Q9QXL2 (KI21A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF21A

Gene names

Name:	Kif21a
Synonyms:	Kiaa1708

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1672 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Ref.1
Subcellular location	Cytoplasm › cytoskeleton. Cell projection › dendrite. Cell projection › axon. Note: In neurons, localized to axons and dendrites. Ref.1
Tissue specificity	Widely expressed, with highest expression in brain. Ref.1
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Contains 7 WD repeats.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat WD repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular_component	axon Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW dendrite Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9QXL2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9QXL2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     558-570: Missing.
     1109-1115: Missing.
     1226-1305: ISRQSSLSEK...QGTPSVQQDK → M

Isoform 3 (identifier: Q9QXL2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     558-570: Missing.
     1227-1318: Missing.

Isoform 4 (identifier: Q9QXL2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1262-1318: HSDSGASETSLSPPSSPPSRPRNELNVFNRLTVPQGTPSVQQDKSDESDSSLSEVHR → Q

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1672	1672	Kinesin-like protein KIF21A		PRO_0000125463
Regions
	Domain	1 – 299	299	Kinesin-motor
	Repeat	1343 – 1380	38	WD 1
	Repeat	1383 – 1421	39	WD 2
	Repeat	1447 – 1485	39	WD 3
	Repeat	1488 – 1530	43	WD 4
	Repeat	1539 – 1576	38	WD 5
	Repeat	1580 – 1619	40	WD 6
	Repeat	1622 – 1659	38	WD 7
	Nucleotide binding	88 – 95	8	ATP By similarity
	Coiled coil	365 – 840	476	Potential
	Coiled coil	933 – 1021	89	Potential
	Coiled coil	1055 – 1085	31	Potential
Amino acid modifications
	Modified residue	80	1	Phosphotyrosine Ref.5
	Modified residue	87	1	Phosphotyrosine Ref.5
	Modified residue	524	1	Phosphoserine By similarity
	Modified residue	1241	1	Phosphoserine By similarity
	Modified residue	1660	1	Phosphoserine Ref.6
	Modified residue	1662	1	Phosphothreonine By similarity
	Modified residue	1671	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	558 – 570	13	Missing in isoform 2 and isoform 3.		VSP_010873
	Alternative sequence	1109 – 1115	7	Missing in isoform 2.		VSP_010874
	Alternative sequence	1226 – 1305	80	ISRQS…VQQDK → M in isoform 2.		VSP_010875
	Alternative sequence	1227 – 1318	92	Missing in isoform 3.		VSP_010876
	Alternative sequence	1262 – 1318	57	HSDSG…SEVHR → Q in isoform 4.		VSP_010877
Experimental info
	Sequence conflict	1127	1	P → A in AAF17083. Ref.1
	Sequence conflict	1311	1	S → F Ref.1
	Sequence conflict	1321	1	I → L Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 1B2480E5129105AB	FASTA	1,672	186,536
