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Protein

G-protein coupled receptor 26

Gene

Gpr26

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 26
Gene namesi
Name:Gpr26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619843. Gpr26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010ExtracellularSequence analysis
Transmembranei11 – 3121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini32 – 4716CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini69 – 8113ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 12321CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini145 – 16824ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini190 – 24556CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 27610ExtracellularSequence analysis
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 33740CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337G-protein coupled receptor 26PRO_0000069547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi79 ↔ 156PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9QXI3.

Expressioni

Tissue specificityi

Detected in extracts of several brain regions including striatum, pons, cerebellum and cortex. Not detected in numerous peripheral tissue extracts, except in testis. In the brain, detected in cortical structures including the anterior cingulate area, posterior cingulate and the frontoparietal, somatosensory and piriform cortices. Prominent also in the olfactory tubercle, the islands of Calleja, ventromedial and posterior nuclei of the hypothalamus, the medial septal nucleus, nucleus of the diagonal band and the ventral tegmental area. Localized also to hippocampal structures, with signals strongest over the CA2 and CA3 regions of Ammon's horn and less so over the dentate gyrus. Expressed in the caudate putamen only in its most caudal portion, with a decreasing gradient of signal from the dorsal to ventral aspect. Strong expression associated with a single pontine structure, the inferior olivary nucleus.

Gene expression databases

BgeeiENSRNOG00000047057.
GenevisibleiQ9QXI3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067319.

Structurei

3D structure databases

ProteinModelPortaliQ9QXI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOVERGENiHBG051804.
InParanoidiQ9QXI3.
KOiK08411.
OMAiTQFVIFT.
OrthoDBiEOG091G0BFV.
PhylomeDBiQ9QXI3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSWDAGLAG LLVGTIGVSL LSNGLVLLCL LHSADIRRQA PALFTLNLTC
60 70 80 90 100
GNLLCTVVNM PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL
110 120 130 140 150
SIDRWVAVVF PLSYRAKMRL RDAAFMVAYT WLHALTFPAT ALALSWLGFH
160 170 180 190 200
QLYASCTLCS RRPDERLRFA VFTSAFHALS FLLSFIVLCF TYLKVLKVAR
210 220 230 240 250
FHCKRIDVIT MQTLVLLVDI HPSVRERCLE EQKRRRQRAT KKISTFIGTF
260 270 280 290 300
LVCFAPYVIT RLVELFSTAP IDSHWGVLSK CLAYSKAASD PFVYSLLRHQ
310 320 330
YRRSCKELLN RIFNRRSIHS VGLTGDSHSQ NILPVSE
Length:337
Mass (Da):37,805
Last modified:May 1, 2000 - v1
Checksum:iCD7E2381F085F2DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208288 mRNA. Translation: AAF21012.1.
RefSeqiNP_620196.1. NM_138841.1.
UniGeneiRn.48779.

Genome annotation databases

EnsembliENSRNOT00000075540; ENSRNOP00000067319; ENSRNOG00000047057.
GeneIDi192153.
KEGGirno:192153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208288 mRNA. Translation: AAF21012.1.
RefSeqiNP_620196.1. NM_138841.1.
UniGeneiRn.48779.

3D structure databases

ProteinModelPortaliQ9QXI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067319.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9QXI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075540; ENSRNOP00000067319; ENSRNOG00000047057.
GeneIDi192153.
KEGGirno:192153.

Organism-specific databases

CTDi2849.
RGDi619843. Gpr26.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOVERGENiHBG051804.
InParanoidiQ9QXI3.
KOiK08411.
OMAiTQFVIFT.
OrthoDBiEOG091G0BFV.
PhylomeDBiQ9QXI3.

Miscellaneous databases

PROiQ9QXI3.

Gene expression databases

BgeeiENSRNOG00000047057.
GenevisibleiQ9QXI3. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR26_RAT
AccessioniPrimary (citable) accession number: Q9QXI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.