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Protein

Complement C1q tumor necrosis factor-related protein 1

Gene

C1qtnf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 1
Alternative name(s):
Putative secreted protein ZSIG37
Gene namesi
Name:C1qtnf1
Synonyms:Zsig37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919254. C1qtnf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 281256Complement C1q tumor necrosis factor-related protein 1PRO_0000320081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QXP7.
PaxDbiQ9QXP7.
PRIDEiQ9QXP7.

PTM databases

PhosphoSiteiQ9QXP7.

Expressioni

Gene expression databases

BgeeiQ9QXP7.
CleanExiMM_C1QTNF1.
ExpressionAtlasiQ9QXP7. baseline and differential.
GenevisibleiQ9QXP7. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QXP7. 1 interaction.
STRINGi10090.ENSMUSP00000017590.

Structurei

3D structure databases

ProteinModelPortaliQ9QXP7.
SMRiQ9QXP7. Positions 104-132, 164-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 14042Collagen-likeAdd
BLAST
Domaini141 – 281141C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IKX5. Eukaryota.
ENOG410XQIM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000101544.
HOVERGENiHBG108220.
InParanoidiQ9QXP7.
OMAiLHIMKNE.
PhylomeDBiQ9QXP7.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCAQGFML GCCLLLAITW GPILSLVPRV QEEQQEWEET EELPSPLDPV
60 70 80 90 100
TRPEETREKY SPRQGEDLPT SRCYRCCDPS TPVYQTIPPP QINITILKGE
110 120 130 140 150
KGDRGDRGLQ GKYGKIGSTG PRGHVGPKGQ KGSIGAPGNH CKSQYAAFSV
160 170 180 190 200
GRKKALHSND YFQPVVFDTE FVNLYKHFNM FTGKFYCYVP GIYFFSLNVH
210 220 230 240 250
TWNQKETYLH IMKNEEEVVI LYAQVSDRSI MQSQSLMMEL REEDEVWVRL
260 270 280
FKGERENAIF SDEFDTYITF SGYLVKPASE P
Length:281
Mass (Da):32,009
Last modified:May 1, 2000 - v1
Checksum:iC9816216DB6419E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91M → L in BAE26237 (PubMed:16141072).Curated
Sequence conflicti9 – 91M → L in AAH49894 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002394 mRNA. Translation: AAY21926.1.
AF192499 mRNA. Translation: AAF06664.1.
AK005484 mRNA. Translation: BAB24070.1.
AK145104 mRNA. Translation: BAE26237.1.
AL591075 Genomic DNA. Translation: CAM15757.1.
BC049894 mRNA. Translation: AAH49894.1.
CCDSiCCDS25703.1.
RefSeqiNP_001191058.1. NM_001204129.1.
NP_001191059.1. NM_001204130.1.
NP_064343.1. NM_019959.3.
XP_006533884.1. XM_006533821.2.
XP_006533885.1. XM_006533822.2.
UniGeneiMm.23845.

Genome annotation databases

EnsembliENSMUST00000017590; ENSMUSP00000017590; ENSMUSG00000017446.
ENSMUST00000106286; ENSMUSP00000101893; ENSMUSG00000017446.
GeneIDi56745.
KEGGimmu:56745.
UCSCiuc007mpg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002394 mRNA. Translation: AAY21926.1.
AF192499 mRNA. Translation: AAF06664.1.
AK005484 mRNA. Translation: BAB24070.1.
AK145104 mRNA. Translation: BAE26237.1.
AL591075 Genomic DNA. Translation: CAM15757.1.
BC049894 mRNA. Translation: AAH49894.1.
CCDSiCCDS25703.1.
RefSeqiNP_001191058.1. NM_001204129.1.
NP_001191059.1. NM_001204130.1.
NP_064343.1. NM_019959.3.
XP_006533884.1. XM_006533821.2.
XP_006533885.1. XM_006533822.2.
UniGeneiMm.23845.

3D structure databases

ProteinModelPortaliQ9QXP7.
SMRiQ9QXP7. Positions 104-132, 164-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QXP7. 1 interaction.
STRINGi10090.ENSMUSP00000017590.

PTM databases

PhosphoSiteiQ9QXP7.

Proteomic databases

MaxQBiQ9QXP7.
PaxDbiQ9QXP7.
PRIDEiQ9QXP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017590; ENSMUSP00000017590; ENSMUSG00000017446.
ENSMUST00000106286; ENSMUSP00000101893; ENSMUSG00000017446.
GeneIDi56745.
KEGGimmu:56745.
UCSCiuc007mpg.2. mouse.

Organism-specific databases

CTDi114897.
MGIiMGI:1919254. C1qtnf1.

Phylogenomic databases

eggNOGiENOG410IKX5. Eukaryota.
ENOG410XQIM. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000101544.
HOVERGENiHBG108220.
InParanoidiQ9QXP7.
OMAiLHIMKNE.
PhylomeDBiQ9QXP7.
TreeFamiTF329591.

Miscellaneous databases

ChiTaRSiC1qtnf1. mouse.
NextBioi313258.
PROiQ9QXP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXP7.
CleanExiMM_C1QTNF1.
ExpressionAtlasiQ9QXP7. baseline and differential.
GenevisibleiQ9QXP7. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of Acrp30/adiponectin structural and functional paralogs."
    Wong G.W., Wang J., Hug C., Tsao T.S., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 101:10302-10307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Adipose tissue.
  2. "Mus musculus putative secreted protein."
    Sheppard P., Deisher T., Grant F., Chen L., Haldeman B., McKnight G., Whitmore T., O'Hara P.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland and Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiC1QT1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXP7
Secondary accession number(s): Q80VI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2000
Last modified: January 20, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.