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Protein

G-protein coupled receptor 26

Gene

Gpr26

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 26
Gene namesi
Name:Gpr26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619843 Gpr26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 47CytoplasmicSequence analysisAdd BLAST16
Transmembranei48 – 68Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini69 – 81ExtracellularSequence analysisAdd BLAST13
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 144Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini145 – 168ExtracellularSequence analysisAdd BLAST24
Transmembranei169 – 189Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini190 – 245CytoplasmicSequence analysisAdd BLAST56
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 276ExtracellularSequence analysis10
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 337CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695471 – 337G-protein coupled receptor 26Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 156PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9QXI3
PRIDEiQ9QXI3

Expressioni

Tissue specificityi

Detected in extracts of several brain regions including striatum, pons, cerebellum and cortex. Not detected in numerous peripheral tissue extracts, except in testis. In the brain, detected in cortical structures including the anterior cingulate area, posterior cingulate and the frontoparietal, somatosensory and piriform cortices. Prominent also in the olfactory tubercle, the islands of Calleja, ventromedial and posterior nuclei of the hypothalamus, the medial septal nucleus, nucleus of the diagonal band and the ventral tegmental area. Localized also to hippocampal structures, with signals strongest over the CA2 and CA3 regions of Ammon's horn and less so over the dentate gyrus. Expressed in the caudate putamen only in its most caudal portion, with a decreasing gradient of signal from the dorsal to ventral aspect. Strong expression associated with a single pontine structure, the inferior olivary nucleus.

Gene expression databases

BgeeiENSRNOG00000047057
GenevisibleiQ9QXI3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067319

Structurei

3D structure databases

ProteinModelPortaliQ9QXI3
SMRiQ9QXI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00390000005107
HOVERGENiHBG051804
InParanoidiQ9QXI3
KOiK08411
OMAiSYHSKMR
OrthoDBiEOG091G0BFV
PhylomeDBiQ9QXI3

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSWDAGLAG LLVGTIGVSL LSNGLVLLCL LHSADIRRQA PALFTLNLTC
60 70 80 90 100
GNLLCTVVNM PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL
110 120 130 140 150
SIDRWVAVVF PLSYRAKMRL RDAAFMVAYT WLHALTFPAT ALALSWLGFH
160 170 180 190 200
QLYASCTLCS RRPDERLRFA VFTSAFHALS FLLSFIVLCF TYLKVLKVAR
210 220 230 240 250
FHCKRIDVIT MQTLVLLVDI HPSVRERCLE EQKRRRQRAT KKISTFIGTF
260 270 280 290 300
LVCFAPYVIT RLVELFSTAP IDSHWGVLSK CLAYSKAASD PFVYSLLRHQ
310 320 330
YRRSCKELLN RIFNRRSIHS VGLTGDSHSQ NILPVSE
Length:337
Mass (Da):37,805
Last modified:May 1, 2000 - v1
Checksum:iCD7E2381F085F2DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208288 mRNA Translation: AAF21012.1
RefSeqiNP_620196.1, NM_138841.1
UniGeneiRn.48779

Genome annotation databases

EnsembliENSRNOT00000075540; ENSRNOP00000067319; ENSRNOG00000047057
GeneIDi192153
KEGGirno:192153

Similar proteinsi

Entry informationi

Entry nameiGPR26_RAT
AccessioniPrimary (citable) accession number: Q9QXI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health