Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9QXV3 (ING1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inhibitor of growth protein 1
Gene names
Name:Ing1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor. Ref.1

Subunit structure

Interacts with H3K4me3 and to a lesser extent with H3K4me2 By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

In the adult, widely expressed with highest levels in thymus and testis. Ref.1

Developmental stage

Expressed throughout the whole embryo at all stages of development examined. At day 10, highest expression is found in the yolk sac while at day 16 and 18, higher levels are found in inner compartments of bone. In the embryo, highest expression of isoform 1 is found at day 11 while highest expression of isoform 2 is found at day 7. Ref.1

Domain

The PHD-type zinc finger mediates the binding to H3K4me3 By similarity.

The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P) By similarity.

Sequence similarities

Belongs to the ING family.

Contains 1 PHD-type zinc finger.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QXV3-1)

Also known as: 1b; p37;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QXV3-2)

Also known as: 1a; 1c; p31;

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Inhibitor of growth protein 1
PRO_0000212662

Regions

Zinc finger210 – 25950PHD-type
Region262 – 27918PBR By similarity

Sites

Binding site2121Histone H3K4me3 By similarity
Binding site2231Histone H3K4me3 By similarity
Binding site2271Histone H3K4me3 By similarity
Binding site2351Histone H3K4me3 By similarity

Natural variations

Alternative sequence1 – 9494Missing in isoform 2.
VSP_050378

Experimental info

Sequence conflict2031L → F in AAF09183. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (1b) (p37) [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 6765C984EEF179F4

FASTA27932,109
        10         20         30         40         50         60 
MLSPANGEQI HLVNYVEDYL DSIESLPFDL QRNVSLMREI DAKYQEILKE LDDYYEKFKR 

        70         80         90        100        110        120 
ETDGTQKRRV LHCIQRALIR SQELGDEKIQ IVSQMVELVE NRSRQVDSHV ELFEAHQDIS 

       130        140        150        160        170        180 
DGTGGSGKAG QDKSKSEAIT QADKPNNKRS RRQRNNENRE NASNNHDHDD ITSGTPKEKK 

       190        200        210        220        230        240 
AKTSKKKKRS KAKAEREASP ADLPIDPNEP TYCLCNQVSY GEMIGCDNDE CPIEWFHFSC 

       250        260        270 
VGLNHKPKGK WYCPKCRGES EKTMDKALEK SKKERAYNR 

« Hide

Isoform 2 (1a) (1c) (p31) [UniParc].

Checksum: 3C855D1C6AB3EC3A
Show »

FASTA18520,968

References

« Hide 'large scale' references
[1]"Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two PHD finger proteins that have opposite effects on p53 function."
Zeremski M., Hill J.E., Kwek S.S.S., Grigorian I.A., Gurova K.V., Garkavtsev I.V., Diatchenko L., Koonin E.V., Gudkov A.V.
J. Biol. Chem. 274:32172-32181(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: 129/SvJ.
Tissue: Brain, Embryonic fibroblast and Spleen.
[2]"Structural organization and expression pattern of the murine ING1 gene."
Rancourt D., Garkavtsev I.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF177753 Genomic DNA. Translation: AAF16911.1.
AF177755 mRNA. Translation: AAF16908.1.
AF177756 mRNA. Translation: AAF16909.1.
AF177757 mRNA. Translation: AAF16910.1.
AF149820 mRNA. Translation: AAF09183.1.
BC016573 mRNA. Translation: AAH16573.1.
BC147770 mRNA. Translation: AAI47771.1.
BC147784 mRNA. Translation: AAI47785.1.
CCDSCCDS22097.1. [Q9QXV3-1]
RefSeqNP_036049.2. NM_011919.4. [Q9QXV3-1]
XP_006508865.1. XM_006508802.1. [Q9QXV3-2]
XP_006508866.1. XM_006508803.1. [Q9QXV3-2]
XP_006508867.1. XM_006508804.1. [Q9QXV3-2]
UniGeneMm.25709.

3D structure databases

ProteinModelPortalQ9QXV3.
SMRQ9QXV3. Positions 15-108, 209-259.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204916. 1 interaction.
STRING10090.ENSMUSP00000062593.

PTM databases

PhosphoSiteQ9QXV3.

Proteomic databases

PRIDEQ9QXV3.

Protocols and materials databases

DNASU26356.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054399; ENSMUSP00000062593; ENSMUSG00000045969. [Q9QXV3-1]
GeneID26356.
KEGGmmu:26356.
UCSCuc009kvk.1. mouse. [Q9QXV3-1]

Organism-specific databases

CTD3621.
MGIMGI:1349481. Ing1.

Phylogenomic databases

eggNOGCOG5034.
GeneTreeENSGT00550000074538.
HOGENOMHOG000239724.
HOVERGENHBG006607.
InParanoidB2RWH0.
OMAFETCQET.
OrthoDBEOG7RBZ9T.
PhylomeDBQ9QXV3.
TreeFamTF352014.

Gene expression databases

ArrayExpressQ9QXV3.
BgeeQ9QXV3.
CleanExMM_ING1.
GenevestigatorQ9QXV3.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamPF12998. ING. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304199.
PROQ9QXV3.
SOURCESearch...

Entry information

Entry nameING1_MOUSE
AccessionPrimary (citable) accession number: Q9QXV3
Secondary accession number(s): B2RWH0 expand/collapse secondary AC list , Q9QUP8, Q9QXV4, Q9QZX3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot