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Q9QXM0

- ABHD2_MOUSE

UniProt

Q9QXM0 - ABHD2_MOUSE

Protein

Abhydrolase domain-containing protein 2

Gene

Abhd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May play a role in smooth muscle cells migration.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei207 – 2071Charge relay systemBy similarity
    Active sitei345 – 3451Charge relay systemBy similarity
    Active sitei376 – 3761Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of cell migration Source: MGI
    2. response to wounding Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Protein family/group databases

    MEROPSiS33.A56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 2 (EC:3.1.1.-)
    Alternative name(s):
    Lung alpha/beta hydrolase 2
    Short name:
    MmLABH2
    Gene namesi
    Name:Abhd2
    Synonyms:Labh-2, Labh2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1914344. Abhd2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Neointimal hyperplasia.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Abhydrolase domain-containing protein 2PRO_0000280782Add
    BLAST

    Proteomic databases

    PaxDbiQ9QXM0.
    PRIDEiQ9QXM0.

    PTM databases

    PhosphoSiteiQ9QXM0.

    Expressioni

    Tissue specificityi

    Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart.2 Publications

    Developmental stagei

    Detected in embryos from E7 to E17. Weakly expressed in heart at E9.5. Expression is detected in endothelial cells of the dorsal aorta at E10.5 and disappear at E12.5. Expression in smooth muscle cells is first detected at E11.5. Strongly expressed in vitelline vessels at E12.5. Expressed in all smooth muscle cells at E16.5.2 Publications

    Gene expression databases

    BgeeiQ9QXM0.
    CleanExiMM_ABHD2.
    GenevestigatoriQ9QXM0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0429.
    GeneTreeiENSGT00530000062981.
    HOGENOMiHOG000230852.
    HOVERGENiHBG080812.
    InParanoidiQ9QXM0.
    KOiK13697.
    OMAiFSGHVQT.
    OrthoDBiEOG7RBZ87.
    PhylomeDBiQ9QXM0.
    TreeFamiTF313195.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000952. UPF0017_hydro-like_CS.
    [Graphical view]
    PfamiPF00561. Abhydrolase_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS01133. UPF0017. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QXM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG    50
    LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF 100
    ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA 150
    QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKRTYPQTQ 200
    LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD 250
    QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL 300
    MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE 350
    SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY 400
    ANAICQWERN KSQCSDTEQM EAELE 425
    Length:425
    Mass (Da):48,378
    Last modified:May 1, 2000 - v1
    Checksum:i82CC000D4A90004F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211A → V in BAB25836. (PubMed:16141072)Curated
    Sequence conflicti63 – 631T → A in AAH89477. (PubMed:15489334)Curated
    Sequence conflicti338 – 3381M → L in BAE32131. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201730 mRNA. Translation: AAF17566.1.
    AF546701 mRNA. Translation: AAQ12022.1.
    AK008690 mRNA. Translation: BAB25836.1.
    AK139526 mRNA. Translation: BAE24049.1.
    AK153642 mRNA. Translation: BAE32131.1.
    BC027098 mRNA. Translation: AAH27098.1.
    BC089477 mRNA. Translation: AAH89477.1.
    CCDSiCCDS21380.1.
    RefSeqiNP_061281.3. NM_018811.6.
    UniGeneiMm.365490.

    Genome annotation databases

    EnsembliENSMUST00000037315; ENSMUSP00000038361; ENSMUSG00000039202.
    GeneIDi54608.
    KEGGimmu:54608.
    UCSCiuc009hyc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201730 mRNA. Translation: AAF17566.1 .
    AF546701 mRNA. Translation: AAQ12022.1 .
    AK008690 mRNA. Translation: BAB25836.1 .
    AK139526 mRNA. Translation: BAE24049.1 .
    AK153642 mRNA. Translation: BAE32131.1 .
    BC027098 mRNA. Translation: AAH27098.1 .
    BC089477 mRNA. Translation: AAH89477.1 .
    CCDSi CCDS21380.1.
    RefSeqi NP_061281.3. NM_018811.6.
    UniGenei Mm.365490.

    3D structure databases

    ProteinModelPortali Q9QXM0.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S33.A56.

    PTM databases

    PhosphoSitei Q9QXM0.

    Proteomic databases

    PaxDbi Q9QXM0.
    PRIDEi Q9QXM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037315 ; ENSMUSP00000038361 ; ENSMUSG00000039202 .
    GeneIDi 54608.
    KEGGi mmu:54608.
    UCSCi uc009hyc.1. mouse.

    Organism-specific databases

    CTDi 11057.
    MGIi MGI:1914344. Abhd2.

    Phylogenomic databases

    eggNOGi COG0429.
    GeneTreei ENSGT00530000062981.
    HOGENOMi HOG000230852.
    HOVERGENi HBG080812.
    InParanoidi Q9QXM0.
    KOi K13697.
    OMAi FSGHVQT.
    OrthoDBi EOG7RBZ87.
    PhylomeDBi Q9QXM0.
    TreeFami TF313195.

    Miscellaneous databases

    NextBioi 311404.
    PROi Q9QXM0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QXM0.
    CleanExi MM_ABHD2.
    Genevestigatori Q9QXM0.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000952. UPF0017_hydro-like_CS.
    [Graphical view ]
    Pfami PF00561. Abhydrolase_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS01133. UPF0017. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs."
      Edgar A.J., Polak J.M.
      Biochem. Biophys. Res. Commun. 292:617-625(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Lung.
    2. "Cloning of an androgen-regulated a/b hydrolase."
      Utleg A., White J., Lin B.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg, Stomach and Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor and Testis.
    5. "Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene."
      Miyata K., Oike Y., Hoshii T., Maekawa H., Ogawa H., Suda T., Araki K., Yamamura K.
      Biochem. Biophys. Res. Commun. 329:296-304(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiABHD2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXM0
    Secondary accession number(s): Q3U5E8, Q5FWC6, Q9D7Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3