	10 20 30 40 50 60 MLGAADESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYTQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIMEEE QGIISRAVRH 130 140 150 160 170 180 LFKSIDEKKT SAIKNGLPPP EFKVNAQFLE LYNEEVLDLF DTTRDIDAKN KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTEPE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQTDAENATD NKLISESSPM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR ARITQLVSEQ ANQVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARSPYFSAS SAFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKKKKKRLQ KLEESGREER SVAGKDDNAD TDQEKKEEKG VSEKENNELD 610 620 630 640 650 660 VEENQEVSDH EDEEEEEEDE EEEDDIEGEE SSDESDSESD EKANYQADLA NITCEIAIKQ 670 680 690 700 710 720 KLIDELENSQ KRLQTLKKQY EEKLMMLQHK IRDTQLERDQ VLQNLGSVES YSEEKAKKVK 730 740 750 760 770 780 CEYEKKLHAM NKELQRLQTA QKEHARLLKN QSQYEKQLKK LQQDVMEMKK TKVRLMKQMK 790 800 810 820 830 840 EEQEKARLTE SRRNREIAQL KKDQRKRDHQ LRLLEAQKRN QEVVLRRKTE EVTALRRQVR 850 860 870 880 890 900 PMSDKVAGKV TRKLSSSESP APDTGSSAAS GEADTSRPGT QQKMRIPVAR VQALPTPTTN 910 920 930 940 950 960 GTRKKYQRKG FTGRVFTSKT ARMKWQLLER RVTDIIMQKM TISNMEADMN RLLRQREELT 970 980 990 1000 1010 1020 KRREKLSKRR EKIVKESGEG DKSVANIIEE MESLTANIDY INDSIADCQA NIMQMEEAKE 1030 1040 1050 1060 1070 1080 EGETLDVTAV INACTLTEAR YLLDHFLSMG INKGLQAAQK EAQIKVLEGR LKQTEITSAT 1090 1100 1110 1120 1130 1140 QNQLLFHMLK EKAELNPELD ALLGHALQDL DGAPPENEED SSEEDGPLHS PGSEGSTLSS 1150 1160 1170 1180 1190 1200 DLMKLCGEVK PKNKARRRTT TQMELLYADS SEVASDTSAG DASLSGPLAP VAEGQEIGMN 1210 1220 1230 1240 1250 1260 TETSGTSARD KELLAPSGLP SKIGSISRQS SLSEKKVPEP SPVTRRKAYE KADKPKAKEH 1270 1280 1290 1300 1310 1320 KHSDSGASET SLSPPSSPPS RPRNELNVFN RLTVPQGTPS VQQDKSDESD SSLSEVHRGI 1330 1340 1350 1360 1370 1380 INPFPACKGV RASPLQCVHI AEGHTKAVLC VDSTDDLLFT GSKDRTCKVW NLVTGQEIMS 1390 1400 1410 1420 1430 1440 LGVHPNNVVS VKYCNYTSLV FTVSTSYIKV WDIRESAKCI RTLTSSGQVT LGEACSASTS 1450 1460 1470 1480 1490 1500 RTVAIPSGES QINQIALNPT GTFLYAASGN AVRMWDLKRF QSTGKLTGHL GPVMCLTVDQ 1510 1520 1530 1540 1550 1560 ISNGQDLIIT GSKDHYIKMF DVTEGALGTV SPTHNFEPPH YDGIEALAIQ GDNLFSGSRD 1570 1580 1590 1600 1610 1620 NGIKKWDLAQ KGLLQQVPNA HKDWVCALGL VPGHPVLLSG CRGGILKLWN VDTFVPVGEM 1630 1640 1650 1660 1670 RGHDSPINAI CVNSTHVFTA ADDRTVRIWK AHNLQDGQLS DTGDLGEDIA SN
	Isoform 2 [UniParc]. Checksum: D64D0EEBF5E9888B	FASTA	1,573	175,588
	10 20 30 40 50 60 MLGAADESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYTQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIMEEE QGIISRAVRH 130 140 150 160 170 180 LFKSIDEKKT SAIKNGLPPP EFKVNAQFLE LYNEEVLDLF DTTRDIDAKN KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTEPE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQTDAENATD NKLISESSPM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR ARITQLVSEQ ANQVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARSPYFSAS SAFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKKKKKSVA GKDDNADTDQ EKKEEKGVSE KENNELDVEE NQEVSDHEDE 610 620 630 640 650 660 EEEEEDEEEE DDIEGEESSD ESDSESDEKA NYQADLANIT CEIAIKQKLI DELENSQKRL 670 680 690 700 710 720 QTLKKQYEEK