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Q9QXH4

- ITAX_MOUSE

UniProt

Q9QXH4 - ITAX_MOUSE

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Protein
Integrin alpha-X
Gene
Itgax
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi158 – 1581Magnesium By similarity
Metal bindingi160 – 1601Magnesium By similarity
Metal bindingi162 – 1621Magnesium By similarity
Metal bindingi260 – 2601Magnesium By similarity
Metal bindingi467 – 4671Calcium 2 By similarity
Metal bindingi469 – 4691Calcium 2 By similarity
Metal bindingi471 – 4711Calcium 2 By similarity
Metal bindingi473 – 4731Calcium 2; via carbonyl oxygen By similarity
Metal bindingi533 – 5331Calcium 3 By similarity
Metal bindingi535 – 5351Calcium 3 By similarity
Metal bindingi537 – 5371Calcium 3; via carbonyl oxygen By similarity
Metal bindingi594 – 5941Calcium 1 By similarity
Metal bindingi596 – 5961Calcium 1 By similarity
Metal bindingi598 – 5981Calcium 1 By similarity
Metal bindingi600 – 6001Calcium 1; via carbonyl oxygen By similarity
Metal bindingi602 – 6021Calcium 1 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi467 – 4759 By similarity
Calcium bindingi531 – 5399 By similarity
Calcium bindingi594 – 6029 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. defense response to virus Source: MGI
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-X
Alternative name(s):
CD11 antigen-like family member C
Leukocyte adhesion glycoprotein p150,95 alpha chain
Leukocyte adhesion receptor p150,95
CD_antigen: CD11c
Gene namesi
Name:Itgax
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96609. Itgax.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 11161097Extracellular Reviewed prediction
Add
BLAST
Transmembranei1117 – 113721Helical; Reviewed prediction
Add
BLAST
Topological domaini1138 – 116932Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 11691150Integrin alpha-X
PRO_0000016295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 76 By similarity
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 126 By similarity
Disulfide bondi116 ↔ 146 By similarity
Glycosylationi267 – 2671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi496 ↔ 507 By similarity
Disulfide bondi640 ↔ 721 By similarity
Disulfide bondi656 ↔ 711 By similarity
Glycosylationi734 – 7341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi770 ↔ 776 By similarity
Disulfide bondi858 ↔ 873 By similarity
Glycosylationi949 – 9491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1007 ↔ 1031 By similarity
Disulfide bondi1036 ↔ 1041 By similarity
Glycosylationi1059 – 10591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1084 – 10841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QXH4.
PRIDEiQ9QXH4.

Expressioni

Gene expression databases

BgeeiQ9QXH4.
CleanExiMM_ITGAX.
GenevestigatoriQ9QXH4.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 By similarity.

Protein-protein interaction databases

IntActiQ9QXH4. 1 interaction.
MINTiMINT-4099013.

Structurei

3D structure databases

ProteinModelPortaliQ9QXH4.
SMRiQ9QXH4. Positions 20-147, 149-337, 348-1152.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 7856FG-GAP 1
Add
BLAST
Repeati79 – 13860FG-GAP 2
Add
BLAST
Domaini152 – 330179VWFA
Add
BLAST
Repeati341 – 39252FG-GAP 3
Add
BLAST
Repeati393 – 44654FG-GAP 4
Add
BLAST
Repeati447 – 50559FG-GAP 5
Add
BLAST
Repeati508 – 56659FG-GAP 6
Add
BLAST
Repeati571 – 63161FG-GAP 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1140 – 11445GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301393.
GeneTreeiENSGT00750000117471.
HOVERGENiHBG100530.
InParanoidiQ9QXH4.
KOiK06462.
OMAiAVMSQFQ.
OrthoDBiEOG7353W1.
PhylomeDBiQ9QXH4.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXH4-1 [UniParc]FASTAAdd to Basket

