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Protein

Galanin-like peptide

Gene

Galp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin-like peptide
Gene namesi
Name:Galp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620187. Galp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001046724 – 83Galanin-like peptideAdd BLAST60
PropeptideiPRO_000001046886 – 115By similarityAdd BLAST30

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9QXQ6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022129.
GenevisibleiQ9QXQ6. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038710.

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE0F. Eukaryota.
ENOG4111D06. LUCA.
GeneTreeiENSGT00390000016349.
HOGENOMiHOG000112691.
HOVERGENiHBG018628.
InParanoidiQ9QXQ6.
OMAiWKAIDGL.
OrthoDBiEOG091G1256.
PhylomeDBiQ9QXQ6.
TreeFamiTF339481.

Family and domain databases

InterProiView protein in InterPro
IPR008174. Galanin.
PfamiView protein in Pfam
PF01296. Galanin. 1 hit.
PROSITEiView protein in PROSITE
PS00861. GALANIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACSKHLVLF LTILLSLAET PDSAPAHRGR GGWTLNSAGY LLGPVLHLSS
60 70 80 90 100
KANQGRKTDS ALEILDLWKA IDGLPYSRSP RMTKRSMGET FVKPRTGDLR
110
IVDKNVPDEE ATLNL
Length:115
Mass (Da):12,600
Last modified:May 1, 2000 - v1
Checksum:i00BD3A2336AD06C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188491 mRNA. Translation: AAF19723.1.
RefSeqiNP_072155.1. NM_022633.1.
UniGeneiRn.48754.

Genome annotation databases

EnsembliENSRNOT00000034854; ENSRNOP00000038710; ENSRNOG00000022129.
GeneIDi64568.
KEGGirno:64568.
UCSCiRGD:620187. rat.

Similar proteinsi

Entry informationi

Entry nameiGALP_RAT
AccessioniPrimary (citable) accession number: Q9QXQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families