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Q9QXS1 (PLEC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plectin
Short name=PCN
Short name=PLTN
Alternative name(s):
Plectin-1
Plectin-6
Gene names
Name:Plec
Synonyms:Plec1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length4691 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.

Subunit structure

Homodimer or homotetramer By similarity. Interacts (via actin-binding domain) with SYNE3. Interacts (via CH 1 domain) with VIM (via rod region). Interacts (via N-terminus) with DST isoform 2 (via N-terminus). Interacts with FER. Ref.5 Ref.6 Ref.15 Ref.16

Subcellular location

Cytoplasm › cytoskeleton. Cell junction › hemidesmosome By similarity.

Tissue specificity

Expressed at high levels in lung, brain, small intestine, muscle, heart and skin with lower levels found in kidney, liver, uterus, spleen and salivary gland. Ref.2

Domain

The N-terminus interacts with actin, the C-terminus with vimentin, desmin, GFAP, cytokeratins, lamin B; whereas both the N- and the C-terminus can bind integrin beta-4.

Post-translational modification

Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis. Isoform PLEC-1A is phosphorylated on Ser-21 By similarity. Isoform PLEC-1A is phosphorylated on Tyr-26.

Sequence similarities

Belongs to the plakin or cytolinker family.

Contains 1 actin-binding domain.

Contains 2 CH (calponin-homology) domains.

Contains 33 plectin repeats.

Contains 4 spectrin repeats.

Alternative products

This entry describes 16 isoforms produced by alternative splicing. [Align] [Select]
Isoform PLEC-1,2A (identifier: Q9QXS1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PLEC-1 (identifier: Q9QXS1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     202-206: Missing.
Isoform PLEC-1A (identifier: Q9QXS1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MVAGMLMPLDRLRAIYEVLFREGVMVAKKDRRPRSLH → MSQHRLRVPEPEGLGSKRTSSEDNLYLAVLRASEGKK
     38-180: Missing.
     202-206: Missing.
Note: Contains a phosphoserine at position 21 (By similarity). Contains a phosphotyrosine at position 26.
Isoform PLEC-1B,2A (identifier: Q9QXS1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MVAGMLMPLDRLRAIYEVLFREGVMVAKKDRRPRSLH → MEPSGSLFPSLVVVGHVVTLAAVWHWRKGHRQAKDEQ
     38-180: Missing.
Isoform PLEC-1B (identifier: Q9QXS1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MVAGMLMPLDRLRAIYEVLFREGVMVAKKDRRPRSLH → MEPSGSLFPSLVVVGHVVTLAAVWHWRKGHRQAKDEQ
     38-180: Missing.
     202-206: Missing.
Isoform PLEC-0,1C (identifier: Q9QXS1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MVAGMLMPLD...ARGLVRETFA → MSGEDSEVRP...PAERAVIRIA
     67-180: Missing.
     202-206: Missing.
Isoform PLEC-0,1C,2A (identifier: Q9QXS1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MVAGMLMPLD...ARGLVRETFA → MSGEDSEVRP...PAERAVIRIA
     67-180: Missing.
Isoform PLEC-0,1C,2A,3A (identifier: Q9QXS1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MVAGMLMPLD...ARGLVRETFA → MSGEDSEVRP...PAERAVIRIA
     67-180: Missing.
     239-239: E → ERDVIRSVRLPRE
Isoform PLEC-1D,2A (identifier: Q9QXS1-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MVAGM → MKIVP
     6-180: Missing.
Isoform PLEC-1D (identifier: Q9QXS1-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MVAGM → MKIVP
     6-180: Missing.
     202-206: Missing.
Isoform PLEC-1E,2A (identifier: Q9QXS1-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MVAGMLMPLDRLRAI → MDPSRAIQHEISSLK
     16-180: Missing.
Isoform PLEC-1E (identifier: Q9QXS1-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MVAGMLMPLDRLRAI → MDPSRAIQHEISSLK
     16-180: Missing.
     202-206: Missing.
Isoform PLEC-1F (identifier: Q9QXS1-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MVAGMLMPLDRLRAIYEVLFREGVMVAK → MAHLLTSGPPPDEQDFIQAYEEVREKYK
     29-180: Missing.
     202-206: Missing.
Isoform PLEC-1G (identifier: Q9QXS1-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: MVAGMLMPLD...SLHPHVPGVT → MAGTWAAKGV...GYLYGQLCCV
     45-180: Missing.
     202-206: Missing.
Isoform PLEC-1H (identifier: Q9QXS1-15)

