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Q9QXG9

- TINF2_MOUSE

UniProt

Q9QXG9 - TINF2_MOUSE

Protein

TERF1-interacting nuclear factor 2

Gene

Tinf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. telomeric DNA binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of telomere maintenance Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198626. Meiotic synapsis.
    REACT_75800. Meiotic Synapsis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TERF1-interacting nuclear factor 2
    Alternative name(s):
    TRF1-interacting nuclear protein 2
    Gene namesi
    Name:Tinf2
    Synonyms:Tin2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107246. Tinf2.

    Subcellular locationi

    Nucleus By similarity. Chromosometelomere By similarity

    GO - Cellular componenti

    1. chromosome, telomeric region Source: MGI
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Chromosome, Nucleus, Telomere

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 341340TERF1-interacting nuclear factor 2PRO_0000072542Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ9QXG9.

    PTM databases

    PhosphoSiteiQ9QXG9.

    Expressioni

    Gene expression databases

    CleanExiMM_TINF2.
    GenevestigatoriQ9QXG9.

    Interactioni

    Subunit structurei

    Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 By similarity. Interacts with TERF1.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ9QXG9. 1 interaction.
    STRINGi10090.ENSMUSP00000098104.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi243 – 26523TBMAdd
    BLAST
    Motifi249 – 2557Nuclear localization signalSequence Analysis

    Domaini

    The TBM domain mediates interaction with TERF1.By similarity

    Phylogenomic databases

    eggNOGiNOG43106.
    HOVERGENiHBG057120.
    InParanoidiQ9QXG9.

    Family and domain databases

    InterProiIPR029400. TINF2_N.
    [Graphical view]
    PfamiPF14973. TINF2_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QXG9-1 [UniParc]FASTAAdd to Basket

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    MAPPPGVGPA SLRFAAAASW LVVRRRRVEH FPKVVEFLQS LRAAAPGLVC    50
    YRHHERLCMS LKAKVVVELI LQARPWDQVL NALKHHFPAE SRTTKEDRKL 100
    LEARENFCLL VKHLSEDPPS SLQELEQDYG ESFLVAMEKL LFEYLCQLEK 150
    ALPPVRAQEL QDALSWSQPG SFITSSVALH QYGMDMGWTF PESSTSGSGN 200
    LIEPMEESPH QQTRPAFHSP LPKAKLGPHQ PASLEHPEHL AGHRFNLAPL 250
    GKRKSRSHWT SAKACHKERP TVMLLPFRNM GLPAQDLSNP KSREEPGAAS 300
    AASVGTEPVC TEEAKTPSRP LGKRALEETP PDSPAASRRT V 341
    Length:341
    Mass (Da):37,887
    Last modified:July 27, 2011 - v2
    Checksum:i41A07CE00DC2B4D7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti337 – 3371S → G in AAF23504. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF214013 mRNA. Translation: AAF23504.1.
    CT025679 Genomic DNA. No translation available.
    UniGeneiMm.29346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF214013 mRNA. Translation: AAF23504.1 .
    CT025679 Genomic DNA. No translation available.
    UniGenei Mm.29346.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QXG9. 1 interaction.
    STRINGi 10090.ENSMUSP00000098104.

    PTM databases

    PhosphoSitei Q9QXG9.

    Proteomic databases

    PRIDEi Q9QXG9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:107246. Tinf2.

    Phylogenomic databases

    eggNOGi NOG43106.
    HOVERGENi HBG057120.
    InParanoidi Q9QXG9.

    Enzyme and pathway databases

    Reactomei REACT_198626. Meiotic synapsis.
    REACT_75800. Meiotic Synapsis.

    Miscellaneous databases

    PROi Q9QXG9.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TINF2.
    Genevestigatori Q9QXG9.

    Family and domain databases

    InterProi IPR029400. TINF2_N.
    [Graphical view ]
    Pfami PF14973. TINF2_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TIN2 regulates telomere length in mouse cells."
      Cheong C., Lee H.-W.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary and Uterus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "GNL3L stabilizes the TRF1 complex and promotes mitotic transition."
      Zhu Q., Meng L., Hsu J.K., Lin T., Teishima J., Tsai R.Y.
      J. Cell Biol. 185:827-839(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TERF1.

    Entry informationi

    Entry nameiTINF2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QXG9
    Secondary accession number(s): E9Q126
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3