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Protein

Drebrin

Gene

Dbn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: MGI
  • cell communication by chemical coupling Source: MGI
  • cell communication by electrical coupling Source: MGI
  • generation of neurons Source: DFLAT
  • maintenance of protein location in cell Source: MGI
  • neural precursor cell proliferation Source: DFLAT
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Drebrin
Alternative name(s):
Developmentally-regulated brain protein
Gene namesi
Name:Dbn1
Synonyms:Drba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1931838. Dbn1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcell cortex By similarity
  • Cell junction By similarity
  • Cell projection 1 Publication
  • Cell projectiongrowth cone 1 Publication

  • Note: In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (By similarity). Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone (PubMed:24720729).By similarity1 Publication

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cell cortex Source: UniProtKB-SubCell
  • gap junction Source: MGI
  • growth cone Source: UniProtKB
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 706705DrebrinPRO_0000080009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei141 – 1411PhosphoserineBy similarity
Modified residuei142 – 1421PhosphoserineBy similarity
Modified residuei241 – 2411PhosphoserineCombined sources
Modified residuei344 – 3441PhosphoserineBy similarity
Modified residuei379 – 3791PhosphothreonineBy similarity
Modified residuei383 – 3831PhosphothreonineCombined sources
Modified residuei385 – 3851PhosphoserineCombined sources
Modified residuei387 – 3871PhosphoserineBy similarity
Modified residuei393 – 3931PhosphoserineCombined sources
Modified residuei394 – 3941PhosphothreonineCombined sources
Modified residuei468 – 4681PhosphoserineBy similarity
Modified residuei550 – 5501PhosphothreonineBy similarity
Modified residuei658 – 6581PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QXS6.
PaxDbiQ9QXS6.
PeptideAtlasiQ9QXS6.
PRIDEiQ9QXS6.

PTM databases

iPTMnetiQ9QXS6.
PhosphoSiteiQ9QXS6.
SwissPalmiQ9QXS6.

Expressioni

Tissue specificityi

Highly expressed in brain. Also present in stomach and to a lesser degree in kidney, colon, and urinary bladder. The E2 isoform is specifically expressed in adult stomach, kidney, and cultured cells.

Gene expression databases

BgeeiENSMUSG00000034675.
CleanExiMM_DBN1.
ExpressionAtlasiQ9QXS6. baseline and differential.
GenevisibleiQ9QXS6. MM.

Interactioni

Subunit structurei

Interacts with RUFY3 (PubMed:24720729). Binds F-actin. Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207900. 3 interactions.
IntActiQ9QXS6. 7 interactions.
MINTiMINT-4093601.
STRINGi10090.ENSMUSP00000021950.

Structurei

3D structure databases

ProteinModelPortaliQ9QXS6.
SMRiQ9QXS6. Positions 13-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 134132ADF-HPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IP00. Eukaryota.
ENOG410YAV7. LUCA.
GeneTreeiENSGT00530000062953.
HOGENOMiHOG000015304.
HOVERGENiHBG000823.
InParanoidiQ9QXS6.
OMAiCSHLDSH.
OrthoDBiEOG091G05KP.
PhylomeDBiQ9QXS6.
TreeFamiTF318935.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028438. Drebrin.
[Graphical view]
PANTHERiPTHR10829:SF1. PTHR10829:SF1. 2 hits.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform A (identifier: Q9QXS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG
60 70 80 90 100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS
110 120 130 140 150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL
160 170 180 190 200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL
210 220 230 240 250
DARLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ SLEAEEAKRR
260 270 280 290 300
LKEQSIFGDQ RDEEEESQMK KSESEVEEAA AIIAQRPDNP REFFRQQERV
310 320 330 340 350
ASASGGSCDA PAPAPFNHRP GRPYCPFIKA SDSGPSSSSS SSSSPPRTPF
360 370 380 390 400
PYITCHRTPN LSSSLPCSHL DSHRRMAPTP IPTRSPSDSS TASTPIAEQI
410 420 430 440 450
ERALDEVTSS QPPPPPPPPP PTQEAQETTP SLDEELSKEA KVTAAPEVWA
460 470 480 490 500
GCAAEPPQAQ EPPLLQSSPL EDSMCTESPE QAALAAPAEP AASVTSVADV
510 520 530 540 550
HAADTIETTT ATTDTTIANN VTPAAASLID LWPGNGEEAS TLQAEPRVPT
560 570 580 590 600
PPSGAEASLA EVPLLNEAAQ EPLPPVGEGC ANLLNFDELP EPPATFCDPE
610 620 630 640 650
EEVGETLAAS QVLTMPSALE EVDQVLEQEL EPEPHLLTNG ETTQKEGTQA
660 670 680 690 700
SEGYFSQSQE EEFAQSEEPC AKVPPPVFYN KPPEIDITCW DADPVPEEEE

GFEGGD
Length:706
Mass (Da):77,287
Last modified:January 23, 2007 - v4
Checksum:i39E542D2BB859346
GO
Isoform A2 (identifier: Q9QXS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-368: S → R
     369-706: Missing.

