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Q9QXP0

- RHCG_MOUSE

UniProt

Q9QXP0 - RHCG_MOUSE

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Protein
Ammonium transporter Rh type C
Gene
Rhcg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.1 Publication

GO - Molecular functioni

  1. ammonium transmembrane transporter activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. ammonium transport Source: UniProtKB
  2. cellular ion homeostasis Source: Ensembl
  3. regulation of pH Source: UniProtKB
  4. transepithelial ammonium transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198711. Rhesus glycoproteins mediate ammonium transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type C
Alternative name(s):
Rhesus blood group family type C glycoprotein
Short name:
Rh family type C glycoprotein
Short name:
Rh type C glycoprotein
Rhesus blood group-associated C glycoprotein
Short name:
Rhesus-associated C glycoprotein
Gene namesi
Name:Rhcg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1888517. Rhcg.

Subcellular locationi

Apical cell membrane; Multi-pass membrane protein
Note: Also detected at the basolateral membrane and in subapical vesicles By similarity.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic Reviewed prediction
Transmembranei10 – 3021Helical; Reviewed prediction
Add
BLAST
Topological domaini31 – 6131Extracellular Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 864Cytoplasmic Reviewed prediction
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Topological domaini108 – 12417Extracellular Reviewed prediction
Add
BLAST
Transmembranei125 – 14521Helical; Reviewed prediction
Add
BLAST
Topological domaini146 – 1538Cytoplasmic Reviewed prediction
Transmembranei154 – 17421Helical; Reviewed prediction
Add
BLAST
Topological domaini175 – 1795Extracellular Reviewed prediction
Transmembranei180 – 20021Helical; Reviewed prediction
Add
BLAST
Topological domaini201 – 21919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei220 – 24021Helical; Reviewed prediction
Add
BLAST
Topological domaini241 – 25111Extracellular Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Reviewed prediction
Add
BLAST
Topological domaini273 – 2797Cytoplasmic Reviewed prediction
Transmembranei280 – 30223Helical; Reviewed prediction
Add
BLAST
Topological domaini303 – 3042Extracellular Reviewed prediction
Transmembranei305 – 32521Helical; Reviewed prediction
Add
BLAST
Topological domaini326 – 34015Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei341 – 36121Helical; Reviewed prediction
Add
BLAST
Topological domaini362 – 39534Extracellular Reviewed prediction
Add
BLAST
Transmembranei396 – 41621Helical; Reviewed prediction
Add
BLAST
Topological domaini417 – 49882Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. basolateral plasma membrane Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Ammonium transporter Rh type C
PRO_0000283579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9QXP0.

PTM databases

PhosphoSiteiQ9QXP0.

Expressioni

Tissue specificityi

Expressed in the forestomach and the fundus of the stomach. Expressed at the level of villous in duodenum, jejunum, ileum and colon. Expressed in kidney by connecting segments and collecting tubules (at protein level). Expressed in testis by seminiferous tubules.3 Publications

Gene expression databases

BgeeiQ9QXP0.
CleanExiMM_RHCG.
GenevestigatoriQ9QXP0.

Interactioni

Subunit structurei

Homotrimer.

Structurei

3D structure databases

ProteinModelPortaliQ9QXP0.
SMRiQ9QXP0. Positions 2-441.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276393.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
HOVERGENiHBG004374.
InParanoidiQ9QXP0.
KOiK06580.
OMAiENCFEDE.
OrthoDBiEOG73NG3C.
PhylomeDBiQ9QXP0.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QXP0-1 [UniParc]FASTAAdd to Basket