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.
Isoform PLEC-1I (identifier: Q9QXS1-16)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MVAGMLMPLDRLRAIYEVLFREGVMVAKKDRRP → MNETVCRRKLSPSGSTNTLSRLRGTSVTCTKTS
     34-180: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 46914691Plectin
PRO_0000078136

Regions

Domain181 – 411231Actin-binding
Domain185 – 293109CH 1
Domain306 – 408103CH 2
Repeat653 – 72775Spectrin 1
Repeat748 – 83285Spectrin 2
Repeat845 – 93894Spectrin 3
Repeat1323 – 1423101Spectrin 4
Repeat2795 – 283238Plectin 1
Repeat2833 – 287038Plectin 2
Repeat2871 – 290838Plectin 3
Repeat2909 – 294638Plectin 4
Repeat2947 – 298438Plectin 5
Repeat2988 – 302235Plectin 6
Repeat3123 – 316038Plectin 7
Repeat3161 – 319838Plectin 8
Repeat3199 – 323638Plectin 9
Repeat3237 – 327438Plectin 10
Repeat3275 – 331238Plectin 11
Repeat3315 – 335036Plectin 12
Repeat3492 – 352938Plectin 13
Repeat3530 – 356738Plectin 14
Repeat3568 – 360538Plectin 15
Repeat3606 – 364338Plectin 16
Repeat3647 – 368135Plectin 17
Repeat3827 – 386438Plectin 18
Repeat3865 – 390238Plectin 19
Repeat3903 – 394038Plectin 20
Repeat3941 – 397838Plectin 21
Repeat3982 – 401534Plectin 22
Repeat4070 – 410738Plectin 23
Repeat4108 – 414538Plectin 24
Repeat4146 – 418338Plectin 25
Repeat4184 – 422138Plectin 26
Repeat4225 – 425935Plectin 27
Repeat4272 – 431241Plectin 28
Repeat4415 – 445238Plectin 29
Repeat4453 – 449038Plectin 30
Repeat4491 – 452838Plectin 31
Repeat4529 – 456638Plectin 32
Repeat4567 – 460438Plectin 33
Region1 – 14781478Globular 1 By similarity
Region1479 – 27621284Central fibrous rod domain By similarity
Region2763 – 46911929Globular 2 By similarity
Region4257 – 430751Binding to intermediate filaments By similarity
Region4632 – 4647164 X 4 AA tandem repeats of G-S-R-X
Coiled coil1477 – 1697221 Potential
Coiled coil1729 – 27641036 Potential

Amino acid modifications

Modified residue2121Phosphoserine Ref.12
Modified residue7281Phosphoserine Ref.8
Modified residue8231Phosphothreonine Ref.9
Modified residue14431Phosphoserine Ref.8
Modified residue17291Phosphoserine Ref.12
Modified residue27881Phosphotyrosine Ref.7
Modified residue30401Phosphotyrosine Ref.7
Modified residue30981N6-acetyllysine By similarity
Modified residue33691Phosphotyrosine Ref.7
Modified residue34271N6-acetyllysine By similarity
Modified residue37971Phosphotyrosine Ref.7
Modified residue40371Phosphothreonine By similarity
Modified residue43891Phosphoserine Ref.14
Modified residue43911Phosphoserine Ref.11
Modified residue43921Phosphoserine By similarity
Modified residue43931Phosphoserine Ref.8 Ref.10 Ref.11 Ref.12 Ref.14
Modified residue43961Phosphoserine Ref.13
Modified residue43971Phosphoserine Ref.10
Modified residue43981Phosphoserine By similarity
Modified residue43991Phosphoserine Ref.13
Modified residue44031Phosphoserine By similarity
Modified residue44181Phosphothreonine By similarity
Modified residue45461Phosphothreonine; by CDK1 By similarity
Modified residue46201Phosphoserine By similarity
Modified residue46221Phosphotyrosine Ref.7
Modified residue46251Phosphoserine By similarity
Modified residue46291Phosphoserine Ref.10
Modified residue46331Phosphoserine Ref.10 Ref.12
Modified residue46491Phosphoserine By similarity

