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Protein

Protein canopy homolog 2

Gene

Cnpy2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity).By similarity

GO - Biological processi

  • negative regulation of gene expression Source: BHF-UCL
  • positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  • regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 2
Alternative name(s):
MIR-interacting saposin-like protein
Putative secreted protein ZSIG9
Transmembrane protein 4
Gene namesi
Name:Cnpy2
Synonyms:Msap, Tmem4, Zsig9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1928477. Cnpy2.

Subcellular locationi

  • Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 182162Protein canopy homolog 2PRO_0000031667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 171PROSITE-ProRule annotation
Disulfide bondi31 ↔ 164PROSITE-ProRule annotation
Disulfide bondi86 ↔ 137PROSITE-ProRule annotation
Modified residuei115 – 1151Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9QXT0.
PaxDbiQ9QXT0.
PRIDEiQ9QXT0.

2D gel databases

REPRODUCTION-2DPAGEIPI00135512.

PTM databases

PhosphoSiteiQ9QXT0.

Expressioni

Gene expression databases

BgeeiQ9QXT0.
CleanExiMM_CNPY2.
GenevestigatoriQ9QXT0.

Interactioni

Subunit structurei

Interacts with MYLIP/MIR.By similarity

Protein-protein interaction databases

BioGridi208040. 1 interaction.
IntActiQ9QXT0. 5 interactions.
MINTiMINT-1864121.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 175152Saposin B-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi179 – 1824Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the canopy family.Curated
Contains 1 saposin B-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280279.
GeneTreeiENSGT00390000009749.
HOGENOMiHOG000233996.
HOVERGENiHBG052514.
InParanoidiQ9QXT0.
OMAiTTWARRS.
OrthoDBiEOG7XDBHB.
PhylomeDBiQ9QXT0.
TreeFamiTF318578.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR008139. SaposinB.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGWGWLALL LGVLLGTAWA RRSQDLHCGA CRALVDELEW EIARVDPKKT
60 70 80 90 100
IQMGSFRINP DGSQSVVEVP YARSEAHLTE LLEEVCDRMK EYGEQIDPST
110 120 130 140 150
HRKNYVRVVS RNGESSELDL QGIRIDSDIS GTLKFACESI VEEYEDELIE
160 170 180
FFSREADNVK DKLCSKRTDL CDHALHRSHD EL
Length:182
Mass (Da):20,767
Last modified:May 1, 2000 - v1
Checksum:i83E54E7F01EE9B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186115 mRNA. Translation: AAF01433.1.
AK007914 mRNA. Translation: BAB25346.1.
AK013014 mRNA. Translation: BAB28597.1.
AK013568 mRNA. Translation: BAB28909.1.
AK019927 mRNA. Translation: BAB31921.1.
AK150953 mRNA. Translation: BAE29986.1.
BC008261 mRNA. Translation: AAH08261.1.
CCDSiCCDS24272.1.
RefSeqiNP_064337.1. NM_019953.1.
XP_006513965.1. XM_006513902.2.
UniGeneiMm.44220.

Genome annotation databases

EnsembliENSMUST00000026446; ENSMUSP00000026446; ENSMUSG00000025381.
GeneIDi56530.
KEGGimmu:56530.
UCSCiuc007hmi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186115 mRNA. Translation: AAF01433.1.
AK007914 mRNA. Translation: BAB25346.1.
AK013014 mRNA. Translation: BAB28597.1.
AK013568 mRNA. Translation: BAB28909.1.
AK019927 mRNA. Translation: BAB31921.1.
AK150953 mRNA. Translation: BAE29986.1.
BC008261 mRNA. Translation: AAH08261.1.
CCDSiCCDS24272.1.
RefSeqiNP_064337.1. NM_019953.1.
XP_006513965.1. XM_006513902.2.
UniGeneiMm.44220.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208040. 1 interaction.
IntActiQ9QXT0. 5 interactions.
MINTiMINT-1864121.

PTM databases

PhosphoSiteiQ9QXT0.

2D gel databases

REPRODUCTION-2DPAGEIPI00135512.

Proteomic databases

MaxQBiQ9QXT0.
PaxDbiQ9QXT0.
PRIDEiQ9QXT0.

Protocols and materials databases

DNASUi56530.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026446; ENSMUSP00000026446; ENSMUSG00000025381.
GeneIDi56530.
KEGGimmu:56530.
UCSCiuc007hmi.1. mouse.

Organism-specific databases

CTDi10330.
MGIiMGI:1928477. Cnpy2.

Phylogenomic databases

eggNOGiNOG280279.
GeneTreeiENSGT00390000009749.
HOGENOMiHOG000233996.
HOVERGENiHBG052514.
InParanoidiQ9QXT0.
OMAiTTWARRS.
OrthoDBiEOG7XDBHB.
PhylomeDBiQ9QXT0.
TreeFamiTF318578.

Miscellaneous databases

NextBioi312878.
PROiQ9QXT0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXT0.
CleanExiMM_CNPY2.
GenevestigatoriQ9QXT0.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR008139. SaposinB.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus putative secreted protein."
    Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Hippocampus, Pancreas and Pituitary.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCNPY2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXT0
Secondary accession number(s): Q3UBH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.