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Q9QXJ2

- Q9QXJ2_MOUSE

UniProt

Q9QXJ2 - Q9QXJ2_MOUSE

Protein

Signal transducer and activator of transcription

Gene

Stat2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: InterPro
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ActivatorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcriptionUniRule annotation
    Gene namesi
    Name:Stat2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:103039. Stat2.

    Subcellular locationi

    Cytoplasm UniRule annotation
    Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    CytoplasmUniRule annotation, NucleusUniRule annotation

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QXJ2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.UniRule annotation
    Contains 1 SH2 domain.UniRule annotation

    Keywords - Domaini

    SH2 domainUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115175.
    HOVERGENiHBG055669.
    KOiK11221.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR022756. STAT2_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF12188. STAT2_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QXJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQWEMLQNL DSLFLDQLHQ VYSQSILPMD VRQHLATWIE DQNWREAALG    50
    SDDAKANMLY FSILDQLNQW DHYSSDSNHF LLQHNLRKFS RDIQTFPNGP 100
    TQLAEMIFNL LLEEQRILNQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG 150
    LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAQLVQA 200
    TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP 250
    PELQLEQLEQ WLTAGAKFLF HLRQLLKQLK EMSHMLRYKG DMFGQGVDLQ 300
    NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL 350
    QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEEG QRQGLIWDFG 400
    FLTLVEQRAV GAGKGNKGPL AVTEELHVIS FVVEYVYQGL KMKLQTDTLP 450
    VVIISNMNQL SIAWASILWF NMLSPNPKNQ QFFCQAPKAP WSLLGPVLSW 500
    QFSSYVGRGL DSEQLGMLRT KLFGKSCKME DALLSWVDFC KRESPPGKIP 550
    FWTWLDKILE LVHDHLKDLW KDGRIMGFVS RNQERRLLKK MLSGTFLLRF 600
    SETSEGGITC SWVEHQDDDK VEIYSVQPYT KEVLQSLPLT EIIRHYQVLA 650
    EENIPENPLR FLYPRIPRDE AFGCYYQEKV NFEEQRKYLK HKLIVISNRQ 700
    VDELQQPLEL KQDSESLEVN AELLLAHDQE LPLMMQTGLV LGTELKVDPI 750
    LSTAPQVLLE PAPQVLLEPA PQVPLEPAPQ VLLEPAPQVL LEPAPQVLLE 800
    PAPQVLLEPA PQVQLEPAPQ VLLELAPQVL LEPAPQVLLE LAPQVQLEPA 850
    HLLQQPSESD LPEDLQQISV EDLKKLSNPS TEYITTNENP MLAGESSGDE 900
    TSIPYHSHFD ADGLLGWTLD TF 922
    Length:922
    Mass (Da):105,386
    Last modified:May 1, 2000 - v1
    Checksum:i61E73D3276D5354A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC135859 Genomic DNA. No translation available.
    AF206162 mRNA. Translation: AAF17096.1.
    AK150070 mRNA. Translation: BAE29282.1.
    RefSeqiNP_064347.1. NM_019963.1.
    UniGeneiMm.293120.
    Mm.471333.

    Genome annotation databases

    EnsembliENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033.
    GeneIDi20847.
    KEGGimmu:20847.
    UCSCiuc007hma.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC135859 Genomic DNA. No translation available.
    AF206162 mRNA. Translation: AAF17096.1 .
    AK150070 mRNA. Translation: BAE29282.1 .
    RefSeqi NP_064347.1. NM_019963.1.
    UniGenei Mm.293120.
    Mm.471333.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 20847.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000085708 ; ENSMUSP00000082855 ; ENSMUSG00000040033 .
    GeneIDi 20847.
    KEGGi mmu:20847.
    UCSCi uc007hma.1. mouse.

    Organism-specific databases

    CTDi 6773.
    MGIi MGI:103039. Stat2.

    Phylogenomic databases

    GeneTreei ENSGT00740000115175.
    HOVERGENi HBG055669.
    KOi K11221.

    Enzyme and pathway databases

    Reactomei REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.

    Miscellaneous databases

    NextBioi 299619.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9QXJ2.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR022756. STAT2_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF12188. STAT2_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    4. "Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2."
      Farrar J.D., Smith J.D., Murphy T.L., Leung S., Stark G.R., Murphy K.M.
      Nat. Immunol. 1:65-69(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B10.AImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ9QXJ2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXJ2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3