Natural variations

Alternative sequence1 – 242242Missing in isoform PLEC-1H.
VSP_005040
Alternative sequence1 – 6666MVAGM…RETFA → MSGEDSEVRPVAVAEGSSNG SSGSPSPGDTLPWNLGKTQR SRRSGGGSVGNGSVLDPAER AVIRIA in isoform PLEC-0,1C, isoform PLEC-0,1C,2A,3A and isoform PLEC-0,1C,2A.
VSP_005039
Alternative sequence1 – 4444MVAGM…VPGVT → MAGTWAAKGVFTSQREVLLE RPCWLDGGCEQVRRGYLYGQ LCCV in isoform PLEC-1G.
VSP_005038
Alternative sequence1 – 3737MVAGM…PRSLH → MSQHRLRVPEPEGLGSKRTS SEDNLYLAVLRASEGKK in isoform PLEC-1A.
VSP_005036
Alternative sequence1 – 3737MVAGM…PRSLH → MEPSGSLFPSLVVVGHVVTL AAVWHWRKGHRQAKDEQ in isoform PLEC-1B and isoform PLEC-1B,2A.
VSP_005037
Alternative sequence1 – 3333MVAGM…KDRRP → MNETVCRRKLSPSGSTNTLS RLRGTSVTCTKTS in isoform PLEC-1I.
VSP_005035
Alternative sequence1 – 2828MVAGM…VMVAK → MAHLLTSGPPPDEQDFIQAY EEVREKYK in isoform PLEC-1F.
VSP_005034
Alternative sequence1 – 1515MVAGM…RLRAI → MDPSRAIQHEISSLK in isoform PLEC-1E and isoform PLEC-1E,2A.
VSP_005033
Alternative sequence1 – 55MVAGM → MKIVP in isoform PLEC-1D and isoform PLEC-1D,2A.
VSP_005032
Alternative sequence6 – 180175Missing in isoform PLEC-1D and isoform PLEC-1D,2A.
VSP_005041
Alternative sequence16 – 180165Missing in isoform PLEC-1E and isoform PLEC-1E,2A.
VSP_005042
Alternative sequence29 – 180152Missing in isoform PLEC-1F.
VSP_005043
Alternative sequence34 – 180147Missing in isoform PLEC-1I.
VSP_005044
Alternative sequence38 – 180143Missing in isoform PLEC-1A, isoform PLEC-1B and isoform PLEC-1B,2A.
VSP_005045
Alternative sequence45 – 180136Missing in isoform PLEC-1G.
VSP_005046
Alternative sequence67 – 180114Missing in isoform PLEC-0,1C, isoform PLEC-0,1C,2A and isoform PLEC-0,1C,2A,3A.
VSP_005047
Alternative sequence202 – 2065Missing in isoform PLEC-1, isoform PLEC-1A, isoform PLEC-1B, isoform PLEC-1D, isoform PLEC-1E, isoform PLEC-1G, isoform PLEC-1F and isoform PLEC-0,1C.
VSP_005048
Alternative sequence2391E → ERDVIRSVRLPRE in isoform PLEC-0,1C,2A,3A.
VSP_005049

Secondary structure

1 .................................. 4691
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform PLEC-1,2A [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: 9574A9C80E88DA79

FASTA4,691534,216
        10         20         30         40         50         60 
MVAGMLMPLD RLRAIYEVLF REGVMVAKKD RRPRSLHPHV PGVTNLQVMR AMASLKARGL 

        70         80         90        100        110        120 
VRETFAWCHF YWYLTNEGID HLRQYLHLPP EIVPASLQRV RRPVAMVIPA RRRSPHVQTM 

       130        140        150        160        170        180 
QGPLGCPPKR GPLPAEDPAR EERQVYRRKE REEGAPETPV VSATTVGTLA RPGPEPAPAT 

       190        200        210        220        230        240 
DERDRVQKKT FTKWVNKHLI KHWRAEAQRH ISDLYEDLRD GHNLISLLEV LSGDSLPREK 

       250        260        270        280        290        300 
GRMRFHKLQN VQIALDYLRH RQVKLVNIRN DDIADGNPKL TLGLIWTIIL HFQISDIQVS 

       310        320        330        340        350        360 
GQSEDMTAKE KLLLWSQRMV EGYQGLRCDN FTTSWRDGRL FNAIIHRHKP MLIDMNKVYR 

       370        380        390        400        410        420 
QTNLENLDQA FSVAERDLGV TRLLDPEDVD VPQPDEKSII TYVSSLYDAM PRVPGAQDGV 

       430        440        450        460        470        480 
RANELQLRWQ EYRELVLLLL QWIRHHTAAF EERKFPSSFE EIEILWCQFL KFKETELPAK 

       490        500        510        520        530        540 
EADKNRSKVI YQSLEGAVQA GQLKIPPGYH PLDVEKEWGK LHVAILEREK QLRSEFERLE 

       550        560        570        580        590        600 
CLQRIVSKLQ MEAGLCEEQL NQADALLQSD IRLLASGKVA QRAGEVERDL DKADGMIRLL 

