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Protein

Kinesin-like protein KIF21B

Gene

Kif21b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plus-end directed microtubule-dependent motor protein which displays processive activity (PubMed:27117409, PubMed:10225949). Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation (PubMed:27117409). Plays a role in lerning and memory (PubMed:27117409). Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface (PubMed:25172774).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 94ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF21B
Alternative name(s):
Kinesin-like protein KIF6
Gene namesi
Name:Kif21b
Synonyms:Kif6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109234. Kif21b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mutant mice exhibit behavioral changes involving learning and memory deficits.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi96T → N: Abolishes processive activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254651 – 1668Kinesin-like protein KIF21BAdd BLAST1668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei580PhosphoserineCombined sources1
Modified residuei583PhosphothreonineCombined sources1
Modified residuei1150PhosphoserineBy similarity1
Modified residuei1168PhosphoserineCombined sources1
Modified residuei1217PhosphoserineCombined sources1
Modified residuei1239PhosphothreonineCombined sources1
Modified residuei1243PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QXL1.
MaxQBiQ9QXL1.
PaxDbiQ9QXL1.
PRIDEiQ9QXL1.

PTM databases

iPTMnetiQ9QXL1.
PhosphoSitePlusiQ9QXL1.

Expressioni

Tissue specificityi

Expressed in brain (at protein level) (PubMed:27117409, PubMed:25172774). Expressed in spleen and at lower levels in testes (PubMed:10225949).3 Publications

Interactioni

Subunit structurei

Interacts with TRIM3; the interaction positively affects motility of KIF21B (PubMed:24086586). Interacts with GABARAP and GABA(A) receptor subunits: GABRG2, GABRA1 and GABRA2 (By similarity). May interact with GABA(A) receptor subunits: GABRB2 and GABRB3 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi200940. 13 interactors.
IntActiQ9QXL1. 1 interactor.
STRINGi10090.ENSMUSP00000074661.

Structurei

3D structure databases

ProteinModelPortaliQ9QXL1.
SMRiQ9QXL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 371Kinesin motorPROSITE-ProRule annotationAdd BLAST364
Repeati1308 – 1345WD 1Add BLAST38
Repeati1348 – 1386WD 2Add BLAST39
Repeati1412 – 1450WD 3Add BLAST39
Repeati1453 – 1495WD 4Add BLAST43
Repeati1504 – 1541WD 5Add BLAST38
Repeati1545 – 1584WD 6Add BLAST40
Repeati1587 – 1624WD 7Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni401 – 1100Interaction with TRIM31 PublicationAdd BLAST700

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili372 – 465Sequence analysisAdd BLAST94
Coiled coili924 – 1019Sequence analysisAdd BLAST96

