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Protein

Signal transducer and activator of transcription

Gene

Stat2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. identical protein binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. signal transducer activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_336467. Interferon alpha/beta signaling.
REACT_350917. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:Stat2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103039. Stat2.

Subcellular locationi

  1. Cytoplasm UniRule annotation
  1. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ9QXJ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK11221.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWEMLQNL DSLFLDQLHQ VYSQSILPMD VRQHLATWIE DQNWREAALG
60 70 80 90 100
SDDAKANMLY FSILDQLNQW DHYSSDSNHF LLQHNLRKFS RDIQTFPNGP
110 120 130 140 150
TQLAEMIFNL LLEEQRILNQ AQRAQEVQPP PAPEAVVESQ QLEIENRIQG
160 170 180 190 200
LHVDIEFLVR SIRQLKDEQD VFSFRYTVFS LKKTSSSDPH QSQQAQLVQA
210 220 230 240 250
TANKVDRMRK EVLDISKGLV GRLTTLVDLL LPKLDEWKVQ QQKSCIGAPP
260 270 280 290 300
PELQLEQLEQ WLTAGAKFLF HLRQLLKQLK EMSHMLRYKG DMFGQGVDLQ
310 320 330 340 350
NAQVMELLQR LLQRSFVVET QPCMPQTLHR PLILKTGNKF TVRTRLLVRL
360 370 380 390 400
QEGSESLKAE VSVDRNSDLP GFRKFNILTS NQKTLTPEEG QRQGLIWDFG
410 420 430 440 450
FLTLVEQRAV GAGKGNKGPL AVTEELHVIS FVVEYVYQGL KMKLQTDTLP
460 470 480 490 500
VVIISNMNQL SIAWASILWF NMLSPNPKNQ QFFCQAPKAP WSLLGPVLSW
510 520 530 540 550
QFSSYVGRGL DSEQLGMLRT KLFGKSCKME DALLSWVDFC KRESPPGKIP
560 570 580 590 600
FWTWLDKILE LVHDHLKDLW KDGRIMGFVS RNQERRLLKK MLSGTFLLRF
610 620 630 640 650
SETSEGGITC SWVEHQDDDK VEIYSVQPYT KEVLQSLPLT EIIRHYQVLA
660 670 680 690 700
EENIPENPLR FLYPRIPRDE AFGCYYQEKV NFEEQRKYLK HKLIVISNRQ
710 720 730 740 750
VDELQQPLEL KQDSESLEVN AELLLAHDQE LPLMMQTGLV LGTELKVDPI
760 770 780 790 800
LSTAPQVLLE PAPQVLLEPA PQVPLEPAPQ VLLEPAPQVL LEPAPQVLLE
810 820 830 840 850
PAPQVLLEPA PQVQLEPAPQ VLLELAPQVL LEPAPQVLLE LAPQVQLEPA
860 870 880 890 900
HLLQQPSESD LPEDLQQISV EDLKKLSNPS TEYITTNENP MLAGESSGDE
910 920
TSIPYHSHFD ADGLLGWTLD TF
Length:922
Mass (Da):105,386
Last modified:May 1, 2000 - v1
Checksum:i61E73D3276D5354A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135859 Genomic DNA. No translation available.
AF206162 mRNA. Translation: AAF17096.1.
AK150070 mRNA. Translation: BAE29282.1.
RefSeqiNP_064347.1. NM_019963.1.
UniGeneiMm.293120.
Mm.471333.

Genome annotation databases

EnsembliENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033.
GeneIDi20847.
KEGGimmu:20847.
UCSCiuc007hma.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135859 Genomic DNA. No translation available.
AF206162 mRNA. Translation: AAF17096.1.
AK150070 mRNA. Translation: BAE29282.1.
RefSeqiNP_064347.1. NM_019963.1.
UniGeneiMm.293120.
Mm.471333.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi20847.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085708; ENSMUSP00000082855; ENSMUSG00000040033.
GeneIDi20847.
KEGGimmu:20847.
UCSCiuc007hma.1. mouse.

Organism-specific databases

CTDi6773.
MGIiMGI:103039. Stat2.

Phylogenomic databases

GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK11221.

Enzyme and pathway databases

ReactomeiREACT_336467. Interferon alpha/beta signaling.
REACT_350917. Regulation of IFNA signaling.

Miscellaneous databases

NextBioi299619.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9QXJ2.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR022756. STAT2_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF12188. STAT2_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  4. "Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2."
    Farrar J.D., Smith J.D., Murphy T.L., Leung S., Stark G.R., Murphy K.M.
    Nat. Immunol. 1:65-69(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.AImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9QXJ2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.