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Protein

F-box-like/WD repeat-containing protein TBL1X

Gene

Tbl1x

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • histone binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • canonical Wnt signaling pathway Source: MGI
  • fat cell differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
  • proteolysis Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to estrogen Source: MGI
  • response to steroid hormone Source: MGI
  • sensory perception of sound Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1X
Alternative name(s):
Transducin beta-like protein 1X
Gene namesi
Name:Tbl1x
Synonyms:Tbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1336172. Tbl1x.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 527526F-box-like/WD repeat-containing protein TBL1XPRO_0000051265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QXE7.
MaxQBiQ9QXE7.
PaxDbiQ9QXE7.
PRIDEiQ9QXE7.

PTM databases

iPTMnetiQ9QXE7.
PhosphoSiteiQ9QXE7.

Expressioni

Tissue specificityi

Expressed in the cochlea.1 Publication

Gene expression databases

BgeeiQ9QXE7.
CleanExiMM_TBL1X.
GenevisibleiQ9QXE7. MM.

Interactioni

Subunit structurei

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203977. 3 interactions.
IntActiQ9QXE7. 1 interaction.
STRINGi10090.ENSMUSP00000085549.

Structurei

3D structure databases

ProteinModelPortaliQ9QXE7.
SMRiQ9QXE7. Positions 2-75, 165-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 3633LisHPROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8646F-box-likeAdd
BLAST
Repeati180 – 21940WD 1Add
BLAST
Repeati236 – 27540WD 2Add
BLAST
Repeati277 – 31640WD 3Add
BLAST
Repeati319 – 35941WD 4Add
BLAST
Repeati360 – 39940WD 5Add
BLAST
Repeati402 – 45049WD 6Add
BLAST
Repeati453 – 49240WD 7Add
BLAST
Repeati494 – 52633WD 8Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi108 – 12114Poly-AlaAdd
BLAST
Compositional biasi130 – 1334Poly-Ala

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated
Contains 1 F-box-like domain.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0273. Eukaryota.
ENOG410XRSY. LUCA.
GeneTreeiENSGT00750000117536.
HOGENOMiHOG000220902.
InParanoidiQ9QXE7.
KOiK04508.
OMAiTPKNGEA.
OrthoDBiEOG79CXZ3.
PhylomeDBiQ9QXE7.
TreeFamiTF323190.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI
60 70 80 90 100
SILQKGLQYV EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR
110 120 130 140 150
EKLAQQQANA AAAAAAAAAT ATSTAATTPA AAAQQNPPKN GEATVNGEEN
160 170 180 190 200
GAHAINNHSK PMEIDGDVEI PPSKATVLRG HESEVFICAW NPVSDLLASG
210 220 230 240 250
SGDSTARIWN LNENSNGGST QLVLRHCIRE GGHDVPSNKD VTSLDWNSDG
260 270 280 290 300
TLLATGSYDG FARIWTEDGN LASTLGQHKG PIFALKWNKK GNYILSAGVD
310 320 330 340 350
KTTIIWDAHT GEAKQQFPFH SAPALDVDWQ NNTTFASCST DMCIHVCRLG
360 370 380 390 400
CDRPVKTFQG HTNEVNAIKW DPSGMLLASC SDDMTLKIWS MKQDACVHDL
410 420 430 440 450
QAHSKEIYTI KWSPTGPATS NPNSNIMLAS ASFDSTVRLW DVERGVCIHT
460 470 480 490 500
LTKHQEPVYS VAFSPDGKYL ASGSFDKCVH IWNTQSGSLV HSYRGTGGIF
510 520
EVCWNARGDK VGASASDGSV CVLDLRK
Length:527
Mass (Da):56,802
Last modified:April 26, 2004 - v2
Checksum:i146435A9C51DFDA6
GO

Sequence cautioni

The sequence CAB61534.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041A → T in BAC27015 (PubMed:16141072).Curated
Sequence conflicti349 – 3491L → H in BAC27612 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030547 mRNA. Translation: BAC27015.1.
AK031937 mRNA. Translation: BAC27612.1.
AK038674 mRNA. Translation: BAC30092.1.
BC043105 mRNA. Translation: AAH43105.1.
F38006 Genomic DNA. Translation: CAB61534.1. Sequence problems.
CCDSiCCDS41036.1.
RefSeqiNP_065626.1. NM_020601.2.
XP_006528002.1. XM_006527939.1.
UniGeneiMm.258476.
Mm.392769.

Genome annotation databases

EnsembliENSMUST00000088217; ENSMUSP00000085549; ENSMUSG00000025246.
GeneIDi21372.
KEGGimmu:21372.
UCSCiuc009tqo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030547 mRNA. Translation: BAC27015.1.
AK031937 mRNA. Translation: BAC27612.1.
AK038674 mRNA. Translation: BAC30092.1.
BC043105 mRNA. Translation: AAH43105.1.
F38006 Genomic DNA. Translation: CAB61534.1. Sequence problems.
CCDSiCCDS41036.1.
RefSeqiNP_065626.1. NM_020601.2.
XP_006528002.1. XM_006527939.1.
UniGeneiMm.258476.
Mm.392769.

3D structure databases

ProteinModelPortaliQ9QXE7.
SMRiQ9QXE7. Positions 2-75, 165-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203977. 3 interactions.
IntActiQ9QXE7. 1 interaction.
STRINGi10090.ENSMUSP00000085549.

PTM databases

iPTMnetiQ9QXE7.
PhosphoSiteiQ9QXE7.

Proteomic databases

EPDiQ9QXE7.
MaxQBiQ9QXE7.
PaxDbiQ9QXE7.
PRIDEiQ9QXE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088217; ENSMUSP00000085549; ENSMUSG00000025246.
GeneIDi21372.
KEGGimmu:21372.
UCSCiuc009tqo.1. mouse.

Organism-specific databases

CTDi6907.
MGIiMGI:1336172. Tbl1x.

Phylogenomic databases

eggNOGiKOG0273. Eukaryota.
ENOG410XRSY. LUCA.
GeneTreeiENSGT00750000117536.
HOGENOMiHOG000220902.
InParanoidiQ9QXE7.
KOiK04508.
OMAiTPKNGEA.
OrthoDBiEOG79CXZ3.
PhylomeDBiQ9QXE7.
TreeFamiTF323190.

Miscellaneous databases

NextBioi300588.
PROiQ9QXE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QXE7.
CleanExiMM_TBL1X.
GenevisibleiQ9QXE7. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus, Medulla oblongata and Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Botcherby M.R.M., Straw R., Clarke D., Greystrong J.S., Weston P., Hunter G., Kimberly C., Rhodes M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 200-527.
    Strain: 129/SvJ.
  4. "X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats."
    Bassi M.T., Ramesar R.S., Caciotti B., Winship I.M., De Grandi A., Riboni M., Townes P.L., Beighton P., Ballabio A., Borsani G.
    Am. J. Hum. Genet. 64:1604-1616(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiTBL1X_MOUSE
AccessioniPrimary (citable) accession number: Q9QXE7
Secondary accession number(s): Q8BMM0, Q8BYQ4, Q8C0A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 26, 2004
Last modified: May 11, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.