       610        620        630        640        650        660 
FNDVQTLKDG RHPQGEQMYR RVYRLHERLV AIRTEYNLRL KAGVGAPVTQ VTLQSTQRRP 

       670        680        690        700        710        720 
ELEDSTLRYL QDLLAWVEEN QRRIDSAEWG VDLPSVEAQL GSHRGMHQSI EEFRAKIERA 

       730        740        750        760        770        780 
RNDESQLSPA TRGAYRDCLG RLDLQYAKLL NSSKARLRSL ESLHGFVAAA TKELMWLNEK 

       790        800        810        820        830        840 
EEEEVGFDWS DRNTNMAAKK ESYSALMREL EMKEKKIKEI QNTGDRLLRE DHPARPTVES 

       850        860        870        880        890        900 
FQAALQTQWS WMLQLCCCIE AHLKENTAYF QFFSDVREAE EQLQKLQETL RRKYSCDRTI 

       910        920        930        940        950        960 
TVTRLEDLLQ DAQDEKEQLN EYKGHLSGLA KRAKAIVQLK PRNPAHPVRG HVPLIAVCDY 

       970        980        990       1000       1010       1020 
KQVEVTVHKG DQCQLVGPAQ PSHWKVLSGS SSEAAVPSVC FLVPPPNQEA QEAVARLEAQ 

      1030       1040       1050       1060       1070       1080 
HQALVTLWHQ LHVDMKSLLA WQSLSRDIQL IRSWSLVTFR TLKPEEQRQA LRNLELHYQA 

      1090       1100       1110       1120       1130       1140 
FLRDSQDAGG FGPEDRLVAE REYGSCSRHY QQLLQSLEQG EQEESRCQRC ISELKDIRLQ 

      1150       1160       1170       1180       1190       1200 
LEACETRTVH RLRLPLDKDP ARECAQRIAE QQKAQAEVEG LGKGVARLSA EAEKVLALPE 

      1210       1220       1230       1240       1250       1260 
PSPAAPTLRS ELELTLGKLE QVRSLSAIYL EKLKTISLVI RSTQGAEEVL KTHEEQLKEA 

      1270       1280       1290       1300       1310       1320 
QAVPATLQEL EATKASLKKL RAQAEAQQPV FNTLRDELRG AQEVGERLQQ RHGERDVEVE 

      1330       1340       1350       1360       1370       1380 
RWRERVTQLL ERWQAVLAQT DVRQRELEQL GRQLRYYRES ADPLSAWLQD AKRRQEQIQA 

      1390       1400       1410       1420       1430       1440 
VPIANCQAAR EQLRQEKALL EEIERHGEKV EECQKFAKQY INAIKDYELQ LITYKAQLEP 

      1450       1460       1470       1480       1490       1500 
VASPAKKPKV QSGSESVIQE YVDLRTRYSE LTTLTSQYIK FISETLRRME EEERLAEQQR 

      1510       1520       1530       1540       1550       1560 
AEERERLAEV EAALEKQRQL AEAHAQAKAQ AELEAQELQR RMQEEVARRE EAAVDAQQQK 

      1570       1580       1590       1600       1610       1620 
RSIQEELQHL RQSSEAEIQA KAQQVEAAER SRMRIEEEIR VVRLQLETTE RQRGGAEGEL 

      1630       1640       1650       1660       1670       1680 
QALRARAEEA EAQKRQAQEE AERLRRQVQD ESQRKRQAEA ELALRVKAEA EAAREKQRAL 

      1690       1700       1710       1720       1730       1740 
QALDELRLQA EEAERRLRQA EAERARQVQV ALETAQRSAE VELQSKRASF AEKTAQLERT 

      1750       1760       1770       1780       1790       1800 
LQEEHVTVAQ LREEAERRAQ QQAEAERARE EAERELERWQ LKANEALRLR LQAEEVAQQK 

      1810       1820       1830       1840       1850       1860 
SLAQADAEKQ KEEAEREARR RGKAEEQAVR QRELAEQELE KQRQLAEGTA QQRLAAEQEL 

      1870       1880       1890       1900       1910       1920 
IRLRAETEQG EQQRQLLEEE LARLQHEATA ATQKRQELEA ELAKVRAEME VLLASKARAE 

      1930       1940       1950       1960       1970       1980 
EESRSTSEKS KQRLEAEAGR FRELAEEAAR LRALAEEAKR QRQLAEEDAA RQRAEAERVL 

      1990       2000       2010       2020       2030       2040 
TEKLAAISEA TRLKTEAEIA LKEKEAENER LRRLAEDEAF QRRRLEEQAA LHKADIEERL 