LMMLQHKIRD TQLERDQVLQ NLGSVESYSE EKAKKVKCEY EKKLHAMNKE 730 740 750 760 770 780 LQRLQTAQKE HARLLKNQSQ YEKQLKKLQQ DVMEMKKTKV RLMKQMKEEQ EKARLTESRR 790 800 810 820 830 840 NREIAQLKKD QRKRDHQLRL LEAQKRNQEV VLRRKTEEVT ALRRQVRPMS DKVAGKVTRK 850 860 870 880 890 900 LSSSESPAPD TGSSAASGEA DTSRPGTQQK MRIPVARVQA LPTPTTNGTR KKYQRKGFTG 910 920 930 940 950 960 RVFTSKTARM KWQLLERRVT DIIMQKMTIS NMEADMNRLL RQREELTKRR EKLSKRREKI 970 980 990 1000 1010 1020 VKESGEGDKS VANIIEEMES LTANIDYIND SIADCQANIM QMEEAKEEGE TLDVTAVINA 1030 1040 1050 1060 1070 1080 CTLTEARYLL DHFLSMGINK GLQAAQKEAQ IKVLEGRLKQ TEITSATQNQ LLFHMLKEKA 1090 1100 1110 1120 1130 1140 ELNPELDALL GHALQENEED SSEEDGPLHS PGSEGSTLSS DLMKLCGEVK PKNKARRRTT 1150 1160 1170 1180 1190 1200 TQMELLYADS SEVASDTSAG DASLSGPLAP VAEGQEIGMN TETSGTSARD KELLAPSGLP 1210 1220 1230 1240 1250 1260 SKIGSMSDES DSSLSEVHRG IINPFPACKG VRASPLQCVH IAEGHTKAVL CVDSTDDLLF 1270 1280 1290 1300 1310 1320 TGSKDRTCKV WNLVTGQEIM SLGVHPNNVV SVKYCNYTSL VFTVSTSYIK VWDIRESAKC 1330 1340 1350 1360 1370 1380 IRTLTSSGQV TLGEACSAST SRTVAIPSGE SQINQIALNP TGTFLYAASG NAVRMWDLKR 1390 1400 1410 1420 1430 1440 FQSTGKLTGH LGPVMCLTVD QISNGQDLII TGSKDHYIKM FDVTEGALGT VSPTHNFEPP 1450 1460 1470 1480 1490 1500 HYDGIEALAI QGDNLFSGSR DNGIKKWDLA QKGLLQQVPN AHKDWVCALG LVPGHPVLLS 1510 1520 1530 1540 1550 1560 GCRGGILKLW NVDTFVPVGE MRGHDSPINA ICVNSTHVFT AADDRTVRIW KAHNLQDGQL 1570 SDTGDLGEDI ASN
	Isoform 3 [UniParc]. Checksum: C4AC29837E0FC17C	FASTA	1,567	174,806
	10 20 30 40 50 60 MLGAADESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYTQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIMEEE QGIISRAVRH 130 140 150 160 170 180 LFKSIDEKKT SAIKNGLPPP EFKVNAQFLE LYNEEVLDLF DTTRDIDAKN KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTEPE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQTDAENATD NKLISESSPM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR ARITQLVSEQ ANQVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARSPYFSAS SAFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKKKKKSVA GKDDNADTDQ EKKEEKGVSE KENNELDVEE NQEVSDHEDE 610 620 630 640 650 660 EEEEEDEEEE DDIEGEESSD ESDSESDEKA NYQADLANIT CEIAIKQKLI DELENSQKRL 670 680 690 700 710 720 QTLKKQYEEK LMMLQHKIRD TQLERDQVLQ NLGSVESYSE EKAKKVKCEY EKKLHAMNKE 730 740 750 760 770 780 LQRLQTAQKE HARLLKNQSQ YEKQLKKLQQ DVMEMKKTKV RLMKQMKEEQ EKARLTESRR 790 800 810 820 830 840 NREIAQLKKD QRKRDHQLRL LEAQKRNQEV VLRRKTEEVT ALRRQVRPMS DKVAGKVTRK 850 860 870 880 890 900 LSSSESPAPD TGSSAASGEA DTSRPGTQQK MRIPVARVQA LPTPTTNGTR KKYQRKGFTG 910 920 930 940 950 960 RVFTSKTARM KWQLLERRVT DIIMQKMTIS NMEADMNRLL RQREELTKRR EKLSKRREKI 970 980 990 1000 1010 1020 VKESGEGDKS VANIIEEMES LTANIDYIND SIADCQANIM QMEEAKEEGE TLDVTAVINA 1030 1040 1050 1060 1070 1080 CTLTEARYLL DHFLSMGINK GLQAAQKEAQ IKVLEGRLKQ TEITSATQNQ LLFHMLKEKA 1090 1100 1110 1120 1130 1140 ELNPELDALL GHALQDLDGA PPENEEDSSE EDGPLHSPGS EGSTLSSDLM KLCGEVKPKN 1150 1160 1170 1180 1190 1200 KARRRTTTQM