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Q9QXT0

- CNPY2_MOUSE

UniProt

Q9QXT0 - CNPY2_MOUSE

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Protein
Protein canopy homolog 2
Gene
Cnpy2, Msap, Tmem4, Zsig9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation By similarity.

GO - Biological processi

  1. negative regulation of gene expression Source: BHF-UCL
  2. positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  3. regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 2
Alternative name(s):
MIR-interacting saposin-like protein
Putative secreted protein ZSIG9
Transmembrane protein 4
Gene namesi
Name:Cnpy2
Synonyms:Msap, Tmem4, Zsig9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1928477. Cnpy2.

Subcellular locationi

Endoplasmic reticulum Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 182162Protein canopy homolog 2
PRO_0000031667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 171 By similarity
Disulfide bondi31 ↔ 164 By similarity
Disulfide bondi86 ↔ 137 By similarity
Modified residuei115 – 1151Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ9QXT0.
PaxDbiQ9QXT0.
PRIDEiQ9QXT0.

2D gel databases

REPRODUCTION-2DPAGEIPI00135512.

PTM databases

PhosphoSiteiQ9QXT0.

Expressioni

Gene expression databases

BgeeiQ9QXT0.
CleanExiMM_CNPY2.
GenevestigatoriQ9QXT0.

Interactioni

Subunit structurei

Interacts with MYLIP/MIR By similarity.

Protein-protein interaction databases

BioGridi208040. 1 interaction.
IntActiQ9QXT0. 5 interactions.
MINTiMINT-1864121.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 175152Saposin B-type
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi179 – 1824Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the canopy family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280279.
GeneTreeiENSGT00390000009749.
HOGENOMiHOG000233996.
HOVERGENiHBG052514.
InParanoidiQ9QXT0.
OMAiTTWARRS.
OrthoDBiEOG7XDBHB.
PhylomeDBiQ9QXT0.
TreeFamiTF318578.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR008139. SaposinB.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXT0-1 [UniParc]FASTAAdd to Basket

« Hide

MKGWGWLALL LGVLLGTAWA RRSQDLHCGA CRALVDELEW EIARVDPKKT    50
IQMGSFRINP DGSQSVVEVP YARSEAHLTE LLEEVCDRMK EYGEQIDPST 100
HRKNYVRVVS RNGESSELDL QGIRIDSDIS GTLKFACESI VEEYEDELIE 150
FFSREADNVK DKLCSKRTDL CDHALHRSHD EL 182
Length:182
Mass (Da):20,767
Last modified:May 1, 2000 - v1
Checksum:i83E54E7F01EE9B87
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186115 mRNA. Translation: AAF01433.1.
AK007914 mRNA. Translation: BAB25346.1.
AK013014 mRNA. Translation: BAB28597.1.
AK013568 mRNA. Translation: BAB28909.1.
AK019927 mRNA. Translation: BAB31921.1.
AK150953 mRNA. Translation: BAE29986.1.
BC008261 mRNA. Translation: AAH08261.1.
CCDSiCCDS24272.1.
RefSeqiNP_064337.1. NM_019953.1.
XP_006513965.1. XM_006513902.1.
UniGeneiMm.44220.

Genome annotation databases

EnsembliENSMUST00000026446; ENSMUSP00000026446; ENSMUSG00000025381.
GeneIDi56530.
KEGGimmu:56530.
UCSCiuc007hmi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186115 mRNA. Translation: AAF01433.1 .
AK007914 mRNA. Translation: BAB25346.1 .
AK013014 mRNA. Translation: BAB28597.1 .
AK013568 mRNA. Translation: BAB28909.1 .
AK019927 mRNA. Translation: BAB31921.1 .
AK150953 mRNA. Translation: BAE29986.1 .
BC008261 mRNA. Translation: AAH08261.1 .
CCDSi CCDS24272.1.
RefSeqi NP_064337.1. NM_019953.1.
XP_006513965.1. XM_006513902.1.
UniGenei Mm.44220.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 208040. 1 interaction.
IntActi Q9QXT0. 5 interactions.
MINTi MINT-1864121.

PTM databases

PhosphoSitei Q9QXT0.

2D gel databases

REPRODUCTION-2DPAGE IPI00135512.

Proteomic databases

MaxQBi Q9QXT0.
PaxDbi Q9QXT0.
PRIDEi Q9QXT0.

Protocols and materials databases

DNASUi 56530.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026446 ; ENSMUSP00000026446 ; ENSMUSG00000025381 .
GeneIDi 56530.
KEGGi mmu:56530.
UCSCi uc007hmi.1. mouse.

Organism-specific databases

CTDi 10330.
MGIi MGI:1928477. Cnpy2.

Phylogenomic databases

eggNOGi NOG280279.
GeneTreei ENSGT00390000009749.
HOGENOMi HOG000233996.
HOVERGENi HBG052514.
InParanoidi Q9QXT0.
OMAi TTWARRS.
OrthoDBi EOG7XDBHB.
PhylomeDBi Q9QXT0.
TreeFami TF318578.

Miscellaneous databases

NextBioi 312878.
PROi Q9QXT0.
SOURCEi Search...

Gene expression databases

Bgeei Q9QXT0.
CleanExi MM_CNPY2.
Genevestigatori Q9QXT0.

Family and domain databases

InterProi IPR021852. DUF3456.
IPR008139. SaposinB.
[Graphical view ]
Pfami PF11938. DUF3456. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50015. SAP_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus putative secreted protein."
    Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Hippocampus, Pancreas and Pituitary.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCNPY2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXT0
Secondary accession number(s): Q3UBH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi