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Protein

Acetyl-coenzyme A synthetase, cytoplasmic

Gene

Acss2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activates acetate so that it can be used for lipid synthesis or for energy generation.

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei363Coenzyme ABy similarity1
Binding sitei552ATPBy similarity1
Binding sitei567ATPBy similarity1
Binding sitei575Coenzyme A; via carbonyl oxygenBy similarity1
Binding sitei636Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi439 – 441ATPBy similarity3
Nucleotide bindingi463 – 468ATPBy similarity6

GO - Molecular functioni

  • acetate-CoA ligase activity Source: MGI
  • AMP binding Source: InterPro
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetase, cytoplasmic (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acetyl-CoA synthetase
Short name:
ACS
Short name:
AceCS
Acyl-CoA synthetase short-chain family member 2
Acyl-activating enzyme
Gene namesi
Name:Acss2
Synonyms:Acas2, Acecs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1890410. Acss2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2924.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084241 – 701Acetyl-coenzyme A synthetase, cytoplasmicAdd BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei418N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9QXG4.
MaxQBiQ9QXG4.
PaxDbiQ9QXG4.
PRIDEiQ9QXG4.

PTM databases

iPTMnetiQ9QXG4.
PhosphoSitePlusiQ9QXG4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027605.
CleanExiMM_ACSS2.
ExpressionAtlasiQ9QXG4. baseline and differential.
GenevisibleiQ9QXG4. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-61210N.
STRINGi10090.ENSMUSP00000029135.

Structurei

3D structure databases

ProteinModelPortaliQ9QXG4.
SMRiQ9QXG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 222Coenzyme A bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.
InParanoidiQ9QXG4.
KOiK01895.
TreeFamiTF300417.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPEERRKS GSGSRAREET GAEGRVRGWS PPPEVRRSAH VPSLQRYREL
60 70 80 90 100
HRRSVEEPRE FWGNIAKEFY WKTACPGPFL QYNFDVTKGK IFTEWMKGAT
110 120 130 140 150
TNICYNVLDR NVHEKKLGDK VAFYWEGNEP GETTKITYRE LLVQVCQFSN
160 170 180 190 200
VLRKQGIQKG DRVAIYMPMI LELVVAMLAC ARLGALHSIV FAGFSAESLC
210 220 230 240 250
ERILDSSCCL LITTDAFYRG EKLVNLKELA DESLEKCREK GFPVRCCIVV
260 270 280 290 300
KHLGRAELGM NDSPSQSPPV KRPCPDVQIC WNEGVDLWWH ELMQQAGDEC
310 320 330 340 350
EPEWCDAEDP LFILYTSGST GKPKGVVHTI GGYMLYVATT FKYVFDFHPE
360 370 380 390 400
DVFWCTADIG WITGHSYVTY GPLANGATSV LFEGIPTYPD EGRLWSIVDK
410 420 430 440 450
YKVTKFYTAP TAIRMLMKFG DDPVTKHSRA SLQVLGTVGE PINPEAWLWY
460 470 480 490 500
HRVVGSQRCP IVDTFWQTET GGHMLTPLPG ATPMKPGSAS FPFFGVAPAI
510 520 530 540 550
LNESGEELEG EAEGYLVFKQ PWPGIMRTVY GNHTRFETTY FKKFPGYYVT
560 570 580 590 600
GDGCRRDQDG YYWITGRIDD MLNVSGHLLS TAEVESALVE HEAVAEAAVV
610 620 630 640 650
GHPHPVKGEC LYCFVTLCDG HTFSPTLTEE LKKQIREKIG PIATPDYIQN
660 670 680 690 700
APGLPKTRSG KIMRRVLRKI AQNDHDLGDT STVADPSVIN HLFSHRCLTT

Q
Length:701
Mass (Da):78,862
Last modified:July 27, 2011 - v2
Checksum:iD1EA6312CD4527D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti498 – 500PAI → LQS in AAF24510 (PubMed:12049778).Curated3
Sequence conflicti655 – 657PKT → LKP in AAF24510 (PubMed:12049778).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216873 mRNA. Translation: AAF24510.1.
AK053877 mRNA. Translation: BAC35571.1.
AL844852 Genomic DNA. Translation: CAM18931.1.
BC051432 mRNA. Translation: AAH51432.1.
CCDSiCCDS16950.1.
RefSeqiNP_062785.2. NM_019811.3.
UniGeneiMm.255026.

Genome annotation databases

EnsembliENSMUST00000029135; ENSMUSP00000029135; ENSMUSG00000027605.
GeneIDi60525.
KEGGimmu:60525.
UCSCiuc008nku.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216873 mRNA. Translation: AAF24510.1.
AK053877 mRNA. Translation: BAC35571.1.
AL844852 Genomic DNA. Translation: CAM18931.1.
BC051432 mRNA. Translation: AAH51432.1.
CCDSiCCDS16950.1.
RefSeqiNP_062785.2. NM_019811.3.
UniGeneiMm.255026.

3D structure databases

ProteinModelPortaliQ9QXG4.
SMRiQ9QXG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61210N.
STRINGi10090.ENSMUSP00000029135.

Chemistry databases

ChEMBLiCHEMBL2924.

PTM databases

iPTMnetiQ9QXG4.
PhosphoSitePlusiQ9QXG4.

Proteomic databases

EPDiQ9QXG4.
MaxQBiQ9QXG4.
PaxDbiQ9QXG4.
PRIDEiQ9QXG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029135; ENSMUSP00000029135; ENSMUSG00000027605.
GeneIDi60525.
KEGGimmu:60525.
UCSCiuc008nku.1. mouse.

Organism-specific databases

CTDi55902.
MGIiMGI:1890410. Acss2.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.
InParanoidiQ9QXG4.
KOiK01895.
TreeFamiTF300417.

Enzyme and pathway databases

ReactomeiR-MMU-71384. Ethanol oxidation.

Miscellaneous databases

ChiTaRSiAcss2. mouse.
PROiQ9QXG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027605.
CleanExiMM_ACSS2.
ExpressionAtlasiQ9QXG4. baseline and differential.
GenevisibleiQ9QXG4. MM.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSA_MOUSE
AccessioniPrimary (citable) accession number: Q9QXG4
Secondary accession number(s): Q8BK97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.