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Q9QXN4

- MIOX_RAT

UniProt

Q9QXN4 - MIOX_RAT

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Protein

Inositol oxygenase

Gene
Miox, Aldrl6, Ksp32, Rsor
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291Substrate By similarity
Metal bindingi98 – 981Iron 1 By similarity
Metal bindingi123 – 1231Iron 1 By similarity
Metal bindingi124 – 1241Iron 1 By similarity
Metal bindingi124 – 1241Iron 2 By similarity
Binding sitei127 – 1271Substrate By similarity
Metal bindingi194 – 1941Iron 2 By similarity
Metal bindingi220 – 2201Iron 2 By similarity
Metal bindingi253 – 2531Iron 1 By similarity

GO - Molecular functioni

  1. aldo-keto reductase (NADP) activity Source: UniProtKB
  2. ferric iron binding Source: UniProtKB
  3. inositol oxygenase activity Source: UniProtKB
  4. NADP binding Source: RGD
  5. oxidoreductase activity, acting on NAD(P)H Source: Ensembl
  6. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Source: UniProtKB

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.99.1. 5301.
SABIO-RKQ9QXN4.
UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Aldehyde reductase-like 6
Kidney-specific protein 32
Myo-inositol oxygenase
Short name:
MI oxygenase
Renal-specific oxidoreductase
Gene namesi
Name:Miox
Synonyms:Aldrl6, Ksp32, Rsor
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi628739. Miox.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. inclusion body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Inositol oxygenasePRO_0000079152Add
BLAST

Proteomic databases

PRIDEiQ9QXN4.

PTM databases

PhosphoSiteiQ9QXN4.

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

GenevestigatoriQ9QXN4.

Structurei

3D structure databases

ProteinModelPortaliQ9QXN4.
SMRiQ9QXN4. Positions 28-285.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 873Substrate binding By similarity
Regioni141 – 1422Substrate binding By similarity
Regioni220 – 2212Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG135479.
GeneTreeiENSGT00390000016211.
HOGENOMiHOG000163182.
HOVERGENiHBG039556.
InParanoidiQ9QXN4.
KOiK00469.
OMAiNFYREQH.
OrthoDBiEOG7DZ8KD.
PhylomeDBiQ9QXN4.
TreeFamiTF300089.

Family and domain databases

InterProiIPR018170. Aldo/ket_reductase_CS.
IPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]
PROSITEiPS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXN4-1 [UniParc]FASTAAdd to Basket

« Hide

MKVDLGPDPS LVYRPDVDPE MAKSKGSFRN YTSGPLLDRV FTTYKLMHTH    50
QTVDFVMRKR IQFGSFSYKK MTVMEAVDML DDLVDESDPD VDFPNSFHAF 100
QTAEGIRKAH PDKDWFHLVG LLHDLGKILA LWGEPQWAVV GDTFPVGCRP 150
QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLENVLM SWGHDEYLYQ 200
MMKFNKFSLP SEAFYMVRFH SFYPWHTGGD YRQLCSQQDL DMLPWVQEFN 250
KFDLYTKCPD LPEVKSLRPY YQGLIDKYCP GILSW 285
Length:285
Mass (Da):33,185
Last modified:November 8, 2005 - v2
Checksum:iF34A26521979AE89
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 52DL → TV in AAK00767. 1 Publication
Sequence conflicti21 – 211M → V in AAK00767. 1 Publication
Sequence conflicti24 – 263SKG → DKA in AAK00767. 1 Publication
Sequence conflicti57 – 571M → R1 Publication
Sequence conflicti57 – 571M → V in AAV65817. 1 Publication
Sequence conflicti58 – 614RKRI → SKHA1 Publication
Sequence conflicti282 – 2821I → T1 Publication
Sequence conflicti282 – 2821I → T1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF197128 mRNA. Translation: AAF25203.1.
AF230096 mRNA. Translation: AAK00767.1.
AY738259 mRNA. Translation: AAV65817.1.
BC078840 mRNA. Translation: AAH78840.1.
RefSeqiNP_665714.2. NM_145771.2.
UniGeneiRn.19959.

Genome annotation databases

EnsembliENSRNOT00000011941; ENSRNOP00000011941; ENSRNOG00000008694.
GeneIDi252899.
KEGGirno:252899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF197128 mRNA. Translation: AAF25203.1 .
AF230096 mRNA. Translation: AAK00767.1 .
AY738259 mRNA. Translation: AAV65817.1 .
BC078840 mRNA. Translation: AAH78840.1 .
RefSeqi NP_665714.2. NM_145771.2.
UniGenei Rn.19959.

3D structure databases

ProteinModelPortali Q9QXN4.
SMRi Q9QXN4. Positions 28-285.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QXN4.

Proteomic databases

PRIDEi Q9QXN4.

Protocols and materials databases

DNASUi 252899.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011941 ; ENSRNOP00000011941 ; ENSRNOG00000008694 .
GeneIDi 252899.
KEGGi rno:252899.

Organism-specific databases

CTDi 55586.
RGDi 628739. Miox.

Phylogenomic databases

eggNOGi NOG135479.
GeneTreei ENSGT00390000016211.
HOGENOMi HOG000163182.
HOVERGENi HBG039556.
InParanoidi Q9QXN4.
KOi K00469.
OMAi NFYREQH.
OrthoDBi EOG7DZ8KD.
PhylomeDBi Q9QXN4.
TreeFami TF300089.

Enzyme and pathway databases

UniPathwayi UPA00111 ; UER00527 .
BRENDAi 1.13.99.1. 5301.
SABIO-RK Q9QXN4.

Miscellaneous databases

NextBioi 624027.
PROi Q9QXN4.

Gene expression databases

Genevestigatori Q9QXN4.

Family and domain databases

InterProi IPR018170. Aldo/ket_reductase_CS.
IPR007828. Inositol_oxygenase.
[Graphical view ]
PANTHERi PTHR12588. PTHR12588. 1 hit.
Pfami PF05153. DUF706. 1 hit.
[Graphical view ]
PROSITEi PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a renal-specific oxido-reductase in newborn diabetic mice."
    Yang Q., Dixit B., Wada J., Tian Y., Wallner E.I., Srivastva S.K., Kanwar Y.S.
    Proc. Natl. Acad. Sci. U.S.A. 97:9896-9901(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Identification of a novel kidney specific gene, KSP32, that is down regulated in acute ischemic renal failure."
    Hu E., Chen Z., Fredrickson T., Gellai M., Jugus M., Contino L., Spurr N., Sims M., Halsey W., Van Horn S., Mao J., Sathe G., Brooks D.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney."
    Arner R.J., Prabhu K.S., Reddy C.C.
    Biochem. Biophys. Res. Commun. 324:1386-1392(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMIOX_RAT
AccessioniPrimary (citable) accession number: Q9QXN4
Secondary accession number(s): Q5S8C8, Q68G06, Q99PN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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