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Q9QXN3

- TRIP4_MOUSE

UniProt

Q9QXN3 - TRIP4_MOUSE

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Protein
Activating signal cointegrator 1
Gene
Trip4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B By similarity. Plays a role in androgen receptor transactivation and testicular function.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 21953C4-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 1
Short name:
ASC-1
Alternative name(s):
Thyroid receptor-interacting protein 4
Short name:
TR-interacting protein 4
Short name:
TRIP-4
Gene namesi
Name:Trip4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1928469. Trip4.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Cytoplasmic under conditions of serum deprivation. Co- localizes with NEK6 in the centrosome By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. microtubule organizing center Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 581580Activating signal cointegrator 1
PRO_0000065632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei289 – 2891Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated by NEK6 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9QXN3.
PRIDEiQ9QXN3.

PTM databases

PhosphoSiteiQ9QXN3.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

ArrayExpressiQ9QXN3.
BgeeiQ9QXN3.
CleanExiMM_TRIP4.
GenevestigatoriQ9QXN3.

Interactioni

Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction requires the presence of thyroid hormone. Exists as a steady-state complex associated with ASCC1, ASCC2 and HELIC1 By similarity. Interacts with the androgen receptor androgen (AR) in an androgen, testosterone and dihydrotestosterone-dependent manner. Interacts with NEK6 By similarity.1 Publication

Protein-protein interaction databases

BioGridi207956. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QXN3.
SMRiQ9QXN3. Positions 434-581.

Family & Domainsi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG248556.
GeneTreeiENSGT00390000005300.
HOGENOMiHOG000006873.
HOVERGENiHBG061618.
InParanoidiQ9QXN3.
OMAiMSGTENS.
OrthoDBiEOG7RZ5PP.
TreeFamiTF314842.

Family and domain databases

InterProiIPR007374. ASCH_domain.
IPR015947. PUA-like_domain.
IPR009349. Znf_C2HC5.
[Graphical view]
PfamiPF04266. ASCH. 1 hit.
PF06221. zf-C2HC5. 1 hit.
[Graphical view]
SMARTiSM01022. ASCH. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QXN3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVAGAAYRE PLVHWCTQQL QKTFALDVSE EIIQYVLSIE NAEEIREYVT    50
DLLQGNEGKK GQFIEDLITK WQKNDQEFIS DSFQQCLRKD EILDGQRSVD 100
QLKRSRRKGR NKQEVPAFPE PDVAVEVKTP LDLAKAQESN NSVKKKTRFV 150
NLYTREGQDK LAVLLPGRHP CDCLGQKHKL INNCLVCGRI VCEQEGSGPC 200
LFCGSLVCTN EEQDILQRDS NKSQKLLKKL MSGAETSGKV DVSTKDLLPH 250
QESRMKSGLE KAIKHKEKLL EFDRTSIRRT QVIDDESDYF ASDSNQWLSK 300
VEREMLQKRE EELRELRHAS RLSKKVTIDF AGRKILEDEN PLAEYHSRLD 350
ETIQAIASGT LNQSLVTLDR SCEEPLGVLV NPNMYQASPQ WVDNTGSTPQ 400
KKTSLSAGPR LEPSLHQHQL RIQDQEFQEG FDGGWCLSMH QPWASLLVRG 450
IKRVEGRSWY TPHRGRLWIA ATGKRPSPQE VSELQATYRL LRGKDVEFPN 500
DYPSGCLLGC VDLIDCLSQK QFQEQFPDIS QESDSSFVFI CKNPQEMVVK 550
FPIKGNPKIW KLDSKIHQGA KKGLMKQNKA V 581
Length:581
Mass (Da):66,197
Last modified:July 27, 2011 - v2
Checksum:i2CAB3512E3CEDDA7
GO
Isoform 2 (identifier: Q9QXN3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-539: FPDISQESDSSFVF → GNWIPRSIKEQRRG
     540-581: Missing.

Note: No experimental confirmation available.

Show »
Length:539
Mass (Da):61,533
Checksum:iFF965B4855F43891
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei526 – 53914FPDIS…SSFVF → GNWIPRSIKEQRRG in isoform 2.
VSP_011109Add
BLAST
Alternative sequencei540 – 58142Missing in isoform 2.
VSP_011110Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71A → G in BAC30209. 1 Publication
Sequence conflicti388 – 3881S → P in AAF18440. 1 Publication
Sequence conflicti388 – 3881S → P in AAN23117. 1 Publication
Sequence conflicti388 – 3881S → P in AAH21316. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF197574 mRNA. Translation: AAF18440.1.
AF539614 mRNA. Translation: AAN23117.1.
AK039024 mRNA. Translation: BAC30209.1.
AC151906 Genomic DNA. No translation available.
BC021316 mRNA. Translation: AAH21316.1.
CCDSiCCDS23298.1. [Q9QXN3-1]
CCDS52838.1. [Q9QXN3-2]
RefSeqiNP_001164378.1. NM_001170907.1. [Q9QXN3-2]
NP_062771.2. NM_019797.4. [Q9QXN3-1]
XP_006511359.1. XM_006511296.1. [Q9QXN3-1]
XP_006511360.1. XM_006511297.1. [Q9QXN3-1]
XP_006511361.1. XM_006511298.1. [Q9QXN3-1]
XP_006511362.1. XM_006511299.1. [Q9QXN3-1]
XP_006511363.1. XM_006511300.1. [Q9QXN3-2]
UniGeneiMm.208379.

