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Q9QXH4

- ITAX_MOUSE

UniProt

Q9QXH4 - ITAX_MOUSE

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Protein

Integrin alpha-X

Gene

Itgax

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi158 – 1581MagnesiumBy similarity
Metal bindingi160 – 1601MagnesiumBy similarity
Metal bindingi162 – 1621MagnesiumBy similarity
Metal bindingi260 – 2601MagnesiumBy similarity
Metal bindingi467 – 4671Calcium 2By similarity
Metal bindingi469 – 4691Calcium 2By similarity
Metal bindingi471 – 4711Calcium 2By similarity
Metal bindingi473 – 4731Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi533 – 5331Calcium 3By similarity
Metal bindingi535 – 5351Calcium 3By similarity
Metal bindingi537 – 5371Calcium 3; via carbonyl oxygenBy similarity
Metal bindingi594 – 5941Calcium 1By similarity
Metal bindingi596 – 5961Calcium 1By similarity
Metal bindingi598 – 5981Calcium 1By similarity
Metal bindingi600 – 6001Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi602 – 6021Calcium 1By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi467 – 4759By similarity
Calcium bindingi531 – 5399By similarity
Calcium bindingi594 – 6029By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. defense response to virus Source: MGI
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-X
Alternative name(s):
CD11 antigen-like family member C
Leukocyte adhesion glycoprotein p150,95 alpha chain
Leukocyte adhesion receptor p150,95
CD_antigen: CD11c
Gene namesi
Name:Itgax
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96609. Itgax.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 11161097ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1117 – 113721HelicalSequence AnalysisAdd
BLAST
Topological domaini1138 – 116932CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 11691150Integrin alpha-XPRO_0000016295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 76By similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 126By similarity
Disulfide bondi116 ↔ 146By similarity
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi496 ↔ 507By similarity
Disulfide bondi640 ↔ 721By similarity
Disulfide bondi656 ↔ 711By similarity
Glycosylationi734 – 7341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi770 ↔ 776By similarity
Disulfide bondi858 ↔ 873By similarity
Glycosylationi949 – 9491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1007 ↔ 1031By similarity
Disulfide bondi1036 ↔ 1041By similarity
Glycosylationi1059 – 10591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1084 – 10841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QXH4.
PRIDEiQ9QXH4.

Expressioni

Gene expression databases

BgeeiQ9QXH4.
CleanExiMM_ITGAX.
GenevestigatoriQ9QXH4.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9QXH4. 1 interaction.
MINTiMINT-4099013.

