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Protein
Submitted name:

Cytochrome P450 3A25

Gene

Cyp3a25

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 3A25Imported
Gene namesi
Name:Cyp3a25Imported
Synonyms:CYP3A25Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1930638. Cyp3a25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3322HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23319HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9QXK4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065585.

Structurei

3D structure databases

ProteinModelPortaliQ9QXK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELIPNLSIE TWVLLVTSLV LFYIYGTYSH GLFKKLGIPG PKPLPLLGTI
60 70 80 90 100
FNYYDGMWKF DEDCYKKYGK IWGFYEGPQP ILAIMDPEII KIVLVKECYS
110 120 130 140 150
VFTNRRFFGP VGFMKKAITI SEDEEWKRLR TLLSPTFTSG KLKEMFPIMR
160 170 180 190 200
QYGDILVRNL RREEEKGEPI SMKDIFGAYS MDVITGTSFG VNVDSLNNPQ
210 220 230 240 250
DPFVQKAKKI LKFKVFDPFL LSIILFPFLT PIYEMLNFSI FPRDSMNFFK
260 270 280 290 300
KFVKRMKKER LASNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAV
310 320 330 340 350
IFIFGGYDAT STSISLIMYE LATHPDVQKK LQDEIDRTLP NKAPVTYDAL
360 370 380 390 400
MDMEYLDMVV NESLRLYPIA IRLERVSKKD VEINGVFIPK GTVVMIPIYP
410 420 430 440 450
LHRNPEYWPE PQEFCPERFS KENKGNIDPY IYMPFGNGPR NCIGMRFALI
460 470 480 490 500
SIKLAVIGVL QNFTVQPCEE TQIPLKISRE PIFQPEKPII LKVVSRDKPR

TGS
Length:503
Mass (Da):58,108
Last modified:May 1, 2000 - v1
Checksum:i9A5ABCC0AEF50CCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204959 mRNA. Translation: AAF15303.1.
UniGeneiMm.301900.
Mm.384461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204959 mRNA. Translation: AAF15303.1.
UniGeneiMm.301900.
Mm.384461.

3D structure databases

ProteinModelPortaliQ9QXK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065585.

Proteomic databases

PaxDbiQ9QXK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1930638. Cyp3a25.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG108567.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase."
    Dai D., Bai R., Hodgson E., Rose R.L.
    J. Biochem. Mol. Toxicol. 15:90-99(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.

Entry informationi

Entry nameiQ9QXK4_MOUSE
AccessioniPrimary (citable) accession number: Q9QXK4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.