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Q9QXG9

- TINF2_MOUSE

UniProt

Q9QXG9 - TINF2_MOUSE

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Protein
TERF1-interacting nuclear factor 2
Gene
Tinf2, Tin2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. telomeric DNA binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of telomere maintenance Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
TERF1-interacting nuclear factor 2
Alternative name(s):
TRF1-interacting nuclear protein 2
Gene namesi
Name:Tinf2
Synonyms:Tin2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107246. Tinf2.

Subcellular locationi

Nucleus By similarity. Chromosometelomere By similarity

GO - Cellular componenti

  1. chromosome, telomeric region Source: MGI
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 341340TERF1-interacting nuclear factor 2
PRO_0000072542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9QXG9.

PTM databases

PhosphoSiteiQ9QXG9.

Expressioni

Gene expression databases

CleanExiMM_TINF2.
GenevestigatoriQ9QXG9.

Interactioni

Subunit structurei

Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 By similarity. Interacts with TERF1.1 Publication

Protein-protein interaction databases

IntActiQ9QXG9. 1 interaction.
STRINGi10090.ENSMUSP00000098104.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi243 – 26523TBM
Add
BLAST
Motifi249 – 2557Nuclear localization signal Reviewed prediction

Domaini

The TBM domain mediates interaction with TERF1 By similarity.

Phylogenomic databases

eggNOGiNOG43106.
HOVERGENiHBG057120.
InParanoidiQ9QXG9.

Family and domain databases

InterProiIPR029400. TINF2_N.
[Graphical view]
PfamiPF14973. TINF2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXG9-1 [UniParc]FASTAAdd to Basket

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MAPPPGVGPA SLRFAAAASW LVVRRRRVEH FPKVVEFLQS LRAAAPGLVC    50
YRHHERLCMS LKAKVVVELI LQARPWDQVL NALKHHFPAE SRTTKEDRKL 100
LEARENFCLL VKHLSEDPPS SLQELEQDYG ESFLVAMEKL LFEYLCQLEK 150
ALPPVRAQEL QDALSWSQPG SFITSSVALH QYGMDMGWTF PESSTSGSGN 200
LIEPMEESPH QQTRPAFHSP LPKAKLGPHQ PASLEHPEHL AGHRFNLAPL 250
GKRKSRSHWT SAKACHKERP TVMLLPFRNM GLPAQDLSNP KSREEPGAAS 300
AASVGTEPVC TEEAKTPSRP LGKRALEETP PDSPAASRRT V 341
Length:341
Mass (Da):37,887
Last modified:July 27, 2011 - v2
Checksum:i41A07CE00DC2B4D7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371S → G in AAF23504. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF214013 mRNA. Translation: AAF23504.1.
CT025679 Genomic DNA. No translation available.
UniGeneiMm.29346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF214013 mRNA. Translation: AAF23504.1 .
CT025679 Genomic DNA. No translation available.
UniGenei Mm.29346.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QXG9. 1 interaction.
STRINGi 10090.ENSMUSP00000098104.

PTM databases

PhosphoSitei Q9QXG9.

Proteomic databases

PRIDEi Q9QXG9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:107246. Tinf2.

Phylogenomic databases

eggNOGi NOG43106.
HOVERGENi HBG057120.
InParanoidi Q9QXG9.

Enzyme and pathway databases

Reactomei REACT_198626. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Miscellaneous databases

PROi Q9QXG9.
SOURCEi Search...

Gene expression databases

CleanExi MM_TINF2.
Genevestigatori Q9QXG9.

Family and domain databases

InterProi IPR029400. TINF2_N.
[Graphical view ]
Pfami PF14973. TINF2_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TIN2 regulates telomere length in mouse cells."
    Cheong C., Lee H.-W.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary and Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "GNL3L stabilizes the TRF1 complex and promotes mitotic transition."
    Zhu Q., Meng L., Hsu J.K., Lin T., Teishima J., Tsai R.Y.
    J. Cell Biol. 185:827-839(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TERF1.

Entry informationi

Entry nameiTINF2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXG9
Secondary accession number(s): E9Q126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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