      2050       2060       2070       2080       2090       2100 
AQLRKASESE LERQKGLVED TLRQRRQVEE EIMALKVSFE KAAAGKAELE LELGRIRSNA 

      2110       2120       2130       2140       2150       2160 
EDTMRSKEQA ELEAARQRQL AAEEEQRRRE AEERVQRSLA AEEEAARQRK VALEEVERLK 

      2170       2180       2190       2200       2210       2220 
AKVEEARRLR ERAEQESARQ LQLAQEAAQK RLQAEEKAHA FVVQQREEEL QQTLQQEQNM 

      2230       2240       2250       2260       2270       2280 
LDRLRSEAEA ARRAAEEAEE AREQAEREAA QSRKQVEEAE RLKQSAEEQA QAQAQAQAAA 

      2290       2300       2310       2320       2330       2340 
EKLRKEAEQE AARRAQAEQA ALKQKQAADA EMEKHKKFAE QTLRQKAQVE QELTTLRLQL 

      2350       2360       2370       2380       2390       2400 
EETDHQKSIL DEELQRLKAE VTEAARQRSQ VEEELFSVRV QMEELGKLKA RIEAENRALI 

      2410       2420       2430       2440       2450       2460 
LRDKDNTQRF LEEEAEKMKQ VAEEAARLSV AAQEAARLRQ LAEEDLAQQR ALAEKMLKEK 

      2470       2480       2490       2500       2510       2520 
MQAVQEATRL KAEAELLQQQ KELAQEQARR LQEDKEQMAQ QLVEETQGFQ RTLEAERQRQ 

      2530       2540       2550       2560       2570       2580 
LEMSAEAERL KLRMVEMSRA QARAEEDAQR FRKQAEEIGE KLHRTELATQ EKVTLVQTLE 

      2590       2600       2610       2620       2630       2640 
IQRQQSDHDA ERLREAIAEL EREKEKLKQE AKLLQLKSEE MQTVQQEQIL QETQALQKSF 

      2650       2660       2670       2680       2690       2700 
LSEKDSLLQR ERFIEQEKAK LEQLFQDEVA KAKQLREEQQ RQQQQMEQEK QELMASMEEA 

      2710       2720       2730       2740       2750       2760 
RRRQREAEEG VRRKQEELQH LEQQRQQQEK LLAEENQRLR ERLQRLEEEH RAALAHSEIA 

      2770       2780       2790       2800       2810       2820 
TTQAASTKAL PNGRDAPDGP SVEAEPEYTF EGLRQKVPAQ QLQEAGILSQ EELQRLAQGH 

      2830       2840       2850       2860       2870       2880 
TTVAELTQRE DVYRYLKGRS SIAGLLLKPT NEKLSVYTAL QRQLLSPGTA LILLEAQAAS 

      2890       2900       2910       2920       2930       2940 
GFLLDPVRNR RLTVNEAVKE GVVGPELHHK LLSAERAVTG YKDPYTGEQI SLFQAMKKDL 

      2950       2960       2970       2980       2990       3000 
IVRDHGVRLL EAQIATGGII DPVHSHRVPV DVAYKRGYFD EEMNRILSDP SDDTKGFFDP 

      3010       3020       3030       3040       3050       3060 
NTHENLTYLQ LLERCVEDPE TGLRLLPLTD KAAKGGELVY TDTEARDVFE KATVSAPFGK 

      3070       3080       3090       3100       3110       3120 
FQGRTVTIWE IINSEYFTAE QRRDLLQQFR TGHITVEKII KIVITVVEEH ERKGQLCFEG 

      3130       3140       3150       3160       3170       3180 
LRALVPAAEL LDSGVISHEL YQQLQRGERS VREVAEADSV RQALRGTNVI AGVWLEEAGQ 

      3190       3200       3210       3220       3230       3240 
KLSIYEALKK DLLQPEVAVA LLEAQAGTGH IIDPATSARL TVDEAVRAGL VGPELHEKLL 

      3250       3260       3270       3280       3290       3300 
SAEKAVTGYR DPYSGQSVSL FQALKKGLIP REQGLRLLDA QLSTGGIVDP SKSHRVPLDV 

      3310       3320       3330       3340       3350       3360 
AYARGYLDKE TNRALTSPRD DARVYHDPST QEPVTYSQLQ QRCRSDQLTG LSLLPLSEKA 

      3370       3380       3390       3400       3410       3420 
VRARQEEVYS ELQARETLEQ AKVEVPVGSF KGRAMTVWEL ISSEYFTEEQ RQELLRQFRT 