Structurei

3D structure databases

ProteinModelPortaliQ9QXH4.
SMRiQ9QXH4. Positions 20-147, 149-337, 348-1110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 7856FG-GAP 1Add
BLAST
Repeati79 – 13860FG-GAP 2Add
BLAST
Domaini152 – 330179VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati341 – 39252FG-GAP 3Add
BLAST
Repeati393 – 44654FG-GAP 4Add
BLAST
Repeati447 – 50559FG-GAP 5Add
BLAST
Repeati508 – 56659FG-GAP 6Add
BLAST
Repeati571 – 63161FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1140 – 11445GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301393.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG100530.
InParanoidiQ9QXH4.
KOiK06462.
OMAiAVMSQFQ.
OrthoDBiEOG7353W1.
PhylomeDBiQ9QXH4.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCTWIAFLL LLGFVSCLGF NLDAEKLTHF HMDGAEFGHS VLQYDSSWVV
60 70 80 90 100
VGAPKEIKAT NQIGGLYKCG YHTGNCEPIS LQVPPEAVNI SLGLSLAAAT
110 120 130 140 150
NPSWLLACGP TVHHTCRENI YLTGLCFLLS SSFKQSQNFP TAQQECPKQD
160 170 180 190 200
QDIVFLIDGS GSISSTDFEK MLDFVKAVMS QLQRPSTRFS LMQFSDYFRV
210 220 230 240 250
HFTFNNFIST SSPLSLLGSV RQLRGYTYTA SAIKHVITEL FTTQSGARQD
260 270 280 290 300
ATKVLIVITD GRKQGDNLSY DSVIPMAEAA SIIRYAIGVG KAFYNEHSKQ
310 320 330 340 350
ELKAIASMPS HEYVFSVENF DALKDIENQL KEKIFAIEGT ETPSSSTFEL
360 370 380 390 400
EMSQEGFSAV FTPDGPVLGA VGSFSWSGGA FLYPSNMRPT FINMSQENED
410 420 430 440 450
MRDAYLGYST ALAFWKGVHS LILGAPRHQH TGKVVIFTQE SRHWRPKSEV
460 470 480 490 500
RGTQIGSYFG ASLCSVDMDR DGSTDLVLIG VPHYYEHTRG GQVSVCPMPG
510 520 530 540 550
VGSRWHCGTT LHGEQGHPWG RFGAALTVLG DVNGDSLADV AIGAPGEEEN
560 570 580 590 600
RGAVYIFHGA SRQDIAPSPS QRISASQIPS RIQYFGQSLS GGQDLTRDGL
610 620 630 640 650
VDLAVGSKGR VLLLRTRPIL RVSPTVHFTP AEISRSVFEC QEQVAPEQTL
660 670 680 690 700
SDATVCLHIH ESPKTQLGDL RSTVTFDLAL DHGRLSTRAI FKETKTRALT
710 720 730 740 750
RVKTLGLNKH CESVKLLLPA CVEDSVTPIT LRLNFSLVGV PISSLQNLQP
760 770 780 790 800
MLAVDDQTYF TASLPFEKNC GADHICQDDL SVVFGFPDLK TLVVGSDLEL
810 820 830 840 850
NVDVTVSNDG EDSYGTTVTL FYPVGLSFRR VAEGQVFLRK KEDQQWQRRG
860 870 880 890 900
QHSLHLMCDS TPDRSQGLWS TSCSSRHVIF RGGSQMTFLV TFDVSPKAEL
910 920 930 940 950
GDRLLLRARV GSENNVPGTP KTTFQLELPV KYAVYTMISS HDQFTKYLNF
960 970 980 990 1000
STSEKEKTSV VEHRFQVNNL GQRDVPVSIN FWVPIELKGE AVWTVMVSHP
1010 1020 1030 1040 1050
QNPLTQCYRN RLKPTQFDLL THMQKSPVLD CSIADCLHLR CDIPSLGILD
1060 1070 1080 1090 1100
ELYFILKGNL SFGWISQTLQ KKVLLLSEAE ITFNTSVYSQ LPGQEAFLRA
1110 1120 1130 1140 1150
QTKTVLEMYK VHNPVPLIVG SSVGGLLLLA IITAILYKAG FFKRQYKEML
1160
EEANGQFVSD GTPTPQVAQ
Length:1,169
Mass (Da):129,151
Last modified:May 1, 2000 - v1
Checksum:iC616412033C219A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211864 mRNA. Translation: AAF23492.1.
CCDSiCCDS40150.1.
RefSeqiNP_067309.1. NM_021334.2.
UniGeneiMm.22378.

Genome annotation databases

EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789.
GeneIDi16411.
KEGGimmu:16411.
UCSCiuc009jyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211864 mRNA. Translation: AAF23492.1 .
CCDSi CCDS40150.1.
RefSeqi NP_067309.1. NM_021334.2.
UniGenei Mm.22378.

3D structure databases

ProteinModelPortali Q9QXH4.
SMRi Q9QXH4. Positions 20-147, 149-337, 348-1110.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QXH4. 1 interaction.
MINTi MINT-4099013.

Proteomic databases

PaxDbi Q9QXH4.
PRIDEi Q9QXH4.

Protocols and materials databases

DNASUi 16411.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033053 ; ENSMUSP00000033053 ; ENSMUSG00000030789 .
GeneIDi 16411.
KEGGi mmu:16411.
UCSCi uc009jyc.1. mouse.

Organism-specific databases

CTDi 3687.
MGIi MGI:96609. Itgax.

Phylogenomic databases

eggNOGi NOG301393.
GeneTreei ENSGT00760000118782.
HOVERGENi HBG100530.
InParanoidi Q9QXH4.
KOi K06462.
OMAi AVMSQFQ.
OrthoDBi EOG7353W1.
PhylomeDBi Q9QXH4.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi 289593.
PROi Q9QXH4.
SOURCEi Search...

Gene expression databases

Bgeei Q9QXH4.
CleanExi MM_ITGAX.
Genevestigatori Q9QXH4.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of genes selectively expressed by dendritic cells."
    Huang X., Gorski K., Tong C., Rattis F.-M., Tseng S.-Y., Pardoll D., Tsuchiya H.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Dendritic cell.

Entry informationi

Entry nameiITAX_MOUSE
AccessioniPrimary (citable) accession number: Q9QXH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3