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Protein

TERF1-interacting nuclear factor 2

Gene

Tinf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly (By similarity).By similarity

GO - Molecular functioni

  1. telomeric DNA binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of epithelial cell proliferation Source: MGI
  2. negative regulation of protein ADP-ribosylation Source: MGI
  3. negative regulation of telomere maintenance Source: MGI
  4. negative regulation of telomere maintenance via telomerase Source: MGI
  5. positive regulation of telomere maintenance Source: MGI
  6. protein localization to chromosome Source: MGI
  7. protein localization to chromosome, telomeric region Source: MGI
  8. telomere assembly Source: MGI
  9. telomere maintenance via telomere lengthening Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
TERF1-interacting nuclear factor 2
Alternative name(s):
TRF1-interacting nuclear protein 2
Gene namesi
Name:Tinf2
Synonyms:Tin2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107246. Tinf2.

Subcellular locationi

Nucleus By similarity. Chromosometelomere By similarity

GO - Cellular componenti

  1. chromosome, telomeric region Source: MGI
  2. nuclear telomere cap complex Source: MGI
  3. nucleoplasm Source: Reactome
  4. nucleus Source: MGI
  5. perinucleolar chromocenter Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 341340TERF1-interacting nuclear factor 2PRO_0000072542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QXG9.
PRIDEiQ9QXG9.

PTM databases

PhosphoSiteiQ9QXG9.

Expressioni

Gene expression databases

CleanExiMM_TINF2.
GenevestigatoriQ9QXG9.

Interactioni

Subunit structurei

Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 (By similarity). Interacts with TERF1.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9QXG9. 1 interaction.
STRINGi10090.ENSMUSP00000098104.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi243 – 26523TBMAdd
BLAST
Motifi249 – 2557Nuclear localization signalSequence Analysis

Domaini

The TBM domain mediates interaction with TERF1.By similarity

Phylogenomic databases

eggNOGiNOG43106.
HOVERGENiHBG057120.
InParanoidiQ9QXG9.

Family and domain databases

InterProiIPR029400. TINF2_N.
[Graphical view]
PfamiPF14973. TINF2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXG9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPPPGVGPA SLRFAAAASW LVVRRRRVEH FPKVVEFLQS LRAAAPGLVC
60 70 80 90 100
YRHHERLCMS LKAKVVVELI LQARPWDQVL NALKHHFPAE SRTTKEDRKL
110 120 130 140 150
LEARENFCLL VKHLSEDPPS SLQELEQDYG ESFLVAMEKL LFEYLCQLEK
160 170 180 190 200
ALPPVRAQEL QDALSWSQPG SFITSSVALH QYGMDMGWTF PESSTSGSGN
210 220 230 240 250
LIEPMEESPH QQTRPAFHSP LPKAKLGPHQ PASLEHPEHL AGHRFNLAPL
260 270 280 290 300
GKRKSRSHWT SAKACHKERP TVMLLPFRNM GLPAQDLSNP KSREEPGAAS
310 320 330 340
AASVGTEPVC TEEAKTPSRP LGKRALEETP PDSPAASRRT V
Length:341
Mass (Da):37,887
Last modified:July 27, 2011 - v2
Checksum:i41A07CE00DC2B4D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371S → G in AAF23504. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214013 mRNA. Translation: AAF23504.1.
CT025679 Genomic DNA. No translation available.
UniGeneiMm.29346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214013 mRNA. Translation: AAF23504.1.
CT025679 Genomic DNA. No translation available.
UniGeneiMm.29346.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QXG9. 1 interaction.
STRINGi10090.ENSMUSP00000098104.

PTM databases

PhosphoSiteiQ9QXG9.

Proteomic databases

MaxQBiQ9QXG9.
PRIDEiQ9QXG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107246. Tinf2.

Phylogenomic databases

eggNOGiNOG43106.
HOVERGENiHBG057120.
InParanoidiQ9QXG9.

Enzyme and pathway databases

ReactomeiREACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Miscellaneous databases

PROiQ9QXG9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TINF2.
GenevestigatoriQ9QXG9.

Family and domain databases

InterProiIPR029400. TINF2_N.
[Graphical view]
PfamiPF14973. TINF2_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TIN2 regulates telomere length in mouse cells."
    Cheong C., Lee H.-W.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary and Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "GNL3L stabilizes the TRF1 complex and promotes mitotic transition."
    Zhu Q., Meng L., Hsu J.K., Lin T., Teishima J., Tsai R.Y.
    J. Cell Biol. 185:827-839(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TERF1.

Entry informationi

Entry nameiTINF2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXG9
Secondary accession number(s): E9Q126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.