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Protein

Ammonium transporter Rh type C

Gene

Rhcg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ammonium transport Source: UniProtKB
  • cellular ion homeostasis Source: MGI
  • nitrogen utilization Source: GO_Central
  • organic cation transport Source: GO_Central
  • regulation of pH Source: UniProtKB
  • transepithelial ammonium transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-444411. Rhesus glycoproteins mediate ammonium transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type C
Alternative name(s):
Rhesus blood group family type C glycoprotein
Short name:
Rh family type C glycoprotein
Short name:
Rh type C glycoprotein
Rhesus blood group-associated C glycoprotein
Short name:
Rhesus-associated C glycoprotein
Gene namesi
Name:Rhcg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1888517. Rhcg.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 61ExtracellularSequence analysisAdd BLAST31
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 86CytoplasmicSequence analysis4
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 124ExtracellularSequence analysisAdd BLAST17
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 153CytoplasmicSequence analysis8
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 179ExtracellularSequence analysis5
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 219CytoplasmicSequence analysisAdd BLAST19
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 251ExtracellularSequence analysisAdd BLAST11
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 279CytoplasmicSequence analysis7
Transmembranei280 – 302HelicalSequence analysisAdd BLAST23
Topological domaini303 – 304ExtracellularSequence analysis2
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 340CytoplasmicSequence analysisAdd BLAST15
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 395ExtracellularSequence analysisAdd BLAST34
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 498CytoplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835791 – 498Ammonium transporter Rh type CAdd BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QXP0.
PRIDEiQ9QXP0.

PTM databases

PhosphoSitePlusiQ9QXP0.

Expressioni

Tissue specificityi

Expressed in the forestomach and the fundus of the stomach. Expressed at the level of villous in duodenum, jejunum, ileum and colon. Expressed in kidney by connecting segments and collecting tubules (at protein level). Expressed in testis by seminiferous tubules.3 Publications

Gene expression databases

BgeeiENSMUSG00000030549.
CleanExiMM_RHCG.
ExpressionAtlasiQ9QXP0. baseline and differential.
GenevisibleiQ9QXP0. MM.

Interactioni

Subunit structurei

Homotrimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032766.

Structurei

3D structure databases

ProteinModelPortaliQ9QXP0.
SMRiQ9QXP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ9QXP0.
KOiK06580.
OMAiENCFEDE.
OrthoDBiEOG091G06KX.
PhylomeDBiQ9QXP0.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QXP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWNTNLRGR LPITCLILQV TMVVLFGVFV RYDIQADAHW WLEKKRKNIS
60 70 80 90 100
SDVENEFYYR YPSFQDVHAM VFVGFGFLMT FLQRYGFSAV GFNFLLAAFG
110 120 130 140 150
IQWALLMQGW FHYFEEGHIV LSVENIIQAD FCVASSCVAF GAVLGKVSPM
160 170 180 190 200
QLLIMTFFQV TLFTVNEFIL LNLIEAKDAG GSMTIHTFGA YFGLTVTWIL
210 220 230 240 250
YRKNLDQSKQ RQSSVYHSDL FAMIGTLFLW IYWPSFNSAS SFHGDAQHRA
260 270 280 290 300
ALNTYLSLAA SVLTTVTVSS IVHKKGKLDM VHIQNATLAG GVGVGTAAEM
310 320 330 340 350
MLTPYGALIV GFFCGIFSTL GFAYLTPFLE SRHRIQDTCG IHNLHGIPGI
360 370 380 390 400
IGGIVGAVTA AYSSPDVYGE PGIVHSFGFG SYKMDWNKRM QGRSQIFGLL
410 420 430 440 450
LSLAMALVGG IIVGFILKLP FWGQAADENC FEDSIYWEVH EEVNTVYIPE
460 470 480 490
DLAHKHSTSL VPAMPLVLPT TSASIVPPVP PTPPVSLATS APSAALVH
Length:498
Mass (Da):54,972
Last modified:April 3, 2007 - v2
Checksum:iB10F6A09C16DB464
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti333H → L in AAF19373 (PubMed:10852913).Curated1
Sequence conflicti333H → L in AAP81168 (Ref. 2) Curated1
Sequence conflicti333H → L in AAI19046 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193810 mRNA. Translation: AAF19373.1.
AY254686 mRNA. Translation: AAP81168.1.
AK076757 mRNA. Translation: BAC36469.1.
BC119045 mRNA. Translation: AAI19046.1.
CCDSiCCDS21383.1.
RefSeqiNP_062773.2. NM_019799.3.
UniGeneiMm.10909.

Genome annotation databases

EnsembliENSMUST00000032766; ENSMUSP00000032766; ENSMUSG00000030549.
GeneIDi56315.
KEGGimmu:56315.
UCSCiuc009hyo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193810 mRNA. Translation: AAF19373.1.
AY254686 mRNA. Translation: AAP81168.1.
AK076757 mRNA. Translation: BAC36469.1.
BC119045 mRNA. Translation: AAI19046.1.
CCDSiCCDS21383.1.
RefSeqiNP_062773.2. NM_019799.3.
UniGeneiMm.10909.

3D structure databases

ProteinModelPortaliQ9QXP0.
SMRiQ9QXP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032766.

PTM databases

PhosphoSitePlusiQ9QXP0.

Proteomic databases

PaxDbiQ9QXP0.
PRIDEiQ9QXP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032766; ENSMUSP00000032766; ENSMUSG00000030549.
GeneIDi56315.
KEGGimmu:56315.
UCSCiuc009hyo.2. mouse.

Organism-specific databases

CTDi51458.
MGIiMGI:1888517. Rhcg.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ9QXP0.
KOiK06580.
OMAiENCFEDE.
OrthoDBiEOG091G06KX.
PhylomeDBiQ9QXP0.
TreeFamiTF314450.

Enzyme and pathway databases

ReactomeiR-MMU-444411. Rhesus glycoproteins mediate ammonium transport.

Miscellaneous databases

PROiQ9QXP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030549.
CleanExiMM_RHCG.
ExpressionAtlasiQ9QXP0. baseline and differential.
GenevisibleiQ9QXP0. MM.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHCG_MOUSE
AccessioniPrimary (citable) accession number: Q9QXP0
Secondary accession number(s): Q8BVS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.