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Q9QXT0 (CNPY2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein canopy homolog 2
Alternative name(s):
MIR-interacting saposin-like protein
Putative secreted protein ZSIG9
Transmembrane protein 4
Gene names
Name:Cnpy2
Synonyms:Msap, Tmem4, Zsig9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation By similarity.

Subunit structure

Interacts with MYLIP/MIR By similarity.

Subcellular location

Endoplasmic reticulum Potential.

Sequence similarities

Belongs to the canopy family.

Contains 1 saposin B-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 182162Protein canopy homolog 2
PRO_0000031667

Regions

Domain24 – 175152Saposin B-type
Motif179 – 1824Prevents secretion from ER Potential

Amino acid modifications

Modified residue1151Phosphoserine Ref.4
Disulfide bond28 ↔ 171 By similarity
Disulfide bond31 ↔ 164 By similarity
Disulfide bond86 ↔ 137 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QXT0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 83E54E7F01EE9B87

FASTA18220,767
        10         20         30         40         50         60 
MKGWGWLALL LGVLLGTAWA RRSQDLHCGA CRALVDELEW EIARVDPKKT IQMGSFRINP 

        70         80         90        100        110        120 
DGSQSVVEVP YARSEAHLTE LLEEVCDRMK EYGEQIDPST HRKNYVRVVS RNGESSELDL 

       130        140        150        160        170        180 
QGIRIDSDIS GTLKFACESI VEEYEDELIE FFSREADNVK DKLCSKRTDL CDHALHRSHD 


EL 

« Hide

References

« Hide 'large scale' references
[1]"Mus musculus putative secreted protein."
Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Hippocampus, Pancreas and Pituitary.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary tumor.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF186115 mRNA. Translation: AAF01433.1.
AK007914 mRNA. Translation: BAB25346.1.
AK013014 mRNA. Translation: BAB28597.1.
AK013568 mRNA. Translation: BAB28909.1.
AK019927 mRNA. Translation: BAB31921.1.
AK150953 mRNA. Translation: BAE29986.1.
BC008261 mRNA. Translation: AAH08261.1.
CCDSCCDS24272.1.
RefSeqNP_064337.1. NM_019953.1.
XP_006513965.1. XM_006513902.1.
UniGeneMm.44220.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208040. 1 interaction.
IntActQ9QXT0. 5 interactions.
MINTMINT-1864121.

PTM databases

PhosphoSiteQ9QXT0.

2D gel databases

REPRODUCTION-2DPAGEIPI00135512.

Proteomic databases

MaxQBQ9QXT0.
PaxDbQ9QXT0.
PRIDEQ9QXT0.

Protocols and materials databases

DNASU56530.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026446; ENSMUSP00000026446; ENSMUSG00000025381.
GeneID56530.
KEGGmmu:56530.
UCSCuc007hmi.1. mouse.

Organism-specific databases

CTD10330.
MGIMGI:1928477. Cnpy2.

Phylogenomic databases

eggNOGNOG280279.
GeneTreeENSGT00390000009749.
HOGENOMHOG000233996.
HOVERGENHBG052514.
InParanoidQ9QXT0.
OMATTWARRS.
OrthoDBEOG7XDBHB.
PhylomeDBQ9QXT0.
TreeFamTF318578.

Gene expression databases

BgeeQ9QXT0.
CleanExMM_CNPY2.
GenevestigatorQ9QXT0.

Family and domain databases

InterProIPR021852. DUF3456.
IPR008139. SaposinB.
[Graphical view]
PfamPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
PS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312878.
PROQ9QXT0.
SOURCESearch...

Entry information

Entry nameCNPY2_MOUSE
AccessionPrimary (citable) accession number: Q9QXT0
Secondary accession number(s): Q3UBH8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot