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Protein

Signal transducer and activator of transcription

Gene

Stat2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-8854691 Interleukin-20 family signaling
R-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103039 Stat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000040033

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QXJ2, 15 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini570 – 708SH2InterPro annotationAdd BLAST139

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOVERGENiHBG055669
KOiK11221

Family and domain databases

CDDicd10373 SH2_STAT2, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR022756 STAT2_C
IPR035854 STAT2_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12188 STAT2_C, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWEMLQNL DSLFLDQLHQ VYSQSILPMD VRQHLATWIE DQNWREAALG
60 70 80 90 100
SDDAKANMLY FSILDQLNQW DHYSSDSNHF LLQHNLRKFS RDIQTFPNGP
110 120 130 140 150
TQLAEMIFNL LLEEQRILNQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG
160 170 180 190 200
LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAQLVQA
210 220 230 240 250
TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP
260 270 280 290 300
PELQLEQLEQ WLTAGAKFLF HLRQLLKQLK EMSHMLRYKG DMFGQGVDLQ
310 320 330 340 350
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL
360 370 380 390 400
QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEEG QRQGLIWDFG
410 420 430 440 450
FLTLVEQRAV GAGKGNKGPL AVTEELHVIS FVVEYVYQGL KMKLQTDTLP
460 470 480 490 500
VVIISNMNQL SIAWASILWF NMLSPNPKNQ QFFCQAPKAP WSLLGPVLSW
510 520 530 540 550
QFSSYVGRGL DSEQLGMLRT KLFGKSCKME DALLSWVDFC KRESPPGKIP
560 570 580 590 600
FWTWLDKILE LVHDHLKDLW KDGRIMGFVS RNQERRLLKK MLSGTFLLRF
610 620 630 640 650
SETSEGGITC SWVEHQDDDK VEIYSVQPYT KEVLQSLPLT EIIRHYQVLA
660 670 680 690 700
EENIPENPLR FLYPRIPRDE AFGCYYQEKV NFEEQRKYLK HKLIVISNRQ
710 720 730 740 750
VDELQQPLEL KQDSESLEVN AELLLAHDQE LPLMMQTGLV LGTELKVDPI
760 770 780 790 800
LSTAPQVLLE PAPQVLLEPA PQVPLEPAPQ VLLEPAPQVL LEPAPQVLLE
810 820 830 840 850
PAPQVLLEPA PQVQLEPAPQ VLLELAPQVL LEPAPQVLLE LAPQVQLEPA
860 870 880 890 900
HLLQQPSESD LPEDLQQISV EDLKKLSNPS TEYITTNENP MLAGESSGDE
910 920
TSIPYHSHFD ADGLLGWTLD TF
Length:922
Mass (Da):105,386
Last modified:May 1, 2000 - v1
Checksum:i61E73D3276D5354A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135859 Genomic DNA No translation available.
AF206162 mRNA Translation: AAF17096.1
AK150070 mRNA Translation: BAE29282.1
RefSeqiNP_064347.1, NM_019963.1
UniGeneiMm.293120
Mm.471333

Genome annotation databases

EnsembliENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033
GeneIDi20847
KEGGimmu:20847
UCSCiuc007hma.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ9QXJ2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXJ2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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