      3430       3440       3450       3460       3470       3480 
GKVTVEKVIK IVITIVEEVE TRRQERLSFS GLRAPVPASE LLDAKILSRA QFDQLKDGKT 

      3490       3500       3510       3520       3530       3540 
SVKELSEVGS VRTLLQGSGC LAGIYLEDSK EKVTIYEAMR RGLLRPSTAT LLLEAQAATG 

      3550       3560       3570       3580       3590       3600 
FLVDPVRNQR LYVHEAVKAG VVGPELHEKL LSAEKAVTGY KDPYSGNTIS LFQAMKKGLV 

      3610       3620       3630       3640       3650       3660 
LRDHAIRLLE AQVATGGIID PVHSHRLPVD VAYQRGYFDE EMNRVLADPS DDTKGFFDPN 

      3670       3680       3690       3700       3710       3720 
THENLTYLQL LERCVEDPET GLRLLPLKGA EKTEVVETTQ VYTEEETRRA FEETQIDIPG 

      3730       3740       3750       3760       3770       3780 
GGSHGGSSMS LWEVMQSNMI PEDQRARLMA DFQAGRVTKE RMIIIIIEII EKTEIIRQQN 

      3790       3800       3810       3820       3830       3840 
LASYDYVRRR LTAEDLYEAR IISLETYNLF REGTKNLREV LEMESAWRYL YGTGAVAGVY 

      3850       3860       3870       3880       3890       3900 
LPGSRQTLTI YQALKKGLLS AEVARLLLEA QAATGFLLDP VKGERLTVDE AVRKGLVGPE 

      3910       3920       3930       3940       3950       3960 
LHDRLLSAER AVTGYRDPYT EQTISLFQAM KKELIPAEEA LRLLDAQLAT GGIVDPRLGF 

      3970       3980       3990       4000       4010       4020 
HLPLEVAYQR GYLNKDTHDQ LSEPSEVRSY VDPSTDERLS YTQLLKRCRR DDPSGQMLLL 

      4030       4040       4050       4060       4070       4080 
LSDARKLTFR GLRKQITVEE LVRSQVMDEA TALQLQEGLT SIEEVTKNLQ KFLEGTSCIA 

      4090       4100       4110       4120       4130       4140 
GVFVDATKER LSVYQAMKKG IIRPGTAFEL LEAQAATGYV IDPIKGLKLT VEEAVRMGIV 

      4150       4160       4170       4180       4190       4200 
GPEFKDKLLS AERAVTGYKD PYSGKLISLF QAMKKGLILK DHGIRLLEAQ IATGGIIDPE 

      4210       4220       4230       4240       4250       4260 
ESHRLPVEVA YKRGLFDEEM NEILTDPSDD TKGFFDPNTE ENLTYLQLME RCITDPQTGL 

      4270       4280       4290       4300       4310       4320 
CLLPLKEKKR ERKTSSKSSV RKRRVVIVDP ETGKEMSVYE AYRKGLIDHQ TYLELSEQEC 

      4330       4340       4350       4360       4370       4380 
EWEEITISSS DGVVKSMIID RRSGRQYDID DAITKNLIDR SALDQYRAGT LSITEFADML 

      4390       4400       4410       4420       4430       4440 
SGNAGGFRSR SSSVGSSSSY PISSAGPRTQ LASWSDPTEE TGPVAGILDT ETLEKVSITE 

      4450       4460       4470       4480       4490       4500 
AMHRNLVDNI TGQRLLEAQA CTGGIIDPST GERFPVTEAV NKGLVDKIMV DRINLAQKAF 

      4510       4520       4530       4540       4550       4560 
CGFEDPRTKT KMSAAQALKK GWLYYEAGQR FLEVQYLTGG LIEPDTPGRV SLDEALQRGT 

      4570       4580       4590       4600       4610       4620 
VDARTAQKLR DVSAYSKYLT CPKTKLKISY KDALDRSMVE EGTGLRLLEA AAQSSKGYYS 

      4630       4640       4650       4660       4670       4680 
PYSVSGSGST AGSRTGSRTG SRAGSRRGSF DATGSGFSMT FSSSSYSSSG YGRRYASGPS 

      4690 
ASLGGPESAV A

« Hide

Isoform PLEC-1 [UniParc].

Checksum: 2CB5A50937DB6FA2
Show »

FASTA4,686533,536
Isoform PLEC-1A [UniParc].

Checksum: 093B24129516DCBF
Show »

FASTA4,543517,315
Isoform PLEC-1B,2A [UniParc].

