Q9QXG9 (TINF2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TERF1-interacting nuclear factor 2

Alternative name(s):
TRF1-interacting nuclear protein 2

Gene names

Name:	Tinf2
Synonyms:	Tin2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly By similarity.
Subunit structure	Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 By similarity. Interacts with TERF1. Ref.3
Subcellular location	Nucleus By similarity. Chromosome › telomere By similarity.
Domain	The TBM domain mediates interaction with TERF1 By similarity.

Ontologies

Keywords
Cellular component	Chromosome Nucleus Telomere
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of telomere maintenance Inferred from direct assay PubMed 12676566. Source: MGI
Cellular_component	chromosome, telomeric region Inferred from direct assay PubMed 12676566. Source: MGI nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	telomeric DNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	TERF1-interacting nuclear factor 2		PRO_0000072542
Regions
	Motif	243 – 265	23	TBM
	Motif	249 – 255	7	Nuclear localization signal Potential
Experimental info
	Sequence conflict	337	1	S → G in AAF23504. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9QXG9 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 41A07CE00DC2B4D7	FASTA	341	37,887
	10 20 30 40 50 60 MAPPPGVGPA SLRFAAAASW LVVRRRRVEH FPKVVEFLQS LRAAAPGLVC YRHHERLCMS 70 80 90 100 110 120 LKAKVVVELI LQARPWDQVL NALKHHFPAE SRTTKEDRKL LEARENFCLL VKHLSEDPPS 130 140 150 160 170 180 SLQELEQDYG ESFLVAMEKL LFEYLCQLEK ALPPVRAQEL QDALSWSQPG SFITSSVALH 190 200 210 220 230 240 QYGMDMGWTF PESSTSGSGN LIEPMEESPH QQTRPAFHSP LPKAKLGPHQ PASLEHPEHL 250 260 270 280 290 300 AGHRFNLAPL GKRKSRSHWT SAKACHKERP TVMLLPFRNM GLPAQDLSNP KSREEPGAAS 310 320 330 340 AASVGTEPVC TEEAKTPSRP LGKRALEETP PDSPAASRRT V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TIN2 regulates telomere length in mouse cells." Cheong C., Lee H.-W. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary and Uterus.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"GNL3L stabilizes the TRF1 complex and promotes mitotic transition." Zhu Q., Meng L., Hsu J.K., Lin T., Teishima J., Tsai R.Y. J. Cell Biol. 185:827-839(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TERF1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF214013 mRNA. Translation: AAF23504.1. CT025679 Genomic DNA. No translation available.
IPI	IPI00986138.
UniGene	Mm.29346.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000098104.
PTM databases
PhosphoSite	Q9QXG9.
Proteomic databases
PRIDE	Q9QXG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:107246. Tinf2.
Phylogenomic databases
eggNOG	NOG43106.
HOVERGEN	HBG057120.
InParanoid	Q9QXG9.
OrthoDB	EOG4R503S.
Enzyme and pathway databases
Reactome	REACT_118161. Cell Cycle. REACT_120463. Meiosis. REACT_75800. Meiotic Synapsis (mouse).
Gene expression databases
CleanEx	MM_TINF2.
Genevestigator	Q9QXG9.
GermOnline	ENSMUSG00000007589. Mus musculus.
Family and domain databases
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

TINF2_MOUSE

Accession

Primary (citable) accession number: Q9QXG9
Secondary accession number(s): E9Q126

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program