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000280728.
HOVERGENiHBG052247.
InParanoidiQ9QXL1.
KOiK10395.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR009053. Prefoldin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 5 hits.
PfamiPF00225. Kinesin. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQGDCCVK VAVRIRPQLS KEKIEGCHIC TSVTPGEPQV LLGKDKAFTY
60 70 80 90 100
DFVFDLDTWQ EQIYSTCVSK LIEGCFEGYN ATVLAYGQTG AGKTYTMGTG
110 120 130 140 150
FDTVTSEEEQ GIIPRAIAHL FRGIDERKRR AQEKGVTGPE FKVSAQFLEL
160 170 180 190 200
YNEEILDLFD STRDPDARHR RSNIKIHEDA NGGIYTTGVT SRLINSQEEL
210 220 230 240 250
IQCLKQGALS RTTASTQMNV QSSRSHAIFT IHLCQMRVCA QPDLVNETVT
260 270 280 290 300
GLPDGAAPTG TEYETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG
310 320 330 340 350
LLALGNVISA LGDQSKKVVH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP
360 370 380 390 400
SDRDFMETLN TLKYANRARN IKNKVVVNQD KTSQQISALR AEIARLQMEL
410 420 430 440 450
MEYKAGKRVI GEDGTEGYSD LFRENAMLQK ENGALRLRVK AMQEAIDAIN
460 470 480 490 500
NRVTQLMSQE ANLLLAKAGD GNEAIGALIQ NYIREIEELR TKLLESEAMN
510 520 530 540 550
ESLRRSLSRA SARNPYSLGA SPAGPAFGGS PATSMEDASE VIRKAKQDLE
560 570 580 590 600
RLKKKEVRQR RKSPEKEAFK KRAKLQAENS EETDENEAEE EEEERDESGC
610 620 630 640 650
EEEEGREDED EDSGSEESLV DSDSDPEEKE VNFQADLADL TCEIEIKQKL
660 670 680 690 700
IDELENSQRR LQTLKHQYEE KLILLQNKIR DTQLERDRVL QNLSTMECYT
710 720 730 740 750
EEKANKIKAD YEKRLREMNR DLQKLQAAQK EHARLLKNQS RYERELKKLQ
760 770 780 790 800
AEVAEMKKAK VALMKQMREE QQRRRLVETK RNREIAQLKK EQRRQEFQIR
810 820 830 840 850
ALESQKRQQE IVLRRKTQEV SALRRLAKPM SERVAGRVGL KPPNMDSGAE
860 870 880 890 900
VSASTTSSEA ESGARSVSSI VRQWNRKIDH FLGDRPTATV NGGRPARKKF
910 920 930 940 950
QKKGASQSFS KAARLKWQSL ERRIIDIVMQ RMTIVNLEAD MERLIKKREE
960 970 980 990 1000
LFLLQEALRR KREHLQAESP EEEKGLQELA EEIEVLAANI DYINDSITDC
1010 1020 1030 1040 1050
QATIVQLEET KEELDSTDTS VVISSCSLAE ARLLLDNFLK ASIDKGLQVA
1060 1070 1080 1090 1100
QKEAQIRLLE GRLRQTDMTG SSQNHLLLDA LREKAEAHPE LQALIYNVQH
1110 1120 1130 1140 1150
ENGYASTDEE VSEFSEGSFS QSFTMKGSTS HDDFKFKGEP KLSAQMKAVS
1160 1170 1180 1190 1200
AECLGPPLDS STKNITKSLA SLVEIKEDGV GFSIRDPYYR DKVSRTVSLP
1210 1220 1230 1240 1250
TRGSTFPRQS RGATDTSPLT RRKSYDRGQP IRSTDMGFTP PSSPPTRPRN
1260 1270 1280 1290 1300
DRNVFSRLTS NQSQGSALDK SDDSDSSLSE VLRGIITPIG GAKGARTAPL
1310 1320 1330 1340 1350
QCISMAEGHT KPILCLDATD ELLFTGSKDR SCKMWNLVTG QEIAALKGHP
1360 1370 1380 1390 1400
NNVVSIKYCS HSGLVFSVSS SYIKVWDIRD SAKCIRTLTS SGQVISGDAC
1410 1420 1430 1440 1450
IATSTRAITS AQGEHQINQM ALSPSGSMLY VASGNAVRIW ELNRFQPIGK
1460 1470 1480 1490 1500
LTGHIGPVMC LTVTQTSNQH DLVVTGSKDH YVKMFQLGDC VTGTIGPTHN
1510 1520 1530 1540 1550
FEPPHYDGIE CLAIQGDILF SGSRDNGIKK WDLDQQELIQ QIPNAHKDWV
1560 1570 1580 1590 1600
CALAFVPGRP MLLSACRAGF IKVWNVDNFT PIGEIKGHDS PINAICTNSK
1610 1620 1630 1640 1650
HIFTASSDCR VKLWNYVPGL TPCLPRRVLA IKGRAPPCPD LPPPPLTLPI
1660
LPFPVFPPPR SELLLHVT
Length:1,668
Mass (Da):186,180
Last modified:July 27, 2011 - v2
Checksum:i99691F966387A577
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1276S → A in AAF17084 (PubMed:10225949).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202893 mRNA. Translation: AAF17084.1.
AC124550 Genomic DNA. No translation available.
U71298 mRNA. Translation: AAB39695.1.
RefSeqiNP_001034561.1. NM_001039472.1.
UniGeneiMm.276135.

Genome annotation databases

GeneIDi16565.
KEGGimmu:16565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202893 mRNA. Translation: AAF17084.1.
AC124550 Genomic DNA. No translation available.
U71298 mRNA. Translation: AAB39695.1.
RefSeqiNP_001034561.1. NM_001039472.1.
UniGeneiMm.276135.

3D structure databases

ProteinModelPortaliQ9QXL1.
SMRiQ9QXL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200940. 13 interactors.
IntActiQ9QXL1. 1 interactor.
STRINGi10090.ENSMUSP00000074661.

PTM databases

iPTMnetiQ9QXL1.
PhosphoSitePlusiQ9QXL1.

Proteomic databases

EPDiQ9QXL1.
MaxQBiQ9QXL1.
PaxDbiQ9QXL1.
PRIDEiQ9QXL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16565.
KEGGimmu:16565.

Organism-specific databases

CTDi23046.
MGIiMGI:109234. Kif21b.

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000280728.
HOVERGENiHBG052247.
InParanoidiQ9QXL1.
KOiK10395.

Miscellaneous databases

ChiTaRSiKif21b. mouse.
PROiQ9QXL1.
SOURCEiSearch...

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR009053. Prefoldin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 5 hits.
PfamiPF00225. Kinesin. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKI21B_MOUSE
AccessioniPrimary (citable) accession number: Q9QXL1
Secondary accession number(s): E9PUY6, P97424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.