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Q9QXP0

- RHCG_MOUSE

UniProt

Q9QXP0 - RHCG_MOUSE

Protein

Ammonium transporter Rh type C

Gene

Rhcg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.1 Publication

    GO - Molecular functioni

    1. ammonium transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. ammonium transport Source: UniProtKB
    2. cellular ion homeostasis Source: Ensembl
    3. regulation of pH Source: UniProtKB
    4. transepithelial ammonium transport Source: Ensembl

    Keywords - Biological processi

    Ammonia transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198711. Rhesus glycoproteins mediate ammonium transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ammonium transporter Rh type C
    Alternative name(s):
    Rhesus blood group family type C glycoprotein
    Short name:
    Rh family type C glycoprotein
    Short name:
    Rh type C glycoprotein
    Rhesus blood group-associated C glycoprotein
    Short name:
    Rhesus-associated C glycoprotein
    Gene namesi
    Name:Rhcg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1888517. Rhcg.

    Subcellular locationi

    Apical cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Also detected at the basolateral membrane and in subapical vesicles.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basolateral plasma membrane Source: Ensembl
    3. integral component of plasma membrane Source: Ensembl
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Ammonium transporter Rh type CPRO_0000283579Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9QXP0.

    PTM databases

    PhosphoSiteiQ9QXP0.

    Expressioni

    Tissue specificityi

    Expressed in the forestomach and the fundus of the stomach. Expressed at the level of villous in duodenum, jejunum, ileum and colon. Expressed in kidney by connecting segments and collecting tubules (at protein level). Expressed in testis by seminiferous tubules.3 Publications

    Gene expression databases

    BgeeiQ9QXP0.
    CleanExiMM_RHCG.
    GenevestigatoriQ9QXP0.

    Interactioni

    Subunit structurei

    Homotrimer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXP0.
    SMRiQ9QXP0. Positions 2-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 6131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini83 – 864CytoplasmicSequence Analysis
    Topological domaini108 – 12417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini146 – 1538CytoplasmicSequence Analysis
    Topological domaini175 – 1795ExtracellularSequence Analysis
    Topological domaini201 – 21919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini241 – 25111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini273 – 2797CytoplasmicSequence Analysis
    Topological domaini303 – 3042ExtracellularSequence Analysis
    Topological domaini326 – 34015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini362 – 39534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini417 – 49882CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276393.
    GeneTreeiENSGT00390000005787.
    HOGENOMiHOG000007656.
    HOVERGENiHBG004374.
    InParanoidiQ9QXP0.
    KOiK06580.
    OMAiENCFEDE.
    OrthoDBiEOG73NG3C.
    PhylomeDBiQ9QXP0.
    TreeFamiTF314450.

    Family and domain databases

    Gene3Di1.10.3430.10. 1 hit.
    InterProiIPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view]
    PfamiPF00909. Ammonium_transp. 1 hit.
    [Graphical view]
    PRINTSiPR00342. RHESUSRHD.
    SUPFAMiSSF111352. SSF111352. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QXP0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWNTNLRGR LPITCLILQV TMVVLFGVFV RYDIQADAHW WLEKKRKNIS    50
    SDVENEFYYR YPSFQDVHAM VFVGFGFLMT FLQRYGFSAV GFNFLLAAFG 100
    IQWALLMQGW FHYFEEGHIV LSVENIIQAD FCVASSCVAF GAVLGKVSPM 150
    QLLIMTFFQV TLFTVNEFIL LNLIEAKDAG GSMTIHTFGA YFGLTVTWIL 200
    YRKNLDQSKQ RQSSVYHSDL FAMIGTLFLW IYWPSFNSAS SFHGDAQHRA 250
    ALNTYLSLAA SVLTTVTVSS IVHKKGKLDM VHIQNATLAG GVGVGTAAEM 300
    MLTPYGALIV GFFCGIFSTL GFAYLTPFLE SRHRIQDTCG IHNLHGIPGI 350
    IGGIVGAVTA AYSSPDVYGE PGIVHSFGFG SYKMDWNKRM QGRSQIFGLL 400
    LSLAMALVGG IIVGFILKLP FWGQAADENC FEDSIYWEVH EEVNTVYIPE 450
    DLAHKHSTSL VPAMPLVLPT TSASIVPPVP PTPPVSLATS APSAALVH 498
    Length:498
    Mass (Da):54,972
    Last modified:April 3, 2007 - v2
    Checksum:iB10F6A09C16DB464
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti333 – 3331H → L in AAF19373. (PubMed:10852913)Curated
    Sequence conflicti333 – 3331H → L in AAP81168. 1 PublicationCurated
    Sequence conflicti333 – 3331H → L in AAI19046. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193810 mRNA. Translation: AAF19373.1.
    AY254686 mRNA. Translation: AAP81168.1.
    AK076757 mRNA. Translation: BAC36469.1.
    BC119045 mRNA. Translation: AAI19046.1.
    CCDSiCCDS21383.1.
    RefSeqiNP_062773.2. NM_019799.3.
    UniGeneiMm.10909.

