Q9QXM0 (ABHD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 86.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Abhydrolase domain-containing protein 2 EC=3.1.1.- Alternative name(s): Lung alpha/beta hydrolase 2 Short name=MmLABH2 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 425 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | May play a role in smooth muscle cells migration. Ref.5 |
| Subcellular location | Membrane; Single-pass type II membrane protein Potential. |
| Tissue specificity | Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart. Ref.1 Ref.5 |
| Developmental stage | Detected in embryos from E7 to E17. Weakly expressed in heart at E9.5. Expression is detected in endothelial cells of the dorsal aorta at E10.5 and disappear at E12.5. Expression in smooth muscle cells is first detected at E11.5. Strongly expressed in vitelline vessels at E12.5. Expressed in all smooth muscle cells at E16.5. Ref.1 Ref.5 |
| Disruption phenotype | Neointimal hyperplasia. Ref.5 |
| Sequence similarities | Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Hydrolase Serine esterase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | negative regulation of cell migration Inferred from mutant phenotype Ref.5. Source: MGI response to woundingInferred from mutant phenotype Ref.5. Source: MGI |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular_function | carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 425 | 425 | Abhydrolase domain-containing protein 2 | PRO_0000280782 | |||||
Regions | |||||||||
| Transmembrane | 10 – 30 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||
Sites | |||||||||
| Active site | 207 | 1 | Charge relay system By similarity | ||||||
| Active site | 345 | 1 | Charge relay system By similarity | ||||||
| Active site | 376 | 1 | Charge relay system By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 21 | 1 | A → V in BAB25836. Ref.3 | ||||||
| Sequence conflict | 63 | 1 | T → A in AAH89477. Ref.4 | ||||||
| Sequence conflict | 338 | 1 | M → L in BAE32131. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs." Edgar A.J., Polak J.M. Biochem. Biophys. Res. Commun. 292:617-625(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Lung. |
| [2] | "Cloning of an androgen-regulated a/b hydrolase." Utleg A., White J., Lin B. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.  Hayashizaki Y.Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Egg, Stomach and Thymus. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor and Testis. |
| [5] | "Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene." Miyata K., Oike Y., Hoshii T., Maekawa H., Ogawa H., Suda T., Araki K., Yamamura K. Biochem. Biophys. Res. Commun. 329:296-304(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF201730 mRNA. Translation: AAF17566.1. AF546701 mRNA. Translation: AAQ12022.1. AK008690 mRNA. Translation: BAB25836.1. AK139526 mRNA. Translation: BAE24049.1. AK153642 mRNA. Translation: BAE32131.1. BC027098 mRNA. Translation: AAH27098.1. BC089477 mRNA. Translation: AAH89477.1. |
| IPI | IPI00471236. |
| RefSeq | NP_061281.3. NM_018811.6. |
| UniGene | Mm.365490. |
3D structure databases | |
| ProteinModelPortal | Q9QXM0. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S33.A56. |
PTM databases | |
| PhosphoSite | Q9QXM0. |
Proteomic databases | |
| PaxDb | Q9QXM0. |
| PRIDE | Q9QXM0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000037315; ENSMUSP00000038361; ENSMUSG00000039202. |
| GeneID | 54608. |
| KEGG | mmu:54608. |
| UCSC | uc009hyc.1. mouse. |
Organism-specific databases | |
| CTD | 11057. |
| MGI | MGI:1914344. Abhd2. |
Phylogenomic databases | |
| eggNOG | COG0429. |
| GeneTree | ENSGT00530000062981. |
| HOGENOM | HOG000230852. |
| HOVERGEN | HBG080812. |
| InParanoid | Q9QXM0. |
| KO | K13697. |
| OMA | YPQTQLV. |
| OrthoDB | EOG4PK27S. |
Gene expression databases | |
| Bgee | Q9QXM0. |
| CleanEx | MM_ABHD2. |
| Genevestigator | Q9QXM0. |
Family and domain databases | |
| InterPro | IPR012020. AB-Hydro_YheT. IPR000073. AB_hydrolase_1. IPR000952. UPF0017_hydro-like_CS. [Graphical view] |
| Pfam | PF00561. Abhydrolase_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF005211. Ab_hydro_YheT. 1 hit. |
| PROSITE | PS01133. UPF0017. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 311404. |
| SOURCE | Search... |
Entry information
| Entry name | ABHD2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9QXM0 Secondary accession number(s): Q3U5E8, Q5FWC6, Q9D7Y8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |