Reviewed, UniProtKB/Swiss-Prot Q9QXQ1 (PDE7B_MOUSE)

Names and origin

Protein names

Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 7B
    EC=3.1.4.17

Gene names

Name:

Pde7b

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
Cofactor	Divalent cations By similarity.
Enzyme regulation	Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone.
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Tissue specificity	Highly expressed in brain.
Domain	Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
Ligand	cAMP
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-AMP phosphodiesterase activity Ref.2 Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	cAMP-specific 3',5'-cyclic phosphodiesterase 7B		PRO_0000198837
Regions
	Region	172 – 410	239	Catalytic By similarity
Amino acid modifications
	Modified residue	45	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QXQ1-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7C052664B693A5A8	FASTA	446	51,337
	10 20 30 40 50 60 MSCLMVERCG EVLFESPEQS VKCVCMLGDV RLRGQTGVPA ERRGSYPFID FRLLNNTTHS 70 80 90 100 110 120 GEIGTKKKVK RLLSFQRYFH ASRLLRGIIP QAPLHLLDED YLGQARHMLS KVGTWDFDIF 130 140 150 160 170 180 LFDRLTNGNS LVTLLCHLFN SHGLIHHFKL DMVTLHRFLV MVQEDYHGHN PYHNAVHAAD 190 200 210 220 230 240 VTQAMHCYLK EPKLASFLTP LDIMLGLLAA AAHDVDHPGV NQPFLIKTNH HLANLYQNMS 250 260 270 280 290 300 VLENHHWRST IGMLRESRLL AHLPKEMTQD IEQQLGSLIL ATDINRQNEF LTRLKAHLHN 310 320 330 340 350 360 KDLRLENVQD RHFMLQIALK CADICNPCRI WEMSKQWSER VCEEFYRQGD LEQKFELEIS 370 380 390 400 410 420 PLCNQQKDSI PSIQIGFMTY IVEPLFREWA RFTGNSTLSE NMLSHLAHNK AQWKSLLSNQ 430 440 HRRRGSGQDL AGPAPETLEQ TEGATP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase." Hetman J.M., Soderling S.H., Glavas N.A., Beavo J.A. Proc. Natl. Acad. Sci. U.S.A. 97:472-476(2000) [PubMed: 10618442] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase." Gardner C.E., Robas N.M., Cawkill D., Fidock M.D. Biochem. Biophys. Res. Commun. 272:186-192(2000) [PubMed: 10872825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF190639 mRNA. Translation: AAF25195.1. AJ251859 mRNA. Translation: CAB92530.1. BC130267 mRNA. Translation: AAI30268.1.
IPI	IPI00135368.
RefSeq	NP_038903.3.
UniGene	Mm.425617
3D structure databases
HSSP	HSSP built from PDB template 1OYN based on UniProtKB Q08499.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9QXQ1.
PTM databases
PhosphoSite	Q9QXQ1.
Proteomic databases
PRIDE	Q9QXQ1.
Genome annotation databases
Ensembl	ENSMUST00000020165; ENSMUSP00000020165; ENSMUSG00000019990; Mus musculus. [Genome view]
GeneID	29863.
KEGG	mmu:29863.
UCSC	uc007eob.1. mouse.
Organism-specific databases
CTD	29863.
MGI	MGI:1352752. Pde7b.
Phylogenomic databases
HOGENOM	Q9QXQ1.
HOVERGEN	Q9QXQ1.
OMA	VHDRHFM.
Enzyme and pathway databases
BRENDA	3.1.4.17. 244.
Gene expression databases
ArrayExpress	Q9QXQ1.
Bgee	Q9QXQ1.
CleanEx	MM_PDE7B.
Genevestigator	Q9QXQ1.
GermOnline	ENSMUSG00000019990. Mus musculus.
Family and domain databases
InterPro	IPR003607. Met-dep_phosphohydro_HD. IPR002073. PDEase. [Graphical view]
Pfam	PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	307074.
SOURCE	Search...

Entry information

Entry name

PDE7B_MOUSE

Accession

Primary (citable) accession number: Q9QXQ1
Secondary accession number(s): A1L3T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)