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Protein

Neuromedin-U

Gene

Nmu

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates muscle contractions of specific regions of the gastrointestinal tract.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U
Cleaved into the following chain:
Neuromedin-U-23
Short name:
NmU-23
Gene namesi
Name:Nmu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1860476. Nmu.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence analysisAdd
BLAST
Propeptidei38 – 10568By similarityPRO_0000019775Add
BLAST
Propeptidei106 – 14035By similarityPRO_0000262497Add
BLAST
Propeptidei141 – 1433By similarityPRO_0000262498
Peptidei144 – 16623Neuromedin-U-23PRO_0000019776Add
BLAST
Propeptidei170 – 1745By similarityPRO_0000019777

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661Asparagine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9QXK8.
PRIDEiQ9QXK8.

PTM databases

iPTMnetiQ9QXK8.

Expressioni

Gene expression databases

BgeeiQ9QXK8.
CleanExiMM_NMU.
ExpressionAtlasiQ9QXK8. baseline and differential.
GenevisibleiQ9QXK8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031146.

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZAW. Eukaryota.
ENOG41120HH. LUCA.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiQ9QXK8.
KOiK05249.
OMAiFQSPFAS.
OrthoDBiEOG7SJD6G.
PhylomeDBiQ9QXK8.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamiPF02070. NMU. 1 hit.
[Graphical view]
SMARTiSM00084. NMU. 1 hit.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAAGHRPG LSAGQLAAAT ASPLLSLLLL LACCADACKG VPISPQRLQP
60 70 80 90 100
EQELQLWNEI HEACASFLSI DSRPQASVAL RELCRIVMEI SQKPQEQSEK
110 120 130 140 150
DNTKRFLFHY SKTQKLGNSN VVSSVVHPLL QLVPQLHERR MKRFKAEYQS
160 170
PSVGQSKGYF LFRPRNGKRS TSFI
Length:174
Mass (Da):19,429
Last modified:May 1, 2000 - v1
Checksum:iD6E86FD7F5731130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203444 mRNA. Translation: AAF20198.1.
AK077478 mRNA. Translation: BAC36820.1.
CCDSiCCDS19362.1.
RefSeqiNP_062388.1. NM_019515.1.
UniGeneiMm.154879.

Genome annotation databases

EnsembliENSMUST00000031146; ENSMUSP00000031146; ENSMUSG00000029236.
GeneIDi56183.
KEGGimmu:56183.
UCSCiuc008xuw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203444 mRNA. Translation: AAF20198.1.
AK077478 mRNA. Translation: BAC36820.1.
CCDSiCCDS19362.1.
RefSeqiNP_062388.1. NM_019515.1.
UniGeneiMm.154879.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031146.

PTM databases

iPTMnetiQ9QXK8.

Proteomic databases

PaxDbiQ9QXK8.
PRIDEiQ9QXK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031146; ENSMUSP00000031146; ENSMUSG00000029236.
GeneIDi56183.
KEGGimmu:56183.
UCSCiuc008xuw.1. mouse.

Organism-specific databases

CTDi10874.
MGIiMGI:1860476. Nmu.

Phylogenomic databases

eggNOGiENOG410IZAW. Eukaryota.
ENOG41120HH. LUCA.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiQ9QXK8.
KOiK05249.
OMAiFQSPFAS.
OrthoDBiEOG7SJD6G.
PhylomeDBiQ9QXK8.
TreeFamiTF338319.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9QXK8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXK8.
CleanExiMM_NMU.
ExpressionAtlasiQ9QXK8. baseline and differential.
GenevisibleiQ9QXK8. MM.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamiPF02070. NMU. 1 hit.
[Graphical view]
SMARTiSM00084. NMU. 1 hit.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterisation of the cDNA encoding the mouse neuromedin U (NmU) precursor peptide."
    Sharma S.K., Bloom S.R.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiNMU_MOUSE
AccessioniPrimary (citable) accession number: Q9QXK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.