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Protein

Integrin alpha-X

Gene

Itgax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi158MagnesiumBy similarity1
Metal bindingi160MagnesiumBy similarity1
Metal bindingi162MagnesiumBy similarity1
Metal bindingi260MagnesiumBy similarity1
Metal bindingi467Calcium 2By similarity1
Metal bindingi469Calcium 2By similarity1
Metal bindingi471Calcium 2By similarity1
Metal bindingi473Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi533Calcium 3By similarity1
Metal bindingi535Calcium 3By similarity1
Metal bindingi537Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi594Calcium 1By similarity1
Metal bindingi596Calcium 1By similarity1
Metal bindingi598Calcium 1By similarity1
Metal bindingi600Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi602Calcium 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi467 – 475By similarity9
Calcium bindingi531 – 539By similarity9
Calcium bindingi594 – 602By similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-X
Alternative name(s):
CD11 antigen-like family member C
Leukocyte adhesion glycoprotein p150,95 alpha chain
Leukocyte adhesion receptor p150,95
CD_antigen: CD11c
Gene namesi
Name:Itgax
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96609. Itgax.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1116ExtracellularSequence analysisAdd BLAST1097
Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Topological domaini1138 – 1169CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001629520 – 1169Integrin alpha-XAdd BLAST1150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 76By similarity
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 126By similarity
Disulfide bondi116 ↔ 146By similarity
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi496 ↔ 507By similarity
Disulfide bondi640 ↔ 721By similarity
Disulfide bondi656 ↔ 711By similarity
Glycosylationi734N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi770 ↔ 776By similarity
Disulfide bondi858 ↔ 873By similarity
Glycosylationi949N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1007 ↔ 1031By similarity
Disulfide bondi1036 ↔ 1041By similarity
Glycosylationi1059N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1084N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QXH4.
PaxDbiQ9QXH4.
PRIDEiQ9QXH4.

PTM databases

PhosphoSitePlusiQ9QXH4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030789.
CleanExiMM_ITGAX.
ExpressionAtlasiQ9QXH4. baseline and differential.
GenevisibleiQ9QXH4. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9QXH4. 1 interactor.
MINTiMINT-4099013.
STRINGi10090.ENSMUSP00000033053.

