Reviewed, UniProtKB/Swiss-Prot Q9QXL8 (NDK7_MOUSE)

Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase 7
      Short name=NDP kinase 7
      Short name=NDK 7
    EC=2.7.4.6
Alternative name(s):
    nm23-M7

Gene names

Name:

Nme7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family. Contains 1 DM10 domain.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Nucleoside diphosphate kinase 7		PRO_0000137131
Regions
	Domain	22 – 110	89	DM10
Sites
	Active site	225	1	Pros-phosphohistidine intermediate By similarity
	Binding site	118	1	ATP By similarity
	Binding site	164	1	ATP By similarity
	Binding site	212	1	ATP By similarity
	Binding site	222	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QXL8-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 57FF65826B80DC0A	FASTA	395	44,434
	10 20 30 40 50 60 MRACQQGRSS SLVSPYMAPK NQSERFAFIA EWYDPNASLL RRYELLFYPV DGSVEMHDVK 70 80 90 100 110 120 NRRTFLKRTK YEDLRLEDLF IGNKVNVFSR QLVLIDYGDQ YTARQLGSRK EKTLALIKPD 130 140 150 160 170 180 AVSKAGEIIE MINKSGFTIT KLRMMTLTRK EAADFHVDHH SRPFYNELIQ FITSGPVIAM 190 200 210 220 230 240 EILRDDAICE WKRLLGPANS GLSRTDAPGS IRALFGTDGV RNAAHGPDTF ASAAREMELF 250 260 270 280 290 300 FPSSGGCGPA NTAKFTNCTC CIIKPHAISE GMLGKNLIAI RDACFGMSAI QMFNLDRANV 310 320 330 340 350 360 EEFYEVYKGV VSEYNDMVTE LCSGPCVAIE IQQSNPTKTF REFCGPADPE IARHLRPETL 370 380 390 RAIFGKTKVQ NAVHCTDLPE DGLLEVQYFF KILDN

References

[1]	Mehus J.G., Johnson J.D., Lambeth D.O. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF202048 mRNA. Translation: AAF20906.1.
IPI	IPI00135143.
UniGene	Mm.219428
3D structure databases
HSSP	HSSP built from PDB template 1LEO based on UniProtKB P22887.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9QXL8.
2-D gel databases
REPRODUCTION-2DPAGE	Q9QXL8.
Proteomic databases
PRIDE	Q9QXL8.
Genome annotation databases
Ensembl	ENSMUST00000027862; ENSMUSP00000027862; ENSMUSG00000026575; Mus musculus. [Genome view]
UCSC	uc007dio.1. mouse.
Organism-specific databases
CTD	171567.
MGI	MGI:2449121. Nme7.
Phylogenomic databases
HOGENOM	Q9QXL8.
HOVERGEN	Q9QXL8.
Enzyme and pathway databases
BRENDA	2.7.4.6. 244.
Gene expression databases
ArrayExpress	Q9QXL8.
Bgee	Q9QXL8.
Genevestigator	Q9QXL8.
GermOnline	ENSMUSG00000026575. Mus musculus.
Family and domain databases
InterPro	IPR006602. DUF_DM10. IPR011410. NDK7. IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 2 hits.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PIRSF	PIRSF036503. NDK7. 1 hit.
PRINTS	PR01243. NUCDPKINASE.
ProDom	PD001018. NDK. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00676. DM10. 1 hit. SM00562. NDK. 2 hits. [Graphical view]
PROSITE	PS51336. DM10. 1 hit. PS00469. NDP_KINASES. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	371070.
SOURCE	Search...

Entry information

Entry name

NDK7_MOUSE

Accession

Primary (citable) accession number: Q9QXL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	October 13, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)