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Q9QXN4

- MIOX_RAT

UniProt

Q9QXN4 - MIOX_RAT

Protein

Inositol oxygenase

Gene

Miox

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Myo-inositol + O2 = D-glucuronate + H2O.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291SubstrateBy similarity
    Metal bindingi98 – 981Iron 1By similarity
    Metal bindingi123 – 1231Iron 1By similarity
    Metal bindingi124 – 1241Iron 1By similarity
    Metal bindingi124 – 1241Iron 2By similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Metal bindingi194 – 1941Iron 2By similarity
    Metal bindingi220 – 2201Iron 2By similarity
    Metal bindingi253 – 2531Iron 1By similarity

    GO - Molecular functioni

    1. aldo-keto reductase (NADP) activity Source: UniProtKB
    2. ferric iron binding Source: UniProtKB
    3. inositol oxygenase activity Source: UniProtKB
    4. NADP binding Source: RGD
    5. oxidoreductase activity, acting on NAD(P)H Source: Ensembl
    6. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Source: UniProtKB

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BRENDAi1.13.99.1. 5301.
    SABIO-RKQ9QXN4.
    UniPathwayiUPA00111; UER00527.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol oxygenase (EC:1.13.99.1)
    Alternative name(s):
    Aldehyde reductase-like 6
    Kidney-specific protein 32
    Myo-inositol oxygenase
    Short name:
    MI oxygenase
    Renal-specific oxidoreductase
    Gene namesi
    Name:Miox
    Synonyms:Aldrl6, Ksp32, Rsor
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi628739. Miox.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. inclusion body Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Inositol oxygenasePRO_0000079152Add
    BLAST

    Proteomic databases

    PRIDEiQ9QXN4.

    PTM databases

    PhosphoSiteiQ9QXN4.

    Expressioni

    Tissue specificityi

    Kidney specific.

    Gene expression databases

    GenevestigatoriQ9QXN4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXN4.
    SMRiQ9QXN4. Positions 28-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni85 – 873Substrate bindingBy similarity
    Regioni141 – 1422Substrate bindingBy similarity
    Regioni220 – 2212Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the myo-inositol oxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG135479.
    GeneTreeiENSGT00390000016211.
    HOGENOMiHOG000163182.
    HOVERGENiHBG039556.
    InParanoidiQ9QXN4.
    KOiK00469.
    OMAiNFYREQH.
    OrthoDBiEOG7DZ8KD.
    PhylomeDBiQ9QXN4.
    TreeFamiTF300089.

    Family and domain databases

    InterProiIPR018170. Aldo/ket_reductase_CS.
    IPR007828. Inositol_oxygenase.
    [Graphical view]
    PANTHERiPTHR12588. PTHR12588. 1 hit.
    PfamiPF05153. DUF706. 1 hit.
    [Graphical view]
    PROSITEiPS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QXN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVDLGPDPS LVYRPDVDPE MAKSKGSFRN YTSGPLLDRV FTTYKLMHTH    50
    QTVDFVMRKR IQFGSFSYKK MTVMEAVDML DDLVDESDPD VDFPNSFHAF 100
    QTAEGIRKAH PDKDWFHLVG LLHDLGKILA LWGEPQWAVV GDTFPVGCRP 150
    QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLENVLM SWGHDEYLYQ 200
    MMKFNKFSLP SEAFYMVRFH SFYPWHTGGD YRQLCSQQDL DMLPWVQEFN 250
    KFDLYTKCPD LPEVKSLRPY YQGLIDKYCP GILSW 285
    Length:285
    Mass (Da):33,185
    Last modified:November 8, 2005 - v2
    Checksum:iF34A26521979AE89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 52DL → TV in AAK00767. 1 PublicationCurated
    Sequence conflicti21 – 211M → V in AAK00767. 1 PublicationCurated
    Sequence conflicti24 – 263SKG → DKA in AAK00767. 1 PublicationCurated
    Sequence conflicti57 – 571M → R1 PublicationCurated
    Sequence conflicti57 – 571M → V in AAV65817. (PubMed:15504367)Curated
    Sequence conflicti58 – 614RKRI → SKHA1 PublicationCurated
    Sequence conflicti282 – 2821I → T(PubMed:10944187)Curated
    Sequence conflicti282 – 2821I → T(PubMed:15504367)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF197128 mRNA. Translation: AAF25203.1.
    AF230096 mRNA. Translation: AAK00767.1.
    AY738259 mRNA. Translation: AAV65817.1.
    BC078840 mRNA. Translation: AAH78840.1.
    RefSeqiNP_665714.2. NM_145771.2.
    UniGeneiRn.19959.

    Genome annotation databases

    EnsembliENSRNOT00000011941; ENSRNOP00000011941; ENSRNOG00000008694.
    GeneIDi252899.
    KEGGirno:252899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF197128 mRNA. Translation: AAF25203.1 .
    AF230096 mRNA. Translation: AAK00767.1 .
    AY738259 mRNA. Translation: AAV65817.1 .
    BC078840 mRNA. Translation: AAH78840.1 .
    RefSeqi NP_665714.2. NM_145771.2.
    UniGenei Rn.19959.

    3D structure databases

    ProteinModelPortali Q9QXN4.
    SMRi Q9QXN4. Positions 28-285.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QXN4.

    Proteomic databases

    PRIDEi Q9QXN4.

    Protocols and materials databases

    DNASUi 252899.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011941 ; ENSRNOP00000011941 ; ENSRNOG00000008694 .
    GeneIDi 252899.
    KEGGi rno:252899.

    Organism-specific databases

    CTDi 55586.
    RGDi 628739. Miox.

    Phylogenomic databases

    eggNOGi NOG135479.
    GeneTreei ENSGT00390000016211.
    HOGENOMi HOG000163182.
    HOVERGENi HBG039556.
    InParanoidi Q9QXN4.
    KOi K00469.
    OMAi NFYREQH.
    OrthoDBi EOG7DZ8KD.
    PhylomeDBi Q9QXN4.
    TreeFami TF300089.

    Enzyme and pathway databases

    UniPathwayi UPA00111 ; UER00527 .
    BRENDAi 1.13.99.1. 5301.
    SABIO-RK Q9QXN4.

    Miscellaneous databases

    NextBioi 624027.
    PROi Q9QXN4.

    Gene expression databases

    Genevestigatori Q9QXN4.

    Family and domain databases

    InterProi IPR018170. Aldo/ket_reductase_CS.
    IPR007828. Inositol_oxygenase.
    [Graphical view ]
    PANTHERi PTHR12588. PTHR12588. 1 hit.
    Pfami PF05153. DUF706. 1 hit.
    [Graphical view ]
    PROSITEi PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a renal-specific oxido-reductase in newborn diabetic mice."
      Yang Q., Dixit B., Wada J., Tian Y., Wallner E.I., Srivastva S.K., Kanwar Y.S.
      Proc. Natl. Acad. Sci. U.S.A. 97:9896-9901(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "Identification of a novel kidney specific gene, KSP32, that is down regulated in acute ischemic renal failure."
      Hu E., Chen Z., Fredrickson T., Gellai M., Jugus M., Contino L., Spurr N., Sims M., Halsey W., Van Horn S., Mao J., Sathe G., Brooks D.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney."
      Arner R.J., Prabhu K.S., Reddy C.C.
      Biochem. Biophys. Res. Commun. 324:1386-1392(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Long Evans.
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiMIOX_RAT
    AccessioniPrimary (citable) accession number: Q9QXN4
    Secondary accession number(s): Q5S8C8, Q68G06, Q99PN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3