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Q9QXK3 (COPG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coatomer subunit gamma-2
Alternative name(s):
Gamma-2-coat protein
Short name=Gamma-2-COP
Gene names
Name:Copg2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length871 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.

Subunit structure

Oligomeric complex. Binds to CDC42 By similarity.

Subcellular location

Cytoplasmcytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi By similarity. Ref.5

Sequence similarities

Belongs to the COPG family.

Contains 6 HEAT repeats.

Ontologies

Keywords
   Biological processER-Golgi transport
Protein transport
Transport
   Cellular componentCytoplasm
Cytoplasmic vesicle
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular protein transport

Inferred from electronic annotation. Source: InterPro

vesicle-mediated transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentCOPI vesicle coat

Inferred from electronic annotation. Source: InterPro

cytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QXK3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QXK3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     247-250: HESP → LQRN
     251-871: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9QXK3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     377-382: VVVVQA → ALLYPM
     383-871: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9QXK3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     795-795: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 871871Coatomer subunit gamma-2
PRO_0000193863

Regions

Repeat64 – 10138HEAT 1
Repeat283 – 32038HEAT 2
Repeat321 – 35535HEAT 3
Repeat356 – 39237HEAT 4
Repeat395 – 43036HEAT 5
Repeat467 – 50438HEAT 6

Natural variations

Alternative sequence247 – 2504HESP → LQRN in isoform 2.
VSP_034480
Alternative sequence251 – 871621Missing in isoform 2.
VSP_034481
Alternative sequence377 – 3826VVVVQA → ALLYPM in isoform 3.
VSP_034482
Alternative sequence383 – 871489Missing in isoform 3.
VSP_034483
Alternative sequence7951Missing in isoform 4.
VSP_034484

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B3F49178ABDE4A7F

FASTA87197,681
        10         20         30         40         50         60 
MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK ILYLLNQGEH 

        70         80         90        100        110        120 
FGTMEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE DVIIVTSSLT KDMTGKEDVY 

       130        140        150        160        170        180 
RGPAIRALCR ITDGTMLQAV ERYMKQAIVD KVSSVASSAL VSSLHMMKIS YDVVKRWINE 

       190        200        210        220        230        240 
AQEAASSDNI MVQYHALGVL YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL 

       250        260        270        280        290        300 
KESEDGHESP LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK 

       310        320        330        340        350        360 
PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK TGSESSVDRL 

       370        380        390        400        410        420 
MKQISSFVSE ISDEFKVVVV QAISALCHKY PRKHSVMMTF LSNMLRDDGG FEYKKAIVDC 

       430        440        450        460        470        480 
IISIVEENPE SKEAGLAHLC EFIEDCEHTV LATKILHLLG KEGPRTPVPS KYIRFIFNRV 

       490        500        510        520        530        540 
VLENEAVRAA AVSALAKFGA QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM 

       550        560        570        580        590        600 
ALNATYIFNG LTVSIPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK SEITLVTPKP 

       610        620        630        640        650        660 
EKLAPSRQDI FQEQLAAIPE FMNLGPLFKS SEPVQLTEAE TEYFVRCVKH MFTDHIVFQF 

       670        680        690        700        710        720 
DCTNTLNDQL LEKVTVQMEP SDSYEVLCCI PAPSLPYNQP GICYTLVRLP DEDPTAVAGT 

       730        740        750        760        770        780 
FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL EDLEVTVSDH IQKILKPNFA AAWEEVGDAF 

       790        800        810        820        830        840 
EKEETFALSS TKTLEEAVNN IITFLGMQPC ERSDKVPENK NSHSLYLAGV YRGGYDLLVR 

       850        860        870 
SRLALADGVT MQVTVRSKER TPVDVILASV G 

« Hide

Isoform 2 [UniParc].

Checksum: 37184C062A9D587E
Show »

FASTA25028,488
Isoform 3 [UniParc].

Checksum: 1EDAC5265B9F7A6A
Show »

FASTA38242,941
Isoform 4 [UniParc].

Checksum: FB91CC3CCC29A4ED
Show »

FASTA87097,551

References

« Hide 'large scale' references
[1]"Imprinted Copg2 gene for gamma2-COP from mouse."
Lee Y.J., Chung J.H.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis."
Brunner B., Gruetzner F., Yaspo M.-L., Ropers H.-H., Haaf T., Kalscheuer V.M.
Chromosome Res. 8:465-476(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Testis.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
Strain: C57BL/6J and NOD.
Tissue: Liver, Medulla oblongata and Thymus.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Olfactory epithelium.
[5]"Differential localization of coatomer complex isoforms within the Golgi apparatus."
Moelleken J., Malsam J., Betts M.J., Movafeghi A., Reckmann I., Meissner I., Hellwig A., Russell R.B., Sollner T., Brugger B., Wieland F.T.
Proc. Natl. Acad. Sci. U.S.A. 104:4425-4430(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF205065 mRNA. Translation: AAF17607.1.
AJ251067 mRNA. Translation: CAB96146.1.
AK088492 mRNA. Translation: BAC40387.1.
AK149462 mRNA. Translation: BAE28895.1.
AK163668 mRNA. Translation: BAE37449.1.
BC049178 mRNA. Translation: AAH49178.1.
BC145898 mRNA. Translation: AAI45899.1.
BC145900 mRNA. Translation: AAI45901.1.
RefSeqNP_059506.1. NM_017478.3. [Q9QXK3-1]
UniGeneMm.335639.
Mm.381860.
Mm.39896.

3D structure databases

ProteinModelPortalQ9QXK3.
SMRQ9QXK3. Positions 20-311, 602-871.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207586. 1 interaction.
MINTMINT-1870143.

PTM databases

PhosphoSiteQ9QXK3.

Proteomic databases

MaxQBQ9QXK3.
PaxDbQ9QXK3.
PRIDEQ9QXK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048774; ENSMUSP00000038368; ENSMUSG00000025607. [Q9QXK3-1]
ENSMUST00000166192; ENSMUSP00000126726; ENSMUSG00000025607. [Q9QXK3-3]
GeneID54160.
KEGGmmu:54160.
UCSCuc029vty.1. mouse. [Q9QXK3-1]

Organism-specific databases

CTD26958.
MGIMGI:1858683. Copg2.

Phylogenomic databases

eggNOGCOG5240.
GeneTreeENSGT00390000016313.
HOGENOMHOG000184434.
HOVERGENHBG004368.
InParanoidQ9QXK3.
KOK17267.
OMAPMELTEA.
OrthoDBEOG75XGK5.
PhylomeDBQ9QXK3.
TreeFamTF300324.

Gene expression databases

ArrayExpressQ9QXK3.
BgeeQ9QXK3.
CleanExMM_COPG2.
GenevestigatorQ9QXK3.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERPTHR10261. PTHR10261. 1 hit.
PfamPF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMSSF48371. SSF48371. 2 hits.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCOPG2. mouse.
NextBio311000.
PROQ9QXK3.
SOURCESearch...

Entry information

Entry nameCOPG2_MOUSE
AccessionPrimary (citable) accession number: Q9QXK3
Secondary accession number(s): A6H6J5 expand/collapse secondary AC list , Q3TQD5, Q3UEL6, Q8C2J6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot