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Q9QXH4

- ITAX_MOUSE

UniProt

Q9QXH4 - ITAX_MOUSE

Protein

Integrin alpha-X

Gene

Itgax

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi158 – 1581MagnesiumBy similarity
    Metal bindingi160 – 1601MagnesiumBy similarity
    Metal bindingi162 – 1621MagnesiumBy similarity
    Metal bindingi260 – 2601MagnesiumBy similarity
    Metal bindingi467 – 4671Calcium 2By similarity
    Metal bindingi469 – 4691Calcium 2By similarity
    Metal bindingi471 – 4711Calcium 2By similarity
    Metal bindingi473 – 4731Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi533 – 5331Calcium 3By similarity
    Metal bindingi535 – 5351Calcium 3By similarity
    Metal bindingi537 – 5371Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi594 – 5941Calcium 1By similarity
    Metal bindingi596 – 5961Calcium 1By similarity
    Metal bindingi598 – 5981Calcium 1By similarity
    Metal bindingi600 – 6001Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi602 – 6021Calcium 1By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi467 – 4759By similarity
    Calcium bindingi531 – 5399By similarity
    Calcium bindingi594 – 6029By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. defense response to virus Source: MGI
    3. integrin-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_216309. Integrin cell surface interactions.
    REACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-X
    Alternative name(s):
    CD11 antigen-like family member C
    Leukocyte adhesion glycoprotein p150,95 alpha chain
    Leukocyte adhesion receptor p150,95
    CD_antigen: CD11c
    Gene namesi
    Name:Itgax
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:96609. Itgax.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integrin complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 11691150Integrin alpha-XPRO_0000016295Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi69 ↔ 76By similarity
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 126By similarity
    Disulfide bondi116 ↔ 146By similarity
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi496 ↔ 507By similarity
    Disulfide bondi640 ↔ 721By similarity
    Disulfide bondi656 ↔ 711By similarity
    Glycosylationi734 – 7341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi770 ↔ 776By similarity
    Disulfide bondi858 ↔ 873By similarity
    Glycosylationi949 – 9491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1007 ↔ 1031By similarity
    Disulfide bondi1036 ↔ 1041By similarity
    Glycosylationi1059 – 10591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1084 – 10841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9QXH4.
    PRIDEiQ9QXH4.

    Expressioni

    Gene expression databases

    BgeeiQ9QXH4.
    CleanExiMM_ITGAX.
    GenevestigatoriQ9QXH4.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9QXH4. 1 interaction.
    MINTiMINT-4099013.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QXH4.
    SMRiQ9QXH4. Positions 20-147, 149-337, 348-1152.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 11161097ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1138 – 116932CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1117 – 113721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati23 – 7856FG-GAP 1Add
    BLAST
    Repeati79 – 13860FG-GAP 2Add
    BLAST
    Domaini152 – 330179VWFAPROSITE-ProRule annotationAdd
    BLAST
    Repeati341 – 39252FG-GAP 3Add
    BLAST
    Repeati393 – 44654FG-GAP 4Add
    BLAST
    Repeati447 – 50559FG-GAP 5Add
    BLAST
    Repeati508 – 56659FG-GAP 6Add
    BLAST
    Repeati571 – 63161FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1140 – 11445GFFKR motif

    Domaini

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301393.
    GeneTreeiENSGT00750000117471.
    HOVERGENiHBG100530.
    InParanoidiQ9QXH4.
    KOiK06462.
    OMAiAVMSQFQ.
    OrthoDBiEOG7353W1.
    PhylomeDBiQ9QXH4.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QXH4-1 [UniParc]FASTAAdd to Basket

