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Q9QXJ2 (Q9QXJ2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Signal transducer and activator of transcription RuleBase RU046415
Gene names
Name:Stat2 MGI 103039 EMBL AAF17096.1 Ensembl ENSMUSP00000082855
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length922 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm By similarity RuleBase RU046415.

Nucleus By similarity RuleBase RU046415.

Sequence similarities

Belongs to the transcription factor STAT family. RuleBase RU046415

Contains 1 SH2 domain. RuleBase RU046415

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cops4O885446EBI-646643,EBI-646659
Irf9Q611799EBI-646643,EBI-646653

Sequences

Sequence LengthMass (Da)Tools
Q9QXJ2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 61E73D3276D5354A

FASTA922105,386
        10         20         30         40         50         60 
MAQWEMLQNL DSLFLDQLHQ VYSQSILPMD VRQHLATWIE DQNWREAALG SDDAKANMLY 

        70         80         90        100        110        120 
FSILDQLNQW DHYSSDSNHF LLQHNLRKFS RDIQTFPNGP TQLAEMIFNL LLEEQRILNQ 

       130        140        150        160        170        180 
AQRAQEVQPP PAPEAVVESQ QLEIENRIQG LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS 

       190        200        210        220        230        240 
LKKTSSSDPH QSQQAQLVQA TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ 

       250        260        270        280        290        300 
QQKSCIGAPP PELQLEQLEQ WLTAGAKFLF HLRQLLKQLK EMSHMLRYKG DMFGQGVDLQ 

       310        320        330        340        350        360 
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL QEGSESLKAE 

       370        380        390        400        410        420 
VSVDRNSDLP GFRKFNILTS NQKTLTPEEG QRQGLIWDFG FLTLVEQRAV GAGKGNKGPL 

       430        440        450        460        470        480 
AVTEELHVIS FVVEYVYQGL KMKLQTDTLP VVIISNMNQL SIAWASILWF NMLSPNPKNQ 

       490        500        510        520        530        540 
QFFCQAPKAP WSLLGPVLSW QFSSYVGRGL DSEQLGMLRT KLFGKSCKME DALLSWVDFC 

       550        560        570        580        590        600 
KRESPPGKIP FWTWLDKILE LVHDHLKDLW KDGRIMGFVS RNQERRLLKK MLSGTFLLRF 

       610        620        630        640        650        660 
SETSEGGITC SWVEHQDDDK VEIYSVQPYT KEVLQSLPLT EIIRHYQVLA EENIPENPLR 

       670        680        690        700        710        720 
FLYPRIPRDE AFGCYYQEKV NFEEQRKYLK HKLIVISNRQ VDELQQPLEL KQDSESLEVN 

       730        740        750        760        770        780 
AELLLAHDQE LPLMMQTGLV LGTELKVDPI LSTAPQVLLE PAPQVLLEPA PQVPLEPAPQ 

       790        800        810        820        830        840 
VLLEPAPQVL LEPAPQVLLE PAPQVLLEPA PQVQLEPAPQ VLLELAPQVL LEPAPQVLLE 

       850        860        870        880        890        900 
LAPQVQLEPA HLLQQPSESD LPEDLQQISV EDLKKLSNPS TEYITTNENP MLAGESSGDE 

       910        920 
TSIPYHSHFD ADGLLGWTLD TF 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[4]"Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2."
Farrar J.D., Smith J.D., Murphy T.L., Leung S., Stark G.R., Murphy K.M.
Nat. Immunol. 1:65-69(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B10.A EMBL AAF17096.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[7]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE29282.1.
Tissue: Bone marrow EMBL BAE29282.1.
[10]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000082855.
[11]Ensembl
Submitted (JUN-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000082855.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC135859 Genomic DNA. No translation available.
AF206162 mRNA. Translation: AAF17096.1.
AK150070 mRNA. Translation: BAE29282.1.
RefSeqNP_064347.1. NM_019963.1.
UniGeneMm.293120.
Mm.471333.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU20847.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033.
GeneID20847.
KEGGmmu:20847.
UCSCuc007hma.1. mouse.

Organism-specific databases

CTD6773.
MGIMGI:103039. Stat2.

Phylogenomic databases

GeneTreeENSGT00740000115175.
HOVERGENHBG055669.
KOK11221.

Gene expression databases

GenevestigatorQ9QXJ2.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERPTHR11801. PTHR11801. 1 hit.
PfamPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299619.
SOURCESearch...

Entry information

Entry nameQ9QXJ2_MOUSE
AccessionPrimary (citable) accession number: Q9QXJ2
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)