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Protein

Acetyl-coenzyme A synthetase, cytoplasmic

Gene

Acss2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates acetate so that it can be used for lipid synthesis or for energy generation.

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei363Coenzyme ABy similarity1
Binding sitei552ATPBy similarity1
Binding sitei567ATPBy similarity1
Binding sitei575Coenzyme A; via carbonyl oxygenBy similarity1
Binding sitei636Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi439 – 441ATPBy similarity3
Nucleotide bindingi463 – 468ATPBy similarity6

GO - Molecular functioni

  • acetate-CoA ligase activity Source: MGI
  • AMP binding Source: InterPro
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2151201 Transcriptional activation of mitochondrial biogenesis
R-MMU-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetase, cytoplasmic (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acetyl-CoA synthetase
Short name:
ACS
Short name:
AceCS
Acyl-CoA synthetase short-chain family member 2
Acyl-activating enzyme
Gene namesi
Name:Acss2
Synonyms:Acas2, Acecs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1890410 Acss2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2924

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084241 – 701Acetyl-coenzyme A synthetase, cytoplasmicAdd BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei418N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9QXG4
MaxQBiQ9QXG4
PaxDbiQ9QXG4
PRIDEiQ9QXG4

PTM databases

iPTMnetiQ9QXG4
PhosphoSitePlusiQ9QXG4
SwissPalmiQ9QXG4

Expressioni

Gene expression databases

BgeeiENSMUSG00000027605
CleanExiMM_ACSS2
ExpressionAtlasiQ9QXG4 baseline and differential
GenevisibleiQ9QXG4 MM

Interactioni

Protein-protein interaction databases

DIPiDIP-61210N
IntActiQ9QXG4, 3 interactors
STRINGi10090.ENSMUSP00000029135

Structurei

3D structure databases

ProteinModelPortaliQ9QXG4
SMRiQ9QXG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 222Coenzyme A bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00760000119178
HOGENOMiHOG000229981
HOVERGENiHBG014401
InParanoidiQ9QXG4
KOiK01895
TreeFamiTF300417

Family and domain databases

CDDicd05966 ACS, 1 hit
InterProiView protein in InterPro
IPR011904 Ac_CoA_lig
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QXG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPEERRKS GSGSRAREET GAEGRVRGWS PPPEVRRSAH VPSLQRYREL
60 70 80 90 100
HRRSVEEPRE FWGNIAKEFY WKTACPGPFL QYNFDVTKGK IFTEWMKGAT
110 120 130 140 150
TNICYNVLDR NVHEKKLGDK VAFYWEGNEP GETTKITYRE LLVQVCQFSN
160 170 180 190 200
VLRKQGIQKG DRVAIYMPMI LELVVAMLAC ARLGALHSIV FAGFSAESLC
210 220 230 240 250
ERILDSSCCL LITTDAFYRG EKLVNLKELA DESLEKCREK GFPVRCCIVV
260 270 280 290 300
KHLGRAELGM NDSPSQSPPV KRPCPDVQIC WNEGVDLWWH ELMQQAGDEC
310 320 330 340 350
EPEWCDAEDP LFILYTSGST GKPKGVVHTI GGYMLYVATT FKYVFDFHPE
360 370 380 390 400
DVFWCTADIG WITGHSYVTY GPLANGATSV LFEGIPTYPD EGRLWSIVDK
410 420 430 440 450
YKVTKFYTAP TAIRMLMKFG DDPVTKHSRA SLQVLGTVGE PINPEAWLWY
460 470 480 490 500
HRVVGSQRCP IVDTFWQTET GGHMLTPLPG ATPMKPGSAS FPFFGVAPAI
510 520 530 540 550
LNESGEELEG EAEGYLVFKQ PWPGIMRTVY GNHTRFETTY FKKFPGYYVT
560 570 580 590 600
GDGCRRDQDG YYWITGRIDD MLNVSGHLLS TAEVESALVE HEAVAEAAVV
610 620 630 640 650
GHPHPVKGEC LYCFVTLCDG HTFSPTLTEE LKKQIREKIG PIATPDYIQN
660 670 680 690 700
APGLPKTRSG KIMRRVLRKI AQNDHDLGDT STVADPSVIN HLFSHRCLTT

Q
Length:701
Mass (Da):78,862
Last modified:July 27, 2011 - v2
Checksum:iD1EA6312CD4527D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti498 – 500PAI → LQS in AAF24510 (PubMed:12049778).Curated3
Sequence conflicti655 – 657PKT → LKP in AAF24510 (PubMed:12049778).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216873 mRNA Translation: AAF24510.1
AK053877 mRNA Translation: BAC35571.1
AL844852 Genomic DNA No translation available.
BC051432 mRNA Translation: AAH51432.1
CCDSiCCDS16950.1
RefSeqiNP_062785.2, NM_019811.3
UniGeneiMm.255026

Genome annotation databases

EnsembliENSMUST00000029135; ENSMUSP00000029135; ENSMUSG00000027605
GeneIDi60525
KEGGimmu:60525
UCSCiuc008nku.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACSA_MOUSE
AccessioniPrimary (citable) accession number: Q9QXG4
Secondary accession number(s): Q8BK97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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