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Q9QXT0

- CNPY2_MOUSE

UniProt

Q9QXT0 - CNPY2_MOUSE

Protein

Protein canopy homolog 2

Gene

Cnpy2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation By similarity.By similarity

    GO - Biological processi

    1. negative regulation of gene expression Source: BHF-UCL
    2. positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
    3. regulation of low-density lipoprotein particle clearance Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein canopy homolog 2
    Alternative name(s):
    MIR-interacting saposin-like protein
    Putative secreted protein ZSIG9
    Transmembrane protein 4
    Gene namesi
    Name:Cnpy2
    Synonyms:Msap, Tmem4, Zsig9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1928477. Cnpy2.

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 182162Protein canopy homolog 2PRO_0000031667Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 171PROSITE-ProRule annotation
    Disulfide bondi31 ↔ 164PROSITE-ProRule annotation
    Disulfide bondi86 ↔ 137PROSITE-ProRule annotation
    Modified residuei115 – 1151Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QXT0.
    PaxDbiQ9QXT0.
    PRIDEiQ9QXT0.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00135512.

    PTM databases

    PhosphoSiteiQ9QXT0.

    Expressioni

    Gene expression databases

    BgeeiQ9QXT0.
    CleanExiMM_CNPY2.
    GenevestigatoriQ9QXT0.

    Interactioni

    Subunit structurei

    Interacts with MYLIP/MIR.By similarity

    Protein-protein interaction databases

    BioGridi208040. 1 interaction.
    IntActiQ9QXT0. 5 interactions.
    MINTiMINT-1864121.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 175152Saposin B-typePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi179 – 1824Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the canopy family.Curated
    Contains 1 saposin B-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280279.
    GeneTreeiENSGT00390000009749.
    HOGENOMiHOG000233996.
    HOVERGENiHBG052514.
    InParanoidiQ9QXT0.
    OMAiTTWARRS.
    OrthoDBiEOG7XDBHB.
    PhylomeDBiQ9QXT0.
    TreeFamiTF318578.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    IPR008139. SaposinB.
    [Graphical view]
    PfamiPF11938. DUF3456. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50015. SAP_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QXT0-1 [UniParc]FASTAAdd to Basket

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    MKGWGWLALL LGVLLGTAWA RRSQDLHCGA CRALVDELEW EIARVDPKKT    50
    IQMGSFRINP DGSQSVVEVP YARSEAHLTE LLEEVCDRMK EYGEQIDPST 100
    HRKNYVRVVS RNGESSELDL QGIRIDSDIS GTLKFACESI VEEYEDELIE 150
    FFSREADNVK DKLCSKRTDL CDHALHRSHD EL 182
    Length:182
    Mass (Da):20,767
    Last modified:May 1, 2000 - v1
    Checksum:i83E54E7F01EE9B87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186115 mRNA. Translation: AAF01433.1.
    AK007914 mRNA. Translation: BAB25346.1.
    AK013014 mRNA. Translation: BAB28597.1.
    AK013568 mRNA. Translation: BAB28909.1.
    AK019927 mRNA. Translation: BAB31921.1.
    AK150953 mRNA. Translation: BAE29986.1.
    BC008261 mRNA. Translation: AAH08261.1.
    CCDSiCCDS24272.1.
    RefSeqiNP_064337.1. NM_019953.1.
    XP_006513965.1. XM_006513902.1.
    UniGeneiMm.44220.

    Genome annotation databases

    EnsembliENSMUST00000026446; ENSMUSP00000026446; ENSMUSG00000025381.
    GeneIDi56530.
    KEGGimmu:56530.
    UCSCiuc007hmi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186115 mRNA. Translation: AAF01433.1 .
    AK007914 mRNA. Translation: BAB25346.1 .
    AK013014 mRNA. Translation: BAB28597.1 .
    AK013568 mRNA. Translation: BAB28909.1 .
    AK019927 mRNA. Translation: BAB31921.1 .
    AK150953 mRNA. Translation: BAE29986.1 .
    BC008261 mRNA. Translation: AAH08261.1 .
    CCDSi CCDS24272.1.
    RefSeqi NP_064337.1. NM_019953.1.
    XP_006513965.1. XM_006513902.1.
    UniGenei Mm.44220.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208040. 1 interaction.
    IntActi Q9QXT0. 5 interactions.
    MINTi MINT-1864121.

    PTM databases

    PhosphoSitei Q9QXT0.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00135512.

    Proteomic databases

    MaxQBi Q9QXT0.
    PaxDbi Q9QXT0.
    PRIDEi Q9QXT0.

    Protocols and materials databases

    DNASUi 56530.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026446 ; ENSMUSP00000026446 ; ENSMUSG00000025381 .
    GeneIDi 56530.
    KEGGi mmu:56530.
    UCSCi uc007hmi.1. mouse.

    Organism-specific databases

    CTDi 10330.
    MGIi MGI:1928477. Cnpy2.

    Phylogenomic databases

    eggNOGi NOG280279.
    GeneTreei ENSGT00390000009749.
    HOGENOMi HOG000233996.
    HOVERGENi HBG052514.
    InParanoidi Q9QXT0.
    OMAi TTWARRS.
    OrthoDBi EOG7XDBHB.
    PhylomeDBi Q9QXT0.
    TreeFami TF318578.

    Miscellaneous databases

    NextBioi 312878.
    PROi Q9QXT0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QXT0.
    CleanExi MM_CNPY2.
    Genevestigatori Q9QXT0.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    IPR008139. SaposinB.
    [Graphical view ]
    Pfami PF11938. DUF3456. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50015. SAP_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mus musculus putative secreted protein."
      Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Hippocampus, Pancreas and Pituitary.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary tumor.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCNPY2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXT0
    Secondary accession number(s): Q3UBH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3