« Hide

MAWNTNLRGR LPITCLILQV TMVVLFGVFV RYDIQADAHW WLEKKRKNIS    50
SDVENEFYYR YPSFQDVHAM VFVGFGFLMT FLQRYGFSAV GFNFLLAAFG 100
IQWALLMQGW FHYFEEGHIV LSVENIIQAD FCVASSCVAF GAVLGKVSPM 150
QLLIMTFFQV TLFTVNEFIL LNLIEAKDAG GSMTIHTFGA YFGLTVTWIL 200
YRKNLDQSKQ RQSSVYHSDL FAMIGTLFLW IYWPSFNSAS SFHGDAQHRA 250
ALNTYLSLAA SVLTTVTVSS IVHKKGKLDM VHIQNATLAG GVGVGTAAEM 300
MLTPYGALIV GFFCGIFSTL GFAYLTPFLE SRHRIQDTCG IHNLHGIPGI 350
IGGIVGAVTA AYSSPDVYGE PGIVHSFGFG SYKMDWNKRM QGRSQIFGLL 400
LSLAMALVGG IIVGFILKLP FWGQAADENC FEDSIYWEVH EEVNTVYIPE 450
DLAHKHSTSL VPAMPLVLPT TSASIVPPVP PTPPVSLATS APSAALVH 498
Length:498
Mass (Da):54,972
Last modified:April 3, 2007 - v2
Checksum:iB10F6A09C16DB464
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti333 – 3331H → L in AAF19373. 1 Publication
Sequence conflicti333 – 3331H → L in AAP81168. 1 Publication
Sequence conflicti333 – 3331H → L in AAI19046. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193810 mRNA. Translation: AAF19373.1.
AY254686 mRNA. Translation: AAP81168.1.
AK076757 mRNA. Translation: BAC36469.1.
BC119045 mRNA. Translation: AAI19046.1.
CCDSiCCDS21383.1.
RefSeqiNP_062773.2. NM_019799.3.
UniGeneiMm.10909.

Genome annotation databases

EnsembliENSMUST00000032766; ENSMUSP00000032766; ENSMUSG00000030549.
GeneIDi56315.
KEGGimmu:56315.
UCSCiuc009hyo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193810 mRNA. Translation: AAF19373.1 .
AY254686 mRNA. Translation: AAP81168.1 .
AK076757 mRNA. Translation: BAC36469.1 .
BC119045 mRNA. Translation: AAI19046.1 .
CCDSi CCDS21383.1.
RefSeqi NP_062773.2. NM_019799.3.
UniGenei Mm.10909.

3D structure databases

ProteinModelPortali Q9QXP0.
SMRi Q9QXP0. Positions 2-441.
ModBasei Search...

PTM databases

PhosphoSitei Q9QXP0.

Proteomic databases

PRIDEi Q9QXP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032766 ; ENSMUSP00000032766 ; ENSMUSG00000030549 .
GeneIDi 56315.
KEGGi mmu:56315.
UCSCi uc009hyo.2. mouse.

Organism-specific databases

CTDi 51458.
MGIi MGI:1888517. Rhcg.

Phylogenomic databases

eggNOGi NOG276393.
GeneTreei ENSGT00390000005787.
HOGENOMi HOG000007656.
HOVERGENi HBG004374.
InParanoidi Q9QXP0.
KOi K06580.
OMAi ENCFEDE.
OrthoDBi EOG73NG3C.
PhylomeDBi Q9QXP0.
TreeFami TF314450.

Enzyme and pathway databases

Reactomei REACT_198711. Rhesus glycoproteins mediate ammonium transport.

Miscellaneous databases

NextBioi 312264.
PROi Q9QXP0.
SOURCEi Search...

Gene expression databases

Bgeei Q9QXP0.
CleanExi MM_RHCG.
Genevestigatori Q9QXP0.

Family and domain databases

Gene3Di 1.10.3430.10. 1 hit.
InterProi IPR029020. Ammonium/urea_transptr.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view ]
Pfami PF00909. Ammonium_transp. 1 hit.
[Graphical view ]
PRINTSi PR00342. RHESUSRHD.
SUPFAMi SSF111352. SSF111352. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis."
    Liu Z., Chen Y., Mo R., Hui C.-C., Cheng J.-F., Mohandas N., Huang C.-H.
    J. Biol. Chem. 275:25641-25651(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Functional characterization of Rhcg glycoprotein."
    Nakhoul N.L., Hamm L.L., Abdulnour-Nakhoul S.M., De Jong H., Palmer S.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
    Tissue: Kidney cortex.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney."
    Verlander J.W., Miller R.T., Frank A.E., Royaux I.E., Kim Y.-H., Weiner I.D.
    Am. J. Physiol. 284:F323-F337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract."
    Handlogten M.E., Hong S.-P., Zhang L., Vander A.W., Steinbaum M.L., Campbell-Thompson M., Weiner I.D.
    Am. J. Physiol. 288:G1036-G1047(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  7. "Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG."
    Mak D.-O., Dang B., Weiner I.D., Foskett J.K., Westhoff C.M.
    Am. J. Physiol. 290:F297-F305(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRHCG_MOUSE
AccessioniPrimary (citable) accession number: Q9QXP0
Secondary accession number(s): Q8BVS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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