    Genome annotation databases

    EnsembliENSMUST00000032766; ENSMUSP00000032766; ENSMUSG00000030549.
    GeneIDi56315.
    KEGGimmu:56315.
    UCSCiuc009hyo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193810 mRNA. Translation: AAF19373.1 .
    AY254686 mRNA. Translation: AAP81168.1 .
    AK076757 mRNA. Translation: BAC36469.1 .
    BC119045 mRNA. Translation: AAI19046.1 .
    CCDSi CCDS21383.1.
    RefSeqi NP_062773.2. NM_019799.3.
    UniGenei Mm.10909.

    3D structure databases

    ProteinModelPortali Q9QXP0.
    SMRi Q9QXP0. Positions 2-441.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QXP0.

    Proteomic databases

    PRIDEi Q9QXP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032766 ; ENSMUSP00000032766 ; ENSMUSG00000030549 .
    GeneIDi 56315.
    KEGGi mmu:56315.
    UCSCi uc009hyo.2. mouse.

    Organism-specific databases

    CTDi 51458.
    MGIi MGI:1888517. Rhcg.

    Phylogenomic databases

    eggNOGi NOG276393.
    GeneTreei ENSGT00390000005787.
    HOGENOMi HOG000007656.
    HOVERGENi HBG004374.
    InParanoidi Q9QXP0.
    KOi K06580.
    OMAi ENCFEDE.
    OrthoDBi EOG73NG3C.
    PhylomeDBi Q9QXP0.
    TreeFami TF314450.

    Enzyme and pathway databases

    Reactomei REACT_198711. Rhesus glycoproteins mediate ammonium transport.

    Miscellaneous databases

    NextBioi 312264.
    PROi Q9QXP0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QXP0.
    CleanExi MM_RHCG.
    Genevestigatori Q9QXP0.

    Family and domain databases

    Gene3Di 1.10.3430.10. 1 hit.
    InterProi IPR029020. Ammonium/urea_transptr.
    IPR024041. NH4_transpt_AmtB-like_dom.
    IPR002229. RhesusRHD.
    [Graphical view ]
    Pfami PF00909. Ammonium_transp. 1 hit.
    [Graphical view ]
    PRINTSi PR00342. RHESUSRHD.
    SUPFAMi SSF111352. SSF111352. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis."
      Liu Z., Chen Y., Mo R., Hui C.-C., Cheng J.-F., Mohandas N., Huang C.-H.
      J. Biol. Chem. 275:25641-25651(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Functional characterization of Rhcg glycoprotein."
      Nakhoul N.L., Hamm L.L., Abdulnour-Nakhoul S.M., De Jong H., Palmer S.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
      Tissue: Kidney cortex.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney."
      Verlander J.W., Miller R.T., Frank A.E., Royaux I.E., Kim Y.-H., Weiner I.D.
      Am. J. Physiol. 284:F323-F337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract."
      Handlogten M.E., Hong S.-P., Zhang L., Vander A.W., Steinbaum M.L., Campbell-Thompson M., Weiner I.D.
      Am. J. Physiol. 288:G1036-G1047(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    7. "Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG."
      Mak D.-O., Dang B., Weiner I.D., Foskett J.K., Westhoff C.M.
      Am. J. Physiol. 290:F297-F305(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRHCG_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXP0
    Secondary accession number(s): Q8BVS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3