Structurei

3D structure databases

ProteinModelPortaliQ9QXH4.
SMRiQ9QXH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 78FG-GAP 1PROSITE-ProRule annotationAdd BLAST56
Repeati79 – 138FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
Domaini152 – 330VWFAPROSITE-ProRule annotationAdd BLAST179
Repeati341 – 392FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati393 – 444FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati445 – 505FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati508 – 566FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati571 – 631FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1140 – 1144GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG100530.
InParanoidiQ9QXH4.
KOiK06462.
OMAiAVMSQFQ.
OrthoDBiEOG091G01BZ.
PhylomeDBiQ9QXH4.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCTWIAFLL LLGFVSCLGF NLDAEKLTHF HMDGAEFGHS VLQYDSSWVV
60 70 80 90 100
VGAPKEIKAT NQIGGLYKCG YHTGNCEPIS LQVPPEAVNI SLGLSLAAAT
110 120 130 140 150
NPSWLLACGP TVHHTCRENI YLTGLCFLLS SSFKQSQNFP TAQQECPKQD
160 170 180 190 200
QDIVFLIDGS GSISSTDFEK MLDFVKAVMS QLQRPSTRFS LMQFSDYFRV
210 220 230 240 250
HFTFNNFIST SSPLSLLGSV RQLRGYTYTA SAIKHVITEL FTTQSGARQD
260 270 280 290 300
ATKVLIVITD GRKQGDNLSY DSVIPMAEAA SIIRYAIGVG KAFYNEHSKQ
310 320 330 340 350
ELKAIASMPS HEYVFSVENF DALKDIENQL KEKIFAIEGT ETPSSSTFEL
360 370 380 390 400
EMSQEGFSAV FTPDGPVLGA VGSFSWSGGA FLYPSNMRPT FINMSQENED
410 420 430 440 450
MRDAYLGYST ALAFWKGVHS LILGAPRHQH TGKVVIFTQE SRHWRPKSEV
460 470 480 490 500
RGTQIGSYFG ASLCSVDMDR DGSTDLVLIG VPHYYEHTRG GQVSVCPMPG
510 520 530 540 550
VGSRWHCGTT LHGEQGHPWG RFGAALTVLG DVNGDSLADV AIGAPGEEEN
560 570 580 590 600
RGAVYIFHGA SRQDIAPSPS QRISASQIPS RIQYFGQSLS GGQDLTRDGL
610 620 630 640 650
VDLAVGSKGR VLLLRTRPIL RVSPTVHFTP AEISRSVFEC QEQVAPEQTL
660 670 680 690 700
SDATVCLHIH ESPKTQLGDL RSTVTFDLAL DHGRLSTRAI FKETKTRALT
710 720 730 740 750
RVKTLGLNKH CESVKLLLPA CVEDSVTPIT LRLNFSLVGV PISSLQNLQP
760 770 780 790 800
MLAVDDQTYF TASLPFEKNC GADHICQDDL SVVFGFPDLK TLVVGSDLEL
810 820 830 840 850
NVDVTVSNDG EDSYGTTVTL FYPVGLSFRR VAEGQVFLRK KEDQQWQRRG
860 870 880 890 900
QHSLHLMCDS TPDRSQGLWS TSCSSRHVIF RGGSQMTFLV TFDVSPKAEL
910 920 930 940 950
GDRLLLRARV GSENNVPGTP KTTFQLELPV KYAVYTMISS HDQFTKYLNF
960 970 980 990 1000
STSEKEKTSV VEHRFQVNNL GQRDVPVSIN FWVPIELKGE AVWTVMVSHP
1010 1020 1030 1040 1050
QNPLTQCYRN RLKPTQFDLL THMQKSPVLD CSIADCLHLR CDIPSLGILD
1060 1070 1080 1090 1100
ELYFILKGNL SFGWISQTLQ KKVLLLSEAE ITFNTSVYSQ LPGQEAFLRA
1110 1120 1130 1140 1150
QTKTVLEMYK VHNPVPLIVG SSVGGLLLLA IITAILYKAG FFKRQYKEML
1160
EEANGQFVSD GTPTPQVAQ
Length:1,169
Mass (Da):129,151
Last modified:May 1, 2000 - v1
Checksum:iC616412033C219A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211864 mRNA. Translation: AAF23492.1.
CCDSiCCDS40150.1.
RefSeqiNP_067309.1. NM_021334.2.
UniGeneiMm.22378.

Genome annotation databases

EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789.
GeneIDi16411.
KEGGimmu:16411.
UCSCiuc009jyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF211864 mRNA. Translation: AAF23492.1.
CCDSiCCDS40150.1.
RefSeqiNP_067309.1. NM_021334.2.
UniGeneiMm.22378.

3D structure databases

ProteinModelPortaliQ9QXH4.
SMRiQ9QXH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QXH4. 1 interactor.
MINTiMINT-4099013.
STRINGi10090.ENSMUSP00000033053.

PTM databases

PhosphoSitePlusiQ9QXH4.

Proteomic databases

MaxQBiQ9QXH4.
PaxDbiQ9QXH4.
PRIDEiQ9QXH4.

Protocols and materials databases

DNASUi16411.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033053; ENSMUSP00000033053; ENSMUSG00000030789.
GeneIDi16411.
KEGGimmu:16411.
UCSCiuc009jyc.1. mouse.

Organism-specific databases

CTDi3687.
MGIiMGI:96609. Itgax.

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG100530.
InParanoidiQ9QXH4.
KOiK06462.
OMAiAVMSQFQ.
OrthoDBiEOG091G01BZ.
PhylomeDBiQ9QXH4.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9QXH4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030789.
CleanExiMM_ITGAX.
ExpressionAtlasiQ9QXH4. baseline and differential.
GenevisibleiQ9QXH4. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITAX_MOUSE
AccessioniPrimary (citable) accession number: Q9QXH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.