Show »
Length:368
Mass (Da):41,718
Checksum:i585010710EA49488
GO
Isoform E2 (identifier: Q9QXS6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-367: Missing.

Show »
Length:660
Mass (Da):72,416
Checksum:i95375DD52994C689
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791K → T in AAF25189 (PubMed:10633083).Curated
Sequence conflicti79 – 791K → T in AAF25190 (PubMed:10633083).Curated
Sequence conflicti79 – 791K → T in BAB86904 (PubMed:11991718).Curated
Sequence conflicti649 – 6491Q → QQ in BAE20965 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei322 – 36746Missing in isoform E2. 3 PublicationsVSP_004198Add
BLAST
Alternative sequencei368 – 3681S → R in isoform A2. 1 PublicationVSP_004199
Alternative sequencei369 – 706338Missing in isoform A2. 1 PublicationVSP_004200Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187147 mRNA. Translation: AAF25189.1.
AF187148 mRNA. Translation: AAF25190.1.
AB064321 mRNA. Translation: BAB86904.1.
AK132060 mRNA. Translation: BAE20965.1.
CT009762 Genomic DNA. Translation: CAM17636.1.
BC006714 mRNA. Translation: AAH06714.1.
AB028740 Genomic DNA. Translation: BAB87811.1.
CCDSiCCDS36677.1. [Q9QXS6-3]
CCDS49274.1. [Q9QXS6-1]
RefSeqiNP_001170842.1. NM_001177371.1. [Q9QXS6-1]
NP_001170843.1. NM_001177372.1.
NP_062787.2. NM_019813.4. [Q9QXS6-3]
UniGeneiMm.19016.

Genome annotation databases

EnsembliENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675. [Q9QXS6-1]
ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675. [Q9QXS6-3]
GeneIDi56320.
KEGGimmu:56320.
UCSCiuc007qrc.2. mouse. [Q9QXS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187147 mRNA. Translation: AAF25189.1.
AF187148 mRNA. Translation: AAF25190.1.
AB064321 mRNA. Translation: BAB86904.1.
AK132060 mRNA. Translation: BAE20965.1.
CT009762 Genomic DNA. Translation: CAM17636.1.
BC006714 mRNA. Translation: AAH06714.1.
AB028740 Genomic DNA. Translation: BAB87811.1.
CCDSiCCDS36677.1. [Q9QXS6-3]
CCDS49274.1. [Q9QXS6-1]
RefSeqiNP_001170842.1. NM_001177371.1. [Q9QXS6-1]
NP_001170843.1. NM_001177372.1.
NP_062787.2. NM_019813.4. [Q9QXS6-3]
UniGeneiMm.19016.

3D structure databases

ProteinModelPortaliQ9QXS6.
SMRiQ9QXS6. Positions 13-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207900. 3 interactions.
IntActiQ9QXS6. 7 interactions.
MINTiMINT-4093601.
STRINGi10090.ENSMUSP00000021950.

PTM databases

iPTMnetiQ9QXS6.
PhosphoSiteiQ9QXS6.
SwissPalmiQ9QXS6.

Proteomic databases

MaxQBiQ9QXS6.
PaxDbiQ9QXS6.
PeptideAtlasiQ9QXS6.
PRIDEiQ9QXS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021950; ENSMUSP00000021950; ENSMUSG00000034675. [Q9QXS6-1]
ENSMUST00000109923; ENSMUSP00000105549; ENSMUSG00000034675. [Q9QXS6-3]
GeneIDi56320.
KEGGimmu:56320.
UCSCiuc007qrc.2. mouse. [Q9QXS6-1]

Organism-specific databases

CTDi1627.
MGIiMGI:1931838. Dbn1.

Phylogenomic databases

eggNOGiENOG410IP00. Eukaryota.
ENOG410YAV7. LUCA.
GeneTreeiENSGT00530000062953.
HOGENOMiHOG000015304.
HOVERGENiHBG000823.
InParanoidiQ9QXS6.
OMAiCSHLDSH.
OrthoDBiEOG091G05KP.
PhylomeDBiQ9QXS6.
TreeFamiTF318935.

Miscellaneous databases

ChiTaRSiDbn1. mouse.
PROiQ9QXS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034675.
CleanExiMM_DBN1.
ExpressionAtlasiQ9QXS6. baseline and differential.
GenevisibleiQ9QXS6. MM.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028438. Drebrin.
[Graphical view]
PANTHERiPTHR10829:SF1. PTHR10829:SF1. 2 hits.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDREB_MOUSE
AccessioniPrimary (citable) accession number: Q9QXS6
Secondary accession number(s): A2CG16
, Q3V234, Q922X1, Q9QXS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 132 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.