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    MSCTWIAFLL LLGFVSCLGF NLDAEKLTHF HMDGAEFGHS VLQYDSSWVV     50
    VGAPKEIKAT NQIGGLYKCG YHTGNCEPIS LQVPPEAVNI SLGLSLAAAT 100
    NPSWLLACGP TVHHTCRENI YLTGLCFLLS SSFKQSQNFP TAQQECPKQD 150
    QDIVFLIDGS GSISSTDFEK MLDFVKAVMS QLQRPSTRFS LMQFSDYFRV 200
    HFTFNNFIST SSPLSLLGSV RQLRGYTYTA SAIKHVITEL FTTQSGARQD 250
    ATKVLIVITD GRKQGDNLSY DSVIPMAEAA SIIRYAIGVG KAFYNEHSKQ 300
    ELKAIASMPS HEYVFSVENF DALKDIENQL KEKIFAIEGT ETPSSSTFEL 350
    EMSQEGFSAV FTPDGPVLGA VGSFSWSGGA FLYPSNMRPT FINMSQENED 400
    MRDAYLGYST ALAFWKGVHS LILGAPRHQH TGKVVIFTQE SRHWRPKSEV 450
    RGTQIGSYFG ASLCSVDMDR DGSTDLVLIG VPHYYEHTRG GQVSVCPMPG 500
    VGSRWHCGTT LHGEQGHPWG RFGAALTVLG DVNGDSLADV AIGAPGEEEN 550
    RGAVYIFHGA SRQDIAPSPS QRISASQIPS RIQYFGQSLS GGQDLTRDGL 600
    VDLAVGSKGR VLLLRTRPIL RVSPTVHFTP AEISRSVFEC QEQVAPEQTL 650
    SDATVCLHIH ESPKTQLGDL RSTVTFDLAL DHGRLSTRAI FKETKTRALT 700
    RVKTLGLNKH CESVKLLLPA CVEDSVTPIT LRLNFSLVGV PISSLQNLQP 750
    MLAVDDQTYF TASLPFEKNC GADHICQDDL SVVFGFPDLK TLVVGSDLEL 800
    NVDVTVSNDG EDSYGTTVTL FYPVGLSFRR VAEGQVFLRK KEDQQWQRRG 850
    QHSLHLMCDS TPDRSQGLWS TSCSSRHVIF RGGSQMTFLV TFDVSPKAEL 900
    GDRLLLRARV GSENNVPGTP KTTFQLELPV KYAVYTMISS HDQFTKYLNF 950
    STSEKEKTSV VEHRFQVNNL GQRDVPVSIN FWVPIELKGE AVWTVMVSHP 1000
    QNPLTQCYRN RLKPTQFDLL THMQKSPVLD CSIADCLHLR CDIPSLGILD 1050
    ELYFILKGNL SFGWISQTLQ KKVLLLSEAE ITFNTSVYSQ LPGQEAFLRA 1100
    QTKTVLEMYK VHNPVPLIVG SSVGGLLLLA IITAILYKAG FFKRQYKEML 1150
    EEANGQFVSD GTPTPQVAQ 1169
    Length:1,169
    Mass (Da):129,151
    Last modified:May 1, 2000 - v1
    Checksum:iC616412033C219A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF211864 mRNA. Translation: AAF23492.1.
    CCDSiCCDS40150.1.
    RefSeqiNP_067309.1. NM_021334.2.
    UniGeneiMm.22378.

    Genome annotation databases

    EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789.
    GeneIDi16411.
    KEGGimmu:16411.
    UCSCiuc009jyc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF211864 mRNA. Translation: AAF23492.1 .
    CCDSi CCDS40150.1.
    RefSeqi NP_067309.1. NM_021334.2.
    UniGenei Mm.22378.

    3D structure databases

    ProteinModelPortali Q9QXH4.
    SMRi Q9QXH4. Positions 20-147, 149-337, 348-1152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QXH4. 1 interaction.
    MINTi MINT-4099013.

    Proteomic databases

    PaxDbi Q9QXH4.
    PRIDEi Q9QXH4.

    Protocols and materials databases

    DNASUi 16411.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033053 ; ENSMUSP00000033053 ; ENSMUSG00000030789 .
    GeneIDi 16411.
    KEGGi mmu:16411.
    UCSCi uc009jyc.1. mouse.

    Organism-specific databases

    CTDi 3687.
    MGIi MGI:96609. Itgax.

    Phylogenomic databases

    eggNOGi NOG301393.
    GeneTreei ENSGT00750000117471.
    HOVERGENi HBG100530.
    InParanoidi Q9QXH4.
    KOi K06462.
    OMAi AVMSQFQ.
    OrthoDBi EOG7353W1.
    PhylomeDBi Q9QXH4.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_216309. Integrin cell surface interactions.
    REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    NextBioi 289593.
    PROi Q9QXH4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QXH4.
    CleanExi MM_ITGAX.
    Genevestigatori Q9QXH4.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of genes selectively expressed by dendritic cells."
      Huang X., Gorski K., Tong C., Rattis F.-M., Tseng S.-Y., Pardoll D., Tsuchiya H.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Dendritic cell.

    Entry informationi

    Entry nameiITAX_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3