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Protein

Surfeit locus protein 1

Gene

Surf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 1
Gene namesi
Name:Surf1
Synonyms:Surf-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620527 Surf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 86HelicalSequence analysisAdd BLAST19
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156541 – 306Surfeit locus protein 1Add BLAST306

Proteomic databases

PaxDbiQ9QXU2
PRIDEiQ9QXU2

PTM databases

iPTMnetiQ9QXU2
PhosphoSitePlusiQ9QXU2

Expressioni

Gene expression databases

BgeeiENSRNOG00000005247
GenevisibleiQ9QXU2 RN

Interactioni

Subunit structurei

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, the core components of this complex being COA3/MITRAC12 and COX14. Interacts with COA3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006855

Family & Domainsi

Sequence similaritiesi

Belongs to the SURF1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDF7 Eukaryota
COG3346 LUCA
GeneTreeiENSGT00530000064194
HOGENOMiHOG000097776
HOVERGENiHBG058486
InParanoidiQ9QXU2
KOiK14998
OrthoDBiEOG091G0IWR

Family and domain databases

CDDicd06662 SURF1, 1 hit
InterProiView protein in InterPro
IPR002994 Surf1/Shy1
PfamiView protein in Pfam
PF02104 SURF1, 1 hit
PROSITEiView protein in PROSITE
PS50895 SURF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVMALTVL RSRITRWPQW ACAGPAPFCA VRRSVFGFSV RSGMVCRPHR
60 70 80 90 100
CCSSTAETAA AKAEDDSFLQ WFLLFIPATA FGLGTWQVQR RKWKLKLIAE
110 120 130 140 150
LESRVMAEPI PLPADPMELK NLEYRPVKVR GHFDHSKELY IMPRTMVDPV
160 170 180 190 200
REARDAGRLS STESGAYVVT PFHCSDLGVT ILVNRGFVPR KKVNPETRQQ
210 220 230 240 250
GQVLGEVDLV GIVRLTENRK PFVPENNPER SLWYYRDLDA MAKRTGTDPI
260 270 280 290 300
FIDADFNSTT PGGPIGGQTR VTLRNEHMQY IITWYGLCAA TSYLWFRKFV

RRTPGV
Length:306
Mass (Da):34,683
Last modified:May 1, 2000 - v1
Checksum:i2CB7E4F5B8A94850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182952 mRNA Translation: AAF19608.1
RefSeqiNP_742065.1, NM_172068.1
XP_006233790.1, XM_006233728.3
UniGeneiRn.74313

Genome annotation databases

EnsembliENSRNOT00000061242; ENSRNOP00000057954; ENSRNOG00000005247
GeneIDi100912008
64463
KEGGirno:100912008
rno:64463
UCSCiRGD:620527 rat

Similar proteinsi

Entry informationi

Entry nameiSURF1_RAT
AccessioniPrimary (citable) accession number: Q9QXU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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