Genome annotation databases

EnsembliENSMUST00000117083; ENSMUSP00000113949; ENSMUSG00000032386. [Q9QXN3-1]
ENSMUST00000119245; ENSMUSP00000112385; ENSMUSG00000032386. [Q9QXN3-1]
ENSMUST00000122410; ENSMUSP00000112866; ENSMUSG00000032386. [Q9QXN3-2]
ENSMUST00000179395; ENSMUSP00000137304; ENSMUSG00000032386. [Q9QXN3-2]
GeneIDi56404.
KEGGimmu:56404.
UCSCiuc009qdz.2. mouse. [Q9QXN3-2]
uc012gvn.1. mouse. [Q9QXN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF197574 mRNA. Translation: AAF18440.1 .
AF539614 mRNA. Translation: AAN23117.1 .
AK039024 mRNA. Translation: BAC30209.1 .
AC151906 Genomic DNA. No translation available.
BC021316 mRNA. Translation: AAH21316.1 .
CCDSi CCDS23298.1. [Q9QXN3-1 ]
CCDS52838.1. [Q9QXN3-2 ]
RefSeqi NP_001164378.1. NM_001170907.1. [Q9QXN3-2 ]
NP_062771.2. NM_019797.4. [Q9QXN3-1 ]
XP_006511359.1. XM_006511296.1. [Q9QXN3-1 ]
XP_006511360.1. XM_006511297.1. [Q9QXN3-1 ]
XP_006511361.1. XM_006511298.1. [Q9QXN3-1 ]
XP_006511362.1. XM_006511299.1. [Q9QXN3-1 ]
XP_006511363.1. XM_006511300.1. [Q9QXN3-2 ]
UniGenei Mm.208379.

3D structure databases

ProteinModelPortali Q9QXN3.
SMRi Q9QXN3. Positions 434-581.
ModBasei Search...

Protein-protein interaction databases

BioGridi 207956. 3 interactions.

PTM databases

PhosphoSitei Q9QXN3.

Proteomic databases

MaxQBi Q9QXN3.
PRIDEi Q9QXN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000117083 ; ENSMUSP00000113949 ; ENSMUSG00000032386 . [Q9QXN3-1 ]
ENSMUST00000119245 ; ENSMUSP00000112385 ; ENSMUSG00000032386 . [Q9QXN3-1 ]
ENSMUST00000122410 ; ENSMUSP00000112866 ; ENSMUSG00000032386 . [Q9QXN3-2 ]
ENSMUST00000179395 ; ENSMUSP00000137304 ; ENSMUSG00000032386 . [Q9QXN3-2 ]
GeneIDi 56404.
KEGGi mmu:56404.
UCSCi uc009qdz.2. mouse. [Q9QXN3-2 ]
uc012gvn.1. mouse. [Q9QXN3-1 ]

Organism-specific databases

CTDi 9325.
MGIi MGI:1928469. Trip4.

Phylogenomic databases

eggNOGi NOG248556.
GeneTreei ENSGT00390000005300.
HOGENOMi HOG000006873.
HOVERGENi HBG061618.
InParanoidi Q9QXN3.
OMAi MSGTENS.
OrthoDBi EOG7RZ5PP.
TreeFami TF314842.

Miscellaneous databases

ChiTaRSi TRIP4. mouse.
NextBioi 312526.
PROi Q9QXN3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QXN3.
Bgeei Q9QXN3.
CleanExi MM_TRIP4.
Genevestigatori Q9QXN3.

Family and domain databases

InterProi IPR007374. ASCH_domain.
IPR015947. PUA-like_domain.
IPR009349. Znf_C2HC5.
[Graphical view ]
Pfami PF04266. ASCH. 1 hit.
PF06221. zf-C2HC5. 1 hit.
[Graphical view ]
SMARTi SM01022. ASCH. 1 hit.
[Graphical view ]
SUPFAMi SSF88697. SSF88697. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel transcription coactivator complex containing activating signal cointegrator 1."
    Jung D.-J., Sung H.-S., Goo Y.-W., Lee H.M., Park O.K., Jung S.-Y., Lim J., Kim H.-J., Lee S.-K., Kim T.S., Lee J.W., Lee Y.C.
    Mol. Cell. Biol. 22:5203-5211(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ASCC1; ASCC2 AND HELIC1.
    Tissue: Liver.
  2. "Activating signal cointegrator 1 is highly expressed in murine testicular Leydig cells and enhances the ligand-dependent transactivation of androgen receptor."
    Lee Y.S., Kim H.-J., Lee H.J., Lee J.W., Chun S.-Y., Ko S.-K., Lee K.
    Biol. Reprod. 67:1580-1587(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: Testis.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 89-97, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  7. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-289, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.

Entry informationi

Entry nameiTRIP4_MOUSE
AccessioniPrimary (citable) accession number: Q9QXN3
Secondary accession number(s): E9QK64, Q8CAD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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