ELLYADSSEV ASDTSAGDAS LSGPLAPVAE GQEIGMNTET SGTSARDKEL 1210 1220 1230 1240 1250 1260 LAPSGLPSKI GSIGIINPFP ACKGVRASPL QCVHIAEGHT KAVLCVDSTD DLLFTGSKDR 1270 1280 1290 1300 1310 1320 TCKVWNLVTG QEIMSLGVHP NNVVSVKYCN YTSLVFTVST SYIKVWDIRE SAKCIRTLTS 1330 1340 1350 1360 1370 1380 SGQVTLGEAC SASTSRTVAI PSGESQINQI ALNPTGTFLY AASGNAVRMW DLKRFQSTGK 1390 1400 1410 1420 1430 1440 LTGHLGPVMC LTVDQISNGQ DLIITGSKDH YIKMFDVTEG ALGTVSPTHN FEPPHYDGIE 1450 1460 1470 1480 1490 1500 ALAIQGDNLF SGSRDNGIKK WDLAQKGLLQ QVPNAHKDWV CALGLVPGHP VLLSGCRGGI 1510 1520 1530 1540 1550 1560 LKLWNVDTFV PVGEMRGHDS PINAICVNST HVFTAADDRT VRIWKAHNLQ DGQLSDTGDL GEDIASN
	Isoform 4 [UniParc]. Checksum: 430FD674A10FFB34	FASTA	1,616	180,550
	10 20 30 40 50 60 MLGAADESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 70 80 90 100 110 120 QEQIYTQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIMEEE QGIISRAVRH 130 140 150 160 170 180 LFKSIDEKKT SAIKNGLPPP EFKVNAQFLE LYNEEVLDLF DTTRDIDAKN KKSNIRIHED 190 200 210 220 230 240 STGGIYTVGV TTRTVNTEPE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 250 260 270 280 290 300 PQTDAENATD NKLISESSPM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 310 320 330 340 350 360 LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 370 380 390 400 410 420 TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 430 440 450 460 470 480 MFHENAMLQT ENNNLRVRIK AMQETVDALR ARITQLVSEQ ANQVLARAGE GNEEISNMIH 490 500 510 520 530 540 SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARSPYFSAS SAFSPTILSS DKETIEIIDL 550 560 570 580 590 600 AKKDLEKLKR KEKKKKKRLQ KLEESGREER SVAGKDDNAD TDQEKKEEKG VSEKENNELD 610 620 630 640 650 660 VEENQEVSDH EDEEEEEEDE EEEDDIEGEE SSDESDSESD EKANYQADLA NITCEIAIKQ 670 680 690 700 710 720 KLIDELENSQ KRLQTLKKQY EEKLMMLQHK IRDTQLERDQ VLQNLGSVES YSEEKAKKVK 730 740 750 760 770 780 CEYEKKLHAM NKELQRLQTA QKEHARLLKN QSQYEKQLKK LQQDVMEMKK TKVRLMKQMK 790 800 810 820 830 840 EEQEKARLTE SRRNREIAQL KKDQRKRDHQ LRLLEAQKRN QEVVLRRKTE EVTALRRQVR 850 860 870 880 890 900 PMSDKVAGKV TRKLSSSESP APDTGSSAAS GEADTSRPGT QQKMRIPVAR VQALPTPTTN 910 920 930 940 950 960 GTRKKYQRKG FTGRVFTSKT ARMKWQLLER RVTDIIMQKM TISNMEADMN RLLRQREELT 970 980 990 1000 1010 1020 KRREKLSKRR EKIVKESGEG DKSVANIIEE MESLTANIDY INDSIADCQA NIMQMEEAKE 1030 1040 1050 1060 1070 1080 EGETLDVTAV INACTLTEAR YLLDHFLSMG INKGLQAAQK EAQIKVLEGR LKQTEITSAT 1090 1100 1110 1120 1130 1140 QNQLLFHMLK EKAELNPELD ALLGHALQDL DGAPPENEED SSEEDGPLHS PGSEGSTLSS 1150 1160 1170 1180 1190 1200 DLMKLCGEVK PKNKARRRTT TQMELLYADS SEVASDTSAG DASLSGPLAP VAEGQEIGMN 1210 1220 1230 1240 1250 1260 TETSGTSARD KELLAPSGLP SKIGSISRQS SLSEKKVPEP SPVTRRKAYE KADKPKAKEH 1270 1280 1290 1300 1310 1320 KQGIINPFPA CKGVRASPLQ CVHIAEGHTK AVLCVDSTDD LLFTGSKDRT CKVWNLVTGQ 1330 1340 1350 1360 1370 1380 EIMSLGVHPN NVVSVKYCNY TSLVFTVSTS YIKVWDIRES AKCIRTLTSS GQVTLGEACS 1390 1400 1410 1420 1430 1440 ASTSRTVAIP SGESQINQIA LNPTGTFLYA ASGNAVRMWD LKRFQSTGKL TGHLGPVMCL 1450 1460 