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Protein

Interleukin-17B

Gene

Il17b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.By similarity

GO - Molecular functioni

  • cytokine activity Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17B
Short name:
IL-17B
Alternative name(s):
Cytokine CX1
Cytokine-like protein ZCYTO7
Neuronal interleukin-17-related factor
Gene namesi
Name:Il17b
Synonyms:Nirf, Zcyto7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1928397. Il17b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 180158Interleukin-17BPRO_0000015428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 176By similarity
Disulfide bondi126 ↔ 178By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9QXT6.
PaxDbiQ9QXT6.
PRIDEiQ9QXT6.

Expressioni

Gene expression databases

BgeeiQ9QXT6.
CleanExiMM_IL17B.
GenevisibleiQ9QXT6. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • receptor binding Source: MGI

Structurei

3D structure databases

ProteinModelPortaliQ9QXT6.
SMRiQ9QXT6. Positions 96-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXUM. Eukaryota.
ENOG410ZKTD. LUCA.
GeneTreeiENSGT00730000110983.
HOGENOMiHOG000113030.
HOVERGENiHBG052095.
InParanoidiQ9QXT6.
KOiK05490.
OMAiPEAQCLC.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ9QXT6.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWPHSLLFL LAISIFLAPS HPRNTKGKRK GQGRPSPLAP GPHQVPLDLV
60 70 80 90 100
SRVKPYARME EYERNLGEMV AQLRNSSEPA KKKCEVNLQL WLSNKRSLSP
110 120 130 140 150
WGYSINHDPS RIPADLPEAR CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR
160 170 180
RRLCPQPPRP GPCRQRVVME TIAVGCTCIF
Length:180
Mass (Da):20,309
Last modified:May 1, 2000 - v1
Checksum:iE26F4C72001997C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 77MDWPHSL → YPTSTFS (PubMed:16141072).Curated
Sequence conflicti33 – 331G → R (PubMed:16141072).Curated
Sequence conflicti34 – 341R → K in AAK37427 (Ref. 3) Curated
Sequence conflicti65 – 651N → T in AAK37427 (Ref. 3) Curated
Sequence conflicti76 – 761S → I (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184970 mRNA. Translation: AAF01319.1.
AF218726 mRNA. Translation: AAG44135.1.
AF250308 mRNA. Translation: AAK37427.1.
AK003506 mRNA. No translation available.
BC002271 mRNA. Translation: AAH02271.1.
CCDSiCCDS29286.1.
RefSeqiNP_062381.1. NM_019508.1.
UniGeneiMm.59313.

Genome annotation databases

EnsembliENSMUST00000025471; ENSMUSP00000025471; ENSMUSG00000024578.
GeneIDi56069.
KEGGimmu:56069.
UCSCiuc008fck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184970 mRNA. Translation: AAF01319.1.
AF218726 mRNA. Translation: AAG44135.1.
AF250308 mRNA. Translation: AAK37427.1.
AK003506 mRNA. No translation available.
BC002271 mRNA. Translation: AAH02271.1.
CCDSiCCDS29286.1.
RefSeqiNP_062381.1. NM_019508.1.
UniGeneiMm.59313.

3D structure databases

ProteinModelPortaliQ9QXT6.
SMRiQ9QXT6. Positions 96-179.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiQ9QXT6.
PaxDbiQ9QXT6.
PRIDEiQ9QXT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025471; ENSMUSP00000025471; ENSMUSG00000024578.
GeneIDi56069.
KEGGimmu:56069.
UCSCiuc008fck.1. mouse.

Organism-specific databases

CTDi27190.
MGIiMGI:1928397. Il17b.

Phylogenomic databases

eggNOGiENOG410IXUM. Eukaryota.
ENOG410ZKTD. LUCA.
GeneTreeiENSGT00730000110983.
HOGENOMiHOG000113030.
HOVERGENiHBG052095.
InParanoidiQ9QXT6.
KOiK05490.
OMAiPEAQCLC.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ9QXT6.
TreeFamiTF314701.

Miscellaneous databases

ChiTaRSiIl17b. mouse.
PROiQ9QXT6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXT6.
CleanExiMM_IL17B.
GenevisibleiQ9QXT6. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Presnell S., Gilbert T., Whitmore T., Foster D., Hart C., Lehner J., Martinez T., Hoffman R., O'Hara P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of a novel IL-17 related factor: demonstration of neuronal expression and evaluation as a candidate for the chromosome 5q-linked form of Charcot-Marie-Tooth disease."
    Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D., Yao L., Whitmore T.E., Gilbert T., Kuestner R.E.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Zhang W., Cao X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIL17B_MOUSE
AccessioniPrimary (citable) accession number: Q9QXT6
Secondary accession number(s): Q99MY3, Q9CTI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.