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Q9QXK3

- COPG2_MOUSE

UniProt

Q9QXK3 - COPG2_MOUSE

Protein

Coatomer subunit gamma-2

Gene

Copg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coatomer subunit gamma-2
    Alternative name(s):
    Gamma-2-coat protein
    Short name:
    Gamma-2-COP
    Gene namesi
    Name:Copg2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1858683. Copg2.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi.By similarity

    GO - Cellular componenti

    1. COPI vesicle coat Source: InterPro
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 871871Coatomer subunit gamma-2PRO_0000193863Add
    BLAST

    Proteomic databases

    MaxQBiQ9QXK3.
    PaxDbiQ9QXK3.
    PRIDEiQ9QXK3.

    PTM databases

    PhosphoSiteiQ9QXK3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QXK3.
    BgeeiQ9QXK3.
    CleanExiMM_COPG2.
    GenevestigatoriQ9QXK3.

    Interactioni

    Subunit structurei

    Oligomeric complex. Binds to CDC42 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi207586. 1 interaction.
    MINTiMINT-1870143.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXK3.
    SMRiQ9QXK3. Positions 20-311, 602-871.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati64 – 10138HEAT 1Add
    BLAST
    Repeati283 – 32038HEAT 2Add
    BLAST
    Repeati321 – 35535HEAT 3Add
    BLAST
    Repeati356 – 39237HEAT 4Add
    BLAST
    Repeati395 – 43036HEAT 5Add
    BLAST
    Repeati467 – 50438HEAT 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the COPG family.Curated
    Contains 6 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5240.
    GeneTreeiENSGT00390000016313.
    HOGENOMiHOG000184434.
    HOVERGENiHBG004368.
    InParanoidiQ9QXK3.
    KOiK17267.
    OMAiPMELTEA.
    OrthoDBiEOG75XGK5.
    PhylomeDBiQ9QXK3.
    TreeFamiTF300324.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view]
    PANTHERiPTHR10261. PTHR10261. 1 hit.
    PfamiPF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QXK3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK    50
    ILYLLNQGEH FGTMEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE 100
    DVIIVTSSLT KDMTGKEDVY RGPAIRALCR ITDGTMLQAV ERYMKQAIVD 150
    KVSSVASSAL VSSLHMMKIS YDVVKRWINE AQEAASSDNI MVQYHALGVL 200
    YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL KESEDGHESP 250
    LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK 300
    PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK 350
    TGSESSVDRL MKQISSFVSE ISDEFKVVVV QAISALCHKY PRKHSVMMTF 400
    LSNMLRDDGG FEYKKAIVDC IISIVEENPE SKEAGLAHLC EFIEDCEHTV 450
    LATKILHLLG KEGPRTPVPS KYIRFIFNRV VLENEAVRAA AVSALAKFGA 500
    QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM ALNATYIFNG 550
    LTVSIPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK SEITLVTPKP 600
    EKLAPSRQDI FQEQLAAIPE FMNLGPLFKS SEPVQLTEAE TEYFVRCVKH 650
    MFTDHIVFQF DCTNTLNDQL LEKVTVQMEP SDSYEVLCCI PAPSLPYNQP 700
    GICYTLVRLP DEDPTAVAGT FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL 750
    EDLEVTVSDH IQKILKPNFA AAWEEVGDAF EKEETFALSS TKTLEEAVNN 800
    IITFLGMQPC ERSDKVPENK NSHSLYLAGV YRGGYDLLVR SRLALADGVT 850
    MQVTVRSKER TPVDVILASV G 871
    Length:871
    Mass (Da):97,681
    Last modified:May 1, 2000 - v1
    Checksum:iB3F49178ABDE4A7F
    GO
    Isoform 2 (identifier: Q9QXK3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         247-250: HESP → LQRN
         251-871: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:250
    Mass (Da):28,488
    Checksum:i37184C062A9D587E
    GO
    Isoform 3 (identifier: Q9QXK3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         377-382: VVVVQA → ALLYPM
         383-871: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:382
    Mass (Da):42,941
    Checksum:i1EDAC5265B9F7A6A
    GO
    Isoform 4 (identifier: Q9QXK3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         795-795: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:870
    Mass (Da):97,551
    Checksum:iFB91CC3CCC29A4ED
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei247 – 2504HESP → LQRN in isoform 2. 1 PublicationVSP_034480
    Alternative sequencei251 – 871621Missing in isoform 2. 1 PublicationVSP_034481Add
    BLAST
    Alternative sequencei377 – 3826VVVVQA → ALLYPM in isoform 3. 1 PublicationVSP_034482
    Alternative sequencei383 – 871489Missing in isoform 3. 1 PublicationVSP_034483Add
    BLAST
    Alternative sequencei795 – 7951Missing in isoform 4. 1 PublicationVSP_034484