Checksum: 7AADFAB6ECF64CBB
Show »

FASTA4,548518,008
Isoform PLEC-1B [UniParc].

Checksum: C22367A8716FA2BD
Show »

FASTA4,543517,328
Isoform PLEC-0,1C [UniParc].

Checksum: 36454032F16FC6E8
Show »

FASTA4,572519,783
Isoform PLEC-0,1C,2A [UniParc].

Checksum: B795FAEA5C722A9C
Show »

FASTA4,577520,463
Isoform PLEC-0,1C,2A,3A [UniParc].

Checksum: 121E9CE9B59C1A0B
Show »

FASTA4,589521,941
Isoform PLEC-1D,2A [UniParc].

Checksum: 326AD0A775FAE6F5
Show »

FASTA4,516514,441
Isoform PLEC-1D [UniParc].

Checksum: 9E8929D719B96496
Show »

FASTA4,511513,761
Isoform PLEC-1E,2A [UniParc].

Checksum: 54B6ADD9CC4CB49D
Show »

FASTA4,526515,566
Isoform PLEC-1E [UniParc].

Checksum: D8DB419A2823910B
Show »

FASTA4,521514,886
Isoform PLEC-1F [UniParc].

Checksum: 51F56FF0317AB387
Show »

FASTA4,534516,467
Isoform PLEC-1G [UniParc].

Checksum: E72065D99911AC19
Show »

FASTA4,550518,126
Isoform PLEC-1H [UniParc].

Checksum: C57454930B77C434
Show »

FASTA4,449506,455
Isoform PLEC-1I [UniParc].

Checksum: C834C53C1D3120C5
Show »

FASTA4,544517,427

References

« Hide 'large scale' references
[1]"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
Zhang T., Haws P., Wu Q.
Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]"Unusual 5' transcript complexity of plectin isoforms: novel tissue-specific exons modulate actin binding activity."
Fuchs P., Zoerer M., Rezniczek G.A., Spazierer D., Oehler S., Castanon M.J., Hauptmann R., Wiche G.
Hum. Mol. Genet. 8:2461-2472(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-964, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Tissue: Brain, Embryo, Heart, Kidney, Skeletal muscle and Testis.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-812.
Strain: C57BL/6J.
Tissue: Embryo.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 629-633, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[5]"Direct binding of plectin to Fer kinase and negative regulation of its catalytic activity."
Lunter P.C., Wiche G.
Biochem. Biophys. Res. Commun. 296:904-910(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FER.
[6]"Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin."
Wilhelmsen K., Litjens S.H.M., Kuikman I., Tshimbalanga N., Janssen H., van den Bout I., Raymond K., Sonnenberg A.
J. Cell Biol. 171:799-810(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SYNE3.
[7]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2788; TYR-3040; TYR-3369; TYR-3797 AND TYR-4622, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-26 (ISOFORM PLEC-1A), MASS SPECTROMETRY.
Tissue: Mast cell.
[8]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-728; SER-1443 AND SER-4393, MASS SPECTROMETRY.
Tissue: Brain cortex.
[9]"Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS."
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.
Mol. Cell. Proteomics 6:669-676(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-823, MASS SPECTROMETRY.
Tissue: Liver.
[10]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4393; SER-4397; SER-4629 AND SER-4633, MASS SPECTROMETRY.
Tissue: Liver.
[11]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4391 AND SER-4393, MASS SPECTROMETRY.
Tissue: Liver.
[12]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212; SER-1729; SER-4393 AND SER-4633, MASS SPECTROMETRY.
Tissue: Melanoma.
[13]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4396 AND SER-4399, MASS SPECTROMETRY.
Tissue: Macrophage.
[14]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4389 AND SER-4393, MASS SPECTROMETRY.
Tissue: Embryonic fibroblast.
[15]"BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin."
Steiner-Champliaud M.F., Schneider Y., Favre B., Paulhe F., Praetzel-Wunder S., Faulkner G., Konieczny P., Raith M., Wiche G., Adebola A., Liem R.K., Langbein L., Sonnenberg A., Fontao L., Borradori L.
Exp. Cell Res. 316:297-313(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DST.
[16]"Actin-binding domain of mouse plectin. Crystal structure and binding to vimentin."
Sevcik J., Urbanikova L., Kost'an J., Janda L., Wiche G.
Eur. J. Biochem. 271:1873-1884(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 181-417, INTERACTION WITH VIM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY480033 mRNA. Translation: AAR95666.1.
AY480038 mRNA. Translation: AAR95671.1.
AY480043 mRNA. Translation: AAR95676.1.
AF188006 mRNA. Translation: AAF18066.1.
AF188007 mRNA. Translation: AAF18067.1.
AF188008 mRNA. Translation: AAF18068.1.
AF188009 mRNA. Translation: AAF18069.1.
AF188010 mRNA. Translation: AAF18070.1.
AF188011 mRNA. Translation: AAF18071.1.
AF188012 mRNA. Translation: AAF18072.1.
AF188013 mRNA. Translation: AAF18073.1.
AF188014 mRNA. Translation: AAF18074.1.
AF188015 mRNA. Translation: AAF18075.1.
AF188016 mRNA. Translation: AAF18076.1.
AF188017 mRNA. Translation: AAF18077.1.
AF188018 mRNA. Translation: AAF18078.1.
AF188019 mRNA. Translation: AAF18079.1.
AF188020 mRNA. Translation: AAF18080.1.
AF188021 mRNA. Translation: AAF18081.1.
AF188022 mRNA. Translation: AAF18082.1.
AF188023 mRNA. Translation: AAF18083.1.
AK017743 mRNA. No translation available.
IPIIPI00229509.
IPI00400214.
IPI00421267.
IPI00421268.
IPI00421271.
IPI00468273.
IPI00626385.
IPI00944107.
IPI01008141.
IPI01008579.
PIRD59404.
RefSeqNP_001157012.1. NM_001163540.1.
NP_001157014.1. NM_001163542.1.
NP_001157021.1. NM_001163549.1.
NP_001157675.1. NM_001164203.1.
NP_035247.2. NM_011117.2.
NP_958791.2. NM_201389.2.
NP_958796.2. NM_201394.2.
UniGeneMm.234912.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SH5X-ray2.00A/B181-417[»]
1SH6X-ray2.00A181-417[»]
ProteinModelPortalQ9QXS1.
SMRQ9QXS1. Positions 5-101, 181-411, 424-641, 661-1117, 2836-3026, 3118-3358, 3448-3688, 3783-4023, 4028-4267, 4390-4612.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9QXS1. 3 interactions.

