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Protein

Neuromedin-U

Gene

Nmu

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates muscle contractions of specific regions of the gastrointestinal tract.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U
Cleaved into the following chain:
Neuromedin-U-23
Short name:
NmU-23
Gene namesi
Name:Nmu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1860476. Nmu.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
PropeptideiPRO_000001977538 – 105By similarityAdd BLAST68
PropeptideiPRO_0000262497106 – 140By similarityAdd BLAST35
PropeptideiPRO_0000262498141 – 143By similarity3
PeptideiPRO_0000019776144 – 166Neuromedin-U-23Add BLAST23
PropeptideiPRO_0000019777170 – 174By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9QXK8.
PRIDEiQ9QXK8.

PTM databases

iPTMnetiQ9QXK8.
PhosphoSitePlusiQ9QXK8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029236.
CleanExiMM_NMU.
ExpressionAtlasiQ9QXK8. baseline and differential.
GenevisibleiQ9QXK8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031146.

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZAW. Eukaryota.
ENOG41120HH. LUCA.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiQ9QXK8.
KOiK05249.
OMAiLWNEIDD.
OrthoDBiEOG091G0V1C.
PhylomeDBiQ9QXK8.
TreeFamiTF338319.

Family and domain databases

InterProiView protein in InterPro
IPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
PfamiView protein in Pfam
PF02070. NMU. 1 hit.
SMARTiView protein in SMART
SM00084. NMU. 1 hit.
PROSITEiView protein in PROSITE
PS00967. NMU. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAAGHRPG LSAGQLAAAT ASPLLSLLLL LACCADACKG VPISPQRLQP
60 70 80 90 100
EQELQLWNEI HEACASFLSI DSRPQASVAL RELCRIVMEI SQKPQEQSEK
110 120 130 140 150
DNTKRFLFHY SKTQKLGNSN VVSSVVHPLL QLVPQLHERR MKRFKAEYQS
160 170
PSVGQSKGYF LFRPRNGKRS TSFI
Length:174
Mass (Da):19,429
Last modified:May 1, 2000 - v1
Checksum:iD6E86FD7F5731130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203444 mRNA. Translation: AAF20198.1.
AK077478 mRNA. Translation: BAC36820.1.
CCDSiCCDS19362.1.
RefSeqiNP_062388.1. NM_019515.1.
UniGeneiMm.154879.

Genome annotation databases

EnsembliENSMUST00000031146; ENSMUSP00000031146; ENSMUSG00000029236.
GeneIDi56183.
KEGGimmu:56183.
UCSCiuc008xuw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNMU_MOUSE
AccessioniPrimary (citable) accession number: Q9QXK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families