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Protein

Coatomer subunit gamma-2

Gene

Copg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-2
Alternative name(s):
Gamma-2-coat protein
Short name:
Gamma-2-COP
Gene namesi
Name:Copg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1858683. Copg2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Coatomer subunit gamma-2PRO_0000193863Add
BLAST

Proteomic databases

MaxQBiQ9QXK3.
PaxDbiQ9QXK3.
PRIDEiQ9QXK3.

PTM databases

PhosphoSiteiQ9QXK3.

Expressioni

Gene expression databases

BgeeiQ9QXK3.
CleanExiMM_COPG2.
ExpressionAtlasiQ9QXK3. baseline and differential.
GenevisibleiQ9QXK3. MM.

Interactioni

Subunit structurei

Oligomeric complex. Binds to CDC42. Interacts with JAGN1.By similarity

Protein-protein interaction databases

BioGridi207586. 1 interaction.
MINTiMINT-1870143.
STRINGi10090.ENSMUSP00000038368.

Structurei

3D structure databases

ProteinModelPortaliQ9QXK3.
SMRiQ9QXK3. Positions 20-311, 602-871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 10138HEAT 1Add
BLAST
Repeati283 – 32038HEAT 2Add
BLAST
Repeati321 – 35535HEAT 3Add
BLAST
Repeati356 – 39237HEAT 4Add
BLAST
Repeati395 – 43036HEAT 5Add
BLAST
Repeati467 – 50438HEAT 6Add
BLAST

Sequence similaritiesi

Belongs to the COPG family.Curated
Contains 6 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5240.
GeneTreeiENSGT00390000016313.
HOGENOMiHOG000184434.
HOVERGENiHBG004368.
InParanoidiQ9QXK3.
KOiK17267.
OMAiCENTAVP.
OrthoDBiEOG75XGK5.
PhylomeDBiQ9QXK3.
TreeFamiTF300324.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QXK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKKFDKKDE ESGSGSNPFQ HLEKSAVLQE ARIFNETPIN PRRCLHILTK
60 70 80 90 100
ILYLLNQGEH FGTMEATEAF FAMTRLFQSN DQTLRRMCYL TIKEMATISE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDVY RGPAIRALCR ITDGTMLQAV ERYMKQAIVD
160 170 180 190 200
KVSSVASSAL VSSLHMMKIS YDVVKRWINE AQEAASSDNI MVQYHALGVL
210 220 230 240 250
YHLRKNDRLA VSKMLNKFTK SGLKSQFAYC MLIRIASRLL KESEDGHESP
260 270 280 290 300
LFDFIESCLR NKHEMVIYEA ASAIIHLPNC TARELAPAVS VLQLFCSSPK
310 320 330 340 350
PALRYAAVRT LNKVAMKHPS AVTACNLDLE NLITDSNRSI ATLAITTLLK
360 370 380 390 400
TGSESSVDRL MKQISSFVSE ISDEFKVVVV QAISALCHKY PRKHSVMMTF
410 420 430 440 450
LSNMLRDDGG FEYKKAIVDC IISIVEENPE SKEAGLAHLC EFIEDCEHTV
460 470 480 490 500
LATKILHLLG KEGPRTPVPS KYIRFIFNRV VLENEAVRAA AVSALAKFGA
510 520 530 540 550
QNESLLPSIL VLLQRCMMDT DDEVRDRATF YLNVLQQRQM ALNATYIFNG
560 570 580 590 600
LTVSIPGMEK ALHQYTLEPS EKPFDMKSIP LAMAPVFEQK SEITLVTPKP
610 620 630 640 650
EKLAPSRQDI FQEQLAAIPE FMNLGPLFKS SEPVQLTEAE TEYFVRCVKH
660 670 680 690 700
MFTDHIVFQF DCTNTLNDQL LEKVTVQMEP SDSYEVLCCI PAPSLPYNQP
710 720 730 740 750
GICYTLVRLP DEDPTAVAGT FSCTMKFTVR DCDPNTGVPD EDGYDDEYVL
760 770 780 790 800
EDLEVTVSDH IQKILKPNFA AAWEEVGDAF EKEETFALSS TKTLEEAVNN
810 820 830 840 850
IITFLGMQPC ERSDKVPENK NSHSLYLAGV YRGGYDLLVR SRLALADGVT
860 870
MQVTVRSKER TPVDVILASV G
Length:871
Mass (Da):97,681
Last modified:May 1, 2000 - v1
Checksum:iB3F49178ABDE4A7F
GO
Isoform 2 (identifier: Q9QXK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-250: HESP → LQRN
     251-871: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):28,488
Checksum:i37184C062A9D587E
GO
Isoform 3 (identifier: Q9QXK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-382: VVVVQA → ALLYPM
     383-871: Missing.

