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Q9QXN4 (MIOX_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol oxygenase

EC=1.13.99.1
Alternative name(s):
Aldehyde reductase-like 6
Kidney-specific protein 32
Myo-inositol oxygenase
Short name=MI oxygenase
Renal-specific oxidoreductase
Gene names
Name:Miox
Synonyms:Aldrl6, Ksp32, Rsor
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Kidney specific.

Sequence similarities

Belongs to the myo-inositol oxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Inositol oxygenase
PRO_0000079152

Regions

Region85 – 873Substrate binding By similarity
Region141 – 1422Substrate binding By similarity
Region220 – 2212Substrate binding By similarity

Sites

Metal binding981Iron 1 By similarity
Metal binding1231Iron 1 By similarity
Metal binding1241Iron 1 By similarity
Metal binding1241Iron 2 By similarity
Metal binding1941Iron 2 By similarity
Metal binding2201Iron 2 By similarity
Metal binding2531Iron 1 By similarity
Binding site291Substrate By similarity
Binding site1271Substrate By similarity

Experimental info

Sequence conflict4 – 52DL → TV in AAK00767. Ref.2
Sequence conflict211M → V in AAK00767. Ref.2
Sequence conflict24 – 263SKG → DKA in AAK00767. Ref.2
Sequence conflict571M → R Ref.2
Sequence conflict571M → V in AAV65817. Ref.3
Sequence conflict58 – 614RKRI → SKHA Ref.2
Sequence conflict2821I → T Ref.1
Sequence conflict2821I → T Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9QXN4 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: F34A26521979AE89

FASTA28533,185
        10         20         30         40         50         60 
MKVDLGPDPS LVYRPDVDPE MAKSKGSFRN YTSGPLLDRV FTTYKLMHTH QTVDFVMRKR 

        70         80         90        100        110        120 
IQFGSFSYKK MTVMEAVDML DDLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG 

       130        140        150        160        170        180 
LLHDLGKILA LWGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ 

       190        200        210        220        230        240 
PHCGLENVLM SWGHDEYLYQ MMKFNKFSLP SEAFYMVRFH SFYPWHTGGD YRQLCSQQDL 

       250        260        270        280 
DMLPWVQEFN KFDLYTKCPD LPEVKSLRPY YQGLIDKYCP GILSW 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a renal-specific oxido-reductase in newborn diabetic mice."
Yang Q., Dixit B., Wada J., Tian Y., Wallner E.I., Srivastva S.K., Kanwar Y.S.
Proc. Natl. Acad. Sci. U.S.A. 97:9896-9901(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"Identification of a novel kidney specific gene, KSP32, that is down regulated in acute ischemic renal failure."
Hu E., Chen Z., Fredrickson T., Gellai M., Jugus M., Contino L., Spurr N., Sims M., Halsey W., Van Horn S., Mao J., Sathe G., Brooks D.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney."
Arner R.J., Prabhu K.S., Reddy C.C.
Biochem. Biophys. Res. Commun. 324:1386-1392(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Long Evans.
Tissue: Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF197128 mRNA. Translation: AAF25203.1.
AF230096 mRNA. Translation: AAK00767.1.
AY738259 mRNA. Translation: AAV65817.1.
BC078840 mRNA. Translation: AAH78840.1.
RefSeqNP_665714.2. NM_145771.2.
UniGeneRn.19959.

3D structure databases

ProteinModelPortalQ9QXN4.
SMRQ9QXN4. Positions 28-285.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QXN4.

Proteomic databases

PRIDEQ9QXN4.

Protocols and materials databases

DNASU252899.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011941; ENSRNOP00000011941; ENSRNOG00000008694.
GeneID252899.
KEGGrno:252899.

Organism-specific databases

CTD55586.
RGD628739. Miox.

Phylogenomic databases

eggNOGNOG135479.
GeneTreeENSGT00390000016211.
HOGENOMHOG000163182.
HOVERGENHBG039556.
InParanoidQ9QXN4.
KOK00469.
OMANFYREQH.
OrthoDBEOG7DZ8KD.
PhylomeDBQ9QXN4.
TreeFamTF300089.

Enzyme and pathway databases

BRENDA1.13.99.1. 5301.
SABIO-RKQ9QXN4.
UniPathwayUPA00111; UER00527.

Gene expression databases

GenevestigatorQ9QXN4.

Family and domain databases

InterProIPR018170. Aldo/ket_reductase_CS.
IPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERPTHR12588. PTHR12588. 1 hit.
PfamPF05153. DUF706. 1 hit.
[Graphical view]
PROSITEPS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio624027.
PROQ9QXN4.

Entry information

Entry nameMIOX_RAT
AccessionPrimary (citable) accession number: Q9QXN4
Secondary accession number(s): Q5S8C8, Q68G06, Q99PN7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways