Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal transducer and activator of transcription

Gene

Stat2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103039. Stat2.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000040033.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082855.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini570 – 708139SH2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK11221.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWEMLQNL DSLFLDQLHQ VYSQSILPMD VRQHLATWIE DQNWREAALG
60 70 80 90 100
SDDAKANMLY FSILDQLNQW DHYSSDSNHF LLQHNLRKFS RDIQTFPNGP
110 120 130 140 150
TQLAEMIFNL LLEEQRILNQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG
160 170 180 190 200
LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAQLVQA
210 220 230 240 250
TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP
260 270 280 290 300
PELQLEQLEQ WLTAGAKFLF HLRQLLKQLK EMSHMLRYKG DMFGQGVDLQ
310 320 330 340 350
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL
360 370 380 390 400
QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEEG QRQGLIWDFG
410 420 430 440 450
FLTLVEQRAV GAGKGNKGPL AVTEELHVIS FVVEYVYQGL KMKLQTDTLP
460 470 480 490 500
VVIISNMNQL SIAWASILWF NMLSPNPKNQ QFFCQAPKAP WSLLGPVLSW
510 520 530 540 550
QFSSYVGRGL DSEQLGMLRT KLFGKSCKME DALLSWVDFC KRESPPGKIP
560 570 580 590 600
FWTWLDKILE LVHDHLKDLW KDGRIMGFVS RNQERRLLKK MLSGTFLLRF
610 620 630 640 650
SETSEGGITC SWVEHQDDDK VEIYSVQPYT KEVLQSLPLT EIIRHYQVLA
660 670 680 690 700
EENIPENPLR FLYPRIPRDE AFGCYYQEKV NFEEQRKYLK HKLIVISNRQ
710 720 730 740 750
VDELQQPLEL KQDSESLEVN AELLLAHDQE LPLMMQTGLV LGTELKVDPI
760 770 780 790 800
LSTAPQVLLE PAPQVLLEPA PQVPLEPAPQ VLLEPAPQVL LEPAPQVLLE
810 820 830 840 850
PAPQVLLEPA PQVQLEPAPQ VLLELAPQVL LEPAPQVLLE LAPQVQLEPA
860 870 880 890 900
HLLQQPSESD LPEDLQQISV EDLKKLSNPS TEYITTNENP MLAGESSGDE
910 920
TSIPYHSHFD ADGLLGWTLD TF
Length:922
Mass (Da):105,386
Last modified:May 1, 2000 - v1
Checksum:i61E73D3276D5354A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135859 Genomic DNA. No translation available.
AF206162 mRNA. Translation: AAF17096.1.
AK150070 mRNA. Translation: BAE29282.1.
RefSeqiNP_064347.1. NM_019963.1.
UniGeneiMm.293120.
Mm.471333.

Genome annotation databases

EnsembliENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033.
GeneIDi20847.
KEGGimmu:20847.
UCSCiuc007hma.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135859 Genomic DNA. No translation available.
AF206162 mRNA. Translation: AAF17096.1.
AK150070 mRNA. Translation: BAE29282.1.
RefSeqiNP_064347.1. NM_019963.1.
UniGeneiMm.293120.
Mm.471333.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082855.

Protocols and materials databases

DNASUi20847.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033.
GeneIDi20847.
KEGGimmu:20847.
UCSCiuc007hma.1. mouse.

Organism-specific databases

CTDi6773.
MGIiMGI:103039. Stat2.

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK11221.

Enzyme and pathway databases

ReactomeiR-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040033.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9QXJ2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.