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):42,941
Checksum:i1EDAC5265B9F7A6A
GO
Isoform 4 (identifier: Q9QXK3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-795: Missing.

Note: No experimental confirmation available.
Show »
Length:870
Mass (Da):97,551
Checksum:iFB91CC3CCC29A4ED
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei247 – 2504HESP → LQRN in isoform 2. 1 PublicationVSP_034480
Alternative sequencei251 – 871621Missing in isoform 2. 1 PublicationVSP_034481Add
BLAST
Alternative sequencei377 – 3826VVVVQA → ALLYPM in isoform 3. 1 PublicationVSP_034482
Alternative sequencei383 – 871489Missing in isoform 3. 1 PublicationVSP_034483Add
BLAST
Alternative sequencei795 – 7951Missing in isoform 4. 1 PublicationVSP_034484

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205065 mRNA. Translation: AAF17607.1.
AJ251067 mRNA. Translation: CAB96146.1.
AK088492 mRNA. Translation: BAC40387.1.
AK149462 mRNA. Translation: BAE28895.1.
AK163668 mRNA. Translation: BAE37449.1.
BC049178 mRNA. Translation: AAH49178.1.
BC145898 mRNA. Translation: AAI45899.1.
BC145900 mRNA. Translation: AAI45901.1.
RefSeqiNP_059506.1. NM_017478.3. [Q9QXK3-1]
UniGeneiMm.335639.
Mm.381860.
Mm.39896.

Genome annotation databases

EnsembliENSMUST00000048774; ENSMUSP00000038368; ENSMUSG00000025607. [Q9QXK3-1]
ENSMUST00000166192; ENSMUSP00000126726; ENSMUSG00000025607. [Q9QXK3-3]
GeneIDi54160.
KEGGimmu:54160.
UCSCiuc029vty.1. mouse. [Q9QXK3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205065 mRNA. Translation: AAF17607.1.
AJ251067 mRNA. Translation: CAB96146.1.
AK088492 mRNA. Translation: BAC40387.1.
AK149462 mRNA. Translation: BAE28895.1.
AK163668 mRNA. Translation: BAE37449.1.
BC049178 mRNA. Translation: AAH49178.1.
BC145898 mRNA. Translation: AAI45899.1.
BC145900 mRNA. Translation: AAI45901.1.
RefSeqiNP_059506.1. NM_017478.3. [Q9QXK3-1]
UniGeneiMm.335639.
Mm.381860.
Mm.39896.

3D structure databases

ProteinModelPortaliQ9QXK3.
SMRiQ9QXK3. Positions 20-311, 602-871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207586. 1 interaction.
MINTiMINT-1870143.
STRINGi10090.ENSMUSP00000038368.

PTM databases

PhosphoSiteiQ9QXK3.

Proteomic databases

MaxQBiQ9QXK3.
PaxDbiQ9QXK3.
PRIDEiQ9QXK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048774; ENSMUSP00000038368; ENSMUSG00000025607. [Q9QXK3-1]
ENSMUST00000166192; ENSMUSP00000126726; ENSMUSG00000025607. [Q9QXK3-3]
GeneIDi54160.
KEGGimmu:54160.
UCSCiuc029vty.1. mouse. [Q9QXK3-1]

Organism-specific databases

CTDi26958.
MGIiMGI:1858683. Copg2.

Phylogenomic databases

eggNOGiCOG5240.
GeneTreeiENSGT00390000016313.
HOGENOMiHOG000184434.
HOVERGENiHBG004368.
InParanoidiQ9QXK3.
KOiK17267.
OMAiCENTAVP.
OrthoDBiEOG75XGK5.
PhylomeDBiQ9QXK3.
TreeFamiTF300324.

Miscellaneous databases

ChiTaRSiCopg2. mouse.
NextBioi311000.
PROiQ9QXK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXK3.
CleanExiMM_COPG2.
ExpressionAtlasiQ9QXK3. baseline and differential.
GenevisibleiQ9QXK3. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Imprinted Copg2 gene for gamma2-COP from mouse."
    Lee Y.J., Chung J.H.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis."
    Brunner B., Gruetzner F., Yaspo M.-L., Ropers H.-H., Haaf T., Kalscheuer V.M.
    Chromosome Res. 8:465-476(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Testis.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Strain: C57BL/6J and NOD.
    Tissue: Liver, Medulla oblongata and Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Olfactory epithelium.
  5. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCOPG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXK3
Secondary accession number(s): A6H6J5
, Q3TQD5, Q3UEL6, Q8C2J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.