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205065 mRNA. Translation: AAF17607.1.
    AJ251067 mRNA. Translation: CAB96146.1.
    AK088492 mRNA. Translation: BAC40387.1.
    AK149462 mRNA. Translation: BAE28895.1.
    AK163668 mRNA. Translation: BAE37449.1.
    BC049178 mRNA. Translation: AAH49178.1.
    BC145898 mRNA. Translation: AAI45899.1.
    BC145900 mRNA. Translation: AAI45901.1.
    RefSeqiNP_059506.1. NM_017478.3. [Q9QXK3-1]
    UniGeneiMm.335639.
    Mm.381860.
    Mm.39896.

    Genome annotation databases

    EnsembliENSMUST00000048774; ENSMUSP00000038368; ENSMUSG00000025607. [Q9QXK3-1]
    ENSMUST00000166192; ENSMUSP00000126726; ENSMUSG00000025607. [Q9QXK3-3]
    GeneIDi54160.
    KEGGimmu:54160.
    UCSCiuc029vty.1. mouse. [Q9QXK3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205065 mRNA. Translation: AAF17607.1 .
    AJ251067 mRNA. Translation: CAB96146.1 .
    AK088492 mRNA. Translation: BAC40387.1 .
    AK149462 mRNA. Translation: BAE28895.1 .
    AK163668 mRNA. Translation: BAE37449.1 .
    BC049178 mRNA. Translation: AAH49178.1 .
    BC145898 mRNA. Translation: AAI45899.1 .
    BC145900 mRNA. Translation: AAI45901.1 .
    RefSeqi NP_059506.1. NM_017478.3. [Q9QXK3-1 ]
    UniGenei Mm.335639.
    Mm.381860.
    Mm.39896.

    3D structure databases

    ProteinModelPortali Q9QXK3.
    SMRi Q9QXK3. Positions 20-311, 602-871.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207586. 1 interaction.
    MINTi MINT-1870143.

    PTM databases

    PhosphoSitei Q9QXK3.

    Proteomic databases

    MaxQBi Q9QXK3.
    PaxDbi Q9QXK3.
    PRIDEi Q9QXK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048774 ; ENSMUSP00000038368 ; ENSMUSG00000025607 . [Q9QXK3-1 ]
    ENSMUST00000166192 ; ENSMUSP00000126726 ; ENSMUSG00000025607 . [Q9QXK3-3 ]
    GeneIDi 54160.
    KEGGi mmu:54160.
    UCSCi uc029vty.1. mouse. [Q9QXK3-1 ]

    Organism-specific databases

    CTDi 26958.
    MGIi MGI:1858683. Copg2.

    Phylogenomic databases

    eggNOGi COG5240.
    GeneTreei ENSGT00390000016313.
    HOGENOMi HOG000184434.
    HOVERGENi HBG004368.
    InParanoidi Q9QXK3.
    KOi K17267.
    OMAi PMELTEA.
    OrthoDBi EOG75XGK5.
    PhylomeDBi Q9QXK3.
    TreeFami TF300324.

    Miscellaneous databases

    ChiTaRSi COPG2. mouse.
    NextBioi 311000.
    PROi Q9QXK3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QXK3.
    Bgeei Q9QXK3.
    CleanExi MM_COPG2.
    Genevestigatori Q9QXK3.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view ]
    PANTHERi PTHR10261. PTHR10261. 1 hit.
    Pfami PF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Imprinted Copg2 gene for gamma2-COP from mouse."
      Lee Y.J., Chung J.H.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis."
      Brunner B., Gruetzner F., Yaspo M.-L., Ropers H.-H., Haaf T., Kalscheuer V.M.
      Chromosome Res. 8:465-476(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Testis.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Strain: C57BL/6J and NOD.
      Tissue: Liver, Medulla oblongata and Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Olfactory epithelium.
    5. Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCOPG2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXK3
    Secondary accession number(s): A6H6J5
    , Q3TQD5, Q3UEL6, Q8C2J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3