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Q9QXH4 (ITAX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-X
Alternative name(s):
CD11 antigen-like family member C
Leukocyte adhesion glycoprotein p150,95 alpha chain
Leukocyte adhesion receptor p150,95
CD_antigen=CD11c
Gene names
Name:Itgax
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 11691150Integrin alpha-X
PRO_0000016295

Regions

Topological domain20 – 11161097Extracellular Potential
Transmembrane1117 – 113721Helical; Potential
Topological domain1138 – 116932Cytoplasmic Potential
Repeat23 – 7856FG-GAP 1
Repeat79 – 13860FG-GAP 2
Domain152 – 330179VWFA
Repeat341 – 39252FG-GAP 3
Repeat393 – 44654FG-GAP 4
Repeat447 – 50559FG-GAP 5
Repeat508 – 56659FG-GAP 6
Repeat571 – 63161FG-GAP 7
Calcium binding467 – 4759 By similarity
Calcium binding531 – 5399 By similarity
Calcium binding594 – 6029 By similarity
Motif1140 – 11445GFFKR motif

Sites

Metal binding1581Magnesium By similarity
Metal binding1601Magnesium By similarity
Metal binding1621Magnesium By similarity
Metal binding2601Magnesium By similarity
Metal binding4671Calcium 2 By similarity
Metal binding4691Calcium 2 By similarity
Metal binding4711Calcium 2 By similarity
Metal binding4731Calcium 2; via carbonyl oxygen By similarity
Metal binding5331Calcium 3 By similarity
Metal binding5351Calcium 3 By similarity
Metal binding5371Calcium 3; via carbonyl oxygen By similarity
Metal binding5941Calcium 1 By similarity
Metal binding5961Calcium 1 By similarity
Metal binding5981Calcium 1 By similarity
Metal binding6001Calcium 1; via carbonyl oxygen By similarity
Metal binding6021Calcium 1 By similarity

Amino acid modifications

Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential
Glycosylation3931N-linked (GlcNAc...) Potential
Glycosylation7341N-linked (GlcNAc...) Potential
Glycosylation9491N-linked (GlcNAc...) Potential
Glycosylation10591N-linked (GlcNAc...) Potential
Glycosylation10841N-linked (GlcNAc...) Potential
Disulfide bond69 ↔ 76 By similarity
Disulfide bond108 ↔ 126 By similarity
Disulfide bond116 ↔ 146 By similarity
Disulfide bond496 ↔ 507 By similarity
Disulfide bond640 ↔ 721 By similarity
Disulfide bond656 ↔ 711 By similarity
Disulfide bond770 ↔ 776 By similarity
Disulfide bond858 ↔ 873 By similarity
Disulfide bond1007 ↔ 1031 By similarity
Disulfide bond1036 ↔ 1041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QXH4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C616412033C219A6

FASTA1,169129,151
        10         20         30         40         50         60 
MSCTWIAFLL LLGFVSCLGF NLDAEKLTHF HMDGAEFGHS VLQYDSSWVV VGAPKEIKAT 

        70         80         90        100        110        120 
NQIGGLYKCG YHTGNCEPIS LQVPPEAVNI SLGLSLAAAT NPSWLLACGP TVHHTCRENI 

       130        140        150        160        170        180 
YLTGLCFLLS SSFKQSQNFP TAQQECPKQD QDIVFLIDGS GSISSTDFEK MLDFVKAVMS 

       190        200        210        220        230        240 
QLQRPSTRFS LMQFSDYFRV HFTFNNFIST SSPLSLLGSV RQLRGYTYTA SAIKHVITEL 

       250        260        270        280        290        300 
FTTQSGARQD ATKVLIVITD GRKQGDNLSY DSVIPMAEAA SIIRYAIGVG KAFYNEHSKQ 

       310        320        330        340        350        360 
ELKAIASMPS HEYVFSVENF DALKDIENQL KEKIFAIEGT ETPSSSTFEL EMSQEGFSAV 