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MSCTWIAFLL LLGFVSCLGF NLDAEKLTHF HMDGAEFGHS VLQYDSSWVV     50
VGAPKEIKAT NQIGGLYKCG YHTGNCEPIS LQVPPEAVNI SLGLSLAAAT 100
NPSWLLACGP TVHHTCRENI YLTGLCFLLS SSFKQSQNFP TAQQECPKQD 150
QDIVFLIDGS GSISSTDFEK MLDFVKAVMS QLQRPSTRFS LMQFSDYFRV 200
HFTFNNFIST SSPLSLLGSV RQLRGYTYTA SAIKHVITEL FTTQSGARQD 250
ATKVLIVITD GRKQGDNLSY DSVIPMAEAA SIIRYAIGVG KAFYNEHSKQ 300
ELKAIASMPS HEYVFSVENF DALKDIENQL KEKIFAIEGT ETPSSSTFEL 350
EMSQEGFSAV FTPDGPVLGA VGSFSWSGGA FLYPSNMRPT FINMSQENED 400
MRDAYLGYST ALAFWKGVHS LILGAPRHQH TGKVVIFTQE SRHWRPKSEV 450
RGTQIGSYFG ASLCSVDMDR DGSTDLVLIG VPHYYEHTRG GQVSVCPMPG 500
VGSRWHCGTT LHGEQGHPWG RFGAALTVLG DVNGDSLADV AIGAPGEEEN 550
RGAVYIFHGA SRQDIAPSPS QRISASQIPS RIQYFGQSLS GGQDLTRDGL 600
VDLAVGSKGR VLLLRTRPIL RVSPTVHFTP AEISRSVFEC QEQVAPEQTL 650
SDATVCLHIH ESPKTQLGDL RSTVTFDLAL DHGRLSTRAI FKETKTRALT 700
RVKTLGLNKH CESVKLLLPA CVEDSVTPIT LRLNFSLVGV PISSLQNLQP 750
MLAVDDQTYF TASLPFEKNC GADHICQDDL SVVFGFPDLK TLVVGSDLEL 800
NVDVTVSNDG EDSYGTTVTL FYPVGLSFRR VAEGQVFLRK KEDQQWQRRG 850
QHSLHLMCDS TPDRSQGLWS TSCSSRHVIF RGGSQMTFLV TFDVSPKAEL 900
GDRLLLRARV GSENNVPGTP KTTFQLELPV KYAVYTMISS HDQFTKYLNF 950
STSEKEKTSV VEHRFQVNNL GQRDVPVSIN FWVPIELKGE AVWTVMVSHP 1000
QNPLTQCYRN RLKPTQFDLL THMQKSPVLD CSIADCLHLR CDIPSLGILD 1050
ELYFILKGNL SFGWISQTLQ KKVLLLSEAE ITFNTSVYSQ LPGQEAFLRA 1100
QTKTVLEMYK VHNPVPLIVG SSVGGLLLLA IITAILYKAG FFKRQYKEML 1150
EEANGQFVSD GTPTPQVAQ 1169
Length:1,169
Mass (Da):129,151
Last modified:May 1, 2000 - v1
Checksum:iC616412033C219A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF211864 mRNA. Translation: AAF23492.1.
CCDSiCCDS40150.1.
RefSeqiNP_067309.1. NM_021334.2.
UniGeneiMm.22378.

Genome annotation databases

EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789.
GeneIDi16411.
KEGGimmu:16411.
UCSCiuc009jyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF211864 mRNA. Translation: AAF23492.1 .
CCDSi CCDS40150.1.
RefSeqi NP_067309.1. NM_021334.2.
UniGenei Mm.22378.

3D structure databases

ProteinModelPortali Q9QXH4.
SMRi Q9QXH4. Positions 20-147, 149-337, 348-1152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QXH4. 1 interaction.
MINTi MINT-4099013.

Proteomic databases

PaxDbi Q9QXH4.
PRIDEi Q9QXH4.

Protocols and materials databases

DNASUi 16411.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033053 ; ENSMUSP00000033053 ; ENSMUSG00000030789 .
GeneIDi 16411.
KEGGi mmu:16411.
UCSCi uc009jyc.1. mouse.

Organism-specific databases

CTDi 3687.
MGIi MGI:96609. Itgax.

Phylogenomic databases

eggNOGi NOG301393.
GeneTreei ENSGT00750000117471.
HOVERGENi HBG100530.
InParanoidi Q9QXH4.
KOi K06462.
OMAi AVMSQFQ.
OrthoDBi EOG7353W1.
PhylomeDBi Q9QXH4.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi 289593.
PROi Q9QXH4.
SOURCEi Search...

Gene expression databases

Bgeei Q9QXH4.
CleanExi MM_ITGAX.
Genevestigatori Q9QXH4.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of genes selectively expressed by dendritic cells."
    Huang X., Gorski K., Tong C., Rattis F.-M., Tseng S.-Y., Pardoll D., Tsuchiya H.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Dendritic cell.

Entry informationi

Entry nameiITAX_MOUSE
AccessioniPrimary (citable) accession number: Q9QXH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi