Q9QXK8 (NMU_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuromedin-U

Cleaved into the following chain:

1. Neuromedin-U-23
   Short name=NmU-23

Gene names

Name:

Nmu

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stimulates muscle contractions of specific regions of the gastrointestinal tract By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the NmU family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Neuropeptide
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Propeptide	38 – 105	68	By similarity		PRO_0000019775
	Propeptide	106 – 140	35	By similarity		PRO_0000262497
	Propeptide	141 – 143	3	By similarity		PRO_0000262498
	Peptide	144 – 166	23	Neuromedin-U-23		PRO_0000019776
	Propeptide	170 – 174	5	By similarity		PRO_0000019777
Amino acid modifications
	Modified residue	166	1	Asparagine amide By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9QXK8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D6E86FD7F5731130	FASTA	174	19,429
	10 20 30 40 50 60 MSRAAGHRPG LSAGQLAAAT ASPLLSLLLL LACCADACKG VPISPQRLQP EQELQLWNEI 70 80 90 100 110 120 HEACASFLSI DSRPQASVAL RELCRIVMEI SQKPQEQSEK DNTKRFLFHY SKTQKLGNSN 130 140 150 160 170 VVSSVVHPLL QLVPQLHERR MKRFKAEYQS PSVGQSKGYF LFRPRNGKRS TSFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterisation of the cDNA encoding the mouse neuromedin U (NmU) precursor peptide." Sharma S.K., Bloom S.R. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF203444 mRNA. Translation: AAF20198.1. AK077478 mRNA. Translation: BAC36820.1.
IPI	IPI00135101.
RefSeq	NP_062388.1. NM_019515.1.
UniGene	Mm.154879.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9QXK8.
Proteomic databases
PRIDE	Q9QXK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031146; ENSMUSP00000031146; ENSMUSG00000029236.
GeneID	56183.
KEGG	mmu:56183.
Organism-specific databases
CTD	10874.
MGI	MGI:1860476. Nmu.
Phylogenomic databases
eggNOG	NOG47198.
GeneTree	ENSGT00510000048726.
HOGENOM	HOG000113806.
HOVERGEN	HBG000378.
InParanoid	Q9QXK8.
KO	K05249.
OMA	EEFQSPF.
OrthoDB	EOG4FN4K4.
Gene expression databases
ArrayExpress	Q9QXK8.
Bgee	Q9QXK8.
CleanEx	MM_NMU.
Genevestigator	Q9QXK8.
GermOnline	ENSMUSG00000029236. Mus musculus.
Family and domain databases
InterPro	IPR018070. Neuromedin-U_amidation-site. IPR008200. NMU_C. [Graphical view]
Pfam	PF02070. NMU. 1 hit. [Graphical view]
PROSITE	PS00967. NMU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	311962.
SOURCE	Search...

Entry information

Entry name

NMU_MOUSE

Accession

Primary (citable) accession number: Q9QXK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	May 1, 2000
Last modified:	May 16, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program