1470 1480 1490 1500 TVDQISNGQD LIITGSKDHY IKMFDVTEGA LGTVSPTHNF EPPHYDGIEA LAIQGDNLFS 1510 1520 1530 1540 1550 1560 GSRDNGIKKW DLAQKGLLQQ VPNAHKDWVC ALGLVPGHPV LLSGCRGGIL KLWNVDTFVP 1570 1580 1590 1600 1610 VGEMRGHDSP INAICVNSTH VFTAADDRTV RIWKAHNLQD GQLSDTGDLG EDIASN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B." Marszalek J.R., Weiner J.A., Farlow S.J., Chun J., Goldstein L.S. J. Cell Biol. 145:469-479(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: C57BL/6. Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-551, NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1129-1672 (ISOFORM 4). Strain: C57BL/6J.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-1672 (ISOFORM 1). Tissue: Brain.
[5]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-80 AND TYR-87, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1660 AND SER-1671, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF202892 mRNA. Translation: AAF17083.1. BC060698 mRNA. Translation: AAH60698.1. BC062896 mRNA. Translation: AAH62896.1. AK129426 mRNA. Translation: BAC98236.1. AK049303 mRNA. Translation: BAC33669.1. AK047350 mRNA. Translation: BAC33031.1.
IPI	IPI00454081. IPI00454082. IPI00454083. IPI00454084.
RefSeq	NP_001102510.1. NM_001109040.1. NP_001102511.1. NM_001109041.1. NP_001102512.1. NM_001109042.1. NP_057914.2. NM_016705.3.
UniGene	Mm.41379.
3D structure databases
ProteinModelPortal	Q9QXL2.
SMR	Q9QXL2. Positions 6-402, 1336-1662.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9QXL2. 2 interactions.
PTM databases
PhosphoSite	Q9QXL2.
Proteomic databases
PaxDb	Q9QXL2.
PRIDE	Q9QXL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000088614; ENSMUSP00000085985; ENSMUSG00000022629. ENSMUST00000109287; ENSMUSP00000104910; ENSMUSG00000022629. ENSMUST00000109288; ENSMUSP00000104911; ENSMUSG00000022629.
GeneID	16564.
KEGG	mmu:16564.
UCSC	uc007xhs.2. mouse. uc007xht.2. mouse. uc007xhv.2. mouse.
Organism-specific databases
CTD	55605.
MGI	MGI:109188. Kif21a.
Rouge	Search...
Phylogenomic databases
eggNOG	COG2319.
GeneTree	ENSGT00680000099754.
HOGENOM	HOG000280728.
HOVERGEN	HBG052247.
InParanoid	Q9QXL2.
KO	K10395.
OMA	HKIRDTQ.
OrthoDB	EOG479F67.
Gene expression databases
ArrayExpress	Q9QXL2.
Bgee	Q9QXL2.
CleanEx	MM_KIF21A.
Genevestigator	Q9QXL2.
GermOnline	ENSMUSG00000022629. Mus musculus.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 3.40.850.10. 1 hit.
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR009053. Prefoldin. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. PF00400. WD40. 5 hits. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF46579. Prefoldin. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KIF21A. mouse.
NextBio	290065.
SOURCE	Search...

Entry information

Entry name

KI21A_MOUSE

Accession

Primary (citable) accession number: Q9QXL2
Secondary accession number(s): Q6P5H1 , Q6ZPJ8, Q8BWZ9, Q8BXF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program