EC3A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031L → F in AAF09183 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_050378Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177753 Genomic DNA. Translation: AAF16911.1.
AF177755 mRNA. Translation: AAF16908.1.
AF177756 mRNA. Translation: AAF16909.1.
AF177757 mRNA. Translation: AAF16910.1.
AF149820 mRNA. Translation: AAF09183.1.
BC016573 mRNA. Translation: AAH16573.1.
BC147770 mRNA. Translation: AAI47771.1.
BC147784 mRNA. Translation: AAI47785.1.
CCDSiCCDS22097.1. [Q9QXV3-1]
RefSeqiNP_001289386.1. NM_001302457.1. [Q9QXV3-2]
NP_001289387.1. NM_001302458.1. [Q9QXV3-2]
NP_001289388.1. NM_001302459.1. [Q9QXV3-2]
NP_001289389.1. NM_001302460.1. [Q9QXV3-2]
NP_036049.2. NM_011919.5. [Q9QXV3-1]
UniGeneiMm.25709.

Genome annotation databases

EnsembliENSMUST00000054399; ENSMUSP00000062593; ENSMUSG00000045969. [Q9QXV3-1]
GeneIDi26356.
KEGGimmu:26356.
UCSCiuc009kvk.1. mouse. [Q9QXV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177753 Genomic DNA. Translation: AAF16911.1.
AF177755 mRNA. Translation: AAF16908.1.
AF177756 mRNA. Translation: AAF16909.1.
AF177757 mRNA. Translation: AAF16910.1.
AF149820 mRNA. Translation: AAF09183.1.
BC016573 mRNA. Translation: AAH16573.1.
BC147770 mRNA. Translation: AAI47771.1.
BC147784 mRNA. Translation: AAI47785.1.
CCDSiCCDS22097.1. [Q9QXV3-1]
RefSeqiNP_001289386.1. NM_001302457.1. [Q9QXV3-2]
NP_001289387.1. NM_001302458.1. [Q9QXV3-2]
NP_001289388.1. NM_001302459.1. [Q9QXV3-2]
NP_001289389.1. NM_001302460.1. [Q9QXV3-2]
NP_036049.2. NM_011919.5. [Q9QXV3-1]
UniGeneiMm.25709.

3D structure databases

ProteinModelPortaliQ9QXV3.
SMRiQ9QXV3. Positions 15-108, 209-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204916. 1 interaction.
STRINGi10090.ENSMUSP00000062593.

PTM databases

PhosphoSiteiQ9QXV3.

Proteomic databases

PRIDEiQ9QXV3.

Protocols and materials databases

DNASUi26356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054399; ENSMUSP00000062593; ENSMUSG00000045969. [Q9QXV3-1]
GeneIDi26356.
KEGGimmu:26356.
UCSCiuc009kvk.1. mouse. [Q9QXV3-1]

Organism-specific databases

CTDi3621.
MGIiMGI:1349481. Ing1.

Phylogenomic databases

eggNOGiCOG5034.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239724.
HOVERGENiHBG006607.
InParanoidiQ9QXV3.
OMAiFETCQET.
OrthoDBiEOG7RBZ9T.
PhylomeDBiQ9QXV3.
TreeFamiTF352014.

Miscellaneous databases

NextBioi304199.
PROiQ9QXV3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXV3.
CleanExiMM_ING1.
ExpressionAtlasiQ9QXV3. baseline and differential.
GenevestigatoriQ9QXV3.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamiPF12998. ING. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two PHD finger proteins that have opposite effects on p53 function."
    Zeremski M., Hill J.E., Kwek S.S.S., Grigorian I.A., Gurova K.V., Garkavtsev I.V., Diatchenko L., Koonin E.V., Gudkov A.V.
    J. Biol. Chem. 274:32172-32181(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/SvJ.
    Tissue: Brain, Embryonic fibroblast and Spleen.
  2. "Structural organization and expression pattern of the murine ING1 gene."
    Rancourt D., Garkavtsev I.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiING1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXV3
Secondary accession number(s): B2RWH0
, Q9QUP8, Q9QXV4, Q9QZX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.