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Protein

Galanin-like peptide

Gene

Galp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion (By similarity).By similarity

GO - Biological processi

  • behavioral response to starvation Source: Ensembl
  • neuropeptide signaling pathway Source: UniProtKB-KW
  • regulation of appetite Source: Ensembl
  • response to hormone Source: RGD
  • response to insulin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin-like peptide
Gene namesi
Name:Galp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620187. Galp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001046724 – 83Galanin-like peptideAdd BLAST60
PropeptideiPRO_000001046886 – 115By similarityAdd BLAST30

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9QXQ6.

Expressioni

Gene expression databases

GenevisibleiQ9QXQ6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038710.

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE0F. Eukaryota.
ENOG4111D06. LUCA.
GeneTreeiENSGT00390000016349.
HOGENOMiHOG000112691.
HOVERGENiHBG018628.
InParanoidiQ9QXQ6.
OMAiWKAIDGL.
OrthoDBiEOG091G1256.
PhylomeDBiQ9QXQ6.
TreeFamiTF339481.

Family and domain databases

InterProiIPR008174. Galanin.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACSKHLVLF LTILLSLAET PDSAPAHRGR GGWTLNSAGY LLGPVLHLSS
60 70 80 90 100
KANQGRKTDS ALEILDLWKA IDGLPYSRSP RMTKRSMGET FVKPRTGDLR
110
IVDKNVPDEE ATLNL
Length:115
Mass (Da):12,600
Last modified:May 1, 2000 - v1
Checksum:i00BD3A2336AD06C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188491 mRNA. Translation: AAF19723.1.
RefSeqiNP_072155.1. NM_022633.1.
UniGeneiRn.48754.

Genome annotation databases

EnsembliENSRNOT00000034854; ENSRNOP00000038710; ENSRNOG00000022129.
GeneIDi64568.
KEGGirno:64568.
UCSCiRGD:620187. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188491 mRNA. Translation: AAF19723.1.
RefSeqiNP_072155.1. NM_022633.1.
UniGeneiRn.48754.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038710.

Proteomic databases

PaxDbiQ9QXQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034854; ENSRNOP00000038710; ENSRNOG00000022129.
GeneIDi64568.
KEGGirno:64568.
UCSCiRGD:620187. rat.

Organism-specific databases

CTDi85569.
RGDi620187. Galp.

Phylogenomic databases

eggNOGiENOG410JE0F. Eukaryota.
ENOG4111D06. LUCA.
GeneTreeiENSGT00390000016349.
HOGENOMiHOG000112691.
HOVERGENiHBG018628.
InParanoidiQ9QXQ6.
OMAiWKAIDGL.
OrthoDBiEOG091G1256.
PhylomeDBiQ9QXQ6.
TreeFamiTF339481.

Miscellaneous databases

PROiQ9QXQ6.

Gene expression databases

GenevisibleiQ9QXQ6. RN.

Family and domain databases

InterProiIPR008174. Galanin.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALP_RAT
AccessioniPrimary (citable) accession number: Q9QXQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.