       370        380        390        400        410        420 
FTPDGPVLGA VGSFSWSGGA FLYPSNMRPT FINMSQENED MRDAYLGYST ALAFWKGVHS 

       430        440        450        460        470        480 
LILGAPRHQH TGKVVIFTQE SRHWRPKSEV RGTQIGSYFG ASLCSVDMDR DGSTDLVLIG 

       490        500        510        520        530        540 
VPHYYEHTRG GQVSVCPMPG VGSRWHCGTT LHGEQGHPWG RFGAALTVLG DVNGDSLADV 

       550        560        570        580        590        600 
AIGAPGEEEN RGAVYIFHGA SRQDIAPSPS QRISASQIPS RIQYFGQSLS GGQDLTRDGL 

       610        620        630        640        650        660 
VDLAVGSKGR VLLLRTRPIL RVSPTVHFTP AEISRSVFEC QEQVAPEQTL SDATVCLHIH 

       670        680        690        700        710        720 
ESPKTQLGDL RSTVTFDLAL DHGRLSTRAI FKETKTRALT RVKTLGLNKH CESVKLLLPA 

       730        740        750        760        770        780 
CVEDSVTPIT LRLNFSLVGV PISSLQNLQP MLAVDDQTYF TASLPFEKNC GADHICQDDL 

       790        800        810        820        830        840 
SVVFGFPDLK TLVVGSDLEL NVDVTVSNDG EDSYGTTVTL FYPVGLSFRR VAEGQVFLRK 

       850        860        870        880        890        900 
KEDQQWQRRG QHSLHLMCDS TPDRSQGLWS TSCSSRHVIF RGGSQMTFLV TFDVSPKAEL 

       910        920        930        940        950        960 
GDRLLLRARV GSENNVPGTP KTTFQLELPV KYAVYTMISS HDQFTKYLNF STSEKEKTSV 

       970        980        990       1000       1010       1020 
VEHRFQVNNL GQRDVPVSIN FWVPIELKGE AVWTVMVSHP QNPLTQCYRN RLKPTQFDLL 

      1030       1040       1050       1060       1070       1080 
THMQKSPVLD CSIADCLHLR CDIPSLGILD ELYFILKGNL SFGWISQTLQ KKVLLLSEAE 

      1090       1100       1110       1120       1130       1140 
ITFNTSVYSQ LPGQEAFLRA QTKTVLEMYK VHNPVPLIVG SSVGGLLLLA IITAILYKAG 

      1150       1160 
FFKRQYKEML EEANGQFVSD GTPTPQVAQ 

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References

[1]"Isolation of genes selectively expressed by dendritic cells."
Huang X., Gorski K., Tong C., Rattis F.-M., Tseng S.-Y., Pardoll D., Tsuchiya H.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Dendritic cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF211864 mRNA. Translation: AAF23492.1.
RefSeqNP_067309.1. NM_021334.2.
UniGeneMm.22378.

3D structure databases

ProteinModelPortalQ9QXH4.
SMRQ9QXH4. Positions 20-1169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9QXH4. 1 interaction.
MINTMINT-4099013.

Proteomic databases

PaxDbQ9QXH4.
PRIDEQ9QXH4.

Protocols and materials databases

DNASU16411.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789.
GeneID16411.
KEGGmmu:16411.
UCSCuc009jyc.1. mouse.

Organism-specific databases

CTD3687.
MGIMGI:96609. Itgax.

Phylogenomic databases

eggNOGNOG301393.
GeneTreeENSGT00750000117471.
HOVERGENHBG100530.
InParanoidQ9QXH4.
KOK06462.
OMAAVMSQFQ.
OrthoDBEOG7353W1.
PhylomeDBQ9QXH4.
TreeFamTF105391.

Gene expression databases

BgeeQ9QXH4.
CleanExMM_ITGAX.
GenevestigatorQ9QXH4.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289593.
PROQ9QXH4.
SOURCESearch...

Entry information

Entry nameITAX_MOUSE
AccessionPrimary (citable) accession number: Q9QXH4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot