Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box-like/WD repeat-containing protein TBL1X

Gene

Tbl1x

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • histone binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: MGI
  • transcription corepressor activity Source: MGI
  • transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  • canonical Wnt signaling pathway Source: MGI
  • fat cell differentiation Source: MGI
  • histone deacetylation Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
  • proteolysis Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to estrogen Source: MGI
  • response to steroid hormone Source: MGI
  • sensory perception of sound Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1X
Alternative name(s):
Transducin beta-like protein 1X
Gene namesi
Name:Tbl1x
Synonyms:Tbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1336172. Tbl1x.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000512652 – 527F-box-like/WD repeat-containing protein TBL1XAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QXE7.
MaxQBiQ9QXE7.
PaxDbiQ9QXE7.
PeptideAtlasiQ9QXE7.
PRIDEiQ9QXE7.

PTM databases

iPTMnetiQ9QXE7.
PhosphoSitePlusiQ9QXE7.

Expressioni

Tissue specificityi

Expressed in the cochlea.1 Publication

Gene expression databases

BgeeiENSMUSG00000025246.
CleanExiMM_TBL1X.
GenevisibleiQ9QXE7. MM.

Interactioni

Subunit structurei

Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203977. 4 interactors.
DIPiDIP-62055N.
IntActiQ9QXE7. 1 interactor.
STRINGi10090.ENSMUSP00000085549.

Structurei

3D structure databases

ProteinModelPortaliQ9QXE7.
SMRiQ9QXE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 36LisHPROSITE-ProRule annotationAdd BLAST33
Domaini41 – 86F-box-likeAdd BLAST46
Repeati180 – 219WD 1Add BLAST40
Repeati236 – 275WD 2Add BLAST40
Repeati277 – 316WD 3Add BLAST40
Repeati319 – 359WD 4Add BLAST41
Repeati360 – 399WD 5Add BLAST40
Repeati402 – 450WD 6Add BLAST49
Repeati453 – 492WD 7Add BLAST40
Repeati494 – 526WD 8Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 121Poly-AlaAdd BLAST14
Compositional biasi130 – 133Poly-Ala4

Domaini

The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated
Contains 1 F-box-like domain.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0273. Eukaryota.
ENOG410XRSY. LUCA.
GeneTreeiENSGT00860000133748.
HOGENOMiHOG000220902.
InParanoidiQ9QXE7.
KOiK04508.
OMAiTPKNGEA.
OrthoDBiEOG091G04MW.
PhylomeDBiQ9QXE7.
TreeFamiTF323190.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI
60 70 80 90 100
SILQKGLQYV EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR
110 120 130 140 150
EKLAQQQANA AAAAAAAAAT ATSTAATTPA AAAQQNPPKN GEATVNGEEN
160 170 180 190 200
GAHAINNHSK PMEIDGDVEI PPSKATVLRG HESEVFICAW NPVSDLLASG
210 220 230 240 250
SGDSTARIWN LNENSNGGST QLVLRHCIRE GGHDVPSNKD VTSLDWNSDG
260 270 280 290 300
TLLATGSYDG FARIWTEDGN LASTLGQHKG PIFALKWNKK GNYILSAGVD
310 320 330 340 350
KTTIIWDAHT GEAKQQFPFH SAPALDVDWQ NNTTFASCST DMCIHVCRLG
360 370 380 390 400
CDRPVKTFQG HTNEVNAIKW DPSGMLLASC SDDMTLKIWS MKQDACVHDL
410 420 430 440 450
QAHSKEIYTI KWSPTGPATS NPNSNIMLAS ASFDSTVRLW DVERGVCIHT
460 470 480 490 500
LTKHQEPVYS VAFSPDGKYL ASGSFDKCVH IWNTQSGSLV HSYRGTGGIF
510 520
EVCWNARGDK VGASASDGSV CVLDLRK
Length:527
Mass (Da):56,802
Last modified:April 26, 2004 - v2
Checksum:i146435A9C51DFDA6
GO

Sequence cautioni

The sequence CAB61534 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104A → T in BAC27015 (PubMed:16141072).Curated1
Sequence conflicti349L → H in BAC27612 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030547 mRNA. Translation: BAC27015.1.
AK031937 mRNA. Translation: BAC27612.1.
AK038674 mRNA. Translation: BAC30092.1.
BC043105 mRNA. Translation: AAH43105.1.
F38006 Genomic DNA. Translation: CAB61534.1. Sequence problems.
CCDSiCCDS41036.1.
RefSeqiNP_065626.1. NM_020601.2.
XP_006528002.1. XM_006527939.2.
UniGeneiMm.258476.
Mm.392769.

Genome annotation databases

EnsembliENSMUST00000088217; ENSMUSP00000085549; ENSMUSG00000025246.
GeneIDi21372.
KEGGimmu:21372.
UCSCiuc009tqo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030547 mRNA. Translation: BAC27015.1.
AK031937 mRNA. Translation: BAC27612.1.
AK038674 mRNA. Translation: BAC30092.1.
BC043105 mRNA. Translation: AAH43105.1.
F38006 Genomic DNA. Translation: CAB61534.1. Sequence problems.
CCDSiCCDS41036.1.
RefSeqiNP_065626.1. NM_020601.2.
XP_006528002.1. XM_006527939.2.
UniGeneiMm.258476.
Mm.392769.

3D structure databases

ProteinModelPortaliQ9QXE7.
SMRiQ9QXE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203977. 4 interactors.
DIPiDIP-62055N.
IntActiQ9QXE7. 1 interactor.
STRINGi10090.ENSMUSP00000085549.

PTM databases

iPTMnetiQ9QXE7.
PhosphoSitePlusiQ9QXE7.

Proteomic databases

EPDiQ9QXE7.
MaxQBiQ9QXE7.
PaxDbiQ9QXE7.
PeptideAtlasiQ9QXE7.
PRIDEiQ9QXE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088217; ENSMUSP00000085549; ENSMUSG00000025246.
GeneIDi21372.
KEGGimmu:21372.
UCSCiuc009tqo.1. mouse.

Organism-specific databases

CTDi6907.
MGIiMGI:1336172. Tbl1x.

Phylogenomic databases

eggNOGiKOG0273. Eukaryota.
ENOG410XRSY. LUCA.
GeneTreeiENSGT00860000133748.
HOGENOMiHOG000220902.
InParanoidiQ9QXE7.
KOiK04508.
OMAiTPKNGEA.
OrthoDBiEOG091G04MW.
PhylomeDBiQ9QXE7.
TreeFamiTF323190.

Enzyme and pathway databases

ReactomeiR-MMU-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Miscellaneous databases

PROiQ9QXE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025246.
CleanExiMM_TBL1X.
GenevisibleiQ9QXE7. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBL1X_MOUSE
AccessioniPrimary (citable) accession number: Q9QXE7
Secondary accession number(s): Q8BMM0, Q8BYQ4, Q8C0A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 26, 2004
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.