PTM databases

PhosphoSiteQ9QXS1.

Proteomic databases

PaxDbQ9QXS1.
PRIDEQ9QXS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000165453; ENSMUSP00000127253; ENSMUSG00000022565.
ENSMUST00000167754; ENSMUSP00000127867; ENSMUSG00000022565.
ENSMUST00000170728; ENSMUSP00000130948; ENSMUSG00000022565.
ENSMUST00000170915; ENSMUSP00000131946; ENSMUSG00000022565.
ENSMUST00000171634; ENSMUSP00000126936; ENSMUSG00000022565.
GeneID18810.
KEGGmmu:18810.
UCSCuc007wir.2. mouse.
uc007wiw.2. mouse.
uc007wjb.2. mouse.
uc007wjc.2. mouse.
uc007wjd.2. mouse.
uc011zuq.1. mouse.

Organism-specific databases

CTD5339.
MGIMGI:1277961. Plec.

Phylogenomic databases

eggNOGCOG5069.
GeneTreeENSGT00700000104432.
HOVERGENHBG053616.
InParanoidQ9QXS1.
KOK10388.
OrthoDBEOG4SN1MR.

Gene expression databases

ArrayExpressQ9QXS1.
BgeeQ9QXS1.
CleanExMM_PLEC1.
GenevestigatorQ9QXS1.
GermOnlineENSMUSG00000022565. Mus musculus.

Family and domain databases

Gene3D1.10.418.10. 2 hits.
InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR001101. Plectin_repeat.
IPR005326. S10_plectin_N.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PfamPF00307. CH. 2 hits.
PF00681. Plectin. 18 hits.
PF03501. S10_plectin. 1 hit.
[Graphical view]
SMARTSM00033. CH. 2 hits.
SM00250. PLEC. 35 hits.
SM00150. SPEC. 6 hits.
[Graphical view]
SUPFAMSSF47576. Calponin-homology. 1 hit.
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9QXS1.
NextBio295126.
SOURCESearch...

Entry information

Entry namePLEC_MOUSE
AccessionPrimary (citable) accession number: Q9QXS1
Secondary accession number(s): Q6S384 expand/collapse secondary AC list , Q6S389, Q6S394, Q9CS65, Q9QUT2, Q9QXQ8, Q9QXQ9, Q9QXR0, Q9QXR1, Q9QXR2, Q9QXR3, Q9QXR4, Q9QXR5, Q9QXR6, Q9QXR7, Q9QXR8, Q9QXR9, Q9QXS0, Q9QXS2, Q9QXS3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 9, 2007
Last modified: May 1, 2013
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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