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Q9QXQ1

- PDE7B_MOUSE

UniProt

Q9QXQ1 - PDE7B_MOUSE

Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 7B

Gene

Pde7b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Enzyme regulationi

    Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei173 – 1731Proton donorBy similarity
    Metal bindingi177 – 1771Divalent metal cation 1By similarity
    Metal bindingi213 – 2131Divalent metal cation 1By similarity
    Metal bindingi214 – 2141Divalent metal cation 1By similarity
    Metal bindingi214 – 2141Divalent metal cation 2By similarity
    Metal bindingi323 – 3231Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP catabolic process Source: UniProtKB-UniPathway
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00762; UER00747.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC:3.1.4.53)
    Gene namesi
    Name:Pde7b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1352752. Pde7b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446cAMP-specific 3',5'-cyclic phosphodiesterase 7BPRO_0000198837Add
    BLAST

    Proteomic databases

    PaxDbiQ9QXQ1.
    PRIDEiQ9QXQ1.

    PTM databases

    PhosphoSiteiQ9QXQ1.

    Expressioni

    Tissue specificityi

    Highly expressed in brain.

    Gene expression databases

    ArrayExpressiQ9QXQ1.
    BgeeiQ9QXQ1.
    CleanExiMM_PDE7B.
    GenevestigatoriQ9QXQ1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXQ1.
    SMRiQ9QXQ1. Positions 100-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni172 – 410239CatalyticBy similarityAdd
    BLAST

    Domaini

    Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG300643.
    GeneTreeiENSGT00730000110321.
    HOGENOMiHOG000220881.
    HOVERGENiHBG053543.
    InParanoidiA1L3T2.
    KOiK01120.
    OrthoDBiEOG7M98G3.
    PhylomeDBiQ9QXQ1.
    TreeFamiTF314638.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QXQ1-1 [UniParc]FASTAAdd to Basket

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    MSCLMVERCG EVLFESPEQS VKCVCMLGDV RLRGQTGVPA ERRGSYPFID    50
    FRLLNNTTHS GEIGTKKKVK RLLSFQRYFH ASRLLRGIIP QAPLHLLDED 100
    YLGQARHMLS KVGTWDFDIF LFDRLTNGNS LVTLLCHLFN SHGLIHHFKL 150
    DMVTLHRFLV MVQEDYHGHN PYHNAVHAAD VTQAMHCYLK EPKLASFLTP 200
    LDIMLGLLAA AAHDVDHPGV NQPFLIKTNH HLANLYQNMS VLENHHWRST 250
    IGMLRESRLL AHLPKEMTQD IEQQLGSLIL ATDINRQNEF LTRLKAHLHN 300
    KDLRLENVQD RHFMLQIALK CADICNPCRI WEMSKQWSER VCEEFYRQGD 350
    LEQKFELEIS PLCNQQKDSI PSIQIGFMTY IVEPLFREWA RFTGNSTLSE 400
    NMLSHLAHNK AQWKSLLSNQ HRRRGSGQDL AGPAPETLEQ TEGATP 446
    Length:446
    Mass (Da):51,337
    Last modified:May 1, 2000 - v1
    Checksum:i7C052664B693A5A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190639 mRNA. Translation: AAF25195.1.
    AJ251859 mRNA. Translation: CAB92530.1.
    BC130267 mRNA. Translation: AAI30268.1.
    CCDSiCCDS35859.1.
    RefSeqiNP_038903.3. NM_013875.5.
    UniGeneiMm.425617.

    Genome annotation databases

    EnsembliENSMUST00000020165; ENSMUSP00000020165; ENSMUSG00000019990.
    GeneIDi29863.
    KEGGimmu:29863.
    UCSCiuc007eoa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190639 mRNA. Translation: AAF25195.1 .
    AJ251859 mRNA. Translation: CAB92530.1 .
    BC130267 mRNA. Translation: AAI30268.1 .
    CCDSi CCDS35859.1.
    RefSeqi NP_038903.3. NM_013875.5.
    UniGenei Mm.425617.

    3D structure databases

    ProteinModelPortali Q9QXQ1.
    SMRi Q9QXQ1. Positions 100-416.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QXQ1.

    Proteomic databases

    PaxDbi Q9QXQ1.
    PRIDEi Q9QXQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020165 ; ENSMUSP00000020165 ; ENSMUSG00000019990 .
    GeneIDi 29863.
    KEGGi mmu:29863.
    UCSCi uc007eoa.2. mouse.

    Organism-specific databases

    CTDi 27115.
    MGIi MGI:1352752. Pde7b.

    Phylogenomic databases

    eggNOGi NOG300643.
    GeneTreei ENSGT00730000110321.
    HOGENOMi HOG000220881.
    HOVERGENi HBG053543.
    InParanoidi A1L3T2.
    KOi K01120.
    OrthoDBi EOG7M98G3.
    PhylomeDBi Q9QXQ1.
    TreeFami TF314638.

    Enzyme and pathway databases

    UniPathwayi UPA00762 ; UER00747 .

    Miscellaneous databases

    NextBioi 307074.
    PROi Q9QXQ1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QXQ1.
    Bgeei Q9QXQ1.
    CleanExi MM_PDE7B.
    Genevestigatori Q9QXQ1.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase."
      Hetman J.M., Soderling S.H., Glavas N.A., Beavo J.A.
      Proc. Natl. Acad. Sci. U.S.A. 97:472-476(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase."
      Gardner C.E., Robas N.M., Cawkill D., Fidock M.D.
      Biochem. Biophys. Res. Commun. 272:186-192(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPDE7B_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXQ1
    Secondary accession number(s): A1L3T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3