SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9QXT5

- EGFL7_MOUSE

UniProt

Q9QXT5 - EGFL7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Epidermal growth factor-like protein 7

Gene
Egfl7, Megf7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.2 Publications

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. Notch binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. blood vessel development Source: UniProtKB
  3. cell adhesion Source: UniProtKB-KW
  4. negative regulation of cell migration Source: MGI
  5. regulation of cell migration Source: UniProtKB
  6. vasculogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Cell adhesion, Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 7
Short name:
EGF-like protein 7
Alternative name(s):
Multiple epidermal growth factor-like domains protein 7
Short name:
Multiple EGF-like domains protein 7
NOTCH4-like protein
Vascular endothelial statin
Short name:
VE-statin
Zneu1
Gene namesi
Name:Egfl7
Synonyms:Megf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2449923. Egfl7.

Subcellular locationi

Secretedextracellular space 2 Publications

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 275254Epidermal growth factor-like protein 7PRO_0000007529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 90 By similarity
Disulfide bondi57 ↔ 63 By similarity
Disulfide bondi89 ↔ 103 By similarity
Disulfide bondi108 ↔ 118 By similarity
Disulfide bondi112 ↔ 124 By similarity
Disulfide bondi126 ↔ 135 By similarity
Disulfide bondi142 ↔ 153 By similarity
Disulfide bondi149 ↔ 162 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9QXT5.

PTM databases

PhosphoSiteiQ9QXT5.

Expressioni

Tissue specificityi

Expressed specifically by endothelial cells of the highly vascularized organs heart, lung and kidney.2 Publications

Developmental stagei

Expressed early during mouse embryogenesis in the yolk sac mesoderm and in the developing vascular system. At E7.5, it is expressed in the primitive blood islands where the first endothelial cells differentiate. At E10.5 and E13.5 expression is restricted to endothelial cells.2 Publications

Gene expression databases

BgeeiQ9QXT5.
CleanExiMM_EGFL7.
GenevestigatoriQ9QXT5.

Interactioni

Subunit structurei

Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility By similarity.

Protein-protein interaction databases

BioGridi237257. 4 interactions.
IntActiQ9QXT5. 5 interactions.
STRINGi10090.ENSMUSP00000099970.

Structurei

3D structure databases

ProteinModelPortaliQ9QXT5.
SMRiQ9QXT5. Positions 87-180.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10578EMIAdd
BLAST
Domaini104 – 13633EGF-like 1Add
BLAST
Domaini138 – 17841EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili196 – 22025 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1333Cell attachment site By similarity

Sequence similaritiesi

Contains 2 EGF-like domains.
Contains 1 EMI domain.

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG292943.
GeneTreeiENSGT00730000110993.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ9QXT5.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QXT5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWGSGELLVA WFLVLAADGT TEHVYRPSRR VCTVGISGGS ISETFVQRVY    50
QPYLTTCDGH RACSTYRTIY RTAYRRSPGV TPARPRYACC PGWKRTSGLP 100
GACGAAICQP PCGNGGSCIR PGHCRCPVGW QGDTCQTDVD ECSTGEASCP 150
QRCVNTVGSY WCQGWEGQSP SADGTRCLSK EGPSPVAPNP TAGVDSMARE 200
EVYRLQARVD VLEQKLQLVL APLHSLASRS TEHGLQDPGS LLAHSFQQLD 250
RIDSLSEQVS FLEEHLGSCS CKKDL 275
Length:275
Mass (Da):29,765
Last modified:January 4, 2005 - v2
Checksum:i54A888CB51CFAA13
GO
Isoform 2 (identifier: Q9QXT5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-269: Missing.

Note: No experimental confirmation available.

Show »
Length:262
Mass (Da):28,305
Checksum:i7AB272F68CB7D4A4
GO

Sequence cautioni

The sequence AAF01322.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAP74732.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB22222.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei257 – 26913Missing in isoform 2. VSP_011765Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY239289 mRNA. Translation: AAP69825.1.
AY239290 mRNA. Translation: AAP69826.1.
AY309459 mRNA. Translation: AAP74732.1. Different initiation.
AF184973 mRNA. Translation: AAF01322.1. Different initiation.
AK002601 mRNA. Translation: BAB22222.1. Different initiation.
BC024610 mRNA. Translation: AAH24610.2.
RefSeqiNP_001158036.1. NM_001164564.1.
NP_848538.3. NM_178444.4.
NP_942017.2. NM_198724.2.
NP_942018.2. NM_198725.2.
UniGeneiMm.268933.

Genome annotation databases

EnsembliENSMUST00000100290; ENSMUSP00000097863; ENSMUSG00000026921.
GeneIDi353156.
KEGGimmu:353156.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY239289 mRNA. Translation: AAP69825.1 .
AY239290 mRNA. Translation: AAP69826.1 .
AY309459 mRNA. Translation: AAP74732.1 . Different initiation.
AF184973 mRNA. Translation: AAF01322.1 . Different initiation.
AK002601 mRNA. Translation: BAB22222.1 . Different initiation.
BC024610 mRNA. Translation: AAH24610.2 .
RefSeqi NP_001158036.1. NM_001164564.1.
NP_848538.3. NM_178444.4.
NP_942017.2. NM_198724.2.
NP_942018.2. NM_198725.2.
UniGenei Mm.268933.

3D structure databases

ProteinModelPortali Q9QXT5.
SMRi Q9QXT5. Positions 87-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 237257. 4 interactions.
IntActi Q9QXT5. 5 interactions.
STRINGi 10090.ENSMUSP00000099970.

PTM databases

PhosphoSitei Q9QXT5.

Proteomic databases

PRIDEi Q9QXT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100290 ; ENSMUSP00000097863 ; ENSMUSG00000026921 .
GeneIDi 353156.
KEGGi mmu:353156.

Organism-specific databases

CTDi 51162.
MGIi MGI:2449923. Egfl7.

Phylogenomic databases

eggNOGi NOG292943.
GeneTreei ENSGT00730000110993.
HOGENOMi HOG000231494.
HOVERGENi HBG051453.
InParanoidi Q9QXT5.

Miscellaneous databases

NextBioi 400295.
PROi Q9QXT5.
SOURCEi Search...

Gene expression databases

Bgeei Q9QXT5.
CleanExi MM_EGFL7.
Genevestigatori Q9QXT5.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR011489. EMI_domain.
[Graphical view ]
Pfami PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "VE-statin, an endothelial repressor of smooth muscle cell migration."
    Soncin F., Mattot V., Lionneton F., Spruyt N., Lepretre F., Begue A., Stehelin D.
    EMBO J. 22:5700-5711(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: B6SJL.
  2. "Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells."
    Fitch M.J., Campagnolo L., Kuhnert F., Stuhlmann H.
    Dev. Dyn. 230:316-324(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
  3. Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Kidney.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver.
  6. "The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation."
    Parker L.H., Schmidt M., Jin S.-W., Gray A.M., Beis D., Pham T., Frantz G., Palmieri S., Hillan K., Stainier D.Y.R., De Sauvage F.J., Ye W.
    Nature 428:754-758(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiEGFL7_MOUSE
AccessioniPrimary (citable) accession number: Q9QXT5
Secondary accession number(s): Q6XD35, Q9DCP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi