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Protein

Tubulin--tyrosine ligase

Gene

Ttl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.1 Publication

Catalytic activityi

ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.1 Publication

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • K+By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • tubulin-tyrosine ligase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDAi6.3.2.25. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase (EC:6.3.2.251 Publication)
Short name:
TTL
Gene namesi
Name:Ttl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621113. Ttl.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124371 – 377Tubulin--tyrosine ligaseAdd BLAST377

Proteomic databases

PaxDbiQ9QXJ0.

PTM databases

PhosphoSitePlusiQ9QXJ0.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024695.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 370TTLPROSITE-ProRule annotationAdd BLAST368

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated
Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
HOGENOMiHOG000231734.
HOVERGENiHBG016579.
InParanoidiQ9QXJ0.
KOiK06047.
PhylomeDBiQ9QXJ0.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTFVVRQEN SSVYAEVSRL LLATGYWKRL RRDNPRFNLM LGGRNRLPFG
60 70 80 90 100
RLGHEPGLAQ LVNYYRGADK LCRKASLVKL VKTSPELSES CSWFPESYVI
110 120 130 140 150
HPTNLKTPVA PAQNGIQLPV SNSRTDEREF FLASYNRKKE DGEGNVWIAK
160 170 180 190 200
SSAGAKGEGI LISSEASELL DFIDNQGQVH VIQKYLEHPL LLEPGHRKFD
210 220 230 240 250
IRSWVLVDHQ YNIYLYREGV LRTASEPYHV DNFQDKTCHL TNHCIQKEYS
260 270 280 290 300
KNYGKYEEGN EMFFEEFNQY LTSALNITLE NSILLQIKHI IRSCLMSVEP
310 320 330 340 350
AISTKHLPYQ SFQLLGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI
360 370
VDIAISSVFP PPDTEQVPQQ PAAFMKL
Length:377
Mass (Da):43,118
Last modified:May 1, 2000 - v1
Checksum:i1CB3B914D088A316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207605 mRNA. Translation: AAF18465.1.
U53214 mRNA. Translation: AAD10402.1.
RefSeqiNP_612545.1. NM_138536.1.
UniGeneiRn.205120.

Genome annotation databases

GeneIDi171572.
KEGGirno:171572.
UCSCiRGD:621113. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207605 mRNA. Translation: AAF18465.1.
U53214 mRNA. Translation: AAD10402.1.
RefSeqiNP_612545.1. NM_138536.1.
UniGeneiRn.205120.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024695.

PTM databases

PhosphoSitePlusiQ9QXJ0.

Proteomic databases

PaxDbiQ9QXJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171572.
KEGGirno:171572.
UCSCiRGD:621113. rat.

Organism-specific databases

CTDi150465.
RGDi621113. Ttl.

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
HOGENOMiHOG000231734.
HOVERGENiHBG016579.
InParanoidiQ9QXJ0.
KOiK06047.
PhylomeDBiQ9QXJ0.

Enzyme and pathway databases

BRENDAi6.3.2.25. 5301.

Miscellaneous databases

PROiQ9QXJ0.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTL_RAT
AccessioniPrimary (citable) accession number: Q9QXJ0
Secondary accession number(s): Q9Z1E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.