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Q9QXJ2

- Q9QXJ2_MOUSE

UniProt

Q9QXJ2 - Q9QXJ2_MOUSE

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Protein

Signal transducer and activator of transcription

Gene
Stat2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
  5. signal transducer activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:103039. Stat2.

Subcellular locationi

Cytoplasm By similarity UniRule annotation
Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ9QXJ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00740000115175.
HOVERGENiHBG055669.
KOiK11221.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXJ2-1 [UniParc]FASTAAdd to Basket

« Hide

MAQWEMLQNL DSLFLDQLHQ VYSQSILPMD VRQHLATWIE DQNWREAALG    50
SDDAKANMLY FSILDQLNQW DHYSSDSNHF LLQHNLRKFS RDIQTFPNGP 100
TQLAEMIFNL LLEEQRILNQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG 150
LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAQLVQA 200
TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP 250
PELQLEQLEQ WLTAGAKFLF HLRQLLKQLK EMSHMLRYKG DMFGQGVDLQ 300
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL 350
QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEEG QRQGLIWDFG 400
FLTLVEQRAV GAGKGNKGPL AVTEELHVIS FVVEYVYQGL KMKLQTDTLP 450
VVIISNMNQL SIAWASILWF NMLSPNPKNQ QFFCQAPKAP WSLLGPVLSW 500
QFSSYVGRGL DSEQLGMLRT KLFGKSCKME DALLSWVDFC KRESPPGKIP 550
FWTWLDKILE LVHDHLKDLW KDGRIMGFVS RNQERRLLKK MLSGTFLLRF 600
SETSEGGITC SWVEHQDDDK VEIYSVQPYT KEVLQSLPLT EIIRHYQVLA 650
EENIPENPLR FLYPRIPRDE AFGCYYQEKV NFEEQRKYLK HKLIVISNRQ 700
VDELQQPLEL KQDSESLEVN AELLLAHDQE LPLMMQTGLV LGTELKVDPI 750
LSTAPQVLLE PAPQVLLEPA PQVPLEPAPQ VLLEPAPQVL LEPAPQVLLE 800
PAPQVLLEPA PQVQLEPAPQ VLLELAPQVL LEPAPQVLLE LAPQVQLEPA 850
HLLQQPSESD LPEDLQQISV EDLKKLSNPS TEYITTNENP MLAGESSGDE 900
TSIPYHSHFD ADGLLGWTLD TF 922
Length:922
Mass (Da):105,386
Last modified:May 1, 2000 - v1
Checksum:i61E73D3276D5354A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC135859 Genomic DNA. No translation available.
AF206162 mRNA. Translation: AAF17096.1.
AK150070 mRNA. Translation: BAE29282.1.
RefSeqiNP_064347.1. NM_019963.1.
UniGeneiMm.293120.
Mm.471333.

Genome annotation databases

EnsembliENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033.
GeneIDi20847.
KEGGimmu:20847.
UCSCiuc007hma.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC135859 Genomic DNA. No translation available.
AF206162 mRNA. Translation: AAF17096.1 .
AK150070 mRNA. Translation: BAE29282.1 .
RefSeqi NP_064347.1. NM_019963.1.
UniGenei Mm.293120.
Mm.471333.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 20847.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085708 ; ENSMUSP00000082855 ; ENSMUSG00000040033 .
GeneIDi 20847.
KEGGi mmu:20847.
UCSCi uc007hma.1. mouse.

Organism-specific databases

CTDi 6773.
MGIi MGI:103039. Stat2.

Phylogenomic databases

GeneTreei ENSGT00740000115175.
HOVERGENi HBG055669.
KOi K11221.

Enzyme and pathway databases

Reactomei REACT_198622. Interferon alpha/beta signaling.
REACT_198627. Regulation of IFNA signaling.

Miscellaneous databases

NextBioi 299619.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9QXJ2.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  4. "Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2."
    Farrar J.D., Smith J.D., Murphy T.L., Leung S., Stark G.R., Murphy K.M.
    Nat. Immunol. 1